Flexion deformity

M13_FLEXION

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M21.2 Cause of death: ICD-10 — M21.2 2 out of 7 registries used, show all original rules.	38
4. Check minimum number of events None	38
5. Include endpoints None	38
6. Filter based on genotype QC (FinnGen only)	38

Control definitions (FinnGen only)

Control exclude: M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M21
Name in latin: Deformitas flexionalis

NAME	M13_FLEXION
CONTROL_EXCLUDE	M13_ARTHROPATHIES
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M212
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M212
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Flexion deformity based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	304	195	109
Only index persons	283	181	102
Unadjusted period prevalence (%)
Whole population	0.00	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	-	54.39	43.13
Only index persons	49.83	53.21	43.84

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	38	26	12
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	55.02	53.93	57.38

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3000991) Gas panel - Venous blood

4.53

2.63

3.0

4.2

—

(3026782) Osmolality of Urine

3.05

2.52

2.6

2.5

629.0

570.3

mosm/kgh2o

0.26

(3044640) Blood type and Crossmatch panel - Blood

2.77

2.32

1.9

2.4

—

(36304419) Bacteria [Presence] in Urine

2.57

1.93

4.1

2.9

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.62

1.86

3.3

4.2

—

(3031040) Bacteria [#/volume] in Urine by Automated count

196

2.63

1.83

4.9

4.2

—

950.5

—

(40758558) Short blood count panel - Blood

2.45

1.72

11.6

8.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

106

2.33

1.69

3.9

3.2

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.36

1.65

2.2

1.3

—

(3044889) 12 lead EKG panel

217

2.42

1.61

3.9

3.6

—

(3049717) Cytology report of Urine Cyto stain

3.67

1.57

3.6

3.1

—

(3018095) Leukocytes [#/volume] in Urine

109

2.24

1.56

4.9

3.8

91.3

76.7

e6/l

0.08

(40760892) CBC W Ordered Manual Differential panel - Blood

2.33

1.56

2.5

7.6

—

(3012544) pH of Venous blood

2.83

1.54

2.7

3.1

—

(3048689) Calprotectin [Mass/mass] in Stool

2.72

1.47

1.6

2.7

98.3

73.6

ug/g

—

(40768797) Stomach Pathology biopsy report

2.49

1.46

1.1

1.3

—

(3003338) MCHC [Mass/volume]

259

2.49

1.37

28.5

17.4

332.9

333.1

g/l

0.06

259

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.28

1.37

2.0

2.4

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

2.77

1.36

3.0

2.0

1.6

1.3

—

(3037467) Urinalysis macro (dipstick) panel - Urine

214

2.17

1.24

4.7

4.1

—

(3020779) Urea [Moles/volume] in Serum or Plasma

2.58

1.12

1.8

6.4

7.0

7.9

mmol/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

2.46

1.06

1.0

1.5

—

(3000494) Fungus identified in Specimen by Culture

2.15

1.03

1.0

1.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

125

1.84

0.97

3.2

3.8

—

(3009542) Hematocrit [Volume Fraction] of Blood

286

2.17

0.80

25.0

12.5

37.2

39.2

0.58

199

(3002256) Pathology report gross observation

1.92

0.76

1.0

1.2

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.90

0.69

3.8

3.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

0.50

0.66

2.2

3.2

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.83

0.66

1.4

1.8

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.83

0.66

2.2

1.6

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

175

1.61

0.66

5.8

8.5

11.5

10.4

umol/l

0.23

165

(3026493) Urate [Moles/volume] in Serum or Plasma

1.71

0.65

2.6

3.4

382.1

13904.6

umol/l

1.05

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.90

0.62

3.8

1.5

34.3

28.0

u/l

—

(3042936) Bacteria identified in Isolate by Culture

1.90

0.62

1.7

2.1

—

(3032080) INR in Blood by Coagulation assay

119

1.60

0.62

3.5

9.7

1.0

1.3

inr

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

178

1.56

0.59

3.8

2.5

—

(3026008) Bacteria identified in Urine by Culture

103

1.57

0.56

4.4

2.3

—

(3022145) Colonoscopy Study observation

1.59

0.54

1.0

1.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.00

0.42

0.0

1.5

—

(3023368) Bacteria identified in Blood by Culture

1.50

0.42

6.4

3.5

—

(3021960) Folate [Moles/volume] in Serum or Plasma

1.42

0.42

1.9

1.5

20.7

nmol/l

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.41

0.0

2.0

—

(3021601) Nitrite [Presence] in Urine by Test strip

149

1.40

0.38

4.9

5.1

—

0.0

—

(42870588) Differential panel, method unspecified - Blood

1.44

0.38

7.8

4.7

—

(3009261) Glucose [Presence] in Urine by Test strip

150

1.38

0.36

3.1

3.8

—

0.0

—

(3035350) Ketones [Presence] in Urine by Test strip

151

1.36

0.34

3.0

3.7

—

0.0

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

115

0.72

0.34

3.2

3.9

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

104

1.38

0.32

2.8

2.4

58.3

54.4

u/l

0.29

(3019150) Specific gravity of Urine by Refractometry

1.32

0.30

3.1

4.0

—

1.0

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

193

1.33

0.30

2.3

3.6

6.6

6.7

mmol/l

0.08

177

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.22

0.22

2.0

2.2

—

(1761868) Lipid panel - Serum or Plasma

121

0.76

0.22

1.4

3.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.22

0.0

1.5

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.22

0.0

1.4

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.21

0.0

1.9

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.8

—

(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(40768793) Breast Pathology biopsy report

0.00

0.21

0.0

1.2

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

150

1.24

0.19

4.5

4.6

1.2

mmol/l

0.25

136

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

117

1.17

0.10

3.0

1.7

83.8

96.7

pmol/l

—

(3029937) Albumin [Presence] in Urine by Test strip

0.82

0.08

3.0

4.2

—

0.0

—

(3013512) EKG study

107

0.91

0.02

5.4

3.5

—

(40768804) Tissue Pathology biopsy report

135

1.06

0.00

2.2

2.1

—

(3040151) Glucose [Moles/volume] in Capillary blood

0.00

0.0

26.3

—

6.0

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

7.2

—

181.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.91

0.00

1.2

1.5

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

0.0

1.2

—

24.1

—

(4306422)

0.00

0.0

1.2

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

2.2

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

1.7

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

328.3

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

191.8

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.0

9.7

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

0.0

1.0

—

6.9

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.0

1.0

—

181.5

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

0.00

0.0

3.3

—

1.4

—

(4268621)

0.00

0.0

2.0

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.7

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.3

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

2.7

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

3.4

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.0

—

(3011985) Renin [Units/volume] in Plasma

0.00

0.0

1.1

—

14.3

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.4

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

2.0

—

(3024980) IgG subclass 4 [Mass/volume] in Serum

0.00

0.0

1.8

—

0.5

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.7

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

2.0

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

4.5

—

18.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

5.6

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

1.6

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

40.8

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.0

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

2.0

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.0

1.4

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

1.4

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

2.3

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(4281824)

0.00

0.0

1.1

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

0.00

0.0

1.4

—

26.7

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.0

—

211.7

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.3

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.4

—

(3003694) ABO and Rh group [Type] in Blood

0.87

0.00

1.3

1.2

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.0

2.6

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.0

1.1

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.0

1.5

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.0

—

(3026179) Normetanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

0.4

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.0

2.1

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.4

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.1

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.0

1.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_FLEXION and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_FLEXION.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: M13_FLEXION – Flexion deformity

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Flexion deformity

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints