ascorbic acid deficiency: A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into scurvy in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
1871 |
6. Filter based on genotype QC (FinnGen only) |
1871 |
Control definitions (FinnGen only)
- Control exclude
- E4_NUTRIDEF
Extra metadata
- First used in FinnGen datafreeze
- DF12
Similar endpoints
↥List of similar endpoints to
Vitamin deficiency, wide
based on the number of shared cases.
Similar with more cases:
- Vitamin deficiency
- Other nutritional deficiencies
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 15478 | 8311 | 7025 |
| Only index persons | 12975 | 7087 | 5888 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.22 | 0.24 | 0.20 |
| Only index persons | 0.24 | 0.26 | 0.22 |
| Median age at first event (years) | |||
| Whole population | 60.22 | 60.18 | 60.20 |
| Only index persons | 58.19 | 57.69 | 58.80 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1871 | 1093 | 778 |
| Unadjusted period prevalence (%) | 0.36 | 0.37 | 0.34 |
| Median age at first event (years) | 55.72 | 50.81 | 62.62 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1703
- Matched controls
- 17028
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
107
Kela drug reimbursment
Pernicious anaemia
46.1
323.0
407
115
E53.8
ICD-10 Finland
Deficiency of other specified B group vitamins
455.4
323.0
356
10
E55.9
ICD-10 Finland
Vitamin D deficiency, unspecified
1098.2
323.0
477
6
B03BA03
ATC
hydroxocobalamin; parenteral
19.1
323.0
581
450
B81
ICPC
Anaemia vit B12/folate deficiency
17.9
224.9
366
256
E51.2
ICD-10 Finland
Wernicke encephalopathy
+∞
141.7
134
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.6
118.4
736
2983
E66.8
ICD-10 Finland
Other obesity
58.5
101.9
120
22
E66.01
ICD-10 Finland
Obesity due to excess calories
15.8
93.6
157
109
K29.4
ICD-10 Finland
Chronic atrophic gastritis
12.9
87.9
161
137
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.8
80.1
710
3437
E50.9
ICD-10 Finland
Vitamin A deficiency, unspecified
+∞
79.8
76
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.3
54.1
217
558
E66.9
ICD-10 Finland
Obesity, unspecified
24.2
50.5
72
31
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
12.1
47.5
88
76
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.4
46.9
180
441
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
45.9
767
4740
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
459.5
45.5
45
*
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
17.2
42.7
68
41
H03AA01
ATC
levothyroxine sodium; systemic
2.3
39.8
458
2357
E66.00
ICD-10 Finland
Metabolic syndrome
9.3
38.7
82
92
D64.9
ICD-10 Finland
Anaemia, unspecified
3.1
38.6
240
867
E53.9
ICD-10 Finland
Vitamin B deficiency, unspecified
57.7
38.5
45
8
C03CA01
ATC
furosemide; systemic
2.1
36.7
532
3018
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.5
35.3
317
1428
N05AH04
ATC
quetiapine; oral
2.4
35.1
334
1549
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.8
34.8
255
1022
SPAT1254
SPAT
Administration of medicine
2.4
33.3
314
1447
A02BC02
ATC
pantoprazole; systemic
1.9
32.4
1070
8110
E50.0
ICD-10 Finland
Vitamin A deficiency with conjunctival xerosis
+∞
31.3
30
*
N06AB04
ATC
citalopram; systemic
2.1
30.9
397
2113
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.5
30.9
115
272
N02AX02
ATC
tramadol; systemic, rectal
1.9
30.8
708
4716
E56.8
ICD-10 Finland
Deficiency of other vitamins
112.1
30.7
33
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
30.4
376
1966
T91
ICPC
Vitamin/nutritional deficiency
14.6
30.3
51
36
AA1AD
NOMESCO Finland
CT of head and brain
2.1
30.2
431
2396
2680A
ICD-9 Finland
Vitamin D deficiency, Rickets, active
+∞
29.2
28
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.9
29.1
193
723
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
28.9
624
4038
A10AE04
ATC
insulin glargine; parenteral
2.9
28.9
185
678
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.5
28.6
257
1147
N06AX11
ATC
mirtazapine; oral
1.9
28.3
554
3458
A28
ICPC
Limited function/disability NOS
2.3
28.1
284
1347
L28
ICPC
Limited function/disability (L)
2.3
28.1
295
1426
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.8
28.0
694
4692
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.9
28.0
526
3235
B03BA01
ATC
cyanocobalamin; nasal, systemic
101.7
27.7
30
*
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.1
27.1
383
2109
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.1
26.7
380
2091
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.5
26.2
232
1024
N02BE01
ATC
paracetamol; systemic, rectal
1.9
25.9
1400
11993
N03AX16
ATC
pregabalin; oral
2.0
25.8
406
2325
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.1
25.2
149
517
103
Kela drug reimbursment
Diabetes, insulin-treated
1.9
24.8
430
2545
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
24.7
252
1195
P15
ICPC
Chronic alcohol abuse
5.6
24.3
72
133
R4190
NOMESCO Finland
Nutritional therapy
4.8
24.0
82
178
N06AX16
ATC
venlafaxine; oral
2.3
23.8
242
1146
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
23.7
372
2115
A11CC03
ATC
alfacalcidol; systemic
5.6
23.2
69
128
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
14.2
23.1
39
28
A06AD11
ATC
lactulose; oral
2.1
23.0
282
1449
E55.0
ICD-10 Finland
Rickets, active
232.9
22.7
23
*
F10.25
ICD-10 Finland
Alcohol dependence continuous use
7.2
22.5
55
79
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
5.6
22.5
66
121
RD210
NOMESCO Finland
NA
6.7
22.3
57
87
UJF32
NOMESCO Finland
Coloscopy
1.8
22.3
432
2644
B03BA02
ATC
cyanocobalamin tannin complex; parenteral
13.8
22.3
38
28
R11
ICD-10 Finland
Nausea and vomiting
2.7
22.2
162
641
SPAT1216
SPAT
Assessment of functional ability
2.1
22.0
279
1454
26500
ICD-8 Finland
Vitamin D deficiency, Rickets active
+∞
21.9
21
*
SPAT1262
SPAT
Handing over of treatment supplies
2.0
21.7
294
1575
E66.0
ICD-10 Finland
Obesity due to excess calories
116.5
21.6
23
*
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
8.7
21.4
46
54
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
6.2
21.3
58
97
H02AB06
ATC
prednisolone; systemic
1.7
21.3
743
5428
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
4.1
21.1
83
208
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
5.1
21.1
67
135
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.1
21.0
260
1338
N06AX21
ATC
duloxetine; oral
2.4
20.9
184
807
-50
ICPC
Medication/prescr/renewal
3.4
20.9
103
313
E83.51
ICD-10 Finland
Hypocalcemia
17.1
20.5
32
19
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.1
20.3
239
1204
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.5
20.2
166
703
A10BA02
ATC
metformin; oral
1.8
20.1
412
2558
E51.9
ICD-10 Finland
Thiamine deficiency, unspecified
+∞
19.8
19
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.1
19.8
254
1328
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.0
19.7
81
212
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.9
19.6
303
1704
EBA15
NOMESCO Finland
Extraction of large number of teeth
4.0
19.5
80
209
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.6
19.4
91
266
L04AX01
ATC
azathioprine; systemic
3.4
19.3
97
299
R53
ICD-10 Finland
Malaise and fatigue
1.9
19.3
351
2087
ZX120
NOMESCO Finland
Intravenous
2.4
19.3
179
808
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.5
19.2
156
655
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
19.1
423
2686
JN3AD
NOMESCO Finland
Abdominal CT examination
2.6
19.0
143
576
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.2
19.0
201
964
R51.80
ICD-10 Finland
Headache
2.1
19.0
247
1295
2662A
ICD-9 Finland
Deficiency of B-complex components, Other B-complex deficiencies[HYPOVITAMINOSIS B12]
+∞
18.8
18
*
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
18.6
289
1624
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.3
18.6
191
903
N03AX12
ATC
gabapentin; oral
2.0
18.4
253
1354
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.5
18.4
157
677
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
18.3
397
2500
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.0
18.3
74
191
N05AH03
ATC
olanzapine; systemic
2.9
18.3
115
415
R42
ICD-10 Finland
Dizziness and giddiness
1.8
18.2
356
2167
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.7
18.2
415
2653
A04
ICPC
Weakness/tiredness general
2.1
18.1
235
1231
UJF30
NOMESCO Finland
Ileoscopy through colon
2.3
18.0
171
779
N05AX08
ATC
risperidone; systemic
2.4
18.0
154
665
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.0
17.9
255
1385
T90
ICPC
Diabetes non-insulin dependent
1.8
17.9
328
1954
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.7
17.8
125
484
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.2
17.7
96
314
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
7.5
17.5
41
56
N03AG01
ATC
valproic acid; systemic, rectal
2.8
17.3
115
431
C07AB07
ATC
bisoprolol; oral
1.6
17.2
710
5322
K50.0
ICD-10 Finland
Crohn disease of small intestine
6.0
17.1
47
80
SPAT1229
SPAT
Assessment of need for aid
2.4
17.1
154
684
A01
ICPC
Pain general/multiple sites
2.4
16.9
144
620
A12AA04
ATC
calcium carbonate; oral
6.2
16.9
45
74
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.6
16.8
515
3568
SPAT1263
SPAT
Sampling
1.6
16.8
672
4986
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.9
16.8
107
390
M79.6
ICD-10 Finland
Pain in limb
1.6
16.8
539
3785
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
+∞
16.7
16
*
N07BB01
ATC
disulfiram; oral
3.4
16.4
79
237
N06AB03
ATC
fluoxetine; oral
2.0
16.2
213
1121
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.2
16.1
87
285
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.0
15.9
93
321
R06.0
ICD-10 Finland
Dyspnoea
1.7
15.9
380
2453
E55
ICD-10 Finland
Vitamin D deficiency
14.6
15.8
26
18
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
15.8
262
1499
I50.9
ICD-10 Finland
Heart failure, unspecified
2.0
15.8
230
1258
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.3
15.6
81
257
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.6
15.6
119
484
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.4
15.5
139
617
T82
ICPC
Obesity
4.4
15.4
55
127
TAB00
NOMESCO Finland
Lumbar puncture
3.1
15.4
87
292
E87.6
ICD-10 Finland
Hypokalaemia
3.8
15.3
65
176
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
15.2
432
2922
B80
ICPC
Iron deficiency anaemia
4.8
15.2
50
106
E83.39
ICD-10 Finland
Other disorder of phosphorus metabolism
45.4
15.1
18
*
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
10.2
15.0
29
29
I10
ICD-10 Finland
Essential (primary) hypertension
1.5
14.9
825
6537
K50.8
ICD-10 Finland
Other Crohn disease
5.7
14.8
42
75
N03AE01
ATC
clonazepam; systemic
2.7
14.8
106
413
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.2
14.8
154
732
C03DA01
ATC
spironolactone; oral
2.1
14.7
176
890
A02BC03
ATC
lansoprazole; oral
1.6
14.7
451
3109
JDF01
NOMESCO Finland
Laparoscopic gastroplasty
+∞
14.6
14
*
SPAT1255
SPAT
Intravenous administration of medicine
2.5
14.6
116
483
N05AA02
ATC
levomepromazine; systemic
3.1
14.5
79
260
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.8
14.5
255
1486
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.3
14.5
142
653
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.6
14.5
444
3054
N06AB06
ATC
sertraline; oral
2.1
14.4
172
868
J45.1
ICD-10 Finland
Nonallergic asthma
2.5
14.4
115
479
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.3
14.4
139
637
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
14.4
269
1603
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
17.1
14.3
22
13
G47.3
ICD-10 Finland
Sleep apnoea
1.8
14.3
260
1538
E86
ICD-10 Finland
Volume depletion
3.9
14.2
59
157
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.9
14.2
215
1190
J01DB01
ATC
cefalexin; oral
1.6
14.2
1279
11227
N06AB10
ATC
escitalopram; oral
1.7
14.1
308
1927
N05CF01
ATC
zopiclone; oral
1.6
14.1
506
3619
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.5
14.0
109
448
N02AA05
ATC
oxycodone; systemic
1.9
13.9
231
1319
P76
ICPC
Depressive disorder
2.7
13.9
98
381
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
13.9
607
4542
M25.5
ICD-10 Finland
Pain in joint
1.6
13.9
413
2814
104
Kela drug reimbursment
Thyroid insufficiency
2.3
13.8
133
609
J01FF01
ATC
clindamycin; systemic
1.6
13.8
400
2706
F10.09
ICD-10 Finland
Alcohol intoxication UNS
4.5
13.7
48
109
C10AC01
ATC
colestyramine; oral
3.6
13.7
62
178
X59
ICD-10 Finland
Exposure to unspecified factor
1.8
13.7
276
1683
N06AA09
ATC
amitriptyline; systemic
2.1
13.7
166
841
SPAT1301
SPAT
No procedures
1.6
13.7
498
3571
E61.2
ICD-10 Finland
Magnesium deficiency
+∞
13.6
13
*
WVA30
SPAT
NA
3.9
13.5
55
144
J01MA02
ATC
ciprofloxacin; systemic
1.5
13.3
586
4382
SPAT1240
SPAT
Therapeutic discussion
2.0
13.3
172
897
N05BA01
ATC
diazepam; systemic, rectal
1.9
13.3
215
1217
K08.3
ICD-10 Finland
Retained dental root
2.4
13.3
114
495
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.2
13.2
132
616
R60.0
ICD-10 Finland
Localized oedema
2.0
13.2
171
889
C07AA05
ATC
propranolol; systemic
1.7
13.2
300
1896
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
3.3
13.2
65
200
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
13.1
679
5253
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.5
13.1
106
446
K70.1
ICD-10 Finland
Alcoholic hepatitis
11.0
13.0
24
22
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.3
12.9
127
588
A09AA02
ATC
multienzymes (lipase, protease etc.)
4.1
12.9
49
121
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
6.2
12.9
34
56
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.9
12.8
197
1095
R50.9
ICD-10 Finland
Fever, unspecified
1.8
12.8
227
1326
P01AB01
ATC
metronidazole; oral, rectal
1.5
12.8
591
4457
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.2
12.8
126
584
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
7.3
12.8
30
42
N05CD07
ATC
temazepam; oral
1.9
12.7
212
1212
WX110
NOMESCO Finland
Local anesthesy
1.5
12.7
1032
8732
SPAT1310
SPAT
Counselling related to known health issue
1.5
12.7
472
3392
UJF92
NOMESCO Finland
Capsular endoscopy
4.5
12.6
44
100
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
12.6
137
665
F10.73
ICD-10 Finland
Residual or late-onset psychosis caused by alcohol dementia
32.3
12.6
16
5
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
4.3
12.5
45
106
R41.0
ICD-10 Finland
Disorientation, unspecified
3.1
12.4
67
221
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.5
12.3
477
3450
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
3.4
12.3
59
178
K29.7
ICD-10 Finland
Gastritis, unspecified
3.1
12.3
66
217
SPAT1172
SPAT
Guidance concerning hydration
3.8
12.3
51
137
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
9.0
12.2
25
28
A02BC05
ATC
esomeprazole; systemic
1.5
12.2
577
4364
A55
ICPC
General and Unspecified, Local injection/infiltration
6.4
12.2
31
49
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.7
12.1
276
1743
S18
ICPC
Laceration/cut
1.5
11.9
595
4544
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.8
11.9
202
1161
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
2.6
11.9
89
358
QBJ30
NOMESCO Finland
Correction of abdominal apron
14.8
11.8
19
13
A07AA02
ATC
nystatin; oral
2.3
11.8
109
491
M54.5
ICD-10 Finland
Low back pain
1.5
11.8
472
3436
J01MA12
ATC
levofloxacin; systemic
1.7
11.8
283
1813
F10.49
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without information about seizures
9.0
11.7
24
27
M04AA01
ATC
allopurinol; systemic
1.9
11.7
190
1075
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.7
11.6
80
307
P01
ICPC
Feeling anxious/nervous/tense
2.0
11.6
157
833
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
6.2
11.5
30
49
E51.8
ICD-10 Finland
Other manifestations of thiamine deficiency
+∞
11.5
11
*
F02.89*E53.8
ICD-10 Finland
Dementia due to vitamin B12 deficiency
+∞
11.5
11
*
N05BA04
ATC
oxazepam; oral
1.6
11.4
390
2736
F10.24
ICD-10 Finland
Alcohol depence active use
5.4
11.3
33
62
N18.8
ICD-10 Finland
Other chronic renal failure
3.3
11.2
56
175
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
11.2
397
2808
JFB00
NOMESCO Finland
Partial resection of small intestine
4.6
11.1
37
81
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
4.6
11.1
37
81
T89
ICPC
Diabetes insulin dependent
2.8
11.0
68
245
A10BB12
ATC
glimepiride; oral
2.2
11.0
111
522
D01
ICPC
Abdominal pain/cramps general
1.9
10.9
173
973
K92.0
ICD-10 Finland
Haematemesis
3.6
10.9
48
136
H03BB01
ATC
carbimazole; oral
2.8
10.9
69
253
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.1
10.9
122
597
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
6.0
10.9
29
49
R4110
NOMESCO Finland
Physiotherapy
1.5
10.9
388
2743
A46
ICD-10 Finland
Erysipelas
1.8
10.9
197
1159
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.7
10.8
264
1697
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
10.8
737
5952
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
3.2
10.8
55
175
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
4.3
10.8
39
93
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.6
10.7
333
2277
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
13.0
10.6
18
14
376
Kela drug reimbursment
Cyanocobalamin
60.4
10.6
12
*
H02AB07
ATC
prednisone; oral
1.7
10.6
211
1277
F29
ICD-10 Finland
Unspecified nonorganic psychosis
2.9
10.6
62
217
WX002
NOMESCO Finland
Sedation and analgesia
1.6
10.6
289
1912
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.8
10.5
184
1070
F05.9
ICD-10 Finland
Delirium, unspecified
3.6
10.5
46
130
JAH01
NOMESCO Finland
Laparoscopy
2.6
10.5
75
296
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
5.1
10.5
32
64
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.6
10.5
74
290
A29
ICPC
General symptom/complaint other
1.8
10.5
176
1009
R03AC03
ATC
terbutaline; inhalant
1.8
10.5
200
1195
K29.3
ICD-10 Finland
Chronic superficial gastritis
2.9
10.4
62
219
26599
ICD-8 Finland
Vitamin D deficiency, Unspecified
+∞
10.4
10
*
G32.0*E53.8
ICD-10 Finland
Subacute combined degeneration of the spinal cord in case of vitamin B12 deficiency
+∞
10.4
10
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.6
10.4
296
1979
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.3
10.3
92
408
P03
ICPC
Feeling depressed
2.0
10.3
135
708
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
5.3
10.3
30
57
K50.9
ICD-10 Finland
Crohn disease, unspecified
4.3
10.3
37
88
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.3
10.3
91
402
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.1
10.2
117
580
A10BH01
ATC
sitagliptin; oral
2.0
10.2
132
690
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
10.1
261
1701
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
10.1
354
2488
A02BC01
ATC
omeprazole; systemic
1.5
10.1
404
2928
EBA00
NOMESCO Finland
Extraction of tooth
1.5
10.1
472
3532
R52.2
ICD-10 Finland
Other chronic pain
3.0
10.1
58
200
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.0
10.1
135
714
Q79.6
ICD-10 Finland
Ehlers-Danlos syndrome
14.7
10.0
16
11
R03AC02
ATC
salbutamol; inhalant
1.4
9.9
760
6232
SPAT1104
SPAT
Monitoring of emergency patient
2.2
9.9
99
464
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
9.8
585
4580
D51
ICD-10 Finland
Vitamin B12deficiency anaemia
8.2
9.8
21
26
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
6.0
9.8
26
44
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.3
9.8
91
412
R06AE07
ATC
cetirizine; oral
1.4
9.8
628
4987
A07EA06
ATC
budesonide; oral, local oral
2.7
9.8
63
235
M81.9
ICD-10 Finland
Osteoporosis, unspecified
2.6
9.8
69
270
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
3.3
9.7
48
150
Z72.1
ICD-10 Finland
Alcohol use
5.4
9.7
28
53
WZC30
NOMESCO Finland
Teaching
1.8
9.7
181
1075
E83.30
ICD-10 Finland
Acid phosphatase deficiency
55.3
9.6
11
*
L17
ICPC
Foot/toe symptom/complaint
1.5
9.6
353
2505
D50.8
ICD-10 Finland
Other iron deficiency anaemias
4.5
9.6
33
75
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.8
9.6
167
966
N05AX12
ATC
aripiprazole; systemic
2.8
9.6
60
217
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.5
9.6
73
299
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
9.6
316
2186
SPAT1211
SPAT
Application of soft bandage
1.9
9.6
143
784
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.1
9.6
106
519
B82
ICPC
Anaemia other/unspecified
3.1
9.6
50
163
-55
ICPC
Local injection/infiltration
6.4
9.6
24
38
A03FA01
ATC
metoclopramide; systemic, rectal
1.6
9.5
304
2089
SPAT1260
SPAT
Consultation of another employee
1.6
9.5
255
1678
H02AB04
ATC
methylprednisolone; systemic
1.7
9.5
209
1303
E21.3
ICD-10 Finland
Hyperparathyroidism, unspecified
4.8
9.5
30
63
K02.1
ICD-10 Finland
Caries of dentine
1.4
9.4
812
6776
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.7
9.4
61
229
26510
ICD-8 Finland
Vitamin D deficiency, Rickets, late effect
+∞
9.4
9
*
E50.7
ICD-10 Finland
Other ocular manifestations of vitamin A deficiency
+∞
9.4
9
*
R10.0
ICD-10 Finland
Acute abdomen
2.9
9.4
54
187
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.9
9.3
132
714
N03AX09
ATC
lamotrigine; oral
2.5
9.3
73
303
K59.09
ICD-10 Finland
Constipation, unspecified
2.2
9.3
97
462
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.2
9.3
97
462
SPAT1234
SPAT
Support of social functional capacity
2.3
9.3
82
362
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.2
9.3
92
428
WZA90
NOMESCO Finland
Other doctors statement
1.5
9.3
326
2289
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.8
9.3
152
865
A50
ICPC
General and Unspecified, Medication/prescr/renewal
2.9
9.3
54
189
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
9.3
687
5583
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
3.1
9.2
48
156
J46
ICD-10 Finland
Status asthmaticus
3.2
9.2
46
145
A10AE05
ATC
insulin detemir; parenteral
2.3
9.2
84
376
Y94.0
ICD-10 Finland
Accident at home
3.7
9.2
39
108
K92.1
ICD-10 Finland
Melaena
2.2
9.2
87
398
P29
ICPC
Psychological sympt/compl other
2.2
9.2
87
398
E21.1
ICD-10 Finland
Secondary hyperparathyroidism, not elsewhere classified
13.7
9.2
15
11
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.7
9.2
206
1293
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
3.0
9.1
52
177
ZX114
NOMESCO Finland
Intramuscular
4.3
9.1
32
75
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.8
9.1
148
839
SPAT1245
SPAT
Provision of support and information to patient’s family members
2.3
9.0
78
342
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.3
9.0
78
342
K70.4
ICD-10 Finland
Alcoholic hepatic failure
10.1
9.0
17
17
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
2.9
9.0
53
187
B01AB05
ATC
enoxaparin; parenteral
1.5
9.0
415
3083
J01DA01
ATC
[U] cefalexin; systemic
1.4
9.0
948
8154
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.6
9.0
281
1920
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
4.1
9.0
33
81
E03.89
ICD-10 Finland
Other specified hypothyroidism
2.8
9.0
56
203
V03AG01
ATC
sodium cellulose phosphate; systemic
18.7
8.9
13
7
N05BA12
ATC
alprazolam; oral
1.8
8.9
145
823
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
1.8
8.9
162
953
E000001
ATC
NA
1.5
8.8
303
2113
A41.9
ICD-10 Finland
Sepsis, unspecified
2.8
8.8
56
207
L76
ICPC
Fracture: other
2.9
8.8
51
178
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.7
8.8
186
1145
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
2.7
8.7
56
209
A12BA01
ATC
potassium chloride; oral
2.3
8.7
81
368
F34.1
ICD-10 Finland
Dysthymia
2.7
8.7
57
216
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.2
8.7
88
415
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.5
8.7
300
2096
Z71.8
ICD-10 Finland
Other specified counselling
1.5
8.7
331
2364
SPAT1252
SPAT
Overall medication plan or its review
2.0
8.6
108
557
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
4.3
8.6
30
70
C09AA02
ATC
enalapril; systemic
1.6
8.6
270
1845
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
8.6
773
6460
R25.1
ICD-10 Finland
Tremor, unspecified
3.0
8.6
49
168
F10.03
ICD-10 Finland
Alcohol-related acute intoxication with delirium
11.6
8.6
15
13
N19
ICD-10 Finland
Unspecified kidney failure
2.7
8.6
56
212
JFB33
NOMESCO Finland
Other resection comprising small intestine and colon
16.4
8.5
13
8
R4140
NOMESCO Finland
Psychotherapy
9.0
8.5
17
19
SPAT1312
SPAT
General health counselling
1.4
8.5
463
3549
E21.0
ICD-10 Finland
Primary hyperparathyroidism
4.3
8.5
30
71
N30.0
ICD-10 Finland
Acute cystitis
1.6
8.5
207
1326
F10.6
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Amnesic syndrome
20.1
8.5
12
6
RF211
NOMESCO Finland
NA
90.5
8.4
9
*
E56.9
ICD-10 Finland
Vitamin deficiency, unspecified
90.5
8.4
9
*
H02AB09
ATC
hydrocortisone; systemic
3.3
8.4
41
128
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
2.7
8.4
55
209
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
2.9
8.4
49
173
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.1
8.4
97
484
X58
ICD-10 Finland
Exposure to other specified factors
1.7
8.4
184
1147
SGB10
NOMESCO Finland
Fiiling of rooth of tooth with one root channel
1.7
8.3
166
1005
XW000
NOMESCO Finland
Bone marrow biopsy
2.5
8.3
64
264
E56.0
ICD-10 Finland
Deficiency of vitamin E
+∞
8.3
8
*
ZXA05
NOMESCO Finland
Left side
1.5
8.3
362
2656
UJD02
NOMESCO Finland
Gastroscopy
2.2
8.3
81
377
C07AB02
ATC
metoprolol; systemic
1.5
8.3
298
2099
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.4
8.3
750
6261
S06.0
ICD-10 Finland
Concussion
1.8
8.3
155
920
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
3.3
8.3
39
119
P06
ICPC
Sleep disturbance
1.8
8.3
134
760
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.3
8.3
75
337
N03AX11
ATC
topiramate; oral
3.0
8.2
44
147
Z02.7
ICD-10 Finland
Issue of medical certificate
2.1
8.2
88
428
XG466
NOMESCO Finland
Sleep oxymetry
3.0
8.2
45
153
N05BE01
ATC
buspirone; oral
3.0
8.2
45
153
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
2.2
8.2
83
394
JN4BD
NOMESCO Finland
Extensive body CT
1.7
8.2
158
950
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.0
8.2
98
498
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
2.5
8.1
60
243
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.8
8.1
149
882
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.9
8.1
118
646
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
1.9
8.1
114
616
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
4.2
8.1
29
70
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.9
8.1
122
677
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.0
8.1
95
478
205
Kela drug reimbursment
Chronic hypertension
1.4
8.1
388
2902
P20
ICPC
Memory disturbance
1.7
8.1
173
1069
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
3.1
8.1
42
138
R51
ICD-10 Finland
Headache
2.2
8.0
79
369
M81.8
ICD-10 Finland
Other osteoporosis
5.6
8.0
22
40
ZXA00
NOMESCO Finland
Right side
1.4
8.0
383
2860
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.9
7.9
111
599
E0000UV
ATC
NA
1.4
7.9
556
4447
P74
ICPC
Anxiety disorder/anxiety state
2.6
7.9
55
216
N03AF01
ATC
carbamazepine; oral, rectal
2.1
7.9
83
400
XG410
NOMESCO Finland
Flow-volume spirometry
2.4
7.9
67
291
M10.9
ICD-10 Finland
Gout, unspecified
2.2
7.9
80
378
M79.7
ICD-10 Finland
Fibromyalgia
2.7
7.8
50
186
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.0
7.8
100
522
G44.2
ICD-10 Finland
Tension-type headache
1.6
7.8
185
1176
N01
ICPC
Headache
1.7
7.8
146
869
S72.0
ICD-10 Finland
Fracture of neck of femur
2.3
7.8
67
295
R02
ICPC
Shortness of breath/dyspnoea
1.7
7.8
161
988
K50.1
ICD-10 Finland
Crohn disease of large intestine
4.0
7.8
29
73
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
3.9
7.8
30
78
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.8
7.7
140
823
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
3.5
7.7
34
99
F41.09
ICD-10 Finland
UNS Panic Syndrome
2.7
7.7
49
182
C08CA01
ATC
amlodipine; oral
1.4
7.7
472
3685
SPAT1167
SPAT
Insertion of urinary catheter
2.7
7.7
51
196
R55
ICD-10 Finland
Syncope and collapse
1.7
7.7
158
964
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.1
7.7
83
403
P16
ICPC
Acute alcohol abuse
4.0
7.7
29
74
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.7
7.7
148
888
UKC02
NOMESCO Finland
Cystoscopy
1.6
7.6
225
1513
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
1.8
7.6
129
745
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.1
7.6
79
380
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.4
7.6
60
253
K91.2
ICD-10 Finland
Postsurgical malabsorption, not elsewhere classified
18.4
7.6
11
6
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.8
7.6
139
821
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
6.7
7.6
18
27
D11
ICPC
Diarrhoea
1.7
7.6
149
899
E66
ICD-10 Finland
Obesity
3.0
7.6
41
139
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.4
7.5
382
2881
D06
ICPC
Abdominal pain localized other
1.9
7.5
115
641
N05BA02
ATC
chlordiazepoxide; systemic
2.9
7.5
43
149
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.5
7.5
242
1660
R03DC03
ATC
montelukast; oral
1.6
7.5
203
1336
J01AA02
ATC
doxycycline; systemic
1.3
7.5
1152
10364
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
3.9
7.5
29
76
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
2.8
7.4
44
158
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
1.8
7.4
123
703
M13.9
ICD-10 Finland
Arthritis, unspecified
1.9
7.4
101
542
M79.1
ICD-10 Finland
Myalgia
1.6
7.4
173
1097
WX290
NOMESCO Finland
Other blockade of nerve
1.3
7.4
597
4871
SPAT1305
SPAT
Counselling and guidance related to physical exercise
1.8
7.4
134
791
L03
ICPC
Low back symptom/complaint
1.4
7.4
324
2374
I50.1
ICD-10 Finland
Left ventricular failure
2.2
7.3
72
338
Z00.0
ICD-10 Finland
General medical examination
1.5
7.3
265
1865
B50
ICPC
Blood and Immunity, Medication/prescr/renewal
8.4
7.3
15
18
SPAT1097
SPAT
Recording of ECG
1.6
7.3
195
1278
XA800
NOMESCO Finland
Neuropsychological investigation
2.3
7.3
64
285
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.3
7.3
599
4898
E53.1
ICD-10 Finland
Pyridoxine deficiency
+∞
7.3
7
*
26520
ICD-8 Finland
Vitamin D deficiency, Osteomalacia
+∞
7.3
7
*
D51.8
ICD-10 Finland
Other vitamin B12deficiency anaemias
9.4
7.3
14
15
D07AB08
ATC
desonide; topical
1.7
7.3
148
904
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
6.3
7.2
18
29
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.4
7.2
400
3062
E83.50
ICD-10 Finland
Hypercalcemia
4.1
7.2
26
64
R4120
NOMESCO Finland
Occupational therapy
2.0
7.2
93
489
D07AB02
ATC
hydrocortisone butyrate; topical
1.4
7.2
381
2895
S97
ICPC
Chronic ulcer skin
2.1
7.2
80
397
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
2.3
7.1
60
262
R47.8
ICD-10 Finland
Other and unspecified speech disturbances
6.6
7.1
17
26
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.5
7.1
218
1481
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
4.2
7.1
25
60
L04AA06
ATC
mycophenolic acid; systemic
3.5
7.1
31
90
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
1.8
7.1
115
652
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
1.9
7.1
100
542
WX892
NOMESCO Finland
Monitored bed care
1.8
7.1
111
622
SAA03
NOMESCO Finland
Extended examination of mouth
1.3
7.0
540
4365
Z72.0
ICD-10 Finland
Tobacco use
2.9
7.0
40
139
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
3.6
7.0
29
81
A03
ICPC
Fever
1.5
7.0
209
1411
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.7
7.0
128
757
A10BG03
ATC
pioglitazone; oral
3.1
7.0
36
119
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
2.2
6.9
64
292
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.5
6.9
52
213
SPAT1215
SPAT
Assessment of need for medical rehabilitation
2.2
6.9
67
313
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
1.7
6.9
153
956
SPAT1125
SPAT
Stoma care and guidance
3.5
6.9
30
87
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
2.4
6.9
55
234
SPAT1153
SPAT
Removal of sutures
1.4
6.9
422
3287
W19
ICD-10 Finland
Unspecified fall
1.7
6.8
139
848
C03AA03
ATC
hydrochlorothiazide; oral
1.7
6.8
132
792
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
2.9
6.8
39
135
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
1.8
6.8
116
669
A07EC01
ATC
sulfasalazine; oral, rectal
1.8
6.8
113
650
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.6
6.8
188
1243
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.6
6.8
156
985
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.2
6.8
65
301
N06AX03
ATC
mianserin; oral
2.1
6.8
73
358
K25.7
ICD-10 Finland
Gastric ulcer, Chronic without haemorrhage or perforation
4.5
6.8
22
49
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.6
6.8
45
174
G62.8
ICD-10 Finland
Other specified polyneuropathies
6.1
6.8
17
28
R03BB04
ATC
tiotropium bromide; inhalant
1.7
6.7
133
805
I50.0
ICD-10 Finland
Congestive heart failure
1.9
6.7
101
560
G40.9
ICD-10 Finland
Epilepsy, unspecified
2.3
6.7
57
250
M01AG02
ATC
tolfenamic acid; oral, rectal
1.5
6.7
199
1339
J01EA01
ATC
trimethoprim; systemic
1.4
6.7
371
2836
K59.1
ICD-10 Finland
Functional diarrhoea
2.1
6.7
74
364
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
3.1
6.7
34
111
D07AA02
ATC
hydrocortisone; topical
1.6
6.7
189
1259
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
3.9
6.7
25
64
R74
ICPC
Upper respiratory infection acute
1.4
6.7
373
2857
F10.20
ICD-10 Finland
Alcohol dependence currently independent
3.2
6.7
33
106
R13
ICD-10 Finland
Dysphagia
1.9
6.7
91
489
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
2.7
6.7
41
152
TPH07
NOMESCO Finland
Cathetrisation of artery
1.7
6.6
140
863
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.7
6.6
127
764
S10
ICPC
Boil/carbuncle
2.1
6.6
69
334
K65.0
ICD-10 Finland
Acute peritonitis
4.0
6.6
24
60
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
2.8
6.6
40
147
A10BH05
ATC
linagliptin; oral
2.2
6.6
66
312
K07
ICPC
Swollen ankles/oedema
2.2
6.6
64
300
D07BA04
ATC
hydrocortisone and antiseptics; topical
1.7
6.5
144
897
B02AA02
ATC
tranexamic acid; systemic
1.5
6.5
200
1355
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
2.6
6.5
43
165
M25.2
ICD-10 Finland
Flail joint
4.4
6.5
22
51
K90.0
ICD-10 Finland
Coeliac disease
2.4
6.5
52
220
K04.4
ICD-10 Finland
Acute apical periodontitis of pulpal origin
1.8
6.5
105
599
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
2.7
6.5
40
149
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
3.1
6.5
32
103
J45.8
ICD-10 Finland
Mixed asthma
2.5
6.5
47
192
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
2.5
6.5
47
192
E83.3
ICD-10 Finland
Disorders of phosphorus metabolism and phosphatases
70.1
6.4
7
*
D09
ICPC
Nausea
2.1
6.4
65
309
SPAT1251
SPAT
Organisation of medication
2.2
6.4
58
264
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
2.0
6.4
79
410
L29.9
ICD-10 Finland
Pruritus, unspecified
2.7
6.4
39
144
E14.8
ICD-10 Finland
Unspecified diabetes mellitus, with unspecified complications
14.4
6.4
10
7
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
2.3
6.4
55
244
R60.9
ICD-10 Finland
Oedema, unspecified
2.1
6.4
67
323
A05AA02
ATC
ursodeoxycholic acid; oral
3.2
6.3
31
99
K59.0
ICD-10 Finland
Constipation
2.0
6.3
80
416
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
2.0
6.3
80
416
P99
ICPC
Psychological disorders other
2.7
6.3
41
155
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
1.8
6.3
96
537
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
3.5
6.3
27
78
E11
ICD-10 Finland
Type 2 diabetes mellitus
1.6
6.3
183
1227
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
1.9
6.3
82
433
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
2.7
6.3
41
156
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
2.7
6.3
41
156
L50.9
ICD-10 Finland
Urticaria, unspecified
2.3
6.3
52
227
E21.2
ICD-10 Finland
Other hyperparathyroidism
9.3
6.3
12
13
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
2.9
6.3
36
126
M05BA04
ATC
alendronic acid; oral
1.7
6.3
122
737
26000
ICD-8 Finland
Vitamin A deficiency, Night blindness
+∞
6.3
6
*
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
1.8
6.2
108
629
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
2.6
6.2
44
174
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
2.8
6.2
37
134
M83.9
ICD-10 Finland
Adult osteomalacia, unspecified
26.8
6.2
8
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.8
6.2
111
650
F03
ICD-10 Finland
Unspecified dementia
2.0
6.2
73
371
C10AA01
ATC
simvastatin; oral
1.3
6.2
566
4674
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
2.3
6.2
53
232
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.1
6.2
62
296
SPAT1307
SPAT
Psychosocial counselling and guidance
1.9
6.2
83
443
A10BK01
ATC
dapagliflozin; oral
2.5
6.2
47
194
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
5.0
6.2
18
36
TK800
NOMESCO Finland
Hemodialysis
3.0
6.2
32
107
F22.0
ICD-10 Finland
Delusional disorder
3.3
6.2
28
85
K70.0
ICD-10 Finland
Alcoholic fatty liver
5.8
6.1
16
28
N39.4
ICD-10 Finland
Other specified urinary incontinence
1.8
6.1
107
625
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
1.7
6.1
134
837
D07CC01
ATC
betamethasone and antibiotics; topical
1.6
6.1
175
1166
3AC01
NOMESCO Finland
NA
4.2
6.1
21
50
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
1.9
6.1
88
480
TGC00
NOMESCO Finland
Bronchial lavation
2.8
6.1
36
130
K06.18
ICD-10 Finland
Another gingival hyperplasia
12.6
6.1
10
8
SFA40
NOMESCO Finland
Replacement of krone of tooth
1.4
6.1
263
1918
I95.9
ICD-10 Finland
Hypotension, unspecified
3.3
6.1
28
86
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
2.9
6.1
33
114
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
2.1
6.1
67
330
N07
ICPC
Convulsion/seizure
8.6
6.1
12
14
JF1DG
NOMESCO Finland
Small bowel very extensive MRI with with high intensity magnet
8.6
6.1
12
14
Z94.4
ICD-10 Finland
Liver transplant status
8.6
6.1
12
14
L16
ICPC
Ankle symptom/complaint
1.7
6.0
133
831
R31
ICD-10 Finland
Unspecified haematuria
1.7
6.0
133
831
R5599
NOMESCO Finland
Other rehabilitation service
2.5
6.0
44
180
127
Kela drug reimbursment
Transplant complication
3.4
6.0
27
81
L15
ICPC
Knee symptom/complaint
1.4
6.0
261
1903
J45
ICD-10 Finland
Asthma
1.7
6.0
118
714
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
4.2
6.0
21
51
Z53.2
ICD-10 Finland
Procedure not carried out because of patient's decision for other and unspecified reasons
4.2
6.0
21
51
Mortality – FinRegistry
↥Association
Association between endpoint VIT_DEF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VIT_DEF | 1.78 [1.58, 2.01] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.37 |
During the follow-up period (1.1.1998 — 31.12.2019), 1968 out of 5963 females with VIT_DEF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VIT_DEF | 2.466 [2.12, 2.87] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 1987 out of 4814 males with VIT_DEF died.
Mortality risk
Mortality risk for people of age
years, who have VIT_DEF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.159% | 0.53% |
| 5 | 1.056% | 2.998% |
| 10 | 2.595% | 6.818% |
| 15 | 5.044% | 12.608% |
| 20 | 8.946% | 20.444% |
Relationships between endpoints
↥Index endpoint: VIT_DEF – Vitamin deficiency, wide
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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