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Vitamin D deficiency

DOID EFO Endpoint Browser PheWeb

E4_VIT_D_DEF

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E55
  • Hospital discharge: ICD-9 — 268
  • Hospital discharge: ICD-8 — 265
  • Cause of death: ICD-10 — E55
  • Cause of death: ICD-9 — 268
  • Cause of death: ICD-8 — 265

2 out of 7 registries used, show all original rules.

722

4. Check minimum number of events

None

722

5. Include endpoints

None

722

6. Filter based on genotype QC (FinnGen only)

664

Control definitions (FinnGen only)

Control exclude
E4_NUTRIDEF

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E50-E64
Name in latin
Deficientia vitamini D

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5671 3233 2399
Only index persons 5177 2942 2235
Unadjusted period prevalence (%)
Whole population 0.08 0.09 0.07
Only index persons 0.10 0.11 0.09
Median age at first event (years)
Whole population 44.36 48.89 38.37
Only index persons 43.19 47.31 37.76

-FinnGen-

Key figures

All Female Male
Number of individuals 664 437 227
Unadjusted period prevalence (%) 0.14 0.16 0.10
Median age at first event (years) 49.59 47.25 54.09

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
722
Matched controls
7220
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E55.9
ICD-10 Finland
Vitamin D deficiency, unspecified
3399.0
307.7
584
8
E66.8
ICD-10 Finland
Other obesity
36.8
110.9
70
21
E66.01
ICD-10 Finland
Obesity due to excess calories
10.6
86.6
101
109
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.6
59.9
322
1334
E66.9
ICD-10 Finland
Obesity, unspecified
21.7
54.3
41
20
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
13.6
53.4
51
40
E66.00
ICD-10 Finland
Metabolic syndrome
10.4
42.3
48
49
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.0
40.7
262
1159
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
6.1
38.7
71
127
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
6.3
35.8
63
108
R4190
NOMESCO Finland
Nutritional therapy
6.2
34.2
61
106
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.3
32.6
90
229
2680A
ICD-9 Finland
Vitamin D deficiency, Rickets, active
+∞
31.5
30
*
A11CC03
ATC
alfacalcidol; systemic
8.4
31.4
42
53
E55.0
ICD-10 Finland
Rickets, active
+∞
29.4
28
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
9.4
28.8
35
39
AA1AD
NOMESCO Finland
CT of head and brain
2.6
28.7
212
980
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.2
27.3
126
451
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
26.3
333
1952
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.2
26.2
114
394
T82
ICPC
Obesity
6.0
24.4
44
77
E55
ICD-10 Finland
Vitamin D deficiency
58.1
24.2
28
5
N06AX16
ATC
venlafaxine; oral
2.8
23.5
143
594
N06AX21
ATC
duloxetine; oral
3.0
22.9
115
430
C03CA01
ATC
furosemide; systemic
2.4
22.8
190
919
H03AA01
ATC
levothyroxine sodium; systemic
2.4
22.3
199
991
E83.51
ICD-10 Finland
Hypocalcemia
30.1
22.0
29
10
26500
ICD-8 Finland
Vitamin D deficiency, Rickets active
+∞
22.0
21
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.9
21.5
111
421
A02BC02
ATC
pantoprazole; systemic
2.2
21.4
484
3471
ZX120
NOMESCO Finland
Intravenous
3.2
21.4
92
314
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.7
21.1
71
207
N03AX12
ATC
[U] gabapentin; oral
2.6
20.9
142
621
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
20.8
173
832
L28
ICPC
Limited function/disability (L)
2.6
20.5
135
581
SPAT1229
SPAT
Assessment of need for aid
3.8
20.4
64
178
N02AX02
ATC
tramadol; systemic, rectal
2.1
20.2
309
1900
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
20.1
124
516
A01
ICPC
Pain general/multiple sites
3.1
20.0
93
332
E53.8
ICD-10 Finland
Deficiency of other specified B group vitamins
59.3
20.0
23
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.6
19.4
134
589
N06AX11
ATC
mirtazapine; oral
2.1
19.1
270
1603
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
6.0
19.0
34
59
E83.39
ICD-10 Finland
Other disorder of phosphorus metabolism
+∞
18.8
18
*
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
+∞
18.8
18
*
E21.0
ICD-10 Finland
Primary hyperparathyroidism
7.2
18.8
28
40
Z72.0
ICD-10 Finland
Tobacco use
5.7
18.5
35
64
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.3
18.5
167
828
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
14.0
18.4
31
23
RD210, ,
NOMESCO Finland
7.1
18.4
28
41
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
18.3
184
955
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.6
18.1
119
510
SPAT1254
SPAT
Administration of medicine
2.5
18.1
130
582
D64.9
ICD-10 Finland
Anaemia, unspecified
3.0
17.7
82
292
N06AB04
ATC
citalopram; systemic
2.3
17.7
165
829
M79.7
ICD-10 Finland
Fibromyalgia
4.3
17.5
46
112
SPAT1301
SPAT
No procedures
2.0
17.2
246
1457
N05AH04
ATC
quetiapine; oral
2.2
17.0
167
856
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
16.8
301
1926
SPAT1255
SPAT
Intravenous administration of medicine
3.6
16.6
57
168
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
4.3
16.5
43
104
N03AX16
ATC
[U] pregabalin
2.2
16.5
178
946
L04AX01
ATC
azathioprine; systemic
4.1
16.2
45
114
E86
ICD-10 Finland
Volume depletion
7.3
16.2
24
34
SPAT1249
SPAT
Treatment-related counselling outside office
1.9
16.2
302
1953
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
3.3
16.0
63
203
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.8
16.0
84
320
N06AB10
ATC
escitalopram; oral
2.1
15.9
188
1034
A09AA02
ATC
multienzymes (lipase, protease etc.); oral
5.6
15.8
30
55
C03DA01
ATC
spironolactone; oral
2.8
15.8
87
340
E21.1
ICD-10 Finland
Secondary hyperparathyroidism, not elsewhere classified
163.4
15.5
16
*
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.2
15.5
65
218
-, ,
ICD-10 Finland
5.6
15.1
29
54
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.0
15.0
71
255
E21.3
ICD-10 Finland
Hyperparathyroidism, unspecified
12.8
15.0
26
21
R51.80
ICD-10 Finland
Headache
2.2
14.6
148
763
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.2
14.6
137
685
H02AB06
ATC
prednisolone; systemic
1.9
14.4
331
2266
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.6
14.4
34
76
SPAT1310
SPAT
Counselling related to known health issue
1.9
14.0
250
1576
UJF32
NOMESCO Finland
Coloscopy
2.0
14.0
176
984
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.5
14.0
96
418
SPAT1260
SPAT
Consultation of another employee
2.2
14.0
143
740
B03BA03
ATC
hydroxocobalamin; parenteral
3.7
13.7
44
124
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.5
13.7
89
378
E87.6
ICD-10 Finland
Hypokalaemia
4.3
13.6
36
88
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.5
13.5
88
374
N03AE01
ATC
clonazepam; systemic
3.3
13.3
50
157
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.0
13.2
62
222
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.9
13.2
202
1208
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
13.1
106
497
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.3
13.1
113
545
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.6
13.0
31
70
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.0
12.8
58
203
SPAT1240
SPAT
Therapeutic discussion
2.3
12.8
103
481
R52.2
ICD-10 Finland
Other chronic pain
3.8
12.8
40
111
ZY010
NOMESCO Finland
Hospital outpatient
2.9
12.7
61
221
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.3
12.7
102
477
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.3
12.6
103
484
R06.0
ICD-10 Finland
Dyspnoea
1.9
12.6
186
1095
SPAT1216
SPAT
Assessment of functional ability
2.3
12.5
105
499
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
+∞
12.5
12
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.8
12.3
65
248
A41.9
ICD-10 Finland
Sepsis, unspecified
4.5
12.3
30
69
P03
ICPC
Feeling depressed
2.3
12.2
97
450
E83.50
ICD-10 Finland
Hypercalcemia
11.3
12.1
22
20
N02AA05
ATC
oxycodone; systemic
2.2
12.1
112
555
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
5.4
12.1
24
46
R51
ICD-10 Finland
Headache
2.9
12.1
59
216
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.5
12.1
79
336
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.0
12.1
145
794
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.6
12.0
40
116
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.9
11.8
56
202
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.8
11.7
60
225
A04
ICPC
Weakness/tiredness general
2.1
11.7
122
633
P76
ICPC
Depressive disorder
2.7
11.7
67
267
R10.0
ICD-10 Finland
Acute abdomen
4.0
11.7
33
85
M79.6
ICD-10 Finland
Pain in limb
1.7
11.6
301
2097
N03AG01
ATC
valproic acid; systemic, rectal
2.8
11.6
58
215
SPAT1172
SPAT
Guidance concerning hydration
5.8
11.5
21
37
EBA15
NOMESCO Finland
Extraction of multiple teeth
4.0
11.5
33
86
E83.30
ICD-10 Finland
Acid phosphatase deficiency
+∞
11.5
11
*
E66.0
ICD-10 Finland
Obesity due to excess calories
121.9
11.5
12
*
Z2445
NOMESCO Finland
Psychologist
3.1
11.4
48
161
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.7
11.4
64
252
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
4.4
11.3
28
65
M54.5
ICD-10 Finland
Low back pain
1.8
11.2
259
1744
B81
ICPC
Anaemia vit B12/folate deficiency
4.1
11.1
31
79
Z3231
NOMESCO Finland
Registered nurse
1.8
11.1
197
1225
R11
ICD-10 Finland
Nausea and vomiting
2.4
11.1
80
356
M81.8
ICD-10 Finland
Other osteoporosis
10.3
11.1
21
21
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.2
11.1
101
497
F32
ICD-10 Finland
Depressive episode
2.8
11.0
55
204
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.4
11.0
39
118
M25.5
ICD-10 Finland
Pain in joint
1.8
10.9
239
1581
103
Kela drug reimbursment
Diabetes, insulin-treated
1.9
10.8
151
869
N06AB06
ATC
sertraline; oral
2.2
10.8
103
516
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.7
10.7
59
230
ZX114
NOMESCO Finland
Intramuscular
5.4
10.6
21
40
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.2
10.5
95
465
G47.3
ICD-10 Finland
Sleep apnoea
2.0
10.5
138
777
SPAT1263
SPAT
Sampling
1.7
10.5
305
2179
26599
ICD-8 Finland
Vitamin D deficiency, Unspecified
+∞
10.4
10
*
E61.2
ICD-10 Finland
Magnesium deficiency
+∞
10.4
10
*
26510
ICD-8 Finland
Vitamin D deficiency, Rickets, late effect
+∞
10.4
10
*
UJF92
NOMESCO Finland
Capsular endoscopy
4.6
10.3
24
53
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.5
10.2
64
267
K92.1
ICD-10 Finland
Melaena
3.3
10.2
39
124
P01
ICPC
Feeling anxious/nervous/tense
2.0
10.1
123
673
N05AH03
ATC
olanzapine; systemic
2.6
10.1
62
255
N05AA02
ATC
levomepromazine; systemic
3.4
10.1
36
109
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.0
10.1
44
151
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
4.6
10.1
24
54
SPAT1262
SPAT
Handing over of treatment supplies
2.1
10.1
106
551
V03AG01
ATC
sodium cellulose phosphate; systemic
40.7
10.0
12
*
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.9
10.0
46
163
SPAT1252
SPAT
Overall medication plan or its review
2.8
10.0
49
180
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.1
10.0
106
553
N18.8
ICD-10 Finland
Other chronic renal failure
5.2
9.9
20
39
SPAT1312
SPAT
General health counselling
1.7
9.9
242
1644
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.8
9.9
203
1313
N02BE01
ATC
paracetamol; systemic, rectal
2.0
9.8
620
5427
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.0
9.7
44
155
R02
ICPC
Shortness of breath/dyspnoea
2.1
9.6
97
495
D01
ICPC
Abdominal pain/cramps general
2.1
9.6
103
538
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
5.1
9.6
20
40
F29
ICD-10 Finland
Unspecified nonorganic psychosis
3.1
9.6
41
139
NH1AD
NOMESCO Finland
Ankle and foot CT
4.9
9.6
21
44
N05BA04
ATC
oxazepam; oral
1.8
9.6
186
1182
N03AX09
ATC
lamotrigine; oral
2.8
9.6
50
190
R53
ICD-10 Finland
Malaise and fatigue
1.8
9.5
180
1134
F33.4
ICD-10 Finland
Recurrent depressive disorder, currently in remission
3.8
9.5
29
79
Z3229
NOMESCO Finland
Other healthcare associate professional
2.5
9.5
63
270
L04AX03
ATC
methotrexate; systemic
2.3
9.4
77
361
F41.09
ICD-10 Finland
UNS Panic Syndrome
3.4
9.4
34
104
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
4.8
9.3
21
45
F61.0
ICD-10 Finland
Mixed personality disorders
4.8
9.3
21
45
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.9
9.3
44
158
B01AB05
ATC
enoxaparin; parenteral
1.7
9.3
191
1232
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
3.6
9.3
31
90
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
3.4
9.3
33
100
A12AA04
ATC
calcium carbonate; oral
7.4
9.3
21
29
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
9.3
309
2266
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
9.3
184
1176
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.4
9.2
66
293
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.8
9.2
46
171
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.4
9.1
32
96
C10AC01
ATC
colestyramine; oral
3.9
9.1
27
72
F10.09
ICD-10 Finland
Alcohol intoxication UNS
4.1
9.1
25
63
R60.0
ICD-10 Finland
Localized oedema
2.2
9.1
80
387
I10
ICD-10 Finland
Essential (primary) hypertension
1.6
9.1
326
2430
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
9.1
154
939
R42
ICD-10 Finland
Dizziness and giddiness
1.8
9.0
144
861
WZC00
NOMESCO Finland
Treatment plan or consultation
1.7
9.0
257
1809
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.7
8.9
50
197
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.3
8.9
70
323
G35
ICD-10 Finland
Multiple sclerosis
4.8
8.9
20
43
N05AX08
ATC
risperidone; systemic
2.3
8.8
66
298
Z2446
NOMESCO Finland
Social worker
2.4
8.8
61
266
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
8.8
294
2149
P29
ICPC
Psychological sympt/compl other
2.3
8.8
65
292
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
2.9
8.8
42
152
A46
ICD-10 Finland
Erysipelas
2.1
8.8
85
427
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
4.2
8.8
23
56
N05CF01
ATC
zopiclone; oral
1.7
8.8
205
1368
C08CA01
ATC
amlodipine; oral
1.7
8.7
206
1378
J45.1
ICD-10 Finland
Nonallergic asthma
2.4
8.7
59
255
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.5
8.6
56
237
A10AE04
ATC
insulin glargine; parenteral
2.4
8.6
63
282
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.7
8.6
223
1528
A28
ICPC
Limited function/disability NOS
2.0
8.5
97
518
A07EC01
ATC
sulfasalazine; oral, rectal
2.4
8.5
62
277
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
3.2
8.5
34
111
Q79.6
ICD-10 Finland
Ehlers-Danlos syndrome
27.9
8.5
11
*
E21.2
ICD-10 Finland
Other hyperparathyroidism
20.3
8.5
12
6
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
8.5
182
1185
UJK02
NOMESCO Finland
ERCP
4.4
8.4
21
49
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.1
8.4
88
455
N06AX03
ATC
mianserin; oral
2.9
8.4
39
139
E66
ICD-10 Finland
Obesity
3.0
8.3
36
123
JDF01
NOMESCO Finland
Laparoscopic gastroplasty
+∞
8.3
8
*
RD130, ,
NOMESCO Finland
+∞
8.3
8
*
M83.9
ICD-10 Finland
Adult osteomalacia, unspecified
+∞
8.3
8
*
E83.3
ICD-10 Finland
Disorders of phosphorus metabolism and phosphatases
+∞
8.3
8
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.8
8.3
129
765
N02BF02
ATC
pregabalin; oral
2.6
8.2
49
200
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
8.2
145
894
A02BC03
ATC
lansoprazole; oral
1.7
8.1
182
1197
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.8
8.1
132
792
SPAT1210
SPAT
Application of cast or individual aid
2.9
8.1
38
136
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
3.8
8.1
24
64
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.3
8.1
64
296
D06
ICPC
Abdominal pain localized other
2.2
8.1
68
323
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
8.1
380
2992
WW200
NOMESCO Finland
Immunization
3.7
8.1
25
69
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
2.5
8.0
50
208
A10BA02
ATC
metformin; oral
1.8
8.0
144
892
EBA00
NOMESCO Finland
Extraction of tooth
1.6
8.0
266
1934
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.9
7.9
36
127
T90
ICPC
Diabetes non-insulin dependent
1.8
7.9
120
705
TPH07
NOMESCO Finland
Cathetrisation of artery
2.2
7.9
69
333
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.2
7.8
70
341
K02.1
ICD-10 Finland
Caries of dentine
1.6
7.7
435
3551
WZA90
NOMESCO Finland
Other medical or dental certificate
1.7
7.7
179
1187
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
7.5
7.7
17
23
M35.7
ICD-10 Finland
Hypermobility syndrome
4.6
7.7
18
40
F99
ICD-10 Finland
Mental disorder, not otherwise specified
3.8
7.7
23
62
XA800
NOMESCO Finland
Neuropsychological investigation
2.8
7.7
37
135
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
3.2
7.6
29
92
D09
ICPC
Nausea
2.5
7.6
49
207
N03AX11
ATC
topiramate; oral
3.4
7.6
27
82
K08.3
ICD-10 Finland
Retained dental root
2.4
7.6
54
239
R5110, ,
SPAT
2.6
7.6
43
171
R96
ICPC
Asthma
2.2
7.5
66
319
SPAT1305
SPAT
Counselling and guidance related to physical exercise
2.2
7.5
67
326
ZXD05
NOMESCO Finland
Urgent procedure
1.6
7.5
206
1425
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
7.5
99
556
XG466
NOMESCO Finland
Sleep oxymetry
4.0
7.5
21
54
N07BB01
ATC
disulfiram; oral
2.9
7.5
34
120
L04AA06
ATC
mycophenolic acid; systemic
4.5
7.5
18
41
R5599
NOMESCO Finland
Other rehabilitation service
3.3
7.5
28
88
C07AB07
ATC
bisoprolol; oral
1.6
7.5
269
1984
SPAT1211
SPAT
Application of soft bandage
2.2
7.4
66
321
26520
ICD-8 Finland
Vitamin D deficiency, Osteomalacia
+∞
7.3
7
*
JN4AD
NOMESCO Finland
Body CT examination
2.3
7.3
57
263
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
3.8
7.2
22
60
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.6
7.2
212
1488
K59.09
ICD-10 Finland
Constipation, unspecified
2.4
7.2
48
206
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.2
7.2
64
311
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
7.2
61
291
ZYC01
NOMESCO Finland
Remote contact by phone
2.4
7.2
50
219
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.2
7.2
62
298
SPAT1283
SPAT
Restricted health certificate
1.7
7.2
151
974
C07AB02
ATC
metoprolol; systemic
1.8
7.2
110
648
XPX04
NOMESCO Finland
Angioscopy
20.2
7.1
10
5
I50.0
ICD-10 Finland
Congestive heart failure
2.7
7.1
39
152
G44.2
ICD-10 Finland
Tension-type headache
1.8
7.1
106
618
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
7.1
125
767
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.8
7.1
104
604
SGA01
NOMESCO Finland
Emergency treatment
1.8
7.1
122
744
P01AB01
ATC
metronidazole; oral, rectal
1.5
7.1
266
1976
L17
ICPC
Foot/toe symptom/complaint
1.6
7.0
191
1315
ZXE20
NOMESCO Finland
More than three and less than five hours
1.9
7.0
89
493
A29
ICPC
General symptom/complaint other
1.9
7.0
85
464
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
4.4
7.0
17
39
ZXE01
NOMESCO Finland
Procedure duration 0 to 9 minutes
4.4
7.0
17
39
N05AX12
ATC
aripiprazole; systemic
2.7
7.0
37
142
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.5
7.0
43
178
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.0
7.0
31
108
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
3.8
7.0
21
57
N06AB03
ATC
fluoxetine; oral
1.9
7.0
88
487
N06AX12
ATC
bupropion; oral
2.2
6.9
60
289
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.9
6.9
90
503
N01
ICPC
Headache
1.8
6.9
104
609
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
3.4
6.9
24
72
D12
ICPC
Constipation
3.0
6.9
29
98
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.4
6.8
46
199
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.7
6.8
131
824
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
3.2
6.8
26
83
S18
ICPC
Laceration/cut
1.5
6.8
285
2164
AN1
HP
Coronary angiography
2.2
6.7
57
272
K04.08
ICD-10 Finland
Other specified pulpit
2.1
6.7
62
306
T36
ICD-10 Finland
Poisoning by systemic antibiotics
2.5
6.7
40
163
M80.8
ICD-10 Finland
Other osteoporosis with pathological fracture
22.8
6.7
9
*
E83.4
ICD-10 Finland
Disorders of magnesium metabolism
22.8
6.7
9
*
A10AB05
ATC
insulin aspart; parenteral
2.2
6.7
53
246
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.8
6.7
113
685
L11
ICPC
Wrist symptom/complaint
2.0
6.7
72
377
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.0
6.7
77
413
J01FF01
ATC
clindamycin; systemic
1.6
6.7
173
1176
F10.25
ICD-10 Finland
Alcohol dependence continuous use
4.1
6.7
18
45
P99
ICPC
Psychological disorders other
3.0
6.7
29
100
S70.0
ICD-10 Finland
Contusion of hip
3.0
6.7
29
100
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
3.2
6.6
26
84
M13.8
ICD-10 Finland
Other specified arthritis
7.9
6.6
14
18
TQW80
NOMESCO Finland
Local dermatologic skincare
3.6
6.6
21
59
G43.9
ICD-10 Finland
Migraine, unspecified
2.2
6.6
56
267
I50.9
ICD-10 Finland
Heart failure, unspecified
2.0
6.6
68
350
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.0
6.6
75
400
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
3.9
6.6
19
50
R03DA04
ATC
theophylline; systemic, rectal
2.7
6.6
35
135
A03
ICPC
Fever
1.7
6.6
139
897
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.1
6.5
63
316
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.8
6.5
103
611
R50.9
ICD-10 Finland
Fever, unspecified
1.8
6.5
102
604
WZC30
NOMESCO Finland
Teaching
1.8
6.5
98
574
JAH01
NOMESCO Finland
Laparoscopy
2.7
6.5
35
136
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.7
6.5
35
136
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.5
6.5
375
3034
D11
ICPC
Diarrhoea
1.8
6.4
94
545
TAB00
NOMESCO Finland
Lumbar puncture
2.4
6.4
42
179
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.8
6.4
32
119
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.3
6.4
47
211
A02BC01
ATC
omeprazole; systemic
1.6
6.4
170
1161
KA1AE
NOMESCO Finland
Kidney ultrasound examination
3.8
6.4
19
51
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
4.1
6.4
17
42
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
4.1
6.4
17
42
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.3
6.4
45
199
M05BA04
ATC
alendronic acid; oral
2.2
6.3
52
245
R04.2
ICD-10 Finland
Haemoptysis
3.3
6.3
23
71
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.7
6.3
119
743
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.5
6.3
256
1923
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
3.9
6.3
18
47
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.8
6.3
30
109
BBA20
NOMESCO Finland
Exploration of parathyroid gland
18.2
6.3
9
5
RD160, ,
NOMESCO Finland
18.2
6.3
9
5
RD140, ,
NOMESCO Finland
+∞
6.3
6
*
2682A
ICD-9 Finland
Vitamin D deficiency, Osteomalacia, unspecified[OSTEOMALACIA]
+∞
6.3
6
*
D55.9
ICD-10 Finland
Anaemia due to enzyme disorder, unspecified
+∞
6.3
6
*
D52.0
ICD-10 Finland
Dietary folate deficiency anaemia
+∞
6.3
6
*
SPAT1104
SPAT
Monitoring of emergency patient
2.4
6.3
41
175
M13.9
ICD-10 Finland
Arthritis, unspecified
2.2
6.3
53
253
C09AA02
ATC
enalapril; systemic
1.8
6.2
100
596
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
3.7
6.2
19
52
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.8
6.2
92
535
R03AC02
ATC
salbutamol; inhalant
1.5
6.2
379
3088
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
6.2
132
852
J20
ICD-10 Finland
Acute bronchitis
2.0
6.2
72
387
M81.0
ICD-10 Finland
Postmenopausal osteoporosis
3.4
6.2
22
67
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
5.8
6.2
16
28
K04.7
ICD-10 Finland
Periapical abscess without sinus
2.4
6.2
43
189
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.0
6.2
67
352
Z71.8
ICD-10 Finland
Other specified counselling
1.5
6.1
221
1616
JN3AD
NOMESCO Finland
Abdominal CT examination
2.0
6.1
69
367
SPAT1245
SPAT
Provision of support and information to patient’s family members
2.9
6.1
27
94
SPAT1153
SPAT
Removal of sutures
1.6
6.1
187
1319
N06AX26
ATC
vortioxetine; oral
2.1
6.1
60
304
T91
ICPC
Vitamin/nutritional deficiency
8.7
6.1
12
14
W17
ICD-10 Finland
Other fall from one level to another
2.7
6.1
31
117
L77
ICPC
Sprain/strain of ankle
3.5
6.0
20
58
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
5.2
6.0
17
33
N06AA09
ATC
amitriptyline; systemic
2.1
6.0
58
291

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
568
2272
8.03
139.29
4.5
2.2
60.08
75.98
nmol/l
30.65
534
2064
204
363
7.44
116.69
4.7
4.1
86.27
77.11
ng/l
0.93
171
329
542
2470
5.79
102.13
10.7
6.5
1.22
1.22
mmol/l
0.25
475
2110
245
612
5.55
96.80
7.4
5.9
1.03
1.06
mmol/l
1.02
228
566
480
2245
4.40
80.23
9.0
5.8
1.21
1.22
mmol/l
1.09
454
2058
78
92
9.38
62.12
2.6
1.7
4.94
4.68
mmol/24h
0.23
67
79
429
2100
3.57
61.44
6.5
4.5
34.98
36.46
g/l
5.73
403
1963
351
1529
3.52
60.37
5.6
3.6
7.39
7.40
ph
0.44
75
288
224
730
4.00
59.87
5.7
3.7
0.80
0.82
mmol/l
1.26
207
698
619
4164
4.41
47.86
11.2
6.7
87.21
76.29
u/l
4.09
603
3909
348
1727
2.96
44.51
3.1
3.3
2.34
2.36
mmol/l
0.92
314
1538
373
1950
2.89
42.84
2.4
1.8
89.51
96.84
pmol/l
2.38
244
992
154
490
3.72
41.27
2.6
2.1
362.99
379.75
nmol/l
0.48
144
456
453
2665
2.88
40.88
8.4
5.7
10.91
10.85
umol/l
0.04
425
2518
484
2958
2.93
40.44
9.6
6.1
0.19
0.18
e9/l
0.30
428
2616
454
2704
2.83
39.47
9.2
6.1
—
—
—
0
0
197
760
3.19
38.65
3.3
2.3
12.47
13.95
umol/l
1.74
191
699
305
1497
2.80
38.55
3.0
2.1
200.63
222.64
u/l
0.14
292
1412
469
2867
2.81
38.29
8.7
5.7
0.04
0.04
e9/l
0.00
413
2498
467
2858
2.80
37.88
8.7
5.7
0.56
0.55
e9/l
0.27
414
2494
275
1291
2.83
37.70
2.8
2.0
3.34
2.90
mg/l
1.84
245
1103
139
438
3.69
37.57
3.0
2.8
10.42
10.26
g/l
0.18
125
400
511
3286
2.90
37.45
12.3
8.7
4.16
3.95
e9/l
1.29
461
2868
200
793
3.11
37.29
1.5
1.4
479.15
477.88
titre
0.00
47
170
245
1114
2.82
35.32
2.0
1.4
16.91
20.52
nmol/l
3.75
221
954
178
688
3.11
34.42
3.4
2.3
2.32
2.36
g/l
0.27
170
635
468
2956
2.66
34.11
8.8
5.8
1.92
1.95
e9/l
0.17
425
2636
55
87
6.76
33.78
3.4
2.9
—
—
—
0
0
309
1622
2.58
32.96
4.3
2.4
60.11
61.45
u/l
0.12
291
1510
116
355
3.70
32.51
1.7
2.5
65.82
67.37
g/l
1.15
106
326
473
3057
2.59
31.97
7.7
4.4
6.89
6.48
mmol/l
2.05
446
2809
165
637
3.06
31.75
3.4
2.3
21.57
23.62
%
0.91
153
546
252
1240
2.59
30.27
5.9
3.9
—
—
—
0
0
249
1247
2.52
28.54
3.2
2.6
2357.84
6932.95
umol/l
1.18
220
1113
141
533
3.04
27.89
9.4
7.2
104.60
104.26
mmol/l
0.32
141
533
115
385
3.36
27.88
10.5
7.7
8.90
8.42
mmol/l
0.30
110
366
35
41
8.92
27.72
1.7
1.1
—
—
—
0
0
571
4180
2.75
27.58
6.2
3.8
13.67
10.37
mm/h
6.44
541
3859
186
823
2.70
27.37
2.2
1.6
1311.11
1213.25
nmol/l
0.44
147
615
120
420
3.23
27.02
4.5
3.2
—
—
—
0
0
361
2186
2.30
26.39
19.3
11.3
1.24
1.18
inr
0.59
114
704
122
440
3.13
26.07
7.0
3.7
1.70
1.70
mmol/l
0.00
97
358
106
352
3.36
25.96
2.2
1.6
1.14
1.23
g/l
0.43
94
319
121
438
3.12
25.68
3.3
2.3
0.20
0.22
g/l
3.47
113
406
79
226
3.80
24.21
1.3
1.3
2.28
2.23
u/ml
0.01
11
13
115
422
3.05
23.75
9.2
6.9
1.68
1.35
mmol/l
1.62
110
414
241
1276
2.33
23.64
6.1
3.6
1.02
1.02
kg/l
0.10
29
167
246
1326
2.30
23.04
1.8
1.4
2.41
2.24
g/l
0.81
158
815
590
4545
2.63
22.89
5.9
3.9
14.75
14.61
pmol/l
0.70
555
4167
121
467
2.91
22.79
7.3
8.8
4.96
5.00
kpa
0.12
115
445
121
467
2.91
22.79
7.3
8.8
11.94
12.59
kpa
0.65
115
447
272
1545
2.22
22.29
6.1
3.7
0.00
0.00
estimate
0.80
76
556
421
2838
2.16
22.20
5.8
3.4
0.00
0.00
estimate
0.50
84
586
405
2703
2.14
21.75
9.2
6.1
8.44
8.38
%
0.12
379
2551
420
2844
2.14
21.69
7.5
4.6
0.00
0.00
estimate
0.50
84
560
268
1528
2.20
21.63
1.4
1.3
0.92
1.81
u/ml
1.30
83
416
403
2689
2.13
21.60
8.9
5.8
2.67
2.82
%
0.62
377
2529
423
2879
2.13
21.47
5.9
3.4
0.00
0.01
estimate
0.50
79
551
118
466
2.83
21.23
7.5
8.9
1.66
0.96
mmol/l
0.94
87
370
278
1625
2.16
20.91
4.1
2.8
—
—
—
0
0
89
302
3.22
20.90
1.6
2.2
—
—
—
0
0
390
2596
2.09
20.73
8.9
5.9
0.64
0.68
%
0.80
362
2432
198
1012
2.32
20.69
1.8
1.6
76470994.19
16686699.58
pmol/l
0.36
170
851
408
2763
2.10
20.69
8.5
5.6
56.52
56.47
%
0.03
384
2609
104
390
2.95
20.55
5.6
3.5
1.21
1.23
mmol/l
1.96
99
342
296
1787
2.11
20.34
4.7
2.9
30.65
30.71
u/l
0.01
286
1714
357
2315
2.07
20.20
5.0
3.1
5.81
5.92
ph
0.22
16
202
184
923
2.33
20.01
2.9
2.8
2.45
2.44
mmol/l
0.19
162
811
142
636
2.53
19.82
2.0
1.5
—
—
—
0
0
387
2598
2.06
19.77
15.0
8.5
0.00
0.00
e9/l
0.51
329
2137
256
1481
2.13
19.51
4.3
3.2
7.77
7.84
mmol/l
0.07
227
1266
407
2794
2.05
19.41
9.0
5.8
28.26
28.92
%
0.56
383
2639
104
402
2.85
19.40
9.3
8.2
—
—
—
0
0
107
420
2.82
19.40
8.0
9.5
95.50
95.93
%
0.28
101
403
196
1033
2.23
18.81
4.9
2.7
562.69
549.05
mosm/kgh2o
0.34
178
874
394
2693
2.02
18.80
4.2
2.7
118.04
93.63
ug/l
1.43
368
2506
678
5800
3.77
18.32
26.3
12.7
139.43
139.66
mmol/l
1.46
665
5630
646
5380
2.91
18.30
7.0
4.5
2.22
2.06
mu/l
0.15
613
4985
229
1296
2.12
18.27
5.7
3.3
—
—
—
0
0
217
1208
2.14
18.04
3.7
2.9
2389.74
1042.92
ng/l
1.57
181
994
201
1091
2.17
17.80
3.3
2.5
8.71
7.13
e6/l
0.58
191
972
85
308
2.99
17.78
5.8
3.8
7.43
7.41
ph
0.56
13
39
78
269
3.13
17.77
4.4
6.1
—
—
—
0
0
298
1877
2.00
17.61
5.0
3.2
57.52
30.28
ng/l
0.54
212
1149
677
5819
3.62
17.46
26.6
12.7
3.93
3.94
mmol/l
0.62
664
5631
92
352
2.85
17.43
3.4
3.2
4.35
4.58
pmol/l
1.00
74
316
41
92
4.66
17.26
1.8
3.9
—
—
—
0
0
153
756
2.30
16.97
2.7
2.1
30.07
29.28
s
0.96
145
733
48
124
4.08
16.89
1.7
3.6
26.93
26.79
mg/l
0.01
32
94
511
3920
2.04
16.58
6.5
4.0
—
—
—
0
0
58
174
3.54
16.50
5.1
4.3
—
—
—
0
0
217
1244
2.06
16.46
2.2
1.7
1.24
0.99
mg/l
0.61
167
915
97
394
2.69
16.37
8.5
9.8
123.79
121.19
g/l
0.51
92
382
678
5883
3.50
16.15
24.1
11.5
19.68
22.06
mg/l
1.54
586
4491
47
124
3.98
16.07
1.7
3.6
32.37
107.52
mg/l
0.79
31
96
110
480
2.52
16.04
3.2
3.1
1.91
1.75
%
0.76
100
431
298
1923
1.94
16.03
6.1
3.5
162.36
99.02
e6/l
0.38
239
1297
242
1456
2.00
15.97
4.5
3.0
0.51
0.36
e6/l
0.67
204
1069
52
150
3.66
15.67
1.5
1.2
87.50
67.86
titre
—
8
14
46
122
3.96
15.62
1.7
3.6
1.18
2.15
ratio
—
7
15
257
1597
1.95
15.32
5.1
3.0
90.35
96.42
e6/l
0.04
221
1193
63
209
3.21
15.28
7.7
2.5
0.68
0.64
%
0.51
63
209
50
150
3.51
14.22
1.4
1.2
—
634.00
—
0
5
218
1315
1.94
13.96
7.0
3.6
90.47
93.39
%
0.88
208
1279
90
384
2.54
13.69
2.7
2.4
6.11
7.08
ug/l
0.25
76
340
600
5015
2.16
13.65
6.6
4.8
39.73
38.61
mmol/mol
1.67
565
4696
48
144
3.50
13.65
1.6
1.4
239.12
305.71
ug/g
1.12
28
81
64
229
2.97
13.64
5.9
3.9
—
—
—
0
0
49
150
3.43
13.51
2.5
2.1
269.05
236.49
ug/l
0.12
44
138
228
1414
1.90
13.33
9.6
6.8
—
—
—
0
0
481
3750
1.85
13.19
6.6
4.1
849.40
1972.53
e6/l
—
10
47
152
828
2.06
12.89
1.8
1.6
—
—
—
0
0
97
443
2.37
12.71
5.3
4.1
0.94
1.08
%
0.23
33
141
37
98
3.93
12.59
3.9
3.0
—
—
—
0
0
23
23
10.29
12.06
1.7
2.2
71.87
80.79
ug/l
0.12
23
23
173
1012
1.93
11.89
1.4
1.3
40.13
30.25
iu/ml
0.16
51
342
169
981
1.94
11.88
1.4
1.2
8.27
10.74
u/ml
0.20
74
401
688
6197
3.34
11.83
16.0
8.9
27.55
26.09
u/l
1.17
678
5986
202
1245
1.86
11.82
3.5
3.3
595.17
265.20
mg/l
0.41
146
805
91
418
2.35
11.74
5.5
4.2
0.11
0.14
%
0.15
27
115
215
1358
1.83
11.60
4.3
3.4
—
—
—
0
0
226
1451
1.81
11.55
4.2
2.9
—
—
—
0
0
81
356
2.44
11.53
3.0
3.0
71.73
71.26
e9/l
0.04
61
266
152
860
1.97
11.48
3.7
2.6
1.27
1.15
e6/l
0.17
103
472
208
1309
1.83
11.31
4.2
3.8
21.43
9.00
mg/mmol
1.58
151
814
47
157
3.13
11.28
4.4
7.6
1.56
1.49
%
0.19
41
143
26
57
4.69
11.26
1.2
1.3
2.58
2.50
g/l
0.07
17
39
26
57
4.69
11.26
1.2
1.3
0.34
0.37
g/l
0.14
16
39
26
57
4.69
11.26
1.2
1.3
5.86
6.79
g/l
0.44
16
40
26
58
4.61
11.03
1.2
1.3
—
—
—
0
0
33
89
3.84
10.96
4.5
2.4
15.86
16.38
%
0.32
23
46
128
695
2.02
10.82
2.7
1.9
—
—
—
0
0
91
433
2.26
10.80
6.0
4.3
—
—
—
0
0
492
3979
1.74
10.66
5.2
2.8
61.68
40.48
u/l
3.23
476
3757
40
126
3.30
10.56
1.8
1.2
—
—
—
0
0
105
546
2.08
9.95
1.5
1.5
—
—
—
0
0
84
400
2.24
9.94
5.5
4.1
0.21
0.66
%
2.15
24
116
31
86
3.72
9.91
1.5
1.3
—
—
—
0
0
33
96
3.55
9.85
1.7
1.4
26.45
24.05
u/l
0.15
28
79
30
83
3.73
9.63
3.7
2.6
—
—
—
0
0
141
828
1.87
9.39
2.1
2.3
138.72
115.26
ug/g
0.21
114
658
32
95
3.48
9.27
5.8
3.0
2.43
2.48
mmol/l
0.03
21
58
74
345
2.28
9.20
3.1
2.2
8452.91
4460.13
u/l
0.42
25
152
44
160
2.86
9.13
6.2
2.7
—
—
—
0
0
56
231
2.54
9.11
2.0
1.7
—
—
—
0
0
457
3713
1.63
8.84
4.6
3.3
—
—
—
0
0
81
400
2.15
8.75
5.8
4.3
0.00
0.13
%
1.24
17
101
137
818
1.83
8.60
5.1
2.7
4.02
3.03
e6/l
0.53
88
434
47
183
2.68
8.59
1.9
2.4
1.47
1.47
g/l
0.01
42
161
30
90
3.43
8.57
1.4
1.5
—
—
—
0
0
16
16
10.20
8.56
1.4
1.3
125.92
157.03
nmol/l
0.69
16
16
19
41
4.73
8.39
1.7
1.5
—
—
—
0
0
341
2607
1.58
8.33
3.1
2.5
—
—
—
0
0
60
269
2.34
8.17
10.8
10.0
0.68
0.65
%
0.21
60
269
60
269
2.34
8.17
10.8
9.8
1.61
1.30
%
1.09
60
269
106
595
1.92
8.04
6.2
2.5
9.44
6.93
umol/l
0.44
86
506
26
74
3.61
8.03
1.3
1.4
68.16
59.83
mmol/l
0.27
19
65
185
1228
1.68
7.97
1.8
1.7
—
—
—
0
0
30
95
3.25
7.89
1.1
1.1
—
—
—
0
0
19
44
4.41
7.72
3.3
2.2
1.61
1.38
g/24h
—
10
23
29
92
3.24
7.61
3.8
2.8
0.81
0.70
nmol/l
0.58
23
78
37
137
2.79
7.46
4.5
3.9
3.76
3.89
mmol/l
0.75
37
137
81
428
2.01
7.31
2.5
2.3
29.02
19.48
au/ml
—
5
30
25
74
3.46
7.31
1.2
1.2
0.66
0.53
nmol/l
1.09
25
67
20
51
4.00
7.20
1.1
1.5
—
—
—
0
0
609
5437
1.77
7.15
4.9
3.9
6.01
5.76
mmol/l
2.91
566
4996
31
107
2.98
7.09
1.1
1.0
—
—
—
0
0
144
920
1.71
7.08
4.8
3.5
116.22
451.75
ng/l
1.73
101
653
233
1679
1.57
7.07
3.3
2.2
—
—
—
0
0
71
365
2.05
6.91
1.4
1.2
—
—
—
0
0
76
403
1.99
6.79
1.5
1.3
224.91
188.15
u/ml
0.19
69
370
17
40
4.33
6.78
1.1
2.4
—
—
—
0
0
118
724
1.75
6.68
1.3
1.2
—
—
—
0
0
22
64
3.51
6.61
1.3
1.2
—
—
nmol/l
—
0
0
42
178
2.44
6.50
2.5
3.4
0.49
0.27
g/l
0.65
27
71
23
70
3.36
6.46
1.2
1.2
—
—
—
0
0
53
251
2.20
6.37
8.0
2.9
—
—
—
0
0
17
31
5.59
6.33
1.9
1.5
21.23
29.65
%
0.42
12
20
215
1554
1.55
6.32
2.0
2.0
—
—
—
0
0
27
93
2.98
6.22
1.2
1.4
0.59
0.52
g/l
0.16
18
70
32
122
2.70
6.14
1.2
1.5
—
—
—
0
0
86
493
1.85
6.09
4.0
2.4
27.41
34.12
u/l
1.48
78
424
672
6250
2.09
6.08
21.6
10.6
—
—
—
0
0
34
136
2.57
5.95
1.2
1.4
31.30
6.61
e6/l
0.70
20
109
34
136
2.57
5.95
1.2
1.5
65.79
194.74
e6/l
0.85
24
112
20
59
3.46
5.90
1.7
1.5
—
—
—
0
0
62
322
2.01
5.88
2.9
2.8
136.86
151.43
ng/l
0.19
55
294
37
158
2.41
5.66
1.8
2.1
10.14
11.36
mg/l
0.38
37
146
585
5256
1.60
5.66
28.1
13.8
14.64
14.43
%
0.49
579
5179
68
371
1.92
5.61
1.5
1.4
—
—
—
0
0
11
13
8.57
5.57
1.5
1.7
92.92
71.77
nmol/24h
0.39
11
13
18
52
3.52
5.48
3.8
2.0
90.88
90.27
%
0.24
18
52
63
343
1.92
5.24
1.4
1.2
—
—
—
0
0
702
6695
2.75
5.14
35.8
16.8
259.48
255.04
e9/l
0.91
694
6554
702
6697
2.74
5.09
36.1
16.9
39.31
41.07
%
1.70
668
6340
56
297
1.96
5.03
4.7
2.0
—
—
—
0
0
31
129
2.47
5.03
5.3
8.9
1.55
1.16
mmol/l
1.16
23
107
23
82
2.86
5.02
1.8
1.3
—
—
—
0
0
702
6702
2.71
4.99
35.8
16.8
4.43
4.52
e12/l
5.11
692
6544
25
94
2.72
4.96
14.8
3.2
—
—
—
0
0
702
6704
2.70
4.95
35.7
16.9
7.01
6.64
e9/l
4.94
693
6543
622
5719
1.63
4.93
5.0
4.2
2.73
2.83
mmol/l
1.80
580
5326
18
56
3.27
4.92
1.8
1.6
32.00
32.50
pg
0.15
18
56
23
85
2.76
4.72
1.3
1.1
—
—
—
0
0
43
214
2.07
4.61
12.0
12.7
—
—
—
0
0
7
5
14.12
4.58
1.3
1.0
15.73
16.92
umol/l
—
7
5
48
251
1.98
4.51
2.5
2.3
—
—
—
0
0
11
19
5.86
4.45
1.7
7.2
56.80
130.08
umol/l
—
5
13
26
106
2.51
4.42
2.1
2.4
106.18
104.49
ug/min
0.01
16
62
15
37
4.12
4.42
4.9
1.7
—
—
—
0
0
32
144
2.28
4.40
1.1
1.2
—
—
—
0
0
611
5630
1.55
4.39
4.7
3.9
4.55
4.74
mmol/l
4.32
569
5272
589
5389
1.50
4.34
4.3
3.5
1.41
1.23
mmol/l
5.98
549
5000
74
450
1.72
4.32
2.6
4.2
3.71
32.19
ug/l
0.98
58
376
608
5606
1.54
4.25
4.6
3.8
1.38
1.50
mmol/l
9.06
567
5233
61
354
1.79
4.19
5.0
2.1
—
—
—
0
0
23
91
2.58
4.17
1.2
1.9
—
—
—
0
0
26
110
2.41
4.11
7.0
3.8
—
—
—
0
0
15
47
3.24
4.07
1.6
1.0
—
—
—
0
0
14
42
3.38
4.06
1.1
1.0
—
—
—
0
0
14
36
3.94
4.01
7.1
2.2
—
—
—
0
0
18
64
2.86
3.98
1.1
1.7
—
—
—
0
0
17
59
2.93
3.92
2.2
1.9
—
—
—
0
0
77
487
1.65
3.90
1.3
1.2
421.85
149.85
iu/ml
0.66
24
206
33
159
2.13
3.88
1.8
1.8
3.37
5.57
iu/l
0.79
14
61
63
378
1.73
3.87
4.9
2.0
—
—
—
0
0
14
38
3.74
3.81
5.9
3.0
278.83
19.23
mg/l
0.89
14
26
32
154
2.13
3.78
1.1
2.2
11.06
10.41
g/l
0.33
27
141
63
381
1.72
3.77
4.9
2.0
—
—
—
0
0
41
217
1.94
3.76
1.3
1.2
—
—
—
0
0
11
24
4.64
3.75
1.0
1.1
1584.36
1704.25
miu/ml
0.10
11
24
11
24
4.64
3.75
2.6
3.2
39645.45
41358.54
ug/l
0.11
11
24
63
384
1.70
3.67
4.9
2.0
—
—
—
0
0
45
770
0.56
3.63
1.3
1.3
—
—
—
0
0
7
9
7.84
3.56
1.9
1.3
—
—
—
0
0
7
9
7.84
3.56
2.3
1.3
—
—
—
0
0
84
557
1.57
3.52
1.2
1.2
—
—
—
0
0
15
52
2.92
3.48
6.8
2.2
—
—
—
0
0
25
113
2.26
3.45
5.3
3.7
56.20
57.19
%
0.20
25
113
61
376
1.68
3.42
3.8
1.8
—
—
—
0
0
88
594
1.55
3.42
1.5
1.3
—
—
—
0
0
19
76
2.54
3.40
1.8
1.7
—
—
—
0
0
177
2229
0.73
3.34
2.7
2.5
—
—
—
0
0
24
109
2.24
3.28
3.9
3.5
4.11
4.17
e9/l
0.04
24
109
48
280
1.77
3.28
1.1
1.1
—
—
—
0
0
44
250
1.81
3.28
1.2
1.3
—
—
—
0
0
6
7
8.63
3.27
4.8
1.0
2.73
2.79
mmol/l
—
6
7
39
214
1.87
3.24
3.3
2.4
20.74
21.37
s
0.39
31
192
24
481
0.48
3.21
1.6
1.4
—
—
—
0
0
204
1628
1.35
3.21
5.1
3.1
—
—
—
0
0
10
24
4.21
3.20
1.2
1.1
125.00
159.65
mmol/24h
—
10
24
49
290
1.74
3.19
1.4
1.5
291.69
300.59
mu/l
0.08
42
258
36
194
1.90
3.17
1.5
1.3
—
—
—
0
0
12
35
3.47
3.11
1.2
1.0
—
—
—
0
0
12
35
3.47
3.11
1.0
1.2
3505.17
31884.74
e6/l
—
6
19
12
36
3.37
3.03
1.2
1.1
—
—
—
0
0
12
36
3.37
3.03
1.2
1.0
—
—
—
0
0
18
75
2.44
2.99
20.8
2.9
72.09
63.17
%
1.17
18
75
29
148
2.00
2.99
4.8
2.7
—
—
—
0
0
55
343
1.65
2.98
3.8
2.6
—
—
—
0
0
55
344
1.65
2.95
1.6
1.5
17.40
23.72
iu/l
0.91
44
296
164
1281
1.36
2.94
3.1
2.1
—
—
—
0
0
7
13
5.43
2.87
1.1
1.1
—
—
—
0
0
17
71
2.43
2.82
1.3
1.2
—
—
—
0
0
8
18
4.48
2.80
3.4
2.6
—
—
—
0
0
7
14
5.04
2.73
1.6
2.4
—
—
—
0
0
26
133
1.99
2.68
1.5
1.2
49.32
24.54
u/ml
—
6
13
16
67
2.42
2.65
1.4
1.4
—
—
—
0
0
12
41
2.96
2.63
2.4
1.1
—
—
—
0
0
12
41
2.96
2.63
1.1
1.2
—
—
—
0
0
34
193
1.80
2.59
1.4
1.2
—
—
—
0
0
9
26
3.49
2.48
1.2
1.5
—
—
—
0
0
25
130
1.96
2.48
1.3
1.4
95.50
105.03
u/ml
—
6
30
8
21
3.84
2.47
4.0
2.3
—
—
—
0
0
12
45
2.69
2.46
4.8
2.8
47.55
39.10
%
1.01
12
45
26
138
1.92
2.44
1.5
1.5
—
—
—
0
0
7
17
4.15
2.36
2.1
1.7
—
—
—
0
0
27
147
1.87
2.36
1.4
2.7
—
—
—
0
0
171
1388
1.30
2.33
1.7
1.6
1.55
1.34
mmol/l
2.00
150
1186
26
142
1.86
2.26
1.2
1.3
229.95
243.64
u/ml
0.12
19
87
7
18
3.92
2.25
1.0
1.2
—
—
—
0
0
6
14
4.31
2.15
1.3
1.1
—
—
—
0
0
38
237
1.64
2.12
6.2
3.0
—
—
—
0
0
6
15
4.02
2.04
1.0
1.0
—
—
—
0
0
10
38
2.65
2.01
1.1
1.4
—
—
—
0
0
84
628
1.38
1.99
1.8
1.4
—
—
—
0
0
7
21
3.36
1.97
1.9
1.2
—
—
—
0
0
6
16
3.77
1.94
3.3
2.4
—
—
—
0
0
7
22
3.20
1.88
3.1
4.5
—
—
—
0
0
6
17
3.55
1.84
2.7
1.8
—
—
—
0
0
5
12
4.19
1.82
2.8
1.5
611.00
10465.40
e6/l
—
5
5
5
12
4.19
1.82
2.4
3.8
—
—
—
0
0
15
73
2.08
1.81
1.9
1.6
—
—
—
0
0
9
36
2.52
1.74
3.0
1.8
—
—
—
0
0
11
48
2.31
1.71
1.1
1.1
342.17
429.26
nmol/l
—
6
42
6
19
3.18
1.66
1.3
1.4
—
—
—
0
0
8
31
2.60
1.66
1.0
1.2
—
—
—
0
0
8
32
2.52
1.60
3.6
3.5
999.37
768.94
u/ml
—
8
32
13
64
2.05
1.55
1.1
1.0
—
—
—
0
0
28
177
1.61
1.54
12.5
8.8
—
—
—
0
0
5
16
3.14
1.44
2.2
1.3
—
—
—
0
0
11
53
2.09
1.39
1.6
2.2
4.15
4.04
mmol/l
0.26
11
53
11
53
2.09
1.39
1.6
2.2
106.64
105.92
mmol/l
0.18
11
53
10
47
2.14
1.34
3.8
4.1
—
—
—
0
0
51
380
1.37
1.29
3.3
2.7
4.62
6.22
e9/l
0.68
35
326
10
48
2.10
1.28
1.6
1.2
—
—
—
0
0
8
35
2.30
1.27
1.4
1.8
3.13
7.45
u/field
—
8
25
9
45
2.01
1.23
1.4
1.6
15.21
17.93
ug/l
—
9
45
39
280
1.42
1.23
1.3
1.3
208.82
258.94
miu/ml
0.37
11
138
8
37
2.17
1.21
1.3
1.7
—
—
—
0
0
8
37
2.17
1.21
1.3
1.1
—
—
—
0
0
13
224
0.57
1.19
1.5
1.5
—
—
—
0
0
13
221
0.58
1.14
1.5
1.4
—
—
—
0
0
13
220
0.58
1.12
1.5
1.4
—
—
—
0
0
250
2271
1.15
1.05
2.2
2.0
—
—
—
0
0
18
114
1.59
1.03
2.6
1.9
145.16
224.11
pmol/l
2.42
18
109
10
53
1.90
1.01
1.7
2.2
—
—
—
0
0
7
37
1.90
0.94
1.0
1.1
—
—
—
0
0
16
101
1.60
0.94
1.4
1.2
6.50
6.19
u/ml
—
6
48
54
673
0.79
0.93
2.9
2.7
0.69
0.72
ug/l
0.15
39
416
18
119
1.53
0.88
1.0
1.1
—
7.58
—
0
10
24
169
1.43
0.88
2.2
3.0
343.84
1560.23
u/ml
0.60
19
149
11
64
1.73
0.86
2.5
4.6
—
—
—
0
0
6
32
1.88
0.82
45.7
4.1
13.02
11.85
%
—
6
32
20
139
1.45
0.80
3.3
2.3
—
—
—
0
0
6
33
1.82
0.79
1.8
1.4
5.51
6.12
mmol/l
—
6
33
5
26
1.93
0.70
4.6
3.0
—
—
—
0
0
7
41
1.71
0.70
2.9
1.5
0.78
1.01
g/l
—
7
41
10
62
1.62
0.65
1.1
1.1
—
—
—
0
0
20
147
1.37
0.62
1.2
1.2
5.32
4.01
u/ml
0.13
15
81
32
253
1.28
0.62
1.1
1.1
—
—
—
0
0
60
511
1.19
0.60
4.8
3.6
—
—
—
0
0
49
412
1.20
0.57
1.8
1.4
—
—
—
0
0
9
63
1.43
0.52
2.1
3.3
—
—
—
0
0
27
215
1.27
0.51
1.6
1.7
—
—
—
0
0
16
120
1.34
0.46
1.2
1.1
3.51
1.63
u/ml
0.35
11
58
17
129
1.33
0.46
1.1
1.1
5.53
1.68
u/ml
0.51
12
69
16
121
1.33
0.44
1.3
1.1
—
—
—
0
0
5
34
1.47
0.40
1.2
1.2
—
—
—
0
0
103
944
1.11
0.40
1.6
1.7
—
—
—
0
0
74
667
1.12
0.39
1.3
1.3
—
—
—
0
0
75
829
0.89
0.39
1.8
1.5
—
—
—
0
0
11
80
1.38
0.38
1.3
1.3
—
—
—
0
0
75
681
1.11
0.35
2.0
1.8
—
—
—
0
0
9
125
0.72
0.35
1.0
1.1
—
—
—
0
0
9
125
0.72
0.35
1.0
1.1
—
—
—
0
0
12
92
1.31
0.32
1.0
1.1
11.79
5.48
u/ml
—
6
33
7
98
0.71
0.31
1.4
1.8
—
—
—
0
0
11
142
0.77
0.31
1.3
1.3
—
—
—
0
0
184
1759
1.06
0.27
1.5
1.6
—
—
—
0
0
11
87
1.27
0.24
1.6
1.1
—
—
—
0
0
11
88
1.25
0.22
2.5
2.6
—
—
—
0
0
5
42
1.19
0.21
1.4
1.4
87.20
72.90
umol/l
—
5
42
5
42
1.19
0.21
1.6
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
6
51
1.18
0.19
1.0
1.2
—
—
—
0
0
36
395
0.91
0.19
1.5
1.7
—
—
—
0
0
58
612
0.94
0.13
1.6
1.4
—
—
—
0
0
16
178
0.90
0.11
1.3
1.1
—
—
—
0
0
116
1141
1.02
0.05
3.7
4.3
1.63
2.34
ug/l
1.43
107
1027
11
101
1.09
0.04
1.3
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
3.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
51
0.98
-0.00
3.6
3.5
55.86
50.53
u/ml
—
5
51
0
9
0.00
-0.00
0.0
1.3
—
1.71
—
0
9
0
6
0.00
-0.00
0.0
1.0
—
19.18
—
0
6
7
72
0.97
-0.00
2.1
1.2
58.64
12.69
u/l
—
7
61
5
56
0.89
-0.00
1.2
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_VIT_D_DEF and mortality.

Females

Parameter HR [95% CI] p-value
E4_VIT_D_DEF 1.849 [1.5, 2.29] < 0.001
Birth year 0.996 [0.99, 1.0] 0.396

During the follow-up period (1.1.1998 — 31.12.2019), 343 out of 2160 females with E4_VIT_D_DEF died.

Males

Parameter HR [95% CI] p-value
E4_VIT_D_DEF 2.763 [1.99, 3.84] < 0.001
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 271 out of 1341 males with E4_VIT_D_DEF died.

Mortality risk

Mortality risk for people of age

years, who have E4_VIT_D_DEF.

N-year risk Females Males
1 0.172% 0.546%
5 1.005% 3.188%
10 2.601% 7.561%
15 5.141% 14.755%
20 9.109% 24.402%

Relationships between endpoints

↥

Index endpoint: E4_VIT_D_DEF – Vitamin D deficiency

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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