Ascorbic acid deficiency

E4_VIT_C_DEF

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E54 Hospital discharge: ICD-9 — 267 Hospital discharge: ICD-8 — 264 Cause of death: ICD-10 — E54 Cause of death: ICD-9 — 267 Cause of death: ICD-8 — 264 KELA reimbursements: KELA codes — 123 KELA reimbursements: ICD-10 — E55.0 3 out of 7 registries used, show all original rules.	29
4. Check minimum number of events None	29
5. Include endpoints None	29
6. Filter based on genotype QC (FinnGen only)	29

Control definitions (FinnGen only)

Control exclude: E4_NUTRIDEF

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E50-E64
Name in latin: Deficientia acidi ascorbici

NAME	E4_VIT_C_DEF
CONTROL_EXCLUDE	E4_NUTRIDEF
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E54
HD_ICD_9	267
HD_ICD_8	264
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E54
COD_ICD_9	267
COD_ICD_8	264
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB	123
KELA_REIMB_ICD	E550
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Ascorbic acid deficiency based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	116	68	47
Only index persons	88	51	37
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	43.57	48.36	36.19
Only index persons	36.92	41.70	30.33

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	29	16	13
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	37.65	36.44	39.15

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

10.34

8.81

8.6

5.6

0.2

g/l

0.52

(3003458) Phosphate [Moles/volume] in Serum or Plasma

6.99

6.32

23.3

7.1

1.3

1.2

mmol/l

0.41

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

7.48

6.13

1.8

1.7

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

7.17

5.88

1.7

1.8

—

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

17.74

4.84

7.4

7.6

—

(3007566) Smooth muscle Ab [Titer] in Serum

14.58

3.95

3.3

2.8

—

(3034770) Mitochondria Ab [Titer] in Serum

14.58

3.95

3.2

3.0

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

14.58

3.95

13.8

6.6

88.5

86.0

—

(3000991) Gas panel - Venous blood

4.83

3.85

18.6

8.4

—

(3015736) pH of Urine

4.45

3.76

7.4

2.9

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

10.38

3.43

1.5

2.1

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

5.71

3.33

31.1

12.9

1.0

1.1

mg/l

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

4.00

3.14

7.5

3.2

—

(3016244) Insulin [Units/volume] in Serum or Plasma

11.67

3.09

5.2

4.6

12.1

16.5

mu/l

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

11.67

3.09

3.2

3.0

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

3.82

3.01

7.5

3.6

—

(36304419) Bacteria [Presence] in Urine

3.66

2.89

6.9

2.9

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

8.31

2.65

1.2

1.7

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

8.31

2.65

1.2

1.7

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

3.83

2.61

10.1

8.2

5.0

kpa

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

5.98

2.54

1.5

2.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

3.30

2.43

2.9

1.9

127.3

91.4

pmol/l

—

(3012544) pH of Venous blood

3.51

2.43

43.5

5.9

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

6.43

2.31

3.0

1.9

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

5.78

2.16

3.2

2.2

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

5.78

2.16

3.0

2.1

—

(3028626) Oxygen [Partial pressure] in Capillary blood

3.69

2.13

7.8

7.2

9.6

9.9

kpa

—

(42870588) Differential panel, method unspecified - Blood

103

2.97

2.04

26.7

7.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

3.08

2.00

5.5

2.9

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

4.16

1.95

1.2

2.3

—

(3007080) Epstein Barr virus nuclear IgG Ab [Units/volume] in Serum

4.79

1.90

1.0

2.6

357.2

152.3

u/ml

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

4.79

1.90

1.0

2.6

—

(3026008) Bacteria identified in Urine by Culture

2.86

1.78

3.6

3.2

—

(3022313) Gas panel - Capillary blood

2.95

1.69

13.5

7.8

—

(3019832) Treponema pallidum Ab [Presence] in Serum

4.08

1.69

1.8

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.06

1.66

58.2

8.3

25.5

25.4

mmol/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

2.50

1.54

8.4

4.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.65

1.51

2.2

1.8

—

(3044640) Blood type and Crossmatch panel - Blood

2.54

1.50

6.5

3.0

—

(3019150) Specific gravity of Urine by Refractometry

2.51

1.43

9.2

3.3

—

1.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.75

1.32

4.3

1.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.39

1.29

1.7

1.9

—

(3037467) Urinalysis macro (dipstick) panel - Urine

145

2.22

1.27

9.9

3.6

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.75

1.22

2.1

1.6

—

(3042936) Bacteria identified in Isolate by Culture

2.65

1.20

4.1

1.5

—

(3019225) pH of Specimen

2.80

1.20

12.0

6.4

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.53

1.08

2.4

1.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

2.14

1.06

2.7

1.7

1.6

2.0

g/l

—

(21494755) Public health laboratory ask at order entry panel

0.00

1.04

0.0

1.2

—

(40768797) Stomach Pathology biopsy report

2.25

0.93

2.3

1.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.41

0.80

2.2

1.2

—

(3000494) Fungus identified in Specimen by Culture

2.30

0.79

2.2

1.3

—

(40758558) Short blood count panel - Blood

1.87

0.78

12.2

8.1

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

190

0.56

0.69

3.6

3.7

—

(40768804) Tissue Pathology biopsy report

1.75

0.59

2.6

1.7

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.56

0.50

4.7

5.8

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.62

0.49

4.5

2.6

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

0.00

0.42

0.0

1.1

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.00

0.41

0.0

2.0

—

(3023368) Bacteria identified in Blood by Culture

1.49

0.35

13.6

3.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.48

0.34

9.0

3.2

—

(3013512) EKG study

1.42

0.25

6.2

3.1

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.28

0.22

1.8

1.5

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.22

0.0

1.2

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

0.00

0.22

0.0

3.0

—

261.4

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

0.00

0.22

0.0

2.9

—

2.8

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

0.00

0.22

0.0

3.0

—

657.0

—

(3008898) HLA-B27 [Presence]

0.00

0.21

0.0

1.0

—

(3003694) ABO and Rh group [Type] in Blood

1.33

0.20

1.7

1.4

—

(3022621) pH of Urine by Test strip

0.00

0.20

0.0

2.7

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

184

1.28

0.16

26.6

11.2

78.4

86.4

ml/min/173m2

0.51

149

(3044889) 12 lead EKG panel

143

0.84

0.10

4.2

3.0

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

1.10

0.09

1.6

1.3

0.8

1.2

mmol/l

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

1.10

0.09

3.4

4.5

3.5

1.6

ug/l

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

189

1.02

0.00

6.6

3.9

15.6

14.6

pmol/l

0.44

180

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.4

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.0

—

(3003338) MCHC [Mass/volume]

227

1.06

0.00

57.0

15.9

334.0

333.9

g/l

0.02

227

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

3.7

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.0

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

2.6

—

35.4

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

25.6

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.0

1.2

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.0

1.3

—

1.4

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.8

—

(4027681)

0.00

0.0

1.2

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.0

1.1

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

154.8

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

3.0

—

12.5

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.4

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.2

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.2

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

35.5

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

2.4

—

(3000330) Specific gravity of Urine by Test strip

0.00

-0.00

0.0

3.5

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

-0.00

0.0

1.3

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

3.0

—

3.8

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

-0.00

0.0

3.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_VIT_C_DEF and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_VIT_C_DEF.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: E4_VIT_C_DEF – Ascorbic acid deficiency

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Ascorbic acid deficiency

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints