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This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

Deficiency of other/unspecified vitamins

MESH Endpoint Browser

E4_VIT_NAS_DEF

Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E56.8, E56.9
  • Hospital discharge: ICD-9 — 269[1-2]
  • Hospital discharge: ICD-8 — 266[8-9]
  • Hospital discharge: excluded ICD-8 — 26688
  • Cause of death: ICD-10 — E56.8, E56.9
  • Cause of death: ICD-9 — 269[1-2]
  • Cause of death: ICD-8 — 266[8-9]
  • Cause of death: excluded ICD-8 — 26688

2 out of 7 registries used, show all original rules.

51

4. Check minimum number of events

None

51

5. Include endpoints

None

51

6. Filter based on genotype QC (FinnGen only)

48

Control definitions (FinnGen only)

Control exclude
E4_NUTRIDEF

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 344 188 154
Only index persons 302 165 137
Unadjusted period prevalence (%)
Whole population 0.00 0.01 0.00
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 60.93 59.56 62.55
Only index persons 61.44 59.66 63.58

-FinnGen-

Key figures

All Female Male
Number of individuals 48 26 22
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 62.28 59.26 65.84

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
51
Matched controls
510
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E56.8
ICD-10 Finland
Deficiency of other vitamins
+∞
39.9
33
*
E56.9
ICD-10 Finland
Vitamin deficiency, unspecified
+∞
11.9
11
*
B03BA03
ATC
hydroxocobalamin; parenteral
12.0
7.3
13
14
B81
ICPC
Anaemia vit B12/folate deficiency
20.2
7.1
10
6

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
20
60
4.84
6.55
2.9
1.6
1553.36
1115.16
nmol/l
0.86
14
49
28
124
3.79
5.21
2.3
1.9
74.25
91.02
pmol/l
1.18
15
55
32
170
3.37
4.23
11.4
6.1
1.18
1.22
mmol/l
1.58
24
145
14
44
4.01
4.14
1.3
1.2
—
—
—
0
0
12
32
4.58
3.69
8.3
2.6
—
—
—
0
0
20
97
2.75
2.87
8.3
4.0
—
—
—
0
0
12
41
3.51
2.87
3.2
1.5
—
—
—
0
0
18
84
2.77
2.76
10.0
4.0
—
—
—
0
0
7
16
4.89
2.57
3.1
3.1
—
—
—
0
0
25
142
2.49
2.56
8.9
4.0
42.06
55.38
ng/l
0.17
18
91
10
35
3.30
2.37
5.9
4.2
—
—
—
0
0
17
85
2.50
2.23
4.0
3.3
120.23
58.59
mg/l
—
10
56
10
38
3.02
2.15
11.3
5.2
103.00
105.58
mmol/l
—
10
38
18
94
2.41
2.14
5.0
3.9
33.38
9.54
mg/mmol
0.58
12
58
8
27
3.32
2.03
15.6
5.4
—
—
—
0
0
7
23
3.36
1.87
3.3
1.8
195.00
124.89
ng/l
—
7
18
5
12
4.49
1.87
9.4
3.0
25.22
24.58
mmol/l
—
5
12
38
285
2.31
1.81
5.3
4.4
15.33
11.40
mm/h
1.04
33
257
5
13
4.14
1.76
2.6
3.5
25.36
23.48
mmol/l
—
5
13
11
50
2.53
1.71
7.0
1.9
—
—
—
0
0
5
14
3.84
1.65
9.4
2.6
0.80
0.70
%
—
5
14
18
108
2.03
1.48
3.8
2.0
—
—
—
0
0
5
16
3.34
1.47
9.4
2.5
1.94
2.31
%
—
5
16
6
23
2.82
1.41
2.0
1.2
—
—
—
0
0
19
119
1.95
1.37
5.6
3.3
—
—
—
0
0
17
106
1.91
1.23
6.4
3.2
7.39
7.39
ph
—
9
17
6
26
2.48
1.22
1.7
1.4
—
—
—
0
0
8
40
2.18
1.18
2.9
2.0
—
—
—
0
0
24
170
1.78
1.15
15.8
9.8
1.21
1.24
inr
—
10
53
25
186
1.67
0.97
9.0
6.5
7.92
8.90
%
0.72
20
172
24
177
1.67
0.96
11.0
7.0
—
—
—
0
0
6
28
2.29
0.95
1.3
1.6
—
—
—
0
0
32
257
1.66
0.90
8.0
4.7
—
—
—
0
0
6
30
2.13
0.90
1.8
1.3
—
—
—
0
0
8
45
1.92
0.89
2.9
1.8
33.88
28.24
s
—
8
45
14
91
1.74
0.86
4.0
2.7
318.86
342.29
umol/l
0.36
14
77
6
33
1.92
0.82
6.2
4.1
—
—
—
0
0
43
380
1.84
0.77
39.4
12.6
20.83
20.18
mg/l
0.06
36
290
14
95
1.65
0.74
1.4
1.3
1.13
1.23
u/ml
—
6
21
7
43
1.73
0.70
2.9
1.3
—
—
—
0
0
38
329
1.61
0.70
8.8
4.9
45.82
39.52
mmol/mol
1.53
33
300
15
106
1.59
0.67
3.1
3.0
—
—
—
0
0
9
60
1.61
0.59
4.2
2.0
9.09
14.07
umol/l
—
9
55
6
37
1.70
0.58
2.7
1.5
—
—
—
0
0
6
37
1.70
0.58
1.3
1.2
—
—
—
0
0
6
38
1.65
0.56
1.0
1.3
—
—
—
0
0
18
139
1.46
0.54
2.2
1.9
—
—
—
0
0
22
180
1.39
0.47
7.0
4.0
0.00
0.00
estimate
—
7
38
38
342
1.44
0.45
4.1
3.7
1.39
1.25
mmol/l
0.59
33
314
5
31
1.68
0.44
1.0
1.3
—
—
—
0
0
14
108
1.41
0.41
7.9
3.8
—
—
—
0
0
21
179
1.29
0.32
11.9
5.6
0.00
0.00
estimate
—
6
34
8
64
1.30
0.29
1.9
1.7
—
—
—
0
0
21
182
1.26
0.27
7.0
4.0
0.00
0.00
estimate
—
5
35
12
98
1.29
0.24
2.5
4.7
2.34
1.93
ug/l
0.21
12
87
42
398
1.31
0.23
38.1
14.5
86.45
75.60
umol/l
0.69
42
398
5
41
1.24
0.22
1.4
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
404.16
—
0
5
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
8.2
—
—
—
0
0
42
403
1.24
0.14
40.4
11.5
—
—
—
0
0
12
104
1.20
0.14
4.6
4.0
0.00
0.00
estimate
—
6
33
5
45
1.12
0.10
1.0
1.4
—
—
—
0
0
11
98
1.16
0.08
8.5
6.3
—
—
—
0
0
7
80
0.86
0.08
4.6
3.7
—
—
—
0
0
9
84
1.09
0.07
2.0
1.7
—
—
—
0
0
13
120
1.11
0.05
1.8
1.6
—
—
—
0
0
26
254
1.05
0.00
6.6
3.4
—
—
—
0
0
11
111
0.99
0.00
2.8
2.5
—
—
—
0
0
33
332
0.98
0.00
41.3
14.9
14.93
14.95
%
0.01
33
325
0
9
0.00
-0.00
0.0
7.6
—
105.44
—
0
9
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
7.6
—
10.56
—
0
9
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
11.06
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_VIT_NAS_DEF and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
E4_VIT_NAS_DEF 1.706 [0.86, 3.38] 0.125
Birth year 0.987 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 118 males with E4_VIT_NAS_DEF died.

Mortality risk

Mortality risk for people of age

years, who have E4_VIT_NAS_DEF.

N-year risk Females Males
1 No data 0.391%
5 No data 1.968%
10 No data 5.044%
15 No data 9.336%
20 No data 15.5%

Relationships between endpoints

↥

Index endpoint: E4_VIT_NAS_DEF – Deficiency of other/unspecified vitamins

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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