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Deficiency of other B group vitamins

DOID EFO Endpoint Browser PheWeb

E4_VIT_B_DEF

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E53
  • Hospital discharge: ICD-9 — 266
  • Hospital discharge: ICD-8 — 264
  • Cause of death: ICD-10 — E53
  • Cause of death: ICD-9 — 266
  • Cause of death: ICD-8 — 264
  • KELA reimbursements: KELA codes — ANY
  • KELA reimbursements: ICD-10 — E53.8

3 out of 7 registries used, show all original rules.

815

4. Check minimum number of events

None

815

5. Include endpoints

None

815

6. Filter based on genotype QC (FinnGen only)

794

Control definitions (FinnGen only)

Control exclude
E4_NUTRIDEF

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E50-E64
Name in latin
Deficientia aliorum vitaminorum B

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4877 2712 2110
Only index persons 3881 2214 1667
Unadjusted period prevalence (%)
Whole population 0.07 0.08 0.06
Only index persons 0.07 0.08 0.06
Median age at first event (years)
Whole population 73.31 74.06 72.33
Only index persons 72.05 72.65 71.25

-FinnGen-

Key figures

All Female Male
Number of individuals 794 448 346
Unadjusted period prevalence (%) 0.16 0.16 0.16
Median age at first event (years) 62.09 56.81 68.91

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
815
Matched controls
8150
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
107
Kela drug reimbursment
Pernicious anaemia
142.4
307.7
435
65
E53.8
ICD-10 Finland
Deficiency of other specified B group vitamins
923.2
307.7
407
9
B81
ICPC
Anaemia vit B12/folate deficiency
51.2
307.7
379
136
B03BA03
ATC
hydroxocobalamin; parenteral
72.0
307.7
578
267
K29.4
ICD-10 Finland
Chronic atrophic gastritis
27.7
231.8
165
74
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
29.6
133.0
90
34
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.1
118.7
447
1563
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
41.5
106.7
65
17
E66.8
ICD-10 Finland
Other obesity
41.9
102.0
62
16
WVA30, ,
SPAT
7.3
73.0
116
181
T91
ICPC
Vitamin/nutritional deficiency
20.3
70.7
55
29
E53.9
ICD-10 Finland
Vitamin B deficiency, unspecified
563.8
54.2
53
*
E66.9
ICD-10 Finland
Obesity, unspecified
22.7
52.8
39
18
E66.01
ICD-10 Finland
Obesity due to excess calories
8.1
49.9
70
94
A55
ICPC
General and Unspecified, Local injection/infiltration
18.6
48.4
39
22
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.3
44.1
129
344
B03BA01
ATC
cyanocobalamin; nasal, systemic
428.4
41.5
41
*
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
+∞
39.9
38
*
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.4
33.5
396
2283
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
33.4
362
2006
K50.0
ICD-10 Finland
Crohn disease of small intestine
9.9
31.7
37
39
K50.8
ICD-10 Finland
Other Crohn disease
11.0
31.5
34
32
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
11.9
30.2
31
27
-50
ICPC
Medication/prescr/renewal
4.8
28.5
68
153
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.9
28.4
153
596
E66.00
ICD-10 Finland
Metabolic syndrome
7.8
27.8
39
52
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
27.2
334
1914
C10AC01
ATC
colestyramine; oral
6.3
26.6
46
77
UJF30
NOMESCO Finland
Ileoscopy through colon
3.2
25.9
116
406
D64.9
ICD-10 Finland
Anaemia, unspecified
2.9
25.5
140
549
B03BA02
ATC
cyanocobalamin tannin complex; parenteral
22.1
24.9
36
17
A07EA06
ATC
budesonide; oral, local oral
4.8
23.4
54
118
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.9
23.4
53
114
H03AA01
ATC
levothyroxine sodium; systemic
2.3
23.0
235
1233
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.0
22.6
111
408
R4190
NOMESCO Finland
Nutritional therapy
5.7
22.6
43
79
UJF32
NOMESCO Finland
Coloscopy
2.2
22.6
256
1398
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
22.6
410
2678
376
Kela drug reimbursment
Cyanocobalamin
118.2
21.7
23
*
SPAT1254
SPAT
Administration of medicine
2.5
21.6
161
732
K50.9
ICD-10 Finland
Crohn disease, unspecified
8.5
21.5
28
34
B80
ICPC
Iron deficiency anaemia
5.7
21.2
40
73
L04AX01
ATC
azathioprine; systemic
4.5
20.7
52
122
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
19.9
209
1100
E55.9
ICD-10 Finland
Vitamin D deficiency, unspecified
29.8
19.7
26
9
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.4
19.7
158
742
2662A
ICD-9 Finland
Deficiency of B-complex components, Other B-complex deficiencies[HYPOVITAMINOSIS B12]
+∞
18.8
18
*
A02BC02
ATC
pantoprazole; systemic
2.0
18.8
567
4316
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
18.7
209
1125
B82
ICPC
Anaemia other/unspecified
4.7
18.4
43
95
N03AX16
ATC
[U] pregabalin
2.1
18.2
218
1203
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
18.1
130
579
D51.8
ICD-10 Finland
Other vitamin B12deficiency anaemias
53.8
18.0
21
*
A50
ICPC
General and Unspecified, Medication/prescr/renewal
4.1
17.9
51
132
RD210, ,
NOMESCO Finland
13.6
17.1
29
22
N02AX02
ATC
tramadol; systemic, rectal
1.9
16.8
373
2529
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.7
16.5
54
154
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.1
16.4
202
1122
A10AE04
ATC
insulin glargine; parenteral
2.7
16.2
95
382
D51
ICD-10 Finland
Vitamin B12deficiency anaemia
17.2
16.2
25
15
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
21.5
16.0
23
11
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
3.8
15.9
49
134
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.2
15.8
158
808
N06AX16
ATC
venlafaxine; oral
2.4
15.7
120
548
A01
ICPC
Pain general/multiple sites
2.6
15.4
93
380
R42
ICD-10 Finland
Dizziness and giddiness
2.0
15.4
213
1230
A10AB05
ATC
insulin aspart; parenteral
2.9
15.3
75
274
K29.7
ICD-10 Finland
Gastritis, unspecified
3.8
14.6
45
123
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.0
14.4
183
1023
C03CA01
ATC
furosemide; systemic
1.8
14.1
313
2094
WVA20, ,
SPAT
4.4
14.0
35
82
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
3.6
13.9
46
132
JFB00
NOMESCO Finland
Partial resection of small intestine
5.7
13.9
26
47
E03.89
ICD-10 Finland
Other specified hypothyroidism
3.8
13.8
42
114
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
4.9
13.6
30
63
QBJ30
NOMESCO Finland
Correction of abdominal apron
76.4
13.6
15
*
UJF92
NOMESCO Finland
Capsular endoscopy
5.3
13.5
27
52
H02AB06
ATC
prednisolone; systemic
1.7
13.5
392
2825
R11
ICD-10 Finland
Nausea and vomiting
2.5
13.5
87
367
103
Kela drug reimbursment
Diabetes, insulin-treated
1.9
13.0
230
1428
WZC00
NOMESCO Finland
Treatment plan or consultation
1.8
12.8
275
1810
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.8
12.6
284
1894
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.0
12.6
152
830
N06AX11
ATC
mirtazapine; oral
1.8
12.6
280
1862
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.8
12.4
220
1367
N06AB04
ATC
citalopram; systemic
1.9
12.2
184
1083
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.9
12.2
173
998
K29.3
ICD-10 Finland
Chronic superficial gastritis
3.5
12.2
42
124
JN3AD
NOMESCO Finland
Abdominal CT examination
2.3
12.0
99
465
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.3
12.0
97
452
D50.8
ICD-10 Finland
Other iron deficiency anaemias
5.8
12.0
22
39
SPAT1262
SPAT
Handing over of treatment supplies
2.0
11.9
147
809
L28
ICPC
Limited function/disability (L)
1.9
11.8
165
946
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
2.2
11.6
99
472
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
11.6
152
853
G32.0*E53.8
ICD-10 Finland
Subacute combined degeneration of the spinal cord in case of vitamin B12 deficiency
+∞
11.5
11
*
F02.89*E53.8
ICD-10 Finland
Dementia due to vitamin B12 deficiency
+∞
11.5
11
*
R53
ICD-10 Finland
Malaise and fatigue
1.8
11.5
210
1312
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.1
11.4
115
586
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.0
11.4
149
835
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
3.8
11.3
35
96
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.6
11.3
68
277
AA1AD
NOMESCO Finland
CT of head and brain
1.8
11.3
234
1516
104
Kela drug reimbursment
Thyroid insufficiency
2.5
11.2
74
315
A07AA02
ATC
nystatin; oral
2.7
11.1
62
243
A06AD11
ATC
lactulose; oral
1.9
11.1
155
889
A10BA02
ATC
metformin; oral
1.8
11.0
231
1499
J01MA02
ATC
ciprofloxacin; systemic
1.7
11.0
328
2344
J01MA12
ATC
levofloxacin; systemic
1.9
10.9
166
978
WX110
NOMESCO Finland
Infiltration anesthesia
1.7
10.8
514
4126
K08.3
ICD-10 Finland
Retained dental root
2.6
10.7
66
272
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
13.1
10.7
18
14
A04
ICPC
Weakness/tiredness general
2.0
10.6
129
704
E66.0
ICD-10 Finland
Obesity due to excess calories
111.4
10.4
11
*
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
+∞
10.4
10
*
JDF01
NOMESCO Finland
Laparoscopic gastroplasty
+∞
10.4
10
*
Z3226
NOMESCO Finland
Physiotherapist
1.9
10.4
159
936
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.3
10.2
38
118
N05AH04
ATC
quetiapine; oral
1.9
10.2
140
797
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
3.9
10.1
30
80
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
10.1
227
1498
P01AB01
ATC
metronidazole; oral, rectal
1.6
10.1
314
2256
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.3
10.1
76
344
E86
ICD-10 Finland
Volume depletion
3.7
10.0
32
90
T90
ICPC
Diabetes non-insulin dependent
1.8
10.0
179
1107
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
3.5
10.0
34
100
SPAT1172
SPAT
Guidance concerning hydration
4.0
9.9
28
72
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
5.2
9.9
20
39
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.1
9.9
106
553
Z2445
NOMESCO Finland
Psychologist
3.5
9.8
33
96
M25.5
ICD-10 Finland
Pain in joint
1.7
9.8
238
1600
ZY010
NOMESCO Finland
Hospital outpatient
3.0
9.7
44
154
E0000UV, ,
ATC
1.6
9.7
314
2272
R25.1
ICD-10 Finland
Tremor, unspecified
3.5
9.5
33
98
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.7
9.5
197
1268
N06AA09
ATC
amitriptyline; systemic
2.2
9.5
87
427
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.7
9.4
51
197
WX002
NOMESCO Finland
Sedation and analgesia
1.8
9.4
162
988
E61.2
ICD-10 Finland
Magnesium deficiency
+∞
9.4
9
*
E000001, ,
ATC
1.8
9.4
156
942
SPAT1216
SPAT
Assessment of functional ability
1.9
9.3
139
812
JN4AD
NOMESCO Finland
Body CT examination
2.2
9.2
82
397
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.1
9.2
93
473
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
4.2
9.2
24
58
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
4.2
9.2
24
58
D07AA02
ATC
hydrocortisone; topical
2.0
9.2
112
610
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.2
9.2
79
378
K50.1
ICD-10 Finland
Crohn disease of large intestine
7.9
9.2
20
26
ZX114, ,
SPAT
5.1
9.1
19
38
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
3.2
9.0
35
112
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.4
9.0
65
289
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.7
8.9
49
191
A28
ICPC
Limited function/disability NOS
1.8
8.9
162
1004
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.0
8.9
106
574
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
8.8
337
2520
ZX120
NOMESCO Finland
Intravenous
2.1
8.8
85
426
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.3
8.7
69
319
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.1
8.7
89
456
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.2
8.6
75
360
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.7
8.6
45
171
SPAT1229
SPAT
Assessment of need for aid
2.2
8.6
72
341
A07EC02
ATC
mesalazine; oral, rectal
2.7
8.6
47
183
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.6
8.5
326
2435
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
2.9
8.4
40
144
SPAT1125
SPAT
Stoma care and guidance
4.4
8.4
21
49
XF402
NOMESCO Finland
ECG with work load test
2.0
8.4
90
468
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.4
8.4
58
252
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
6.8
8.4
20
30
A10BG03
ATC
pioglitazone; oral
3.8
8.4
25
67
T82
ICPC
Obesity
3.8
8.4
25
67
R4110
NOMESCO Finland
Physiotherapy
1.6
8.4
218
1484
S29
ICPC
Skin symptom/complaint other
1.8
8.4
142
860
SPAT1240
SPAT
Therapeutic discussion
2.2
8.4
71
338
E66.1
ICD-10 Finland
Drug-induced obesity
+∞
8.3
8
*
E53.1
ICD-10 Finland
Pyridoxine deficiency
+∞
8.3
8
*
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.2
8.2
70
333
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
3.1
8.2
34
113
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
8.2
148
912
UJD02
NOMESCO Finland
Gastroscopy
2.6
8.2
49
199
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
3.1
8.2
33
108
L17
ICPC
Foot/toe symptom/complaint
1.6
8.2
212
1440
-55
ICPC
Local injection/infiltration
7.6
8.2
18
24
N06AB03
ATC
fluoxetine; oral
2.0
8.1
99
539
SFA30
NOMESCO Finland
Three-surface restoration
1.6
8.1
294
2162
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
4.1
8.1
22
55
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.0
8.1
36
125
J01FF01
ATC
clindamycin; systemic
1.6
8.1
204
1378
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.5
8.1
376
2924
A10BH05
ATC
linagliptin; oral
2.5
8.1
49
201
M79.6
ICD-10 Finland
Pain in limb
1.5
8.0
309
2305
SFC01
NOMESCO Finland
Additional procedure necessary for restorative treatment
1.7
7.9
186
1232
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
7.9
287
2110
N06AX21
ATC
duloxetine; oral
2.0
7.9
88
465
ZXD05
NOMESCO Finland
Urgent procedure
1.6
7.8
248
1766
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.7
7.8
41
156
XW000
NOMESCO Finland
Bone marrow biopsy
2.7
7.8
41
156
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.8
7.8
114
660
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
7.8
199
1347
C07AB07
ATC
bisoprolol; oral
1.5
7.7
400
3171
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
7.7
198
1341
J01DB01
ATC
cefalexin; oral
1.6
7.6
622
5431
XG410
NOMESCO Finland
Flow-volume spirometry
2.8
7.6
37
135
E66
ICD-10 Finland
Obesity
3.1
7.5
31
103
EBA15
NOMESCO Finland
Extraction of multiple teeth
3.1
7.5
31
103
R06AE07
ATC
cetirizine; oral
1.5
7.5
306
2301
D07AB08
ATC
desonide; topical
2.0
7.5
89
480
N02BE01
ATC
paracetamol; systemic, rectal
1.7
7.5
692
6217
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.2
7.5
65
312
N03AX09
ATC
lamotrigine; oral
2.8
7.4
37
137
Q79.6
ICD-10 Finland
Ehlers-Danlos syndrome
80.8
7.4
8
*
E61.1
ICD-10 Finland
Iron deficiency
6.1
7.4
19
32
212
Kela drug reimbursment
Gout
3.8
7.4
22
59
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.8
7.4
130
795
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
4.1
7.4
20
50
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
7.3
228
1615
R50.9
ICD-10 Finland
Fever, unspecified
1.8
7.3
119
712
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
5.9
7.2
19
33
M04AA01
ATC
allopurinol; systemic
1.8
7.2
114
675
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
7.1
137
858
L04AB04
ATC
adalimumab; parenteral
4.1
7.1
19
47
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
2.4
7.1
47
201
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
3.0
7.1
31
107
K90.0
ICD-10 Finland
Coeliac disease
3.2
7.1
28
91
JF1BD
NOMESCO Finland
Very extensive small bowel CT
10.1
7.0
13
13
WX402
NOMESCO Finland
General anaesthesia
1.7
7.0
138
869
TAB00
NOMESCO Finland
Lumbar puncture
2.5
7.0
42
171
Z3231
NOMESCO Finland
Registered nurse
1.6
7.0
213
1497
R52.2
ICD-10 Finland
Other chronic pain
2.7
7.0
36
136
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.7
7.0
36
136
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.6
7.0
186
1268
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.1
7.0
62
301
D11
ICPC
Diarrhoea
1.9
7.0
83
449
SPAT1255
SPAT
Intravenous administration of medicine
2.2
7.0
56
261
B01AB05
ATC
enoxaparin; parenteral
1.5
6.9
241
1745
R06.0
ICD-10 Finland
Dyspnoea
1.6
6.9
213
1501
JFB33
NOMESCO Finland
Other resection comprising small intestine and colon
13.9
6.9
11
8
B50
ICPC
Blood and Immunity, Medication/prescr/renewal
13.9
6.9
11
8
K10.3
ICD-10 Finland
Alveolitis of jaws
2.8
6.8
34
126
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
6.8
129
804
R60.0
ICD-10 Finland
Localized oedema
1.8
6.8
97
556
JAH01
NOMESCO Finland
Laparoscopy
2.5
6.8
41
168
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.8
6.7
113
681
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.9
6.7
88
492
JF1DG
NOMESCO Finland
Small bowel very extensive MRI with with high intensity magnet
22.7
6.7
9
*
N30.0
ICD-10 Finland
Acute cystitis
1.7
6.7
126
785
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
6.6
136
866
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.9
6.6
85
471
SAA03
NOMESCO Finland
Extended examination of mouth
1.5
6.6
259
1922
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
3.5
6.6
22
64
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
6.6
215
1533
IGY02
NOMESCO Finland
Psychiatric monitoring contact
3.4
6.6
23
69
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
3.4
6.6
23
69
SPAT1263
SPAT
Sampling
1.5
6.6
300
2297
WX302
NOMESCO Finland
Thoracal epidural anesthesy
2.5
6.5
41
171
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.5
6.5
227
1641
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.6
6.5
38
153
A10BB12
ATC
glimepiride; oral
2.0
6.5
66
338
B81
ICD-10 Finland
Other intestinal helminthiases, not elsewhere classified
70.4
6.4
7
*
R60.9
ICD-10 Finland
Oedema, unspecified
2.3
6.4
46
204
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.9
6.4
76
410
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.8
6.4
94
544
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.4
6.4
42
179
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
6.4
161
1081
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.8
6.4
99
583
EBA00
NOMESCO Finland
Extraction of tooth
1.5
6.4
235
1720
A10AE05
ATC
insulin detemir; parenteral
2.4
6.4
43
186
SPAT1234
SPAT
Support of social functional capacity
2.3
6.4
48
218
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.6
6.3
172
1176
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.0
6.3
67
348
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
6.3
149
985
S97
ICPC
Chronic ulcer skin
2.2
6.3
54
259
E53
ICD-10 Finland
Deficiency of other B group vitamins
+∞
6.3
6
*
K50
ICD-10 Finland
Crohn disease [regional enteritis]
26.9
6.2
8
*
M54.5
ICD-10 Finland
Low back pain
1.5
6.2
245
1818
R20.2
ICD-10 Finland
Paraesthesia of skin
2.1
6.1
55
268
S50
ICPC
Skin, Medication/prescr/renewal
7.8
6.1
13
17
J45
ICD-10 Finland
Asthma
1.9
6.1
74
402
D09
ICPC
Nausea
2.6
6.1
35
140
K59.1
ICD-10 Finland
Functional diarrhoea
2.3
6.1
46
209
N03AE01
ATC
clonazepam; systemic
2.3
6.1
46
209
SFA10
NOMESCO Finland
One-surface restoration
1.4
6.1
366
2942
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.8
6.1
30
111
C03DA01
ATC
spironolactone; oral
1.8
6.1
101
607
N03AX12
ATC
[U] gabapentin; oral
1.7
6.1
124
789
A99
ICPC
Disease/condition unspecnature/site
1.9
6.1
71
382
SGA02
NOMESCO Finland
Opening and preparing the root canals
1.8
6.0
86
493
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.0
6.0
66
347

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
524
2613
3.82
74.54
3.2
2.0
81.66
93.56
pmol/l
5.39
333
1320
321
1289
3.46
61.64
2.2
1.7
1134.05
1165.51
nmol/l
0.23
254
951
358
1681
3.01
50.70
3.0
2.1
3.10
3.03
mg/l
0.19
310
1432
230
894
3.19
44.57
3.0
2.3
2.40
2.30
g/l
1.64
221
823
241
979
3.08
43.11
3.2
2.3
12.19
12.89
umol/l
0.76
236
907
216
834
3.16
42.08
3.1
2.3
21.16
22.50
%
0.67
195
711
211
825
3.10
40.02
1.4
1.2
—
—
—
0
0
440
2517
2.63
39.85
3.5
2.2
74.57
78.85
nmol/l
2.06
386
2224
293
1373
2.77
39.76
2.2
1.7
36752588.32
22638588.45
pmol/l
0.15
234
1122
315
1561
2.66
37.92
2.2
1.6
17.75
20.98
nmol/l
3.44
278
1318
503
3134
2.58
37.11
8.9
6.3
1.21
1.21
mmol/l
2.12
438
2637
224
952
2.87
36.16
3.8
3.2
0.80
0.82
mmol/l
2.24
211
886
195
772
3.01
35.81
5.0
5.0
1.05
1.03
mmol/l
0.45
186
696
448
2680
2.49
35.54
4.8
2.6
115.68
128.20
ug/l
0.63
419
2442
449
2696
2.48
35.22
6.4
4.4
34.38
35.26
g/l
2.75
423
2482
441
2735
2.33
30.68
7.6
5.6
0.64
0.66
%
0.28
408
2526
448
2826
2.30
29.55
8.0
5.8
8.59
8.68
%
0.24
417
2620
446
2815
2.29
29.29
7.6
5.5
2.87
2.83
%
0.10
413
2604
450
2855
2.29
29.13
8.5
5.5
1.21
1.21
mmol/l
1.34
420
2581
448
2845
2.28
28.83
7.5
5.5
58.71
57.78
%
0.85
418
2647
478
3123
2.28
28.64
7.6
5.7
0.20
0.19
e9/l
0.51
421
2755
452
2888
2.27
28.56
7.8
5.8
26.16
27.16
%
1.07
423
2685
472
3072
2.27
28.49
7.6
5.5
1.81
1.90
e9/l
0.70
424
2742
464
3006
2.26
28.23
7.5
5.4
0.04
0.04
e9/l
0.13
402
2614
462
2995
2.25
27.96
7.6
5.4
0.59
0.58
e9/l
0.24
399
2600
335
1928
2.25
26.89
3.3
2.4
54.28
104.20
u/l
0.64
310
1789
486
3261
2.21
26.42
7.5
5.9
11.01
11.59
umol/l
0.62
459
3087
433
2794
2.17
25.76
8.5
5.9
—
—
—
0
0
157
665
2.69
24.65
3.8
2.1
170.49
122.35
ug/g
1.13
125
524
169
748
2.59
24.25
3.1
2.4
1.73
1.78
%
0.29
142
666
453
3058
2.08
22.97
15.9
16.7
1.29
1.29
inr
0.00
123
880
501
3529
2.09
22.41
11.1
8.7
4.51
4.15
e9/l
1.90
444
3096
508
3634
2.06
21.31
6.9
4.5
6.94
6.67
mmol/l
1.28
490
3426
30
14
22.19
20.94
1.6
1.5
1.82
2.04
umol/l
0.60
30
14
128
531
2.67
20.74
3.0
2.1
0.19
0.21
g/l
1.88
122
489
129
543
2.63
20.28
3.4
2.4
65.58
68.31
e9/l
0.41
101
430
128
542
2.62
19.87
1.7
2.1
395.83
385.22
nmol/l
0.19
114
498
609
4798
2.07
17.80
11.2
7.1
87.13
78.31
u/l
2.54
579
4480
201
1088
2.12
17.57
1.8
1.5
2.70
2.42
g/l
0.68
101
648
132
601
2.43
17.47
5.4
4.0
—
—
—
0
0
120
523
2.52
17.45
5.8
6.4
9.62
10.41
mmol/l
0.52
111
493
151
734
2.30
17.20
1.5
1.3
494.55
520.71
titre
0.05
33
168
224
1274
2.05
17.09
1.3
1.2
2.38
1.65
u/ml
0.21
55
331
552
4275
1.90
16.00
5.6
4.4
—
—
—
0
0
582
4596
1.93
15.76
5.4
4.0
14.34
12.78
mm/h
1.46
539
4187
141
697
2.24
15.32
3.0
2.4
7.12
8.43
umol/l
0.46
124
604
295
1904
1.86
15.18
2.3
2.1
199.19
245.09
u/l
0.21
284
1788
298
1931
1.86
15.13
3.7
3.1
45.63
33.61
u/l
0.51
284
1840
296
1939
1.83
14.35
3.1
2.4
—
—
—
0
0
276
1772
1.84
14.26
4.8
4.0
—
—
—
0
0
105
479
2.37
13.71
3.5
3.6
81.03
87.67
ng/l
0.39
82
419
100
453
2.38
13.25
3.2
2.4
—
—
—
0
0
133
692
2.10
12.57
1.9
1.7
—
—
—
0
0
238
1508
1.82
12.57
4.8
3.6
87.76
88.66
%
0.19
233
1461
87
379
2.45
12.56
5.0
3.8
7.40
7.41
ph
0.20
12
46
33
81
4.20
12.41
1.2
1.1
—
—
—
0
0
52
174
3.12
12.39
1.4
1.5
304.65
278.44
ug/g
0.33
26
102
126
647
2.12
12.31
1.6
1.3
—
—
—
0
0
110
536
2.22
12.26
3.2
2.8
66.21
66.37
g/l
0.09
96
488
79
337
2.49
11.92
2.8
2.4
—
—
—
0
0
72
294
2.59
11.89
1.7
1.8
1.37
1.50
g/l
0.50
54
260
91
416
2.34
11.79
3.1
2.9
10.46
10.48
g/l
0.01
80
377
238
1538
1.77
11.62
7.6
6.3
—
—
—
0
0
314
2193
1.70
11.61
3.4
3.3
2.32
2.35
mmol/l
3.83
269
1913
22
22
10.24
11.55
2.3
1.1
117.20
128.25
nmol/l
0.42
22
22
169
986
1.90
11.48
1.4
1.3
24.97
36.21
iu/ml
1.03
50
330
59
222
2.79
11.43
5.3
4.4
24.39
24.98
mmol/l
0.68
52
211
298
2060
1.70
11.40
3.9
3.2
—
—
—
0
0
225
1442
1.77
11.25
3.1
2.3
—
—
—
0
0
284
1945
1.71
11.20
3.8
3.3
78.97
112.96
e6/l
0.27
221
1515
280
1914
1.71
11.10
5.7
3.7
7.40
7.40
ph
0.19
53
362
344
2491
1.66
10.91
4.6
3.7
38.30
44.28
ng/l
0.22
258
1775
113
582
2.09
10.91
3.9
3.4
1.64
1.76
mmol/l
0.11
94
472
106
539
2.11
10.57
1.5
1.5
—
—
—
0
0
105
538
2.09
10.26
3.4
2.3
35.58
32.76
u/l
0.25
91
452
66
278
2.50
10.23
3.3
3.6
24.10
23.81
mmol/l
0.29
66
268
97
487
2.13
9.99
9.5
7.5
—
—
—
0
0
313
2251
1.63
9.97
4.6
3.7
136.33
126.56
e6/l
0.06
230
1630
77
355
2.29
9.77
1.2
1.2
—
—
—
0
0
65
278
2.45
9.76
4.8
3.9
—
—
—
0
0
27
70
3.96
9.47
1.1
1.3
—
—
—
0
0
277
1956
1.63
9.37
3.2
3.1
1553.32
1667.33
ng/l
0.20
239
1694
71
322
2.32
9.36
2.4
1.7
1.28
1.58
g/l
0.39
63
293
29
81
3.68
9.18
2.7
1.7
32.00
32.69
pg
0.35
29
81
51
200
2.65
9.15
4.7
3.8
54.77
87.43
mg/l
0.50
40
161
25
63
4.06
9.11
1.2
1.6
—
—
—
0
0
560
4688
1.62
9.10
5.7
3.9
15.16
14.80
pmol/l
2.38
490
4209
254
1769
1.63
9.02
3.6
3.2
0.54
0.46
e6/l
0.20
200
1356
31
93
3.43
8.83
2.4
1.8
—
—
—
0
0
690
6121
1.83
8.83
24.7
14.5
25.89
24.94
mg/l
0.23
600
4832
374
2871
1.56
8.71
3.1
2.5
—
—
—
0
0
200
1322
1.68
8.66
3.7
3.0
548.54
542.79
mosm/kgh2o
0.13
168
1131
50
200
2.60
8.64
4.7
3.8
41.19
48.23
mg/l
0.18
39
162
256
1807
1.61
8.52
3.2
3.0
7.17
7.09
mmol/l
0.11
207
1502
117
669
1.87
8.31
1.5
1.5
—
—
—
0
0
257
1826
1.60
8.28
4.0
3.7
13.79
9.29
mg/mmol
0.53
161
1137
474
3861
1.54
8.28
4.7
2.9
63.47
47.94
u/l
1.11
452
3591
146
895
1.77
8.26
2.4
1.9
—
—
—
0
0
42
158
2.75
8.18
1.3
1.2
1.59
13.60
u/ml
0.94
11
25
259
1849
1.59
8.16
5.1
3.9
—
—
—
0
0
69
331
2.18
7.97
4.2
3.3
4.25
4.53
pmol/l
1.79
58
289
223
1544
1.61
7.96
2.8
2.6
8553.86
8385.90
umol/l
0.01
189
1328
241
1725
1.56
7.38
3.4
3.1
584.38
249.73
mg/l
0.43
161
1086
40
155
2.66
7.38
1.3
1.2
1.14
2.72
u/ml
—
7
17
133
819
1.75
7.37
1.7
1.6
—
—
—
0
0
24
69
3.55
7.31
1.1
1.0
—
—
—
0
0
82
437
1.97
7.17
1.2
1.2
—
—
—
0
0
639
5647
1.61
7.13
6.9
4.7
1.90
2.15
mu/l
0.59
565
5097
114
680
1.79
7.04
3.7
4.0
9.78
27.22
ug/l
0.79
96
566
154
1001
1.66
6.98
3.3
3.0
2.92
2.32
e6/l
0.29
83
567
380
3025
1.48
6.93
4.7
3.8
0.00
0.00
estimate
0.50
92
612
701
6356
1.74
6.92
27.5
16.9
139.32
139.64
mmol/l
2.20
685
6175
342
2671
1.48
6.83
14.5
9.2
0.00
0.00
e9/l
0.51
272
2199
147
950
1.67
6.80
1.4
1.2
12.04
13.45
u/ml
0.07
48
361
192
1326
1.59
6.80
2.0
1.6
1.37
1.20
mg/l
0.31
149
1022
49
219
2.32
6.72
1.9
2.2
258.70
463.94
ug/l
0.44
49
208
235
1703
1.53
6.71
3.8
3.2
—
—
—
0
0
197
1374
1.57
6.67
3.0
2.6
5.46
5.67
e6/l
0.09
171
1243
46
201
2.37
6.64
3.4
3.2
0.24
0.26
g/l
0.08
27
72
67
342
2.04
6.61
1.2
1.4
—
—
—
0
0
37
146
2.61
6.61
4.9
4.3
—
—
—
0
0
700
6371
1.70
6.47
27.6
17.0
3.96
3.98
mmol/l
0.94
681
6178
148
972
1.64
6.41
2.4
1.9
30.26
29.59
s
0.71
140
940
182
1257
1.58
6.41
4.1
3.8
152.81
319.12
ng/l
1.09
147
1008
379
3059
1.45
6.20
4.7
3.8
0.00
0.01
estimate
0.80
81
551
13
17
7.75
6.14
2.3
3.4
37346.15
40229.71
ug/l
0.26
13
17
375
3025
1.44
6.14
6.3
5.1
0.00
0.00
estimate
0.50
84
558
39
166
2.42
5.98
1.1
1.1
13.27
6.12
u/ml
—
7
19
156
1056
1.59
5.95
2.9
2.8
0.99
1.13
e6/l
0.29
87
620
193
1372
1.53
5.93
4.0
3.6
—
—
—
0
0
307
2400
1.45
5.87
3.8
3.5
5.81
5.93
ph
0.31
13
155
113
708
1.69
5.85
9.8
7.3
0.53
1.23
mmol/l
0.92
95
549
113
709
1.69
5.82
1.6
1.4
—
—
—
0
0
22
71
3.16
5.65
1.4
1.6
1.60
0.78
g/l
0.43
17
52
77
437
1.84
5.60
5.7
4.2
0.06
0.80
%
0.55
18
128
629
5648
1.50
5.46
7.3
5.6
41.37
39.82
mmol/mol
2.50
565
5202
30
118
2.60
5.43
6.2
3.3
—
—
—
0
0
25
90
2.83
5.34
1.5
1.1
—
—
—
0
0
32
133
2.46
5.19
2.2
2.3
189.20
112.66
ug/min
0.37
21
84
69
388
1.85
5.17
3.0
3.2
4.22
5.59
e9/l
0.62
49
306
79
464
1.78
5.14
5.6
4.1
0.14
0.13
%
0.06
21
154
76
443
1.79
5.08
5.1
4.0
1.14
0.55
%
1.04
22
153
21
71
3.01
5.01
1.0
1.1
111.80
60.70
iu/ml
—
5
10
43
207
2.14
4.99
3.6
2.1
36.69
37.90
g/l
0.83
36
183
82
493
1.74
4.93
5.5
4.0
1.75
0.94
%
1.04
24
183
30
124
2.47
4.93
6.4
3.3
3.03
2.50
mmol/l
0.41
20
82
93
580
1.68
4.90
10.7
8.2
118.47
120.40
g/l
0.40
93
568
47
238
2.03
4.79
3.7
2.1
9.93
10.49
g/l
0.42
38
213
30
126
2.43
4.77
1.3
1.2
21.22
35.15
u/ml
—
6
12
31
133
2.38
4.72
1.5
1.7
—
—
—
0
0
58
321
1.87
4.59
1.4
1.2
—
—
—
0
0
25
98
2.60
4.59
3.1
2.2
—
—
—
0
0
10
16
6.31
4.30
1.0
1.0
—
—
—
0
0
28
121
2.36
4.22
2.2
3.4
19.54
381.47
u/ml
1.07
23
113
15
39
3.90
4.21
1.0
1.1
—
—
—
0
0
21
79
2.70
4.18
1.2
1.4
108.33
114.23
u/ml
—
9
16
10
17
5.94
4.14
1.0
1.1
1361.70
1631.41
miu/ml
—
10
17
19
69
2.80
4.04
1.2
1.2
1064.93
347.95
pmol/l
0.47
14
63
22
87
2.57
3.99
1.2
1.5
—
—
—
0
0
67
405
1.71
3.98
2.3
2.4
—
24.47
—
0
19
15
48
3.16
3.94
1.0
1.2
—
—
—
0
0
38
192
2.03
3.94
2.1
3.5
—
—
—
0
0
25
106
2.40
3.94
4.0
3.4
59.88
58.25
%
0.20
25
106
306
2520
1.34
3.91
2.4
2.1
—
—
—
0
0
61
361
1.75
3.91
1.3
1.3
—
48.05
—
0
24
24
101
2.42
3.84
3.0
3.0
4.65
4.50
e9/l
0.11
24
101
26
115
2.30
3.74
1.3
1.5
—
—
—
0
0
22
91
2.46
3.66
1.9
1.4
—
—
—
0
0
20
79
2.57
3.65
2.2
1.9
90.19
89.85
%
0.12
20
79
30
143
2.14
3.63
1.5
2.6
—
—
—
0
0
18
68
2.68
3.58
2.2
1.3
—
—
—
0
0
14
46
3.08
3.54
1.2
1.3
0.51
0.32
g/l
—
9
31
27
125
2.20
3.51
4.3
2.3
16.45
16.03
%
0.22
14
61
681
6363
1.43
3.49
23.5
13.8
—
—
—
0
0
38
204
1.90
3.35
1.6
1.6
—
—
—
0
0
38
204
1.90
3.35
2.2
1.8
20.30
21.17
s
0.81
33
182
25
115
2.21
3.31
3.9
2.6
—
—
—
0
0
24
109
2.24
3.28
2.0
1.3
—
—
—
0
0
22
97
2.30
3.22
1.3
1.5
—
—
—
0
0
8
15
5.37
3.19
1.0
1.0
—
—
—
0
0
46
268
1.76
3.15
4.8
6.6
1.66
1.56
%
0.27
46
254
17
67
2.57
3.14
1.1
1.1
—
—
—
0
0
640
5954
1.35
3.07
5.3
4.5
6.06
5.92
mmol/l
1.20
570
5355
44
258
1.75
2.96
2.3
1.8
—
—
—
0
0
66
432
1.57
2.93
5.7
5.4
—
—
—
0
0
43
252
1.75
2.91
3.5
3.1
2533.19
1352.66
u/ml
0.19
38
214
80
549
1.51
2.88
2.4
2.9
264.08
246.99
ng/l
0.09
71
500
6
9
6.71
2.87
1.0
1.0
—
—
—
0
0
198
1592
1.32
2.86
1.6
1.6
1.43
1.33
mmol/l
0.84
176
1324
11
33
3.36
2.82
2.5
1.7
—
—
—
0
0
19
84
2.29
2.79
1.4
1.2
275.92
285.61
u/ml
0.06
13
44
7
14
5.03
2.73
1.0
1.1
—
—
—
0
0
27
139
1.97
2.73
1.4
1.3
—
—
—
0
0
21
99
2.15
2.66
2.6
1.5
—
—
—
0
0
9
26
3.49
2.48
1.0
1.2
165.67
147.01
iu/ml
—
9
26
685
6499
1.34
2.42
16.0
10.0
24.96
24.57
u/l
0.21
662
6240
6
12
5.03
2.40
1.3
1.8
—
—
—
0
0
43
267
1.64
2.40
4.8
6.7
0.93
0.90
%
0.12
43
253
37
221
1.71
2.38
1.3
1.3
26.63
29.14
iu/l
0.16
31
193
709
6766
1.37
2.37
36.8
21.4
255.88
247.76
e9/l
2.04
691
6576
7
17
4.14
2.36
1.0
1.1
—
—
—
0
0
709
6768
1.37
2.35
36.7
21.3
91.42
91.39
fl
0.06
695
6646
157
1255
1.31
2.34
3.4
3.0
2.44
2.45
mmol/l
0.82
131
1087
709
6769
1.36
2.34
36.6
21.3
30.21
30.36
pg
1.17
695
6646
709
6770
1.36
2.32
36.8
21.4
4.30
4.42
e12/l
8.30
689
6562
709
6771
1.36
2.31
36.8
21.4
7.05
6.78
e9/l
2.03
690
6561
200
1654
1.28
2.30
5.4
4.0
0.00
0.00
estimate
0.50
79
544
709
6774
1.36
2.28
37.0
21.5
128.79
133.47
g/l
13.58
697
6648
6
13
4.64
2.27
1.3
1.2
-2.23
3.08
mmol/l
—
6
13
708
6766
1.35
2.25
37.2
21.5
38.06
39.60
%
6.79
665
6287
32
188
1.73
2.20
1.2
1.2
—
—
—
0
0
12
48
2.52
2.19
2.6
3.1
—
—
—
0
0
21
108
1.97
2.17
1.7
1.5
—
—
—
0
0
7
19
3.71
2.15
2.0
2.0
—
—
—
0
0
14
62
2.28
2.08
2.5
2.6
—
—
—
0
0
10
37
2.72
2.07
1.4
3.5
—
—
—
0
0
38
240
1.61
2.02
7.2
4.0
—
—
—
0
0
9
32
2.83
2.00
2.0
2.1
0.08
0.13
e9/l
—
9
32
46
306
1.53
1.97
16.4
10.5
—
—
—
0
0
24
134
1.82
1.97
2.1
1.3
—
—
—
0
0
29
470
0.60
1.96
1.4
1.4
—
—
—
0
0
56
392
1.46
1.89
1.2
1.2
224.06
138.56
iu/ml
1.12
24
163
16
79
2.05
1.86
1.1
1.2
—
0.12
nmol/l
—
0
5
18
93
1.96
1.86
3.3
2.8
—
—
—
0
0
6
17
3.55
1.84
1.8
2.2
5.67
4.41
%
—
6
17
6
17
3.55
1.84
1.8
2.1
—
—
—
0
0
473
4362
1.20
1.82
4.6
3.9
—
—
—
0
0
16
80
2.02
1.81
1.1
1.2
0.56
0.57
nmol/l
0.03
16
73
25
146
1.73
1.79
2.0
1.3
—
—
—
0
0
25
147
1.72
1.75
2.5
1.3
—
—
—
0
0
25
147
1.72
1.75
2.0
1.3
—
—
—
0
0
16
81
1.99
1.75
1.1
1.0
—
—
—
0
0
5
13
3.86
1.71
2.2
1.5
—
—
—
0
0
5
13
3.86
1.71
1.2
1.1
—
—
—
0
0
5
13
3.86
1.71
1.0
1.2
—
—
—
0
0
57
409
1.42
1.71
8.8
7.6
23.96
24.32
mmol/l
0.37
57
393
11
48
2.31
1.71
1.3
1.3
—
—
—
0
0
12
55
2.20
1.68
1.1
1.1
—
—
—
0
0
74
559
1.36
1.65
2.8
2.4
3.75
6.81
ug/l
2.75
62
483
14
69
2.05
1.65
1.1
1.2
—
—
—
0
0
58
421
1.41
1.65
1.3
1.5
—
—
—
0
0
559
5261
1.20
1.63
28.3
17.4
15.66
15.06
%
1.43
554
5166
13
63
2.08
1.60
1.2
1.1
—
—
—
0
0
47
330
1.45
1.60
4.5
3.9
—
—
—
0
0
24
144
1.69
1.59
2.2
1.3
—
—
—
0
0
175
2042
0.82
1.58
2.7
2.8
—
—
—
0
0
162
1365
1.23
1.57
4.6
4.1
1.02
1.02
kg/l
0.10
27
198
70
529
1.35
1.57
5.9
3.5
1.22
1.23
mmol/l
0.61
63
458
10
44
2.29
1.56
1.0
1.7
—
—
—
0
0
14
71
1.99
1.54
1.7
1.1
—
—
—
0
0
5
15
3.35
1.52
1.0
1.1
—
—
—
0
0
13
65
2.02
1.49
1.2
1.6
57.00
61.43
%
—
8
49
7
28
2.51
1.45
1.4
1.8
—
—
—
0
0
25
156
1.62
1.45
3.3
2.4
—
—
—
0
0
639
6114
1.21
1.44
5.2
4.9
2.48
2.71
mmol/l
8.47
578
5583
14
74
1.91
1.39
1.1
1.2
—
—
—
0
0
6
23
2.62
1.37
1.8
1.7
0.46
0.96
nmol/l
—
6
17
5
17
2.95
1.36
2.0
1.5
84.20
107.18
nmol/24h
—
5
17
10
47
2.14
1.34
1.1
1.1
—
—
—
0
0
18
105
1.73
1.34
1.6
1.5
—
—
—
0
0
600
5726
1.18
1.31
4.2
3.9
1.35
1.23
mmol/l
2.92
545
5191
6
24
2.51
1.30
1.5
1.9
2.17
9.96
nmol/l
—
6
18
9
43
2.10
1.30
1.9
2.1
—
—
—
0
0
5
18
2.79
1.28
2.0
2.1
—
—
—
0
0
624
5979
1.19
1.28
4.7
4.4
4.37
4.64
mmol/l
8.05
576
5501
20
315
0.63
1.27
1.3
1.4
—
—
—
0
0
9
44
2.06
1.27
1.2
1.2
—
—
—
0
0
14
77
1.83
1.26
1.1
1.3
—
—
—
0
0
6
25
2.41
1.24
1.0
1.2
—
—
—
0
0
22
139
1.60
1.24
1.1
1.1
—
—
—
0
0
5
19
2.64
1.21
1.2
1.1
—
—
—
0
0
5
19
2.64
1.21
1.2
1.1
—
—
—
0
0
5
19
2.64
1.21
1.0
1.2
—
—
—
0
0
5
19
2.64
1.21
1.2
1.1
—
—
—
0
0
13
71
1.84
1.20
1.2
1.2
14125.29
50058.98
e6/l
—
7
41
14
79
1.79
1.17
1.3
1.2
1439.00
1159.96
e6/l
—
9
53
191
1683
1.18
1.16
4.9
3.5
—
—
—
0
0
618
5934
1.17
1.15
4.8
4.3
1.42
1.50
mmol/l
3.69
563
5418
16
96
1.68
1.10
1.2
1.4
36.23
31.30
g/l
1.02
16
82
55
429
1.30
1.06
4.1
3.1
—
—
—
0
0
94
783
1.23
1.05
1.3
1.3
—
—
—
0
0
12
67
1.80
1.05
3.8
2.3
3.14
2.28
u/field
—
7
25
20
130
1.55
1.03
2.5
2.0
18.86
4096.87
u/l
—
7
49
9
47
1.92
1.02
1.2
1.7
—
—
—
0
0
22
147
1.51
1.01
2.0
1.7
4.10
5.41
iu/l
—
8
48
12
68
1.78
1.01
3.3
2.6
—
—
—
0
0
64
515
1.26
0.98
4.6
3.2
—
—
—
0
0
16
101
1.60
0.94
2.8
2.2
—
—
—
0
0
64
519
1.25
0.93
6.5
3.8
—
—
—
0
0
11
63
1.76
0.90
1.1
1.3
—
—
—
0
0
22
152
1.46
0.89
3.4
3.3
0.85
0.92
nmol/l
0.17
13
120
37
283
1.32
0.85
1.2
1.2
—
—
—
0
0
65
540
1.22
0.78
1.4
1.4
—
—
—
0
0
6
34
1.77
0.76
1.0
1.2
3.90
6.36
ug/l
—
6
28
13
83
1.58
0.75
1.2
1.5
—
—
—
0
0
13
83
1.58
0.75
1.2
1.1
—
—
—
0
0
12
75
1.61
0.75
1.3
1.3
—
—
—
0
0
7
39
1.80
0.72
1.6
3.2
—
—
—
0
0
7
39
1.80
0.72
1.9
1.8
13.66
13.91
umol/l
—
7
34
64
538
1.21
0.70
1.3
1.4
—
—
—
0
0
9
58
1.56
0.70
1.0
1.1
—
—
—
0
0
169
1535
1.13
0.69
1.5
1.4
—
—
—
0
0
10
61
1.65
0.68
1.2
1.0
0.12
1.88
u/ml
—
5
29
5
28
1.79
0.66
1.2
2.6
1941.00
784.43
u/ml
—
5
28
26
198
1.32
0.64
1.1
1.1
—
—
—
0
0
11
72
1.53
0.59
1.2
1.0
1.17
5.23
u/ml
—
5
33
6
35
1.72
0.57
1.2
1.3
—
—
—
0
0
6
36
1.67
0.56
1.7
1.4
—
—
—
0
0
6
36
1.67
0.56
2.2
2.2
206.67
478.06
e6/l
—
6
31
9
60
1.51
0.54
1.2
1.1
—
—
—
0
0
6
38
1.58
0.54
4.3
1.7
9.83
9.68
mmol/l
—
6
38
6
38
1.58
0.54
5.5
2.6
—
—
—
0
0
6
39
1.54
0.53
2.2
2.1
43.00
37.33
%
—
6
39
13
92
1.42
0.50
2.2
3.4
—
—
—
0
0
6
41
1.47
0.50
1.0
1.2
—
—
—
0
0
10
67
1.50
0.50
1.2
1.0
0.09
0.89
u/ml
—
5
27
7
46
1.53
0.48
1.3
1.4
10.83
11.08
%
—
7
46
10
68
1.48
0.47
1.1
1.4
7.56
6.80
mmol/l
—
10
63
10
68
1.48
0.47
1.2
1.8
—
—
—
0
0
15
111
1.36
0.47
1.0
1.2
—
—
—
0
0
20
156
1.29
0.45
1.2
1.2
—
—
—
0
0
8
58
1.38
0.41
1.1
1.1
—
—
—
0
0
5
33
1.52
0.41
8.0
13.9
—
—
—
0
0
12
161
0.74
0.41
1.4
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
10
71
1.41
0.39
1.2
1.2
—
—
nmol/l
—
0
0
9
69
1.31
0.37
2.4
11.0
6.00
7.17
mmol/l
—
9
55
50
441
1.14
0.36
1.5
1.4
—
—
—
0
0
5
77
0.65
0.36
1.6
1.5
—
—
—
0
0
6
46
1.31
0.33
1.0
1.2
—
—
—
0
0
6
46
1.31
0.33
1.7
1.0
—
—
—
0
0
105
1128
0.92
0.32
2.9
3.1
0.82
0.82
ug/l
0.00
76
770
43
380
1.14
0.32
1.5
1.5
—
—
—
0
0
32
280
1.15
0.28
2.1
3.0
—
—
—
0
0
22
187
1.18
0.27
6.1
5.2
—
—
—
0
0
5
75
0.66
0.26
1.6
1.3
—
—
—
0
0
5
75
0.66
0.26
1.8
1.3
—
—
—
0
0
5
41
1.22
0.22
2.0
1.5
0.78
0.95
g/l
—
5
41
5
42
1.19
0.21
1.8
1.5
87.60
80.21
umol/l
—
5
42
0
11
0.00
0.21
0.0
1.1
—
280.57
—
0
6
0
11
0.00
0.21
0.0
8.4
—
—
—
0
0
6
51
1.18
0.19
2.0
2.5
—
—
—
0
0
6
52
1.15
0.19
3.7
2.2
14.17
13.26
%
—
6
52
506
5125
0.97
0.17
30.3
19.1
329.53
331.67
g/l
5.23
499
5070
15
132
1.14
0.13
1.3
1.5
12.60
11.00
e6/l
—
10
105
15
132
1.14
0.13
1.5
1.6
3830.50
137.35
e6/l
—
10
110
25
273
0.91
0.13
1.8
1.7
—
—
—
0
0
200
1955
1.03
0.12
5.5
5.2
2.15
2.96
ug/l
1.52
169
1716
22
201
1.10
0.11
9.1
10.6
—
—
—
0
0
11
96
1.15
0.10
2.2
1.4
—
—
—
0
0
6
56
1.07
0.08
1.3
1.9
—
—
—
0
0
7
68
1.03
0.08
5.4
3.8
—
—
—
0
0
16
150
1.07
0.04
2.1
1.7
18780.00
13475.88
e6/l
—
10
109
59
603
0.98
0.03
1.5
1.6
—
—
—
0
0
35
340
1.03
0.03
2.2
2.2
11.98
12.51
nmol/l
0.10
29
302
21
218
0.96
0.02
1.1
1.1
—
—
—
0
0
14
145
0.96
0.00
8.7
9.4
104.93
105.27
mmol/l
0.09
14
134
14
145
0.96
0.00
8.7
9.4
11.79
11.40
mmol/l
0.26
14
134
17
165
1.03
0.00
2.0
1.5
243.94
297.01
mu/l
0.77
17
146
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
6
59
1.02
0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.8
—
0.21
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
68
0.88
-0.00
1.0
1.1
—
—
—
0
0
6
67
0.89
-0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
-0.00
1.1
3.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_VIT_B_DEF and mortality.

Females

Parameter HR [95% CI] p-value
E4_VIT_B_DEF 1.558 [1.34, 1.81] < 0.001
Birth year 0.995 [0.99, 1.0] 0.248

During the follow-up period (1.1.1998 — 31.12.2019), 919 out of 2076 females with E4_VIT_B_DEF died.

Males

Parameter HR [95% CI] p-value
E4_VIT_B_DEF 1.736 [1.45, 2.08] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 800 out of 1606 males with E4_VIT_B_DEF died.

Mortality risk

Mortality risk for people of age

years, who have E4_VIT_B_DEF.

N-year risk Females Males
1 0.131% 0.299%
5 0.919% 1.861%
10 2.566% 4.57%
15 4.72% 8.204%
20 8.144% 13.297%

Relationships between endpoints

↥

Index endpoint: E4_VIT_B_DEF – Deficiency of other B group vitamins

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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