Defect, injury or illness of skull

Z21_DEFECT_INJURY_ILLNE_SKULL

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — ZA8.0 Cause of death: ICD-10 — ZA8.0 2 out of 7 registries used, show all original rules.	32
4. Check minimum number of events None	32
5. Include endpoints None	32
6. Filter based on genotype QC (FinnGen only)	32

Control definitions (FinnGen only)

Control exclude: Z21_ADDIT_CODES_LOCAT_DEFECT_INJURY_ILLNE

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: Z[AB]

NAME	Z21_DEFECT_INJURY_ILLNE_SKULL
CONTROL_EXCLUDE	Z21_ADDIT_CODES_LOCAT_DEFECT_INJURY_ILLNE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	ZA80
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	ZA80
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Defect, injury or illness of skull based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	32	18	14
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	39.43	38.45	40.70

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3030981) Hyaline casts [#/volume] in Urine by Automated count

5.87

2.53

8.8

2.5

0.19

0.06

e6/l

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

7.14

2.46

1.6

1.4

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

5.40

2.39

2.7

1.0

—

(3027944) Amphetamines [Presence] in Urine

4.17

2.20

1.7

1.4

—

(3028300) Cannabinoids [Presence] in Urine

4.17

2.20

1.7

1.4

—

(3000764) Benzodiazepines [Presence] in Urine

4.17

2.20

1.7

1.4

—

(3027008) Opiates [Presence] in Urine

4.17

2.20

1.7

1.4

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

3.12

2.13

1.5

1.4

—

(3042936) Bacteria identified in Isolate by Culture

3.46

2.03

1.5

2.1

—

(3013512) EKG study

2.89

1.97

4.2

3.7

—

(3016879) Cocaine [Presence] in Urine

3.85

1.84

1.7

1.4

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

0.00

1.46

0.0

4.0

—

0.30

—

(4035726)

3.28

1.41

1.0

1.6

—

(1761868) Lipid panel - Serum or Plasma

2.27

1.38

2.3

2.0

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.29

1.37

1.9

1.7

—

(3025941) Bacteria identified in Stool by Culture

3.09

1.34

1.0

1.4

—

(3002256) Pathology report gross observation

2.77

1.20

1.2

1.4

—

(3013707) Erythrocyte sedimentation rate by Westergren method

175

2.11

1.19

4.8

4.3

8.39

9.65

mm/h

0.39

165

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

0.00

1.03

0.0

3.6

—

4.12

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.50

1.00

2.8

1.4

—

(21494755) Public health laboratory ask at order entry panel

2.14

0.97

1.3

—

(40768804) Tissue Pathology biopsy report

1.86

0.83

2.6

1.9

—

(40758558) Short blood count panel - Blood

1.93

0.80

6.0

7.2

—

(3000494) Fungus identified in Specimen by Culture

2.18

0.76

2.4

1.4

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

2.18

0.76

2.4

5.7

166.40

221.28

u/l

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.85

0.74

2.4

2.0

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

127

1.72

0.70

2.8

3.0

69.73

81.92

ug/l

0.31

115

(3023368) Bacteria identified in Blood by Culture

1.80

0.68

4.0

4.7

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

100

1.71

0.67

10.4

8.5

1.23

mmol/l

0.04

(3044889) 12 lead EKG panel

138

1.70

0.67

2.1

3.0

—

(3015736) pH of Urine

0.52

0.65

2.2

3.1

—

(3002582) Erythrocytes [#/volume] in Urine

1.78

0.65

7.1

5.0

27.26

12.56

e6/l

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.73

0.62

1.8

7.9

—

(40761535) Cells panel - Urine sediment

0.00

0.62

0.0

3.4

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.61

0.0

1.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

0.56

0.55

1.6

2.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.67

0.53

2.9

2.2

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.79

0.46

1.0

2.0

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.42

0.0

1.8

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.42

0.0

1.8

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

0.00

0.42

0.0

1.9

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.42

0.0

1.9

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.42

0.42

2.7

3.1

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.42

0.0

1.8

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

0.00

0.42

0.0

6.3

—

23.81

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.42

0.0

1.3

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.42

0.0

1.8

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.42

0.0

1.8

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.42

0.0

1.8

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.42

0.0

1.9

—

(42870588) Differential panel, method unspecified - Blood

1.51

0.38

4.1

7.3

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.37

0.35

2.7

1.5

1.32

1.35

—

(3044640) Blood type and Crossmatch panel - Blood

1.46

0.33

2.8

2.7

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

1.35

0.33

1.6

1.7

1.36

1.55

mmol/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

165

0.73

0.29

4.6

4.8

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

186

1.38

0.28

3.6

3.4

30.62

42.42

u/l

0.82

179

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

166

1.36

0.27

8.6

8.1

66.47

80.58

u/l

1.33

156

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.22

0.0

3.1

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.22

0.0

4.5

—

0.93

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.22

0.0

1.0

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.22

0.0

1.6

—

(3020891) Body temperature

0.00

0.21

0.0

4.0

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.21

0.0

4.3

—

2.30

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

2.2

—

4.02

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.21

0.0

3.1

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.21

0.0

2.2

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.21

0.0

4.0

—

42.95

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.4

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.21

0.0

1.5

—

3.40

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

0.00

0.20

0.0

4.0

—

133.57

—

(4034850)

0.00

0.20

0.0

5.1

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.29

0.20

1.6

1.4

—

(3019150) Specific gravity of Urine by Refractometry

1.24

0.20

1.7

3.3

—

1.02

—

(3026493) Urate [Moles/volume] in Serum or Plasma

1.24

0.20

4.7

3.8

340.14

319.74

umol/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.19

0.17

6.3

4.9

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

107

0.78

0.16

5.9

4.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.11

0.09

3.0

2.8

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

0.83

0.08

1.6

3.0

28.29

27.11

u/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

219

1.18

0.07

4.5

4.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.01

0.00

2.6

3.4

—

(3003694) ABO and Rh group [Type] in Blood

1.05

0.00

1.5

1.7

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.6

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

7.3

—

0.64

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.5

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

0.00

0.0

1.3

—

98.71

—

(3034860) Kappa light chains.free [Mass/volume] in Serum

0.00

0.0

7.5

—

31.27

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.0

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

3.8

—

15.00

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.6

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

12.0

—

985.00

—

(3047169) Lambda light chains.free [Mass/volume] in Serum or Plasma

0.00

0.0

7.5

—

24.17

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.0

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

2.1

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.0

1.3

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.0

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

8.6

—

58.43

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

1.00

0.00

2.3

3.0

2.37

2.34

mmol/l

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.2

—

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

0.00

0.0

1.6

—

0.64

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

1.4

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.8

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

0.00

0.0

4.0

—

22.84

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

13.4

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.0

2.1

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.8

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3012501) Base excess in Blood by calculation

0.00

0.0

12.6

—

3.40

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.0

1.3

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

8.4

—

4.44

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.6

—

(3036489) Thrombin time

0.00

0.0

1.3

—

21.67

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

0.00

0.0

1.9

—

4.26

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

237

1.05

0.00

16.1

13.2

139.58

139.57

mmol/l

0.01

229

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.0

12.6

—

9.48

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.0

1.3

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.6

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

0.00

0.0

7.3

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

1.7

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.0

1.2

—

(3048689) Calprotectin [Mass/mass] in Stool

0.98

0.00

1.4

2.8

79.60

97.86

ug/g

—

(1616796) Gas panel - Central venous blood

0.00

0.0

11.0

—

(3047181) Lactate [Moles/volume] in Blood

0.00

0.0

3.8

—

1.23

—

(3025149) Bordetella pertussis IgA Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.2

—

(3003181) Sodium [Moles/volume] in Urine

0.00

0.0

1.7

—

74.67

—

(3009508) Creatinine [Moles/volume] in Urine

1.00

0.00

6.1

3.2

5.26

8.96

mmol/l

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.4

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.0

12.6

—

4.98

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

3.2

—

1.38

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.0

1.8

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.4

—

5.10

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.6

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.2

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

0.00

0.0

2.6

—

3.31

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

238

1.03

0.00

16.3

13.1

3.97

3.93

mmol/l

0.23

227

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

12.6

—

2117.00

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

0.00

0.0

2.8

—

0.70

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.0

8.6

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

0.00

0.0

2.8

—

1.52

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.05

0.00

1.6

1.7

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: Z21_DEFECT_INJURY_ILLNE_SKULL – Defect, injury or illness of skull

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Defect, injury or illness of skull

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Defect, injury or illness of skull (Z21_DEFECT_INJURY_ILLNE_SKULL)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints