Legal intervention

VWXY20_LEGAL_INTERVEN

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — Y35 Cause of death: ICD-10 — Y35 2 out of 7 registries used, show all original rules.	31
4. Check minimum number of events None	31
5. Include endpoints None	31
6. Filter based on genotype QC (FinnGen only)	31

Control definitions (FinnGen only)

Control exclude: VWXY20_LEGAL_INTERVEN_OPERA_WAR

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: Y3[5-6]

NAME	VWXY20_LEGAL_INTERVEN
CONTROL_EXCLUDE	VWXY20_LEGAL_INTERVEN_OPERA_WAR
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	Y35
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	Y35
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Legal intervention based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	31	9	22
Unadjusted period prevalence (%)	0.01	0.00	0.01
Median age at first event (years)	41.56	48.35	38.77

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3028707) Methadone [Presence] in Urine by Screen method

10.29

4.36

5.5

1.7

—

(3011288) Drugs identified in Urine by Screen method

7.27

3.61

8.9

1.4

—

(3016879) Cocaine [Presence] in Urine

5.59

3.03

6.3

1.6

—

(3028300) Cannabinoids [Presence] in Urine

5.59

3.03

6.3

1.6

—

(3027008) Opiates [Presence] in Urine

5.59

3.03

6.3

1.6

—

(3000764) Benzodiazepines [Presence] in Urine

5.59

3.03

6.3

1.6

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

6.11

2.91

6.1

1.6

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

3.62

2.75

1.5

1.7

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

3.50

2.71

1.6

1.7

—

(3027944) Amphetamines [Presence] in Urine

4.99

2.53

6.9

1.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

3.21

2.50

1.9

2.1

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

5.72

2.15

2.0

2.1

106.00

754.97

ug/l

—

(3042936) Bacteria identified in Isolate by Culture

3.20

2.00

5.2

4.3

—

(3044889) 12 lead EKG panel

148

2.67

1.83

2.9

3.0

—

(3025941) Bacteria identified in Stool by Culture

4.36

1.79

1.4

1.3

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

2.61

1.75

8.7

3.5

30.40

26.49

u/l

0.58

(40760892) CBC W Ordered Manual Differential panel - Blood

2.80

1.67

4.3

6.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.75

1.57

2.1

1.7

—

(40768797) Stomach Pathology biopsy report

3.13

1.52

1.2

—

(3021960) Folate [Moles/volume] in Serum or Plasma

2.46

1.42

1.6

13.12

18.81

nmol/l

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

135

2.36

1.39

4.8

8.4

7.36

6.70

mmol/l

0.26

123

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

3.10

1.34

5.2

2.2

—

(3023368) Bacteria identified in Blood by Culture

2.39

1.32

3.6

5.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

111

2.18

1.23

4.8

—

(3033658) Prothrombin time (PT) actual/Normal

2.16

1.07

4.5

4.0

82.55

95.46

2.18

(3007853) Bacteria identified in Skin by Aerobe culture

2.41

0.98

3.2

2.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.23

0.93

2.0

1.4

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.08

0.87

1.3

1.7

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.83

0.0

1.8

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

163

1.89

0.81

5.3

3.8

14.88

15.03

pmol/l

0.11

144

(3019069) Monocytes/100 leukocytes in Blood

105

1.83

0.81

7.4

9.5

7.65

8.79

1.01

(3006504) Eosinophils/100 leukocytes in Blood

105

1.83

0.81

7.1

9.0

3.11

2.62

0.27

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

2.39

0.80

1.8

2.1

—

(3000494) Fungus identified in Specimen by Culture

2.28

0.78

1.4

2.7

—

(3012544) pH of Venous blood

2.28

0.78

13.0

4.3

—

(3003694) ABO and Rh group [Type] in Blood

1.85

0.75

1.5

—

(3044640) Blood type and Crossmatch panel - Blood

1.85

0.75

3.7

2.8

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.01

0.72

6.6

12.4

103.20

103.93

mmol/l

—

(3018010) Neutrophils/100 leukocytes in Blood

108

1.75

0.71

6.9

8.8

58.98

58.01

0.16

102

(3002030) Lymphocytes/100 leukocytes in Blood

109

1.73

0.69

7.2

9.0

27.20

27.98

0.14

103

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.86

0.67

2.2

1.3

—

(1761868) Lipid panel - Serum or Plasma

0.53

0.66

5.0

2.0

—

(3015736) pH of Urine

1.73

0.64

4.7

2.7

—

(40768804) Tissue Pathology biopsy report

1.69

0.58

2.4

1.8

—

(3026008) Bacteria identified in Urine by Culture

1.51

0.49

4.3

3.2

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.42

0.0

1.9

—

253.20

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.42

0.0

1.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

159

1.50

0.42

4.9

4.1

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.42

0.0

1.7

—

(3013707) Erythrocyte sedimentation rate by Westergren method

171

1.48

0.38

5.5

3.2

9.65

9.54

mm/h

0.02

157

(3009542) Hematocrit [Volume Fraction] of Blood

240

1.52

0.30

23.2

16.2

40.33

41.63

0.48

193

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

186

1.40

0.29

8.0

2.9

67.24

38.41

u/l

0.46

180

(3005322) IgE [Units/volume] in Serum or Plasma

0.00

0.22

0.0

1.1

—

195.67

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

0.00

0.21

0.0

3.2

—

4.85

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.21

0.0

1.7

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

0.00

0.21

0.0

2.9

—

0.60

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

7.1

—

25.69

—

(3014007) Fractional oxyhemoglobin in Arterial blood

0.00

0.20

0.0

18.1

—

92.98

—

(3013512) EKG study

1.29

0.20

14.1

3.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.19

0.19

6.3

1.9

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

1.28

0.16

1.9

2.9

78.10

68.63

nmol/l

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.19

0.10

2.3

2.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.09

0.09

2.8

2.9

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.09

0.09

2.3

2.6

—

(40758558) Short blood count panel - Blood

1.06

0.08

10.0

9.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.10

0.08

5.7

2.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

204

1.09

0.01

2.8

3.2

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

2.4

—

(36304419) Bacteria [Presence] in Urine

0.91

0.00

2.1

2.7

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.0

1.3

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.9

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

0.00

0.0

2.0

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

0.95

0.00

4.1

3.3

2.29

2.37

mmol/l

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

698.17

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

11.78

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(4146454)

0.00

0.0

4.8

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.9

—

(40768443) Skin Pathology biopsy report

0.00

0.0

1.0

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.0

1.1

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.0

1.6

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.6

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.0

1.9

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3022313) Gas panel - Capillary blood

0.00

0.0

3.6

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.0

1.8

—

(4094501)

0.00

0.0

1.4

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.02

0.00

3.2

2.9

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

1.02

0.00

2.0

1.6

1.06

1.54

mmol/l

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

3.56

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.0

1.1

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.00

0.00

1.4

1.5

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.0

1.8

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.0

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.2

—

(42870588) Differential panel, method unspecified - Blood

0.90

0.00

9.7

6.6

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.0

1.1

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: VWXY20_LEGAL_INTERVEN – Legal intervention

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Legal intervention

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Legal intervention (VWXY20_LEGAL_INTERVEN)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints