No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
205 |
4. Check minimum number of eventsNone |
205 |
5. Include endpointsNone |
205 |
6. Filter based on genotype QC (FinnGen only) |
197 |
Control definitions (FinnGen only)
- Control exclude
- E4_NUTRIDEF
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E50-E64
- Name in latin
- Deficientia thiamini
Similar endpoints
↥List of similar endpoints to
Thiamine deficiency
based on the number of shared cases.
Similar with more cases:
- Vitamin deficiency
- Vitamin deficiency, wide
- Other nutritional deficiencies
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2748 | 938 | 1792 |
| Only index persons | 2295 | 816 | 1479 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.03 | 0.05 |
| Only index persons | 0.05 | 0.03 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 59.15 | 58.66 | 59.36 |
| Only index persons | 59.28 | 58.60 | 59.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 197 | 68 | 129 |
| Unadjusted period prevalence (%) | 0.05 | 0.02 | 0.06 |
| Median age at first event (years) | 59.81 | 56.87 | 61.35 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 205
- Matched controls
- 2050
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E51.2
ICD-10 Finland
Wernicke encephalopathy
+∞
207.0
162
*
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
22.2
111.7
107
96
F10.25
ICD-10 Finland
Alcohol dependence continuous use
32.7
67.9
46
18
P15
ICPC
Chronic alcohol abuse
18.0
57.4
51
37
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
15.8
52.4
50
41
N05AH04
ATC
quetiapine; oral
6.9
39.5
85
191
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
6.5
36.5
83
195
R41.0
ICD-10 Finland
Disorientation, unspecified
15.0
33.0
31
24
AA1AD
NOMESCO Finland
CT of head and brain
5.3
31.5
107
351
N07BB01
ATC
disulfiram; oral
8.9
31.4
44
61
F10.09
ICD-10 Finland
Alcohol intoxication UNS
12.0
28.7
31
30
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
36.0
28.3
36
12
R56.8
ICD-10 Finland
Other and unspecified convulsions
9.1
26.8
36
47
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
37.6
25.5
32
10
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
10.2
24.8
30
34
A28
ICPC
Limited function/disability NOS
5.1
24.8
68
182
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
56.6
21.7
25
5
E51.9
ICD-10 Finland
Thiamine deficiency, unspecified
+∞
20.1
19
*
F10.49
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without information about seizures
81.5
20.1
22
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
5.0
19.3
49
121
N05AX08
ATC
risperidone; systemic
6.1
19.0
37
72
K70.1
ICD-10 Finland
Alcoholic hepatitis
73.4
18.1
20
*
A06AD11
ATC
lactulose; oral
4.5
18.0
54
152
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.6
17.9
94
391
F10.20
ICD-10 Finland
Alcohol dependence currently independent
14.4
17.8
30
24
N05BA01
ATC
diazepam; systemic, rectal
4.4
17.7
53
149
N03AG01
ATC
valproic acid; systemic, rectal
6.7
17.5
30
51
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
34.9
17.4
22
7
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
28.5
17.3
23
9
F05.9
ICD-10 Finland
Delirium, unspecified
24.5
17.3
24
11
SPAT1254
SPAT
Administration of medicine
4.5
17.1
50
138
F10.03
ICD-10 Finland
Alcohol-related acute intoxication with delirium
184.4
16.8
17
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.8
16.2
42
105
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
24.5
15.9
22
10
N06AB04
ATC
citalopram; systemic
3.6
15.2
64
227
N06AX11
ATC
mirtazapine; oral
3.2
15.1
98
454
W19
ICD-10 Finland
Unspecified fall
4.9
14.9
37
89
F10.24
ICD-10 Finland
Alcohol depence active use
16.0
14.5
23
16
EBA15
NOMESCO Finland
Extraction of multiple teeth
7.1
14.4
23
36
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.6
14.4
61
217
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
13.4
14.0
24
20
F10.73
ICD-10 Finland
Residual or late-onset psychosis caused by alcohol dementia
80.7
13.8
15
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.9
12.9
44
134
N05AA02
ATC
levomepromazine; systemic
6.2
12.7
23
41
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
15.7
12.6
20
14
K70.0
ICD-10 Finland
Alcoholic fatty liver
32.2
11.8
15
5
E51.8
ICD-10 Finland
Other manifestations of thiamine deficiency
+∞
11.6
11
*
T36
ICD-10 Finland
Poisoning by systemic antibiotics
5.6
11.6
23
45
XF400
NOMESCO Finland
ECG with 12 standard connections
3.3
11.5
54
202
N05AH03
ATC
olanzapine; systemic
4.8
11.4
28
66
C03CA01
ATC
furosemide; systemic
2.8
11.3
80
378
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
11.2
78
364
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
16.7
11.0
17
11
P20
ICPC
Memory disturbance
3.5
11.0
43
143
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
14.0
10.9
18
14
D64.9
ICD-10 Finland
Anaemia, unspecified
3.9
10.9
36
107
N05BA04
ATC
oxazepam; oral
2.9
10.8
70
314
N07
ICPC
Convulsion/seizure
63.4
10.7
12
*
R53
ICD-10 Finland
Malaise and fatigue
2.9
10.5
66
291
S01.0
ICD-10 Finland
Open wound of scalp
4.0
10.4
32
90
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
12.2
10.3
18
16
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
8.9
10.1
21
26
G62.1
ICD-10 Finland
Alcoholic polyneuropathy
42.3
10.1
12
*
K70.4
ICD-10 Finland
Alcoholic hepatic failure
42.3
10.1
12
*
Z72.1
ICD-10 Finland
Alcohol use
13.1
10.1
17
14
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
5.1
10.0
22
47
N05BA02
ATC
chlordiazepoxide; systemic
9.8
9.8
19
21
N05CD07
ATC
temazepam; oral
3.5
9.7
37
121
E87.6
ICD-10 Finland
Hypokalaemia
7.9
9.5
21
29
P16
ICPC
Acute alcohol abuse
11.5
9.5
17
16
A04
ICPC
Weakness/tiredness general
3.3
9.1
38
131
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
38.5
9.1
11
*
A29
ICPC
General symptom/complaint other
3.2
9.1
40
143
L28
ICPC
Limited function/disability (L)
3.0
9.0
47
185
OAB43, ,
SPAT
0.1
8.7
*
305
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.8
8.7
29
86
E86
ICD-10 Finland
Volume depletion
12.3
8.7
15
13
N99
ICPC
Neurological disease other
28.9
8.6
11
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
8.5
61
284
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
13.6
8.5
14
11
N06AB03
ATC
fluoxetine; oral
3.1
8.0
37
136
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
8.0
7.9
17
23
F10.6
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Amnesic syndrome
46.8
7.8
9
*
F05.8
ICD-10 Finland
Other delirium
46.8
7.8
9
*
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
12.5
7.7
13
11
N29
ICPC
Neurological sympt/complt other
14.1
7.5
12
9
F10.4
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Withdrawal state with delirium
83.0
7.5
8
*
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
16.5
7.3
11
7
XA800
NOMESCO Finland
Neuropsychological investigation
6.0
7.3
19
34
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.1
7.2
33
120
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.9
7.1
36
139
JN3AD
NOMESCO Finland
Abdominal CT examination
3.1
7.0
32
116
D64.8
ICD-10 Finland
Other specified anaemias
14.4
7.0
11
8
S82.6
ICD-10 Finland
Fracture of lateral malleolus
4.2
6.9
19
49
SPAT1240
SPAT
Therapeutic discussion
3.3
6.9
28
95
P99
ICPC
Psychological disorders other
7.6
6.8
15
21
N17.9
ICD-10 Finland
Acute renal failure, unspecified
6.3
6.8
17
29
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.8
6.7
37
149
X59
ICD-10 Finland
Exposure to unspecified factor
2.5
6.6
51
244
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
4.0
6.5
19
51
N05CF01
ATC
zopiclone; oral
2.2
6.5
79
457
SPAT1265
SPAT
Breathalyser
14.9
6.5
10
7
K29.2
ICD-10 Finland
Alcoholic gastritis
72.0
6.5
7
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
6.4
63
335
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.0
6.3
30
111
WX872
NOMESCO Finland
Intensive care
3.7
6.3
21
62
SPAT1229
SPAT
Assessment of need for aid
3.7
6.3
21
62
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
18.7
6.3
9
5
B03BA03
ATC
hydroxocobalamin; parenteral
4.2
6.3
17
43
G72.8
ICD-10 Finland
Other specified myopathies
8.1
6.2
13
17
K92.0
ICD-10 Finland
Haematemesis
7.1
6.1
14
21
N02AA05
ATC
oxycodone; systemic
2.4
6.1
47
224
S06.0
ICD-10 Finland
Concussion
2.9
6.1
31
120
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
6.0
105
692
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
80
228
5.11
27.35
3.1
1.9
2.26
1.58
%
2.60
74
196
82
270
4.40
22.77
2.4
1.6
1146.46
1244.96
nmol/l
0.43
72
213
59
152
5.05
22.34
3.2
2.5
0.17
0.22
g/l
5.05
51
137
69
214
4.35
20.50
5.8
6.0
1.00
1.02
mmol/l
0.13
64
199
78
266
4.12
20.34
4.4
3.8
0.76
0.82
mmol/l
4.41
73
253
128
627
3.77
19.19
2.9
1.8
90.60
93.17
pmol/l
0.23
83
318
73
269
3.66
16.56
2.1
1.9
—
—
—
0
0
132
702
3.47
16.53
7.0
5.1
32.19
35.77
g/l
6.18
123
662
105
503
3.23
15.35
4.4
2.3
367.23
240.88
u/l
0.80
98
480
85
377
3.14
13.91
2.2
1.5
15.99
21.08
nmol/l
2.80
79
322
23
38
6.69
13.72
1.1
1.4
1.54
9.81
e6/l
0.60
13
31
23
38
6.69
13.72
1.1
1.5
175.93
224.45
e6/l
0.08
14
31
81
357
3.10
13.30
2.7
1.9
2.68
3.01
mg/l
0.65
75
313
44
144
3.62
11.59
4.3
3.6
-0.44
2.17
mmol/l
1.81
39
117
102
544
2.74
11.38
4.6
2.6
53.95
66.49
u/l
0.78
97
511
31
86
4.07
10.27
2.0
1.6
—
—
—
0
0
125
795
2.47
8.95
12.5
12.5
1.21
1.26
inr
0.29
34
237
24
61
4.32
8.88
1.6
1.8
—
—
—
0
0
48
194
2.92
8.80
2.0
1.9
—
—
—
0
0
116
718
2.42
8.76
9.7
5.9
1.18
1.21
mmol/l
3.89
110
660
23
58
4.34
8.59
1.5
1.6
—
—
—
0
0
34
114
3.38
8.52
2.2
1.6
—
—
—
0
0
30
95
3.53
8.19
2.8
3.0
-0.25
1.83
mmol/l
1.97
24
72
121
778
2.36
8.18
10.4
7.0
1.18
1.21
mmol/l
2.73
105
674
46
190
2.83
8.06
2.1
1.8
—
—
—
0
0
49
215
2.68
7.62
2.9
2.3
28.35
23.87
%
0.75
39
187
11
8
14.43
6.97
1.1
1.3
—
—
—
0
0
45
198
2.63
6.92
12.2
7.6
0.54
1.29
mmol/l
0.42
39
160
62
319
2.35
6.82
1.9
1.7
564.70
456.20
pmol/l
0.65
50
280
13
15
9.17
6.66
1.1
1.1
—
—
—
0
0
43
190
2.60
6.54
3.4
5.3
383.63
241.28
u/l
0.55
43
182
18
47
4.10
6.41
1.3
1.1
—
—
—
0
0
27
97
3.05
6.00
11.7
6.1
23.78
24.65
mmol/l
0.37
27
97
14
22
6.74
5.97
1.0
1.1
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
11
12
9.61
5.86
1.1
1.3
—
—
—
0
0
68
388
2.13
5.69
3.3
2.2
—
—
—
0
0
91
584
2.00
5.50
5.9
3.6
90.91
32.69
u/l
0.81
85
559
13
21
6.53
5.48
1.0
1.1
—
—
—
0
0
163
1292
2.28
5.43
12.2
8.1
87.23
78.82
u/l
1.14
155
1219
91
596
1.95
5.09
2.6
2.2
63.00
77.19
nmol/l
3.62
83
528
16
47
3.61
4.85
1.4
1.9
—
—
—
0
0
55
307
2.08
4.78
5.3
4.0
136.81
297.58
ng/l
0.73
45
246
148
1157
2.00
4.73
8.3
3.2
151.52
53.42
u/l
2.69
141
1097
43
222
2.19
4.55
10.1
6.3
101.30
104.23
mmol/l
1.68
43
222
8
10
8.27
4.10
1.0
1.0
—
—
—
0
0
20
76
2.81
4.03
1.8
2.4
1.38
1.32
%
0.09
20
76
86
588
1.80
3.98
4.5
3.1
—
—
—
0
0
47
264
2.01
3.97
3.8
2.8
1.84
1.50
e6/l
0.16
25
147
19
72
2.81
3.85
1.9
2.4
0.58
0.64
%
0.40
19
72
93
656
1.76
3.83
4.9
3.6
45.87
35.29
ng/l
0.22
76
464
77
522
1.76
3.59
3.6
3.7
2.29
2.35
mmol/l
2.02
66
463
47
280
1.88
3.31
3.7
2.7
1.15
0.97
e6/l
0.23
26
162
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
14
50
2.93
3.15
2.5
2.1
0.30
0.36
u/ml
—
9
24
6
8
7.68
3.07
1.0
1.3
—
—
—
0
0
13
47
2.89
2.87
1.6
1.6
307.80
260.88
ug/g
—
5
32
15
60
2.62
2.77
3.6
2.6
—
—
—
0
0
30
505
0.52
2.75
3.3
2.8
0.70
0.73
ug/l
0.07
19
333
64
446
1.63
2.57
4.9
3.1
0.19
0.38
e6/l
1.53
52
328
11
38
3.00
2.45
1.3
1.6
—
—
—
0
0
98
763
1.54
2.43
3.5
2.5
—
—
—
0
0
9
27
3.44
2.42
3.1
3.8
59.89
57.67
%
—
9
27
20
98
2.15
2.41
1.6
1.4
—
—
—
0
0
5
155
0.31
2.40
3.0
1.8
—
—
—
0
0
6
13
4.72
2.29
1.3
1.8
14.83
14.54
u/l
—
6
13
5
9
5.66
2.22
1.0
1.3
—
—
—
0
0
30
176
1.83
2.21
4.8
3.2
—
—
—
0
0
7
19
3.78
2.17
1.1
1.3
—
—
—
0
0
21
112
1.97
2.05
14.6
8.0
0.56
0.66
%
0.78
21
112
9
32
2.89
2.02
1.1
1.1
—
—
—
0
0
151
1667
0.64
1.97
4.1
4.5
1.40
1.42
mmol/l
0.12
140
1533
145
1614
0.65
1.97
3.7
4.1
1.47
1.29
mmol/l
0.79
130
1481
156
1709
0.64
1.94
4.5
5.1
2.56
2.75
mmol/l
1.94
146
1571
12
52
2.39
1.91
6.9
4.5
—
3.25
—
0
8
7
22
3.26
1.89
1.1
1.5
—
—
—
0
0
7
22
3.26
1.89
1.1
1.5
—
—
—
0
0
7
22
3.26
1.89
1.1
1.5
—
—
—
0
0
7
22
3.26
1.89
1.1
1.5
—
—
—
0
0
7
22
3.26
1.89
1.1
1.5
—
—
—
0
0
6
17
3.60
1.85
1.2
1.1
—
—
—
0
0
5
12
4.24
1.83
1.0
1.3
—
—
—
0
0
7
23
3.11
1.81
1.1
1.5
—
—
—
0
0
51
686
0.66
1.81
3.4
4.2
22.20
21.50
%
0.09
22
321
9
36
2.57
1.76
1.1
1.4
—
—
—
0
0
30
189
1.69
1.75
3.6
5.1
3.87
65.40
ug/l
0.84
25
156
20
112
1.87
1.72
15.1
7.6
1.04
1.34
%
1.12
20
112
153
1670
0.67
1.64
4.2
4.6
4.43
4.62
mmol/l
1.45
142
1553
42
297
1.52
1.54
3.1
3.3
2.44
2.45
mmol/l
0.22
37
257
14
248
0.53
1.48
1.1
1.5
—
—
—
0
0
112
956
1.38
1.46
10.2
10.3
4.32
4.08
e9/l
0.37
96
839
6
22
2.78
1.44
1.2
1.9
—
—
—
0
0
9
40
2.31
1.42
1.1
1.1
—
—
—
0
0
10
47
2.19
1.36
1.6
1.4
—
—
—
0
0
6
24
2.54
1.31
1.0
1.8
—
—
—
0
0
133
1180
1.36
1.29
4.2
3.7
14.53
14.91
pmol/l
0.94
123
1061
177
1650
1.53
1.29
30.2
14.1
29.16
24.26
mg/l
1.27
162
1293
5
19
2.67
1.22
1.2
1.1
—
—
—
0
0
161
1481
1.41
1.19
5.2
4.4
1.86
1.95
mu/l
0.45
152
1345
0
35
0.00
1.16
0.0
1.3
—
—
—
0
0
5
20
2.54
1.16
1.2
2.0
—
—
—
0
0
29
202
1.51
1.15
3.7
4.5
32.48
31.21
%
0.21
23
132
9
163
0.53
1.14
1.3
1.5
—
—
—
0
0
45
343
1.40
1.13
1.2
1.2
0.73
0.78
u/ml
—
8
95
7
30
2.38
1.13
1.4
1.8
—
—
—
0
0
7
32
2.23
1.09
1.4
1.8
—
—
—
0
0
7
33
2.16
1.06
1.4
1.7
—
—
—
0
0
153
1637
0.74
1.02
5.0
4.5
6.03
5.98
mmol/l
0.15
141
1498
112
990
1.29
1.01
2.7
2.8
—
—
—
0
0
7
36
1.98
0.98
1.4
1.2
—
—
—
0
0
6
116
0.50
0.97
1.2
1.8
—
—
—
0
0
6
27
2.26
0.94
1.3
1.8
—
—
—
0
0
180
1870
0.69
0.87
42.0
20.3
37.23
40.99
%
9.71
162
1755
74
850
0.80
0.80
3.7
4.6
2.01
2.38
ug/l
0.30
62
761
0
24
0.00
0.79
0.0
1.6
—
—
—
0
0
0
26
0.00
0.79
0.0
3.3
—
—
—
0
0
6
34
1.79
0.77
1.7
1.5
—
—
—
0
0
6
34
1.79
0.77
1.7
1.5
—
—
—
0
0
11
67
1.68
0.77
2.1
1.5
—
—
—
0
0
132
1214
1.25
0.76
4.3
4.0
16.48
11.66
mm/h
2.47
126
1116
7
41
1.73
0.70
1.4
1.7
—
—
—
0
0
5
28
1.80
0.66
1.6
1.7
—
—
—
0
0
15
104
1.48
0.64
1.1
1.3
—
23.94
—
0
9
60
516
1.23
0.64
4.2
3.8
15.11
8.65
mg/mmol
0.45
40
341
6
104
0.56
0.63
1.0
1.7
—
—
—
0
0
54
460
1.24
0.63
2.7
2.8
398.81
6185.76
umol/l
1.90
48
401
8
50
1.62
0.62
1.5
1.8
—
—
—
0
0
8
51
1.59
0.61
1.5
1.8
—
—
—
0
0
0
20
0.00
0.60
0.0
1.6
—
—
—
0
0
0
21
0.00
0.60
0.0
1.3
—
5.64
—
0
11
6
36
1.69
0.57
1.0
1.3
—
—
—
0
0
11
74
1.51
0.54
2.5
3.1
60.85
48.29
%
1.04
11
74
40
337
1.23
0.52
1.9
1.6
0.95
1.27
mg/l
0.63
33
272
12
84
1.46
0.50
3.1
4.1
13.08
164.92
u/ml
1.08
12
72
57
645
0.84
0.50
4.4
3.3
—
—
—
0
0
0
15
0.00
0.41
0.0
4.5
—
—
—
0
0
5
34
1.48
0.40
1.6
1.1
23.70
24.65
u/l
—
5
29
5
34
1.48
0.40
1.2
1.4
—
96.43
—
0
7
0
18
0.00
0.40
0.0
1.4
—
6.00
—
0
5
14
107
1.33
0.38
1.1
1.2
177.59
141.69
iu/ml
—
7
37
5
37
1.36
0.37
1.8
1.8
—
—
—
0
0
5
37
1.36
0.37
1.8
1.8
—
—
—
0
0
6
43
1.41
0.35
1.5
1.5
—
—
—
0
0
39
440
0.86
0.33
5.0
3.6
0.00
0.00
estimate
-0.00
15
143
164
1592
1.15
0.31
6.0
5.5
38.68
39.92
mmol/mol
0.82
155
1495
53
483
1.13
0.29
2.4
3.0
1131.19
1181.14
ng/l
0.07
48
411
17
204
0.82
0.28
6.5
7.6
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
25.05
—
0
11
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
80.03
—
0
10
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
6
78
0.76
0.16
1.3
1.3
—
—
—
0
0
10
84
1.20
0.14
3.7
3.9
4.41
4.64
pmol/l
—
10
76
10
84
1.20
0.14
1.0
2.2
39.21
38.26
u/l
—
10
75
78
803
0.95
0.09
5.3
4.4
0.00
0.00
estimate
-0.00
16
150
8
74
1.08
0.07
1.0
1.0
—
—
—
0
0
159
1602
0.97
0.04
26.1
13.1
86.79
81.40
ml/min/173m2
2.35
145
1333
80
813
0.97
0.04
4.2
3.3
0.00
0.00
estimate
-0.00
14
141
179
1796
0.97
0.00
32.2
16.6
77.24
79.61
umol/l
0.39
179
1796
80
806
0.99
0.00
4.0
3.3
0.00
0.01
estimate
0.50
15
157
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
34.57
—
0
7
0
7
0.00
-0.00
0.0
1.1
—
99.86
—
0
7
0
6
0.00
-0.00
0.0
1.3
—
0.31
—
0
6
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
5.2
—
220.00
—
0
9
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
1833.43
—
0
7
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
54
0.92
-0.00
1.2
1.1
—
—
—
0
0
5
54
0.92
-0.00
1.2
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
24.73
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_THIA_DEF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THIA_DEF | 4.252 [3.12, 5.8] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.177 |
During the follow-up period (1.1.1998 — 31.12.2019), 230 out of 671 females with E4_THIA_DEF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THIA_DEF | 4.98 [4.14, 5.99] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 604 out of 1344 males with E4_THIA_DEF died.
Mortality risk
Mortality risk for people of age
years, who have E4_THIA_DEF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.316% | 0.751% |
| 5 | 2.24% | 4.701% |
| 10 | 5.913% | 11.842% |
| 15 | 11.245% | 21.364% |
| 20 | 18.957% | 33.304% |
Relationships between endpoints
↥Index endpoint: E4_THIA_DEF – Thiamine deficiency
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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