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Duodenal ulcer - Unspecified as acute or chronic, without haemorrhage or perforation, drug-induced

Endpoint Browser PheWeb

DUODENAL_ULCER_UNSPE_ACUTE_CHRONIC_WO_HAEMORRHAGE_PERFORATION

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ATC codes for adverse effects of Drugs — ANY
  • Hospital discharge: ICD-10 — K26.9#

1 out of 7 registries used, show all original rules.

137

4. Check minimum number of events

None

137

5. Include endpoints

None

137

6. Filter based on genotype QC (FinnGen only)

131

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

All Female Male
Number of individuals 131 46 85
Unadjusted period prevalence (%) 0.03 0.02 0.04
Median age at first event (years) 55.94 54.60 56.66

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
137
Matched controls
1370
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K26.9
ICD-10 Finland
Duodenal ulcer, unspecified as acute or chronic, without haemorrhage or perforation
+∞
186.6
137
7
UJD02
NOMESCO Finland
Gastroscopy
20.4
49.9
43
30
A02BA02
ATC
ranitidine; systemic
6.3
26.4
74
214
A02BC01
ATC
omeprazole; systemic
6.0
24.5
84
286
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.0
19.7
76
274
A02BX
ATC
Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)
32.4
17.1
22
8
A02BC03
ATC
lansoprazole; oral
4.3
15.9
72
283
A02BD01
ATC
omeprazole, amoxicillin and metronidazole; systemic
41.7
12.5
15
*
A02BD03
ATC
lansoprazole, amoxicillin and metronidazole; systemic
5.2
11.9
28
65
A02BA04
ATC
nizatidine; systemic
4.9
10.4
26
63
K26.0
ICD-10 Finland
Duodenal ulcer, acute with haemorrhage
59.3
9.8
11
*
P01AB01
ATC
metronidazole; oral, rectal
2.7
7.5
65
343
A02BA07
ATC
ranitidine bismuth citrate; oral
73.1
6.5
7
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
17
353
0.41
3.11
6.0
4.6
—
—
—
0
0
13
53
2.61
2.35
9.0
9.0
—
—
—
0
0
16
300
0.47
2.15
4.4
3.5
—
—
—
0
0
29
177
1.81
1.97
2.5
1.9
—
—
—
0
0
37
247
1.68
1.84
6.2
7.2
—
—
—
0
0
9
36
2.60
1.77
3.7
3.6
—
—
—
0
0
19
308
0.56
1.58
4.7
4.4
0.00
0.00
estimate
—
5
102
0
45
0.00
1.53
0.0
1.6
—
—
—
0
0
19
302
0.57
1.47
3.8
4.2
—
—
—
0
0
5
16
3.20
1.45
1.4
1.6
—
—
—
0
0
8
36
2.30
1.26
9.9
12.6
—
—
—
0
0
13
71
1.92
1.24
1.7
1.3
—
—
—
0
0
18
114
1.67
1.09
2.3
1.8
—
—
—
0
0
5
107
0.45
1.06
2.4
4.0
1.24
1.21
mmol/l
—
5
89
18
267
0.62
1.05
2.3
1.7
459.44
434.80
pmol/l
0.21
18
218
32
236
1.46
1.02
3.7
3.8
—
—
—
0
0
18
118
1.60
0.97
1.5
1.4
—
—
—
0
0
5
105
0.46
0.93
2.6
4.4
—
—
—
0
0
8
44
1.87
0.87
1.1
1.3
132.45
141.75
u/ml
—
8
38
81
713
1.33
0.87
4.1
4.6
—
—
—
0
0
7
121
0.56
0.82
1.1
1.4
—
—
—
0
0
20
141
1.49
0.80
7.3
7.0
12.99
11.44
kpa
0.47
20
134
20
141
1.49
0.80
7.3
7.0
5.05
5.00
kpa
0.15
20
134
18
125
1.51
0.77
7.2
7.5
92.89
94.82
%
0.19
18
120
25
186
1.42
0.77
2.7
3.0
1.13
2.52
e6/l
0.86
18
111
56
474
1.31
0.77
6.6
5.9
0.61
0.61
e9/l
0.06
51
412
56
475
1.30
0.76
6.6
5.9
0.04
0.04
e9/l
0.10
51
413
57
488
1.29
0.71
6.8
6.0
1.79
1.83
e9/l
0.07
51
437
52
440
1.29
0.71
2.0
2.1
96.53
88.57
pmol/l
0.62
26
220
5
28
1.81
0.67
1.0
1.1
—
—
—
0
0
43
360
1.28
0.63
4.3
4.6
—
—
—
0
0
14
97
1.49
0.62
10.1
9.1
—
—
—
0
0
42
494
0.78
0.61
4.0
4.3
36.30
43.90
ng/l
0.32
31
395
82
893
0.80
0.60
4.1
4.4
1.31
1.28
mmol/l
0.13
77
794
32
388
0.77
0.59
2.5
2.3
—
—
—
0
0
8
121
0.64
0.58
1.0
1.3
—
—
—
0
0
56
489
1.25
0.57
6.7
6.2
0.19
0.19
e9/l
0.04
50
430
9
59
1.56
0.56
1.6
1.4
—
—
—
0
0
13
91
1.47
0.55
4.3
3.7
—
—
—
0
0
6
39
1.56
0.53
1.3
1.8
—
—
—
0
0
39
333
1.24
0.48
2.1
3.1
1.17
0.41
e6/l
1.04
32
257
42
362
1.23
0.48
2.5
3.7
2.32
2.35
mmol/l
0.75
37
312
37
315
1.24
0.47
2.1
3.0
—
—
—
0
0
11
151
0.70
0.46
1.5
3.3
1.59
1.73
%
0.23
11
130
7
51
1.39
0.44
2.9
4.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
3.4
—
—
—
0
0
0
19
0.00
0.39
0.0
2.2
—
—
—
0
0
9
67
1.37
0.39
2.8
5.0
—
—
—
0
0
47
523
0.85
0.37
6.1
5.7
0.00
0.00
estimate
—
5
108
27
228
1.23
0.37
2.2
3.3
2.48
2.46
mmol/l
0.23
20
201
10
134
0.73
0.37
1.2
1.2
0.84
14.15
u/ml
—
5
45
50
450
1.17
0.36
9.0
11.3
0.00
0.01
e9/l
0.54
44
376
79
739
1.16
0.34
3.7
4.4
17.36
14.35
mm/h
0.47
74
659
54
588
0.87
0.32
16.8
15.4
1.49
1.31
inr
—
7
178
11
84
1.34
0.31
2.3
1.5
—
—
—
0
0
46
416
1.16
0.30
3.3
3.9
120.69
95.46
e6/l
0.08
35
313
48
525
0.87
0.29
4.0
4.2
0.00
0.01
estimate
—
7
117
7
57
1.24
0.29
1.0
1.1
—
—
—
0
0
10
76
1.34
0.29
3.7
2.4
—
—
—
0
0
37
411
0.86
0.28
3.8
4.1
—
5.95
—
0
30
88
921
0.88
0.27
4.6
4.9
1.40
1.42
mmol/l
0.19
83
821
41
371
1.15
0.27
2.4
3.4
14.20
231.58
e6/l
0.71
33
295
21
244
0.84
0.27
1.3
1.3
—
—
—
0
0
6
81
0.73
0.25
1.5
1.3
—
—
—
0
0
38
345
1.14
0.24
3.9
3.8
7.05
8.18
mg/mmol
0.11
31
223
8
104
0.76
0.22
2.1
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
2.1
—
10.91
—
0
11
0
11
0.00
0.21
0.0
3.5
—
2.00
—
0
6
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
33.59
—
0
10
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
3.4
—
32.08
—
0
12
0
12
0.00
0.21
0.0
3.2
—
—
—
0
0
77
734
1.11
0.21
4.1
4.4
—
—
—
0
0
68
644
1.11
0.21
5.2
5.1
7.36
6.89
mmol/l
0.60
62
608
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
3.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
26
289
0.88
0.20
1.8
2.9
17449.65
11403.73
umol/l
0.13
26
234
10
81
1.25
0.19
5.5
6.1
25.11
24.53
mmol/l
—
10
76
7
62
1.14
0.17
1.3
2.5
3.53
8.95
e9/l
—
7
46
48
450
1.10
0.17
6.3
6.7
—
—
—
0
0
28
307
0.89
0.17
3.0
3.3
0.65
0.83
ug/l
0.78
22
212
30
275
1.12
0.16
2.5
2.1
2.67
3.10
mg/l
0.57
25
231
9
79
1.15
0.15
8.1
4.6
128.18
88.24
ng/l
—
9
67
7
90
0.77
0.15
1.6
3.8
—
—
—
0
0
103
1053
0.91
0.13
30.2
25.7
37.68
39.43
%
1.09
95
975
49
510
0.94
0.09
5.0
5.6
1.98
2.93
ug/l
0.75
44
448
5
48
1.04
0.09
4.2
5.6
—
—
—
0
0
34
323
1.07
0.08
3.4
3.1
53.41
244.36
mg/l
0.48
26
212
34
357
0.94
0.08
2.5
3.3
—
—
—
0
0
101
1026
0.94
0.07
21.6
21.0
84.87
84.66
umol/l
0.02
101
1026
7
83
0.84
0.07
1.4
1.6
—
—
—
0
0
9
83
1.09
0.07
2.6
1.6
—
—
—
0
0
10
90
1.12
0.05
2.1
1.9
—
—
—
0
0
11
100
1.11
0.05
1.7
2.1
335.18
406.15
nmol/l
0.75
11
86
71
697
1.04
0.04
2.8
3.7
14.41
14.96
pmol/l
1.11
66
596
88
868
1.04
0.04
3.9
4.5
1.96
2.09
mu/l
0.55
83
745
35
339
1.04
0.04
2.8
2.5
—
—
—
0
0
98
970
1.04
0.03
20.6
18.1
29.20
27.30
mg/l
0.23
87
807
99
999
0.97
0.02
18.3
17.2
—
—
—
0
0
11
104
1.06
0.01
1.8
2.2
68.05
66.19
g/l
0.53
11
93
58
574
1.02
0.00
9.2
9.6
4.39
4.30
e9/l
0.11
52
503
26
259
1.00
0.00
2.2
3.4
553.62
556.65
mosm/kgh2o
0.03
21
226
14
137
1.02
0.00
1.1
1.3
—
—
—
0
0
94
945
0.98
0.00
5.2
5.2
6.10
6.10
mmol/l
0.02
89
840
0
8
0.00
0.00
0.0
2.0
—
7.86
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
6
64
0.93
0.00
1.3
2.4
1.63
1.52
g/l
—
6
54
7
72
0.97
-0.00
3.0
3.8
0.14
0.17
e6/l
—
7
72
0
5
0.00
-0.00
0.0
5.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
4.42
—
0
9
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
59
0.84
-0.00
1.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
30.40
—
0
5
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
96
960
1.00
-0.00
5.8
5.5
2.42
2.58
mmol/l
1.06
91
855
5
53
0.94
-0.00
1.2
2.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
80.40
—
0
5
0
5
0.00
-0.00
0.0
2.4
—
2230.00
—
0
5
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
9
93
0.97
-0.00
2.6
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
1.79
—
0
6
0
7
0.00
-0.00
0.0
1.1
—
7.10
—
0
7
0
7
0.00
-0.00
0.0
1.6
—
20.74
—
0
7
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

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Index endpoint: DUODENAL_ULCER_UNSPE_ACUTE_CHRONIC_WO_HAEMORRHAGE_PERFORATION – Duodenal ulcer - Unspecified as acute or chronic, without haemorrhage or perforation, drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).