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This is a non-core endpoint: only basic statistics are computed.

Methaemoglobinaemia

D3_METHAEMOGLOBINAEMIA

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D74
  • Hospital discharge: ICD-9 2897
  • Hospital discharge: ICD-8 2899[0-1]
  • Cause of death: ICD-10 D74
  • Cause of death: ICD-9 2897
  • Cause of death: ICD-8 2899[0-1]

2 out of 7 registries used, show all original rules.

21

4. Check minimum number of events

None

21

5. Include endpoints

None

21

6. Filter based on genotype QC (FinnGen only)

21

Control definitions (FinnGen only)

Control exclude
D3_BLOODOTHER

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D70-D77
Name in latin
Methaemoglobinaemia

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 197 104 91
Only index persons 156 85 71
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population 50.48 45.57 56.13
Only index persons 47.06 45.19 49.30

-FinnGen-

Key figures

All Female Male
Number of individuals 21 12 9
Unadjusted period prevalence (%) 0.00 0.00 0.00
Median age at first event (years) 45.89 32.72 63.45

-FinRegistry-

Age distribution of first events

01020304050607080900246810121416182022242628AgeIndividuals

-FinnGen-

Age distribution of first events

03050012345678910AgeIndividuals

-FinRegistry-

Year distribution of first events

197519801985199019952000200520102015202020220510152025303540YearIndividuals

-FinnGen-

Year distribution of first events

200020102023012345678910YearIndividuals

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
10
41
3.75
2.14
6.0
4.3
—
—
—
0
0
6
18
4.23
1.90
1.5
1.5
—
—
—
0
0
5
19
3.12
1.29
2.0
1.4
—
—
—
0
0
12
160
0.42
1.17
29.5
18.0
332.25
332.96
g/l
0.07
12
160
5
21
2.80
1.16
1.4
1.9
—
—
—
0
0
0
32
0.00
1.05
0.0
2.2
—
—
—
0
0
8
43
2.38
1.03
3.0
3.5
—
—
—
0
0
8
44
2.31
1.01
6.9
4.6
—
—
—
0
0
11
69
2.25
0.92
3.6
4.0
—
—
—
0
0
5
24
2.41
0.81
1.6
1.2
—
—
—
0
0
7
44
1.88
0.57
2.7
2.8
381.43
9588.51
umol/l
—
7
35
7
47
1.73
0.55
5.4
5.7
—
—
—
0
0
7
50
1.60
0.37
3.6
3.6
—
—
—
0
0
13
112
1.42
0.30
13.3
4.1
7.20
6.71
mmol/l
0.24
13
96
5
38
1.41
0.25
2.0
1.9
23.04
25.84
nmol/l
—
5
31
5
40
1.33
0.24
2.6
9.1
—
—
—
0
0
0
10
0.00
0.22
0.0
5.6
—
—
—
0
0
0
12
0.00
0.22
0.0
1.6
—
—
—
0
0
0
12
0.00
0.22
0.0
1.7
—
—
—
0
0
0
12
0.00
0.22
0.0
1.6
—
—
—
0
0
0
12
0.00
0.22
0.0
1.3
—
—
—
0
0
7
57
1.34
0.21
3.3
2.5
—
—
—
0
0
7
57
1.34
0.21
2.1
1.9
—
—
—
0
0
0
14
0.00
0.21
0.0
1.4
—
—
—
0
0
16
164
0.90
0.10
8.1
5.4
42.00
39.20
mmol/mol
0.50
16
156
5
46
1.11
0.10
2.4
3.0
—
—
—
0
0
5
59
0.80
0.10
3.0
1.7
—
—
—
0
0
7
64
1.14
0.09
3.6
3.3
—
—
—
0
0
12
112
1.17
0.09
4.0
3.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
19.40
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
5
54
0.90
0.00
1.6
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
8.7
—
—
—
0
0
0
6
0.00
0.00
0.0
3.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
16
162
0.95
0.00
24.2
15.1
39.67
40.39
%
—
6
112
5
52
0.95
0.00
3.2
3.0
9.58
1161.61
e6/l
—
5
43
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
12
116
1.08
0.00
9.0
4.3
—
—
—
0
0
0
7
0.00
0.00
0.0
3.1
—
2.59
—
0
7
5
48
1.05
0.00
3.0
2.9
1.31
0.55
e6/l
—
5
40
5
49
1.03
0.00
1.4
1.8
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint D3_METHAEMOGLOBINAEMIA and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_METHAEMOGLOBINAEMIA.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: D3_METHAEMOGLOBINAEMIA – Methaemoglobinaemia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
1
-
-
-
-
-
9
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
12
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
1
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
35
-
-
0 (0.00)
-
-
1
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
1
-
-
0 (0.00)
-
-
-
-
-
-
-
-
3
-
-
0 (0.00)
-
-
1
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
0 (0.00)
-
-
1
-
-
0 (0.00)
-
-
2
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
1
-
-
0 (0.00)
-
-
-
-
-
12 (0.01)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
9 (0.01)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
1
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
5
-
-
0 (0.00)
-
-
1
-
-
0 (0.00)
-
-
12
-
-
-
-
-
-
-
-
0 (0.00)
-
-
1
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
5 (0.01)
-
-
-
-
-
0 (0.00)
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
0 (0.00)
-
-
6
-
-
-
-
-
2
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
8
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
1
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
14 (0.01)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
14
-
-
0 (0.00)
-
-
1
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
1
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
1
-
-
0 (0.00)
-
-
6
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
1
-
-
0 (0.00)
-
-
9
-
-
-
-
-
-
-
-
0 (0.00)
-
-
1
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
2
-
-
0 (0.00)
-
-
-
-
-
15 (0.01)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
10
-
-
-
-
-
-
-
-
14 (0.01)
-
-
-
-
-
0 (0.00)
-
-
2
-
-
13 (0.01)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
2
-
-
0 (0.00)
-
-
-
-
-
-
-
-
6
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
1
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
1
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
5
-
-
13 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
21
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
1
-
-
0 (0.00)
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
0 (0.00)
-
-
1
-
-
0 (0.00)
-
-
4
-
-
-
-
-
5
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
27
-
-
-
-
-
1
-
-
-
-
-
-
-
-
0 (0.00)
-
-
3
-
-
-
-
-
48
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
12
-
-
0 (0.00)
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
1
-
-
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131
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78
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327
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300
-
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392
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80 (0.01)
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77 (0.00)
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88 (0.00)
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124 (0.00)
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-
-
101
-
140 (0.00)
-
-
-
33
-