Deficiency of other/unspecified vitamins

E4_VIT_NAS_DEF

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E56.8, E56.9 Hospital discharge: ICD-9 — 269[1-2] Hospital discharge: ICD-8 — 266[8-9] Hospital discharge: excluded ICD-8 — 26688 Cause of death: ICD-10 — E56.8, E56.9 Cause of death: ICD-9 — 269[1-2] Cause of death: ICD-8 — 266[8-9] Cause of death: excluded ICD-8 — 26688 2 out of 7 registries used, show all original rules.	50
4. Check minimum number of events None	50
5. Include endpoints None	50
6. Filter based on genotype QC (FinnGen only)	50

Control definitions (FinnGen only)

Control exclude: E4_NUTRIDEF

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	E4_VIT_NAS_DEF
CONTROL_EXCLUDE	E4_NUTRIDEF
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E56[8-9]
HD_ICD_9	269[1-2]
HD_ICD_8	266[8-9]
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL	26688
COD_MAINONLY
COD_ICD_10	E56[8-9]
COD_ICD_9	269[1-2]
COD_ICD_8	266[8-9]
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL	26688
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Deficiency of other/unspecified vitamins based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	344	188	154
Only index persons	302	165	137
Unadjusted period prevalence (%)
Whole population	0.00	0.01	0.00
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	60.93	59.56	62.55
Only index persons	61.44	59.66	63.58

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	50	28	22
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	61.60	58.26	65.84

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3019309) Folate [Moles/volume] in Red Blood Cells

4.89

6.57

3.3

1.6

1553.4

1115.2

nmol/l

0.86

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

124

3.56

4.66

2.2

1.9

73.7

91.0

pmol/l

1.13

(3012544) pH of Venous blood

4.47

4.22

8.3

2.5

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

169

3.20

3.84

11.7

6.0

1.2

mmol/l

1.51

145

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

4.56

3.73

4.5

1.6

—

(40768797) Stomach Pathology biopsy report

3.64

3.43

1.3

1.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

6.06

2.98

2.1

1.3

—

(3013512) EKG study

2.73

2.82

8.3

4.0

—

(3023368) Bacteria identified in Blood by Culture

2.79

2.77

10.0

4.0

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

141

2.55

2.63

8.9

4.0

42.1

54.9

ng/l

0.17

(3022313) Gas panel - Capillary blood

4.90

2.57

3.1

—

(3019225) pH of Specimen

3.32

2.47

6.0

4.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

3.16

2.46

3.4

1.5

—

(3012516) Albumin [Mass/volume] in Urine

2.45

2.12

4.0

3.3

120.2

65.5

mg/l

—

(3020682) Albumin/Creatinine [Ratio] in Urine

2.37

2.04

5.3

4.0

33.4

11.0

mg/mmol

0.53

(3000991) Gas panel - Venous blood

3.20

1.96

15.7

5.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.53

1.92

3.5

1.6

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

3.86

1.90

2.7

1.9

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

3.36

1.87

3.3

1.8

195.0

124.9

ng/l

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

3.64

1.80

2.8

2.4

—

(3032080) INR in Blood by Coagulation assay

143

2.13

1.78

13.4

7.3

1.2

1.3

inr

—

(3013707) Erythrocyte sedimentation rate by Westergren method

281

2.22

1.65

5.2

4.4

14.9

11.6

mm/h

0.80

254

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.64

1.45

12.6

3.3

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

3.15

1.39

9.4

2.4

1.9

2.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.15

1.39

2.8

1.5

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

231

1.90

1.33

6.3

3.3

55.5

42.5

u/l

0.43

217

(3044640) Blood type and Crossmatch panel - Blood

105

1.94

1.27

3.9

2.1

—

(3042936) Bacteria identified in Isolate by Culture

2.25

1.27

7.6

1.9

—

(3026008) Bacteria identified in Urine by Culture

116

1.86

1.18

5.8

3.3

—

(42870588) Differential panel, method unspecified - Blood

134

1.82

1.16

9.1

5.7

—

(3006504) Eosinophils/100 leukocytes in Blood

181

1.76

1.11

8.8

6.2

1.9

2.8

1.51

165

(3019069) Monocytes/100 leukocytes in Blood

183

1.73

1.06

9.0

6.6

7.9

9.0

0.77

169

(3009542) Hematocrit [Volume Fraction] of Blood

336

1.95

1.05

32.4

13.1

34.4

40.2

1.38

247

(3018418) pH of Serum or Plasma

104

1.79

1.00

6.7

3.2

7.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.87

1.00

6.5

6.0

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

327

1.88

1.00

35.1

12.7

75.0

82.8

ml/min/173m2

1.16

260

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

2.03

0.98

1.7

2.1

—

(4035726)

2.38

0.97

1.7

1.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.29

0.95

1.3

1.6

—

(4010399)

2.29

0.95

1.8

1.4

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

1.92

0.89

2.9

1.8

33.9

28.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

125

1.69

0.89

3.7

3.3

—

(40761536) Microorganisms panel - Urine sediment

2.06

0.87

6.2

4.2

—

(3026493) Urate [Moles/volume] in Serum or Plasma

1.72

0.83

4.0

2.8

316.9

350.3

umol/l

0.58

(3037467) Urinalysis macro (dipstick) panel - Urine

252

1.61

0.81

8.1

4.8

—

(36304419) Bacteria [Presence] in Urine

102

1.67

0.79

3.1

—

(3025941) Bacteria identified in Stool by Culture

2.30

0.78

2.0

1.2

—

(3015736) pH of Urine

138

1.61

0.78

6.7

3.6

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

372

1.80

0.77

40.0

12.9

21.3

20.3

mg/l

0.09

284

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.71

0.74

2.9

2.0

—

(3000494) Fungus identified in Specimen by Culture

1.73

0.70

2.9

1.3

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

320

1.60

0.68

8.9

5.0

46.4

39.7

mmol/mol

1.66

291

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.61

0.0

1.6

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.60

0.0

1.3

—

(3022948) Iron [Moles/volume] in Serum or Plasma

1.61

0.59

4.2

2.0

9.1

14.1

umol/l

—

(3000492) Spirometry study

1.70

0.58

2.7

1.5

—

(40768804) Tissue Pathology biopsy report

138

1.48

0.56

2.2

1.9

—

(3035350) Ketones [Presence] in Urine by Test strip

176

1.45

0.55

6.9

4.1

0.0

estimate

—

(3002256) Pathology report gross observation

1.61

0.55

1.0

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

227

1.41

0.51

3.2

3.1

—

(3041096) Erythrocytes [Presence] in Urine by Automated

104

1.48

0.50

8.0

3.9

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

1.50

0.50

1.3

1.1

2.3

u/ml

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

147

1.35

0.38

7.2

4.1

—

(3021601) Nitrite [Presence] in Urine by Test strip

176

1.33

0.37

11.9

5.7

0.0

estimate

—

(3009261) Glucose [Presence] in Urine by Test strip

179

1.30

0.32

7.0

4.1

0.0

estimate

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

181

1.28

0.29

7.4

3.9

—

(36660697) Celiac disease serology panel - Serum

1.39

0.24

1.4

1.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.35

0.24

4.6

1.3

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

1.30

0.24

2.5

4.7

2.3

1.9

ug/l

0.21

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.31

0.23

4.8

1.3

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

389

1.30

0.23

38.8

14.8

87.2

75.9

umol/l

0.72

389

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.21

0.22

1.4

—

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

5.2

—

(3023351) European house dust mite IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

3.9

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.21

0.0

2.0

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

(4034850)

0.00

0.20

0.0

8.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.15

0.18

1.9

1.7

—

(3029937) Albumin [Presence] in Urine by Test strip

103

1.22

0.15

4.6

4.0

0.0

estimate

—

(40761511) CBC panel - Blood by Automated count

394

1.23

0.14

41.0

11.7

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.10

0.10

2.0

2.1

—

(3044889) 12 lead EKG panel

246

1.12

0.09

6.6

3.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

0.84

0.08

4.6

3.7

—

(40758558) Short blood count panel - Blood

1.04

0.00

9.2

6.4

—

(1761868) Lipid panel - Serum or Plasma

105

1.06

0.00

2.8

2.6

—

(3003694) ABO and Rh group [Type] in Blood

118

1.02

0.00

1.8

1.4

—

(3002385) Erythrocyte distribution width [Ratio]

312

0.98

0.00

42.3

15.4

14.3

13.8

0.75

304

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.3

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.3

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

2.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.99

0.00

1.0

1.5

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.94

0.00

1.0

1.3

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.0

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(3047826) Mullerian inhibiting substance [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

4.4

—

(3018572) Chloride [Moles/volume] in Blood

0.00

0.0

7.6

—

105.4

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.2

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.9

—

(3039000) Anion gap in Blood

0.00

0.0

7.6

—

10.6

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

2.6

—

(4027681)

0.00

0.0

1.0

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.3

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.8

—

(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.6

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.0

1.3

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.4

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.00

0.00

2.0

1.7

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

11.1

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

2.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_VIT_NAS_DEF and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
E4_VIT_NAS_DEF	1.706 [0.86, 3.38]	0.125
Birth year	0.987 [0.98, 1.0]	0.009

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 118 males with E4_VIT_NAS_DEF died.

Mortality risk

Mortality risk for people of age

years, who have E4_VIT_NAS_DEF.

N-year risk	Females	Males
1	No data	0.391%
5	No data	1.968%
10	No data	5.044%
15	No data	9.336%
20	No data	15.5%

Relationships between endpoints

↥

Index endpoint: E4_VIT_NAS_DEF – Deficiency of other/unspecified vitamins

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Deficiency of other/unspecified vitamins

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints