Risteys · AB1_FILARIASIS

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — B74 Hospital discharge: ICD-9 — 125 Hospital discharge: ICD-8 — 125 Hospital discharge: excluded ICD-9 — 125[3\|7] Cause of death: ICD-10 — B74 Cause of death: ICD-9 — 125 Cause of death: ICD-8 — 125 Cause of death: excluded ICD-9 — 125[3\|7] 2 out of 7 registries used, show all original rules.	43
4. Check minimum number of events None	43
5. Include endpoints None	43
6. Filter based on genotype QC (FinnGen only)	43

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	355	232	118
Only index persons	281	212	69
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	42.91	38.85	49.54
Only index persons	38.56	38.65	38.31

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	43	31	12
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	38.49	39.01	37.16

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(42870588) Differential panel, method unspecified - Blood

116

3.42

3.80

10.2

5.6

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

3.84

3.71

8.1

4.4

mmol/l

1.0

1.1

1.62

(40758558) Short blood count panel - Blood

3.33

3.57

16.0

7.8

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

5.39

3.33

1.6

1.4

—

(3019832) Treponema pallidum Ab [Presence] in Serum

5.74

2.86

1.3

1.5

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

9.21

2.82

1.2

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

4.66

2.72

1.3

1.2

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.91

2.70

2.5

3.4

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

7.88

2.62

8.2

2.7

250.4

189.9

—

(3018095) Leukocytes [#/volume] in Urine

128

2.71

2.58

4.6

3.2

e6/l

24.9

31.0

0.11

(3032080) INR in Blood by Coagulation assay

155

2.71

2.54

12.7

6.5

inr

1.2

1.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

4.22

2.51

1.3

1.2

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

6.11

2.27

6.4

2.2

g/l

4.0

3.2

—

(3045414) Leukocytes [Presence] in Urine

6.11

2.27

1.0

1.9

—

(3021960) Folate [Moles/volume] in Serum or Plasma

2.71

2.17

2.0

1.5

nmol/l

21.3

23.5

0.16

(3044889) 12 lead EKG panel

261

2.83

2.11

6.0

3.8

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.87

2.05

1.8

1.7

—

(36660697) Celiac disease serology panel - Serum

3.27

1.98

1.5

1.2

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

116

2.35

1.93

3.6

2.1

u/l

115.0

134.4

0.22

111

(3031040) Bacteria [#/volume] in Urine by Automated count

239

2.64

1.92

4.8

4.3

—

53.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.88

1.92

3.9

1.4

—

(3002582) Erythrocytes [#/volume] in Urine

109

2.33

1.87

4.3

2.9

e6/l

21.9

15.8

0.32

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

135

2.29

1.85

3.1

1.9

pmol/l

104.5

95.3

0.59

(3001122) Ferritin [Mass/volume] in Serum or Plasma

144

2.28

1.84

4.1

2.5

ug/l

66.1

91.9

1.03

134

(3030467) Casts [#/volume] in Urine by Automated count

102

2.32

1.81

4.4

2.7

e6/l

0.1

0.3

1.60

(36304419) Bacteria [Presence] in Urine

104

2.26

1.72

4.4

2.6

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

3.89

1.66

1.0

1.1

—

(3025941) Bacteria identified in Stool by Culture

3.89

1.66

1.2

1.6

—

(3000991) Gas panel - Venous blood

2.89

1.59

6.7

5.7

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

2.78

1.52

5.9

4.3

mmol/l

1.1

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

162

2.09

1.51

2.9

4.2

ng/l

12.0

22.9

1.84

119

(3000330) Specific gravity of Urine by Test strip

3.39

1.48

2.0

3.8

—

(40768443) Skin Pathology biopsy report

3.39

1.48

1.0

1.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

128

2.05

1.43

4.3

2.7

—

(3007164) IgA [Mass/volume] in Serum or Plasma

2.23

1.43

1.6

1.3

g/l

1.7

2.2

—

(3022621) pH of Urine by Test strip

2.86

1.42

1.5

1.8

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

2.19

1.38

1.5

1.2

—

3.0

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

216

2.05

1.34

9.0

4.2

mmol/l

6.7

6.6

0.14

201

(3012544) pH of Venous blood

2.50

1.33

1.8

4.0

—

(3002385) Erythrocyte distribution width [Ratio]

306

2.49

1.33

37.9

16.6

14.2

13.8

0.72

300

(3014007) Fractional oxyhemoglobin in Arterial blood

2.84

1.25

10.4

3.9

95.7

94.0

—

(3023368) Bacteria identified in Blood by Culture

2.02

1.25

7.3

4.3

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.43

1.06

10.4

3.6

1.1

1.8

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.43

1.06

2.4

1.4

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.43

1.06

10.4

3.6

0.6

0.7

—

(3000494) Fungus identified in Specimen by Culture

2.01

1.05

1.6

1.5

—

(3015736) pH of Urine

141

1.78

1.00

2.4

3.5

—

(3026008) Bacteria identified in Urine by Culture

114

1.81

1.00

3.8

2.7

—

(3044640) Blood type and Crossmatch panel - Blood

107

1.79

0.94

5.6

2.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

333

2.21

0.92

37.4

13.4

38.6

39.5

0.24

232

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.84

0.91

3.4

2.2

—

(3020682) Albumin/Creatinine [Ratio] in Urine

126

1.74

0.90

4.5

3.9

mg/mmol

11.6

9.8

0.06

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

154

1.71

0.89

3.9

2.3

nmol/l

80.4

76.6

0.29

134

(3012516) Albumin [Mass/volume] in Urine

119

1.71

0.84

4.6

3.2

mg/l

30.2

74.2

0.55

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

1.73

0.77

2.3

2.9

mmol/l

2.5

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.04

0.73

5.0

1.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

113

0.55

0.70

2.3

3.6

—

(40768804) Tissue Pathology biopsy report

152

1.59

0.70

2.7

1.9

—

(40768797) Stomach Pathology biopsy report

1.77

0.67

1.5

1.4

—

(3000492) Spirometry study

1.83

0.61

1.7

1.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

176

1.51

0.59

5.0

3.9

—

(4035726)

1.72

0.58

1.0

1.4

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

1.67

0.57

2.2

2.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.67

0.57

2.0

1.5

—

(3003396) Base excess in Arterial blood by calculation

1.58

0.54

11.7

6.8

mmol/l

1.4

2.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

249

1.51

0.53

5.6

4.3

—

(3042936) Bacteria identified in Isolate by Culture

1.52

0.46

1.9

1.5

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

1.58

0.43

1.0

1.2

—

(4034850)

0.00

0.42

0.0

7.5

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.42

0.0

1.5

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.42

0.0

1.8

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.42

0.0

3.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.38

0.41

1.7

1.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

153

0.70

0.40

2.6

3.9

—

(1761868) Lipid panel - Serum or Plasma

131

0.69

0.38

3.0

3.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.50

0.37

3.7

1.5

—

(3048689) Calprotectin [Mass/mass] in Stool

1.46

0.37

2.3

1.7

ug/g

48.2

157.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.46

0.37

3.7

1.5

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

120

1.38

0.37

2.0

3.0

mmol/l

2.4

0.05

103

(3022145) Colonoscopy Study observation

1.35

0.34

1.3

1.2

—

(3003694) ABO and Rh group [Type] in Blood

1.37

0.30

1.4

—

(3019150) Specific gravity of Urine by Refractometry

0.69

0.27

2.7

3.8

—

1.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.31

0.24

2.2

5.6

—

(3013512) EKG study

123

0.76

0.24

2.6

3.9

—

(3022217) INR in Platelet poor plasma by Coagulation assay

1.21

0.22

23.6

13.4

—

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.32

0.21

2.3

1.5

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

2.1

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

0.00

0.21

0.0

1.1

—

1.0

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.21

0.0

2.2

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.18

0.19

3.3

1.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.15

0.09

1.5

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

210

1.10

0.05

2.6

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

4.3

—

67.9

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

15.2

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

4.5

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.8

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.8

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

3.2

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.1

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

1.9

—

6.8

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.96

0.00

10.4

5.3

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.8

—

(4062490)

0.00

0.0

1.8

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.8

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.8

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

2.0

—

(4027681)

0.00

0.0

1.0

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.6

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.4

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.8

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

2.3

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.1

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

2.6

—

201.9

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.4

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

1.0

—

34.8

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.1

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

0.0

1.0

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.0

3.8

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.2

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

2.3

—

16.3

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.8

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

2.1

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

2.0

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_FILARIASIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_FILARIASIS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: AB1_FILARIASIS – Filariasis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	AB1_FILARIASIS
CONTROL_EXCLUDE	AB1_HELMINTIASES
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	B74
HD_ICD_9	125
HD_ICD_8	125
HD_ICD_10_EXCL
HD_ICD_9_EXCL	125[3\|7]
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	B74
COD_ICD_9	125
COD_ICD_8	125
COD_ICD_10_EXCL
COD_ICD_9_EXCL	125[3\|7]
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Filariasis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints