No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
783 |
4. Check minimum number of eventsNone |
783 |
5. Include endpointsNone |
783 |
6. Filter based on genotype QC (FinnGen only) |
783 |
Control definitions (FinnGen only)
- Control exclude
- E4_NUTRIDEF
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E50-E64
- Name in latin
- Deficientia aliorum vitaminorum B
Similar endpoints
↥List of similar endpoints to
Deficiency of other B group vitamins
based on the number of shared cases.
Similar with more cases:
- Vitamin deficiency
- Vitamin deficiency, wide
- Other nutritional deficiencies
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4877 | 2712 | 2110 |
| Only index persons | 3881 | 2214 | 1667 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.08 | 0.06 |
| Only index persons | 0.07 | 0.08 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 73.31 | 74.06 | 72.33 |
| Only index persons | 72.05 | 72.65 | 71.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 783 | 442 | 341 |
| Unadjusted period prevalence (%) | 0.15 | 0.15 | 0.15 |
| Median age at first event (years) | 61.90 | 56.54 | 68.84 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 721
- Matched controls
- 7208
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E53.8
ICD-10 Finland
Deficiency of other specified B group vitamins
880.7
323.0
353
8
107
Kela drug reimbursment
Pernicious anaemia
125.6
323.0
391
67
B03BA03
ATC
hydroxocobalamin; parenteral
80.9
323.0
519
221
B81
ICPC
Anaemia vit B12/folate deficiency
46.1
264.0
328
128
K29.4
ICD-10 Finland
Chronic atrophic gastritis
27.1
102.2
143
65
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.8
81.1
381
1362
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
25.2
53.1
75
33
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
28.8
45.0
61
23
E53.9
ICD-10 Finland
Vitamin B deficiency, unspecified
464.8
44.7
44
*
E66.8
ICD-10 Finland
Other obesity
55.8
44.2
52
10
E66.01
ICD-10 Finland
Obesity due to excess calories
25.1
41.2
58
25
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
+∞
32.5
31
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
28.2
307
1640
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.4
27.3
353
2053
T91
ICPC
Vitamin/nutritional deficiency
25.0
27.2
38
16
B03BA01
ATC
cyanocobalamin; nasal, systemic
78.2
27.0
30
*
E66.9
ICD-10 Finland
Obesity, unspecified
32.3
26.1
34
11
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.3
26.0
102
264
B03BA02
ATC
cyanocobalamin tannin complex; parenteral
18.7
22.4
34
19
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.2
21.8
124
433
H03AA01
ATC
levothyroxine sodium; systemic
2.5
20.9
204
993
-50
ICPC
Medication/prescr/renewal
5.4
20.9
64
127
E55.9
ICD-10 Finland
Vitamin D deficiency, unspecified
113.2
20.7
22
*
UJF32
NOMESCO Finland
Coloscopy
2.3
18.8
219
1156
2662A
ICD-9 Finland
Deficiency of B-complex components, Other B-complex deficiencies[HYPOVITAMINOSIS B12]
+∞
18.8
18
*
E66.00
ICD-10 Finland
Metabolic syndrome
12.7
18.7
33
27
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
18.1
279
1664
UJF30
NOMESCO Finland
Ileoscopy through colon
3.2
17.7
98
335
K50.0
ICD-10 Finland
Crohn disease of small intestine
10.1
17.3
34
35
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
13.7
17.1
29
22
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
16.7
334
2192
A10AE04
ATC
insulin glargine; parenteral
3.4
16.5
85
276
D64.9
ICD-10 Finland
Anaemia, unspecified
2.9
16.4
109
421
A02BC02
ATC
pantoprazole; systemic
1.9
16.0
470
3536
WVA30
SPAT
NA
6.4
15.7
41
67
SPAT1254
SPAT
Administration of medicine
2.4
15.2
142
664
N03AX16
ATC
pregabalin; oral
2.2
15.2
188
1005
R4190
NOMESCO Finland
Nutritional therapy
6.9
15.0
37
56
N02AX02
ATC
tramadol; systemic, rectal
1.9
14.7
321
2144
K50.8
ICD-10 Finland
Other Crohn disease
8.7
14.6
31
37
A55
ICPC
General and Unspecified, Local injection/infiltration
11.2
14.6
27
25
RD210
NOMESCO Finland
NA
10.7
14.3
27
26
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.5
14.3
126
569
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
5.1
14.3
45
93
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.7
13.8
98
392
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.2
13.8
171
910
A07EA06
ATC
budesonide; oral, local oral
5.0
13.4
43
91
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
12.9
171
933
K50.9
ICD-10 Finland
Crohn disease, unspecified
8.5
12.6
27
33
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.9
12.3
238
1495
C10AC01
ATC
colestyramine; oral
5.1
12.2
38
78
D51
ICD-10 Finland
Vitamin B12deficiency anaemia
15.0
11.8
19
13
103
Kela drug reimbursment
Diabetes, insulin-treated
1.9
11.8
198
1179
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.0
11.7
175
1000
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
4.2
11.7
44
110
C03CA01
ATC
furosemide; systemic
1.8
11.6
252
1643
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
4.0
11.6
46
121
F02.89*E53.8
ICD-10 Finland
Dementia due to vitamin B12 deficiency
+∞
11.5
11
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.0
11.3
65
228
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
11.3
166
939
R42
ICD-10 Finland
Dizziness and giddiness
2.0
11.2
176
1021
K29.3
ICD-10 Finland
Chronic superficial gastritis
4.3
11.1
40
96
B82
ICPC
Anaemia other/unspecified
5.3
11.0
33
65
A10BA02
ATC
metformin; oral
1.9
10.8
198
1215
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.6
10.7
78
317
376
Kela drug reimbursment
Cyanocobalamin
60.9
10.6
12
*
K29.7
ICD-10 Finland
Gastritis, unspecified
4.0
10.6
42
111
G32.0*E53.8
ICD-10 Finland
Subacute combined degeneration of the spinal cord in case of vitamin B12 deficiency
+∞
10.4
10
*
JDF01
NOMESCO Finland
Laparoscopic gastroplasty
+∞
10.4
10
*
A06AD11
ATC
lactulose; oral
2.1
10.4
135
724
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
16.3
10.4
16
10
B80
ICPC
Iron deficiency anaemia
5.4
10.4
30
57
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
10.3
129
682
N05AH04
ATC
quetiapine; oral
2.2
10.3
115
580
L04AX01
ATC
azathioprine; systemic
3.5
10.2
46
136
N06AB04
ATC
citalopram; systemic
1.9
10.0
162
947
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.8
9.8
212
1368
104
Kela drug reimbursment
Thyroid insufficiency
2.7
9.8
68
269
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.1
9.7
123
655
N06AX11
ATC
mirtazapine; oral
1.8
9.7
221
1445
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.2
9.7
50
164
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
10.2
9.6
18
18
XF402
NOMESCO Finland
ECG with work load test
2.3
9.5
87
399
A50
ICPC
General and Unspecified, Medication/prescr/renewal
3.9
9.4
38
102
QBJ30
NOMESCO Finland
Correction of abdominal apron
30.4
9.4
12
*
E66.0
ICD-10 Finland
Obesity due to excess calories
+∞
9.4
9
*
E61.2
ICD-10 Finland
Magnesium deficiency
+∞
9.4
9
*
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
12.5
9.4
16
13
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.0
9.4
124
671
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
9.3
195
1241
SPAT1262
SPAT
Handing over of treatment supplies
2.0
9.3
129
711
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
9.3
101
502
R4110
NOMESCO Finland
Physiotherapy
1.8
9.2
187
1176
R11
ICD-10 Finland
Nausea and vomiting
2.7
9.2
64
252
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.3
9.2
90
429
K50.1
ICD-10 Finland
Crohn disease of large intestine
7.6
9.0
20
27
N06AX16
ATC
venlafaxine; oral
2.2
9.0
91
440
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.1
8.9
111
584
WX110
NOMESCO Finland
Local anesthesy
1.6
8.9
426
3402
T90
ICPC
Diabetes non-insulin dependent
1.9
8.7
150
893
A28
ICPC
Limited function/disability NOS
2.0
8.7
126
704
H02AB06
ATC
prednisolone; systemic
1.6
8.7
329
2468
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
8.7
131
743
K90.0
ICD-10 Finland
Coeliac disease
5.2
8.5
25
49
JFB00
NOMESCO Finland
Partial resection of small intestine
5.8
8.5
23
41
A07AA02
ATC
nystatin; oral
2.7
8.4
56
216
P01AB01
ATC
metronidazole; oral, rectal
1.6
8.3
266
1901
JN3AD
NOMESCO Finland
Abdominal CT examination
2.6
8.3
62
255
-55
ICPC
Local injection/infiltration
7.7
8.2
18
24
A01
ICPC
Pain general/multiple sites
2.4
8.1
67
291
M25.5
ICD-10 Finland
Pain in joint
1.7
8.1
180
1160
N02BE01
ATC
paracetamol; systemic, rectal
1.7
8.1
592
5218
N06AX21
ATC
duloxetine; oral
2.4
8.1
70
313
N06AA09
ATC
amitriptyline; systemic
2.2
8.1
78
369
UJF92
NOMESCO Finland
Capsular endoscopy
5.4
8.0
23
44
D07AA02
ATC
hydrocortisone; topical
2.1
7.9
92
472
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.7
7.9
206
1392
SPAT1216
SPAT
Assessment of functional ability
1.9
7.8
125
723
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.4
7.8
65
285
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.9
7.7
122
702
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.6
7.6
56
230
JFB33
NOMESCO Finland
Other resection comprising small intestine and colon
18.6
7.6
11
6
J01MA12
ATC
levofloxacin; systemic
1.8
7.6
138
835
N06AB03
ATC
fluoxetine; oral
2.1
7.5
85
429
TAB00
NOMESCO Finland
Lumbar puncture
3.2
7.5
38
124
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
7.2
7.5
17
24
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.1
7.5
39
130
R53
ICD-10 Finland
Malaise and fatigue
1.8
7.5
151
942
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.6
7.5
288
2145
R25.1
ICD-10 Finland
Tremor, unspecified
4.0
7.4
28
72
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
4.0
7.4
28
72
D51.8
ICD-10 Finland
Other vitamin B12deficiency anaemias
13.5
7.4
12
9
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
7.4
136
827
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.4
7.3
60
261
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.9
7.3
43
155
E0000UV
ATC
NA
1.6
7.3
260
1896
JAH01
NOMESCO Finland
Laparoscopy
3.2
7.3
37
121
E53.1
ICD-10 Finland
Pyridoxine deficiency
+∞
7.3
7
*
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
+∞
7.3
7
*
A07EC02
ATC
mesalazine; oral, rectal
2.9
7.2
42
150
L28
ICPC
Limited function/disability (L)
1.8
7.2
125
741
WX002
NOMESCO Finland
Sedation and analgesia
1.8
7.2
139
854
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.5
7.2
56
238
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.2
7.2
76
374
E03.89
ICD-10 Finland
Other specified hypothyroidism
3.6
7.2
30
85
J01MA02
ATC
ciprofloxacin; systemic
1.6
7.1
264
1939
ZX120
NOMESCO Finland
Intravenous
2.2
7.1
75
367
T82
ICPC
Obesity
4.8
7.1
22
47
A10BB12
ATC
glimepiride; oral
2.3
7.0
63
286
SAA03
NOMESCO Finland
Extended examination of mouth
1.6
7.0
225
1600
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
6.9
176
1174
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
3.7
6.8
28
78
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
6.8
289
2187
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
5.7
6.8
18
32
M04AA01
ATC
allopurinol; systemic
1.9
6.8
99
554
WZC30
NOMESCO Finland
Teaching
2.0
6.7
89
481
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.6
6.7
188
1288
R06.0
ICD-10 Finland
Dyspnoea
1.6
6.7
170
1135
R06AE07
ATC
cetirizine; oral
1.5
6.6
267
1997
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.2
6.6
68
332
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
4.9
6.6
20
42
R51.80
ICD-10 Finland
Headache
2.0
6.6
88
477
R03AC02
ATC
salbutamol; inhalant
1.5
6.6
324
2534
A10BG03
ATC
pioglitazone; oral
4.2
6.5
23
56
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.7
6.5
147
948
A10BH01
ATC
sitagliptin; oral
2.2
6.5
65
313
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
4.8
6.4
20
43
A04
ICPC
Weakness/tiredness general
1.9
6.4
96
542
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
6.4
166
1111
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.2
6.4
66
322
T89
ICPC
Diabetes insulin dependent
3.6
6.4
27
78
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.0
6.4
85
462
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
8.2
6.3
13
16
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
5.6
6.3
17
31
B50
ICPC
Blood and Immunity, Medication/prescr/renewal
11.1
6.3
11
10
D52.9
ICD-10 Finland
Folate deficiency anaemia, unspecified
26.9
6.2
8
*
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.3
6.2
55
249
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.4
6.1
52
230
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.5
6.1
230
1685
K08.3
ICD-10 Finland
Retained dental root
2.4
6.1
49
211
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
3.1
6.1
31
103
E000001
ATC
NA
1.7
6.1
140
907
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
6.1
182
1264
J45
ICD-10 Finland
Asthma
2.2
6.1
60
289
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.3
6.0
28
87
Mortality – FinRegistry
↥Association
Association between endpoint E4_VIT_B_DEF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_VIT_B_DEF | 1.558 [1.34, 1.81] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.248 |
During the follow-up period (1.1.1998 — 31.12.2019), 919 out of 2076 females with E4_VIT_B_DEF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_VIT_B_DEF | 1.736 [1.45, 2.08] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 800 out of 1606 males with E4_VIT_B_DEF died.
Mortality risk
Mortality risk for people of age
years, who have E4_VIT_B_DEF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.131% | 0.299% |
| 5 | 0.919% | 1.861% |
| 10 | 2.566% | 4.57% |
| 15 | 4.72% | 8.204% |
| 20 | 8.144% | 13.297% |
Relationships between endpoints
↥Index endpoint: E4_VIT_B_DEF – Deficiency of other B group vitamins
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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