Duodenal ulcer - Chronic without haemorrhage or perforation, drug-induced

DUODENAL_ULCER_CHRONIC_WO_HAEMORRHAGE_PERFORATION

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ATC codes for adverse effects of Drugs — ANY Hospital discharge: ICD-10 — K26.7# 1 out of 7 registries used, show all original rules.	46
4. Check minimum number of events None	46
5. Include endpoints None	46
6. Filter based on genotype QC (FinnGen only)	46

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	DUODENAL_ULCER_CHRONIC_WO_HAEMORRHAGE_PERFORATION
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC	ANY
HD_ICD_10	K267
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Duodenal ulcer - Chronic without haemorrhage or perforation, drug-induced based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	46	20	26
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	51.92	50.61	52.92

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(36304419) Bacteria [Presence] in Urine

103

2.91

3.04

2.6

2.7

—

(1616796) Gas panel - Central venous blood

9.14

2.82

4.6

4.8

—

(3026008) Bacteria identified in Urine by Culture

113

2.36

2.03

2.8

3.0

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

0.00

1.82

0.0

5.4

—

31.0

—

(40761536) Microorganisms panel - Urine sediment

2.90

1.75

3.6

4.5

—

(3037467) Urinalysis macro (dipstick) panel - Urine

243

2.27

1.67

4.4

—

(3049717) Cytology report of Urine Cyto stain

3.60

1.56

2.4

4.1

—

(3029937) Albumin [Presence] in Urine by Test strip

100

2.11

1.50

4.1

4.8

0.0

estimate

—

(3023368) Bacteria identified in Blood by Culture

2.10

1.45

4.0

4.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.35

1.40

1.9

1.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.29

1.36

1.4

1.7

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

2.72

1.35

1.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.18

1.25

2.1

1.7

—

(3019225) pH of Specimen

0.00

1.20

0.0

3.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

135

1.85

1.16

3.5

3.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

129

1.81

1.06

2.1

1.7

79.4

98.1

pmol/l

—

(3015736) pH of Urine

130

1.79

1.03

3.5

4.0

—

(42870588) Differential panel, method unspecified - Blood

104

1.83

1.02

6.5

5.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

159

1.74

0.98

4.2

3.9

—

(3002256) Pathology report gross observation

2.09

0.95

1.3

1.2

—

(40758558) Short blood count panel - Blood

1.80

0.92

8.4

6.4

—

(40768797) Stomach Pathology biopsy report

1.89

0.88

1.4

1.2

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.81

0.85

3.6

4.3

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.00

0.82

0.0

2.3

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

148

1.62

0.78

4.8

4.2

35.1

34.7

g/l

0.11

142

(3014111) Lactate [Moles/volume] in Serum or Plasma

2.21

0.77

1.6

4.8

1.3

mmol/l

—

(3000991) Gas panel - Venous blood

2.03

0.73

1.4

6.3

—

(3003694) ABO and Rh group [Type] in Blood

1.70

0.71

1.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.82

0.60

1.3

1.5

—

(3013512) EKG study

107

0.59

0.57

3.3

3.7

—

(3022145) Colonoscopy Study observation

1.66

0.57

1.3

—

(3035350) Ketones [Presence] in Urine by Test strip

170

1.43

0.50

3.8

4.1

0.0

estimate

—

(3021601) Nitrite [Presence] in Urine by Test strip

171

1.42

0.48

4.2

5.0

0.0

estimate

—

(3042936) Bacteria identified in Isolate by Culture

1.47

0.47

2.1

—

(3044889) 12 lead EKG panel

251

1.42

0.46

5.3

4.0

—

(40761511) CBC panel - Blood by Automated count

357

1.61

0.46

22.1

14.8

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.42

0.0

1.7

—

43.0

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.41

0.0

2.7

—

1.6

—

(3025941) Bacteria identified in Stool by Culture

0.00

0.41

0.0

1.2

—

(3009261) Glucose [Presence] in Urine by Test strip

175

1.37

0.40

3.9

4.0

0.0

estimate

—

(3019150) Specific gravity of Urine by Refractometry

1.47

0.38

4.5

5.4

—

1.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.45

0.36

4.7

5.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

168

1.34

0.36

3.1

2.8

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

354

1.42

0.34

4.7

5.5

2.5

2.6

mmol/l

0.60

315

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

117

0.71

0.32

3.8

334.8

1905.7

ng/l

—

(3032080) INR in Blood by Coagulation assay

152

1.30

0.30

8.6

8.9

1.2

inr

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.38

0.29

1.4

2.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

135

1.28

0.26

4.4

4.3

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

361

1.30

0.24

23.4

17.1

139.4

139.8

mmol/l

0.48

349

(3026493) Urate [Moles/volume] in Serum or Plasma

111

0.77

0.23

2.4

2.7

383.2

10713.7

umol/l

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

0.00

0.21

0.0

1.5

—

24.1

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.21

0.0

2.2

—

(1002224) Polysomnography panel

0.00

0.21

0.0

1.2

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.21

0.0

2.3

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.6

—

(3022217) INR in Platelet poor plasma by Coagulation assay

1.29

0.21

35.7

24.1

—

1.6

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.21

0.0

1.0

—

(3020961) Endomysium IgA Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

365

1.24

0.15

22.8

18.1

76.4

81.7

umol/l

0.73

365

(3023103) Potassium [Moles/volume] in Serum or Plasma

362

1.29

0.15

23.5

17.2

4.0

mmol/l

0.63

349

(3044640) Blood type and Crossmatch panel - Blood

105

1.19

0.12

1.8

2.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

295

1.16

0.11

22.6

15.0

41.5

40.4

0.46

193

(1761868) Lipid panel - Serum or Plasma

122

0.87

0.08

3.5

3.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

100

0.88

0.07

4.0

3.5

—

(3012516) Albumin [Mass/volume] in Urine

100

1.13

0.06

3.7

3.0

25.0

55.1

mg/l

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

126

0.94

0.01

4.8

4.3

27.1

21.3

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

341

0.99

0.00

4.6

4.9

6.1

mmol/l

0.05

309

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

325

1.05

0.00

19.3

14.6

79.0

77.3

ml/min/173m2

0.18

266

(40768804) Tissue Pathology biopsy report

136

1.04

0.00

2.7

2.0

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

156

1.04

0.00

5.6

4.8

19.7

56.6

ng/l

1.38

116

(3020682) Albumin/Creatinine [Ratio] in Urine

108

1.02

0.00

5.2

3.7

2.4

7.6

mg/mmol

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

332

0.98

0.00

5.7

6.0

40.5

40.7

mmol/mol

0.04

306

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.0

1.0

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.1

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.2

—

(4062490)

0.00

0.0

1.4

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

2.0

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.0

2.2

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.3

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

2.4

—

107.4

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.2

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.3

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

2.3

—

(3003181) Sodium [Moles/volume] in Urine

0.00

0.0

1.3

—

44.8

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.2

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.0

1.0

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.0

1.0

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

1.3

—

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.0

1.8

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

2.4

—

4.0

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

0.0

1.4

—

34.8

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

0.00

0.0

2.4

—

80.6

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

2.0

—

1.2

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.0

1.0

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

4.5

—

230.5

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

0.00

0.0

2.9

—

3.1

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.0

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

2.0

—

6.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

5.2

—

214.2

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.0

7.8

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.0

5.2

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

2.0

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.0

1.0

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.2

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

2.4

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

3.8

—

20.6

—

Mortality – FinRegistry

↥

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

↥

Index endpoint: DUODENAL_ULCER_CHRONIC_WO_HAEMORRHAGE_PERFORATION – Duodenal ulcer - Chronic without haemorrhage or perforation, drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Duodenal ulcer - Chronic without haemorrhage or perforation, drug-induced

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Duodenal ulcer - Chronic without haemorrhage or perforation, drug-induced (DUODENAL_ULCER_CHRONIC_WO_HAEMORRHAGE_PERFORATION)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints