≡ Risteys
FG R12 + FR

Documentation Changelog GitHub Contact & Feedback

Duodenal ulcer - Unspecified as acute or chronic, without haemorrhage or perforation, drug-induced

Endpoint Browser PheWeb

DUODENAL_ULCER_UNSPE_ACUTE_CHRONIC_WO_HAEMORRHAGE_PERFORATION

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ATC codes for adverse effects of Drugs — ANY
  • Hospital discharge: ICD-10 — K26.9#

1 out of 7 registries used, show all original rules.

136

4. Check minimum number of events

None

136

5. Include endpoints

None

136

6. Filter based on genotype QC (FinnGen only)

136

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

All Female Male
Number of individuals 136 49 87
Unadjusted period prevalence (%) 0.03 0.02 0.04
Median age at first event (years) 55.81 54.30 56.66

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
126
Matched controls
1259
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K26.9
ICD-10 Finland
Duodenal ulcer, unspecified as acute or chronic, without haemorrhage or perforation
+∞
173.4
126
5
UJD02
NOMESCO Finland
Gastroscopy
15.7
23.6
40
36
A02BC01
ATC
omeprazole; systemic
6.6
21.5
77
241
A02BA02
ATC
ranitidine; systemic
6.5
20.1
68
193
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.7
14.5
68
252
A02BX
ATC
Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)
19.1
14.0
21
13
A02BC03
ATC
lansoprazole; oral
4.5
13.9
66
245
A02BD03
ATC
lansoprazole, amoxicillin and metronidazole; systemic
9.6
11.7
24
30
A02BD01
ATC
omeprazole, amoxicillin and metronidazole; systemic
17.3
9.3
14
9
K26.0
ICD-10 Finland
Duodenal ulcer, acute with haemorrhage
35.8
8.2
10
*
P01AB01
ATC
metronidazole; oral, rectal
2.8
6.9
58
290
A02BA04
ATC
nizatidine; systemic
4.1
6.4
25
72

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
17
352
0.41
3.09
6.0
4.6
—
—
—
0
0
13
53
2.61
2.35
9.0
9.0
—
—
—
0
0
15
295
0.45
2.31
4.5
3.5
—
—
—
0
0
37
245
1.70
1.90
6.2
7.3
—
—
—
0
0
9
36
2.60
1.77
4.0
3.7
—
—
—
0
0
28
176
1.74
1.72
2.5
1.9
—
—
—
0
0
18
299
0.54
1.64
3.9
4.2
—
—
—
0
0
19
307
0.56
1.56
4.7
4.4
0.0
0.0
estimate
—
5
102
14
72
2.05
1.55
1.8
1.4
—
—
—
0
0
0
43
0.00
1.55
0.0
1.6
—
—
—
0
0
5
16
3.20
1.45
1.4
1.6
—
—
—
0
0
8
36
2.30
1.26
9.9
12.6
—
—
—
0
0
18
114
1.67
1.09
2.3
1.8
—
—
—
0
0
5
107
0.45
1.06
2.4
4.0
1.2
1.2
mmol/l
—
5
89
32
235
1.47
1.05
3.7
3.8
—
—
—
0
0
18
267
0.62
1.05
2.3
1.7
459.4
434.8
pmol/l
0.21
18
218
18
117
1.62
1.00
1.5
1.4
—
—
—
0
0
5
105
0.46
0.93
2.6
4.4
—
—
—
0
0
8
44
1.87
0.87
1.1
1.3
132.5
141.8
u/ml
—
8
38
56
470
1.33
0.83
6.6
5.9
0.6
0.6
e9/l
0.09
51
407
7
121
0.56
0.82
1.1
1.4
—
—
—
0
0
80
708
1.32
0.81
4.0
4.7
—
—
—
0
0
20
141
1.49
0.80
7.3
7.0
13.0
11.4
kpa
0.47
20
134
20
141
1.49
0.80
7.3
7.0
5.1
5.0
kpa
0.15
20
134
56
472
1.32
0.80
6.6
5.9
0.0
0.0
e9/l
0.10
51
410
18
125
1.51
0.77
7.2
7.5
92.9
94.8
%
0.19
18
120
57
484
1.31
0.77
6.8
5.9
1.8
1.8
e9/l
0.08
51
429
52
439
1.30
0.72
2.0
2.1
96.5
88.6
pmol/l
0.61
26
219
9
58
1.59
0.71
1.6
1.4
—
—
—
0
0
22
164
1.41
0.68
22.1
29.4
—
1.5
—
0
17
31
384
0.75
0.68
2.5
2.3
—
—
—
0
0
5
28
1.81
0.67
1.0
1.1
—
—
—
0
0
43
507
0.78
0.65
6.7
8.2
1.3
1.3
inr
—
6
156
43
359
1.29
0.64
4.4
4.6
—
—
—
0
0
81
884
0.79
0.62
4.1
4.4
1.3
1.3
mmol/l
0.16
76
785
14
97
1.49
0.62
10.1
9.1
—
—
—
0
0
42
494
0.78
0.61
4.0
4.3
36.3
44.0
ng/l
0.32
31
394
56
486
1.26
0.61
6.7
6.2
0.2
0.2
e9/l
0.04
50
427
8
121
0.64
0.58
1.0
1.3
—
—
—
0
0
15
203
0.71
0.57
3.3
5.4
—
—
—
0
0
39
327
1.27
0.56
6.5
5.8
—
—
—
0
0
13
91
1.47
0.55
4.3
3.7
—
—
—
0
0
6
39
1.56
0.53
1.3
1.8
—
—
—
0
0
11
151
0.70
0.46
1.5
3.3
1.6
1.7
%
0.23
11
130
7
51
1.39
0.45
2.9
4.0
—
—
—
0
0
46
519
0.83
0.44
6.1
5.7
0.0
0.0
estimate
—
5
108
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
14
106
1.36
0.41
7.6
7.1
1.1
1.3
mmol/l
0.80
14
100
0
18
0.00
0.40
0.0
2.2
—
—
—
0
0
9
67
1.37
0.39
2.8
5.0
—
—
—
0
0
38
332
1.20
0.38
2.1
3.1
1.2
0.4
e6/l
1.07
31
256
41
361
1.19
0.37
2.5
3.7
2.3
2.4
mmol/l
0.69
36
307
36
313
1.20
0.37
2.1
3.0
—
—
—
0
0
50
449
1.18
0.37
9.1
11.3
0.0
0.0
e9/l
0.54
44
375
10
132
0.74
0.34
1.2
1.2
0.8
14.7
u/ml
—
5
43
78
734
1.15
0.30
3.7
4.4
17.6
14.4
mm/h
0.50
73
654
7
57
1.24
0.29
1.0
1.1
—
—
—
0
0
10
76
1.34
0.29
3.7
2.4
—
—
—
0
0
87
912
0.87
0.28
4.6
4.9
1.4
1.4
mmol/l
0.19
82
812
26
227
1.18
0.26
2.2
3.3
2.5
2.5
mmol/l
0.39
19
200
38
343
1.15
0.26
4.0
4.0
7.1
8.2
mg/mmol
0.11
31
222
21
243
0.84
0.26
1.3
1.3
—
—
—
0
0
22
253
0.84
0.25
2.1
3.1
539.8
563.2
mosm/kgh2o
0.24
17
220
6
81
0.73
0.25
1.5
1.3
—
—
—
0
0
27
302
0.87
0.22
2.9
3.3
0.7
0.8
ug/l
0.77
21
211
45
415
1.13
0.22
3.4
3.9
124.2
95.3
e6/l
0.09
34
313
8
104
0.75
0.22
2.1
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
2.1
—
10.9
—
0
11
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
3.2
—
—
—
0
0
0
12
0.00
0.21
0.0
3.4
—
32.1
—
0
12
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
3.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
40
369
1.12
0.19
2.4
3.4
14.6
232.4
e6/l
0.71
32
294
10
81
1.25
0.19
5.5
6.1
25.1
24.5
mmol/l
—
10
76
76
727
1.10
0.19
4.1
4.4
—
—
—
0
0
26
287
0.88
0.18
1.8
2.9
17449.7
11596.7
umol/l
0.13
26
230
10
82
1.24
0.17
2.4
1.5
—
—
—
0
0
7
62
1.14
0.17
1.3
2.5
3.5
3.4
e9/l
—
7
43
85
820
1.10
0.17
29.8
18.7
35.7
38.3
%
1.05
64
499
67
640
1.09
0.16
5.3
5.1
7.4
6.9
mmol/l
0.66
61
602
30
275
1.12
0.16
2.5
2.1
2.7
3.1
mg/l
0.57
25
231
9
79
1.15
0.15
8.1
4.6
128.2
88.2
ng/l
—
9
67
7
90
0.77
0.15
1.6
3.8
—
—
—
0
0
48
504
0.93
0.12
4.9
5.6
2.0
3.0
ug/l
0.77
43
442
13
114
1.16
0.12
6.6
4.3
—
—
—
0
0
34
321
1.08
0.10
3.4
3.1
53.4
247.7
mg/l
0.49
26
209
5
48
1.04
0.09
4.2
5.6
—
—
—
0
0
100
1016
0.94
0.07
21.7
21.2
84.8
84.7
umol/l
0.00
100
1016
7
81
0.86
0.07
1.4
1.6
—
—
—
0
0
10
89
1.13
0.07
2.1
1.9
—
—
—
0
0
11
100
1.11
0.05
1.7
2.1
335.2
406.2
nmol/l
0.75
11
86
35
338
1.05
0.04
2.8
2.5
—
—
—
0
0
58
569
1.03
0.03
9.2
9.7
4.4
4.3
e9/l
0.09
52
499
34
350
0.96
0.03
2.5
3.3
—
—
—
0
0
98
990
0.96
0.03
18.4
17.3
—
—
—
0
0
11
103
1.07
0.02
1.8
2.2
68.0
66.2
g/l
0.53
11
92
97
962
1.03
0.02
20.6
18.2
29.0
27.2
mg/l
0.21
86
801
93
938
0.97
0.02
5.2
5.2
6.1
6.1
mmol/l
0.01
88
833
70
692
1.02
0.01
2.7
3.7
14.4
15.0
pmol/l
1.04
65
591
14
137
1.02
0.00
1.1
1.3
—
—
—
0
0
86
861
1.00
0.00
3.9
4.5
2.0
2.1
mu/l
0.45
81
738
8
81
0.99
0.00
2.8
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
1.8
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
6
64
0.93
0.00
1.3
2.4
1.6
1.5
g/l
—
6
54
5
52
0.96
0.00
1.2
2.7
—
—
—
0
0
95
950
1.00
0.00
5.8
5.5
2.4
2.6
mmol/l
1.07
90
845
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
7.9
—
0
8
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
20.7
—
0
7
0
7
0.00
0.00
0.0
1.1
—
7.1
—
0
7
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
5
59
0.84
0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
9
92
0.98
0.00
2.6
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
5.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
3.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
2.4
—
4.4
—
0
9
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
2230.0
—
0
5
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
7
71
0.99
0.00
3.0
3.8
0.1
0.2
e6/l
—
7
71
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

↥

Index endpoint: DUODENAL_ULCER_UNSPE_ACUTE_CHRONIC_WO_HAEMORRHAGE_PERFORATION – Duodenal ulcer - Unspecified as acute or chronic, without haemorrhage or perforation, drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).