Soft tissue disorders in diseases classified elsewhere

M13_SOFTTISSUEINOTH

musculoskeletal system disease: A disease involving the musculoskeletal system. [database_cross_reference: MONDO:DesignPattern]

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M73* Cause of death: ICD-10 — M73* 2 out of 7 registries used, show all original rules.	27
4. Check minimum number of events None	27
5. Include endpoints None	27
6. Filter based on genotype QC (FinnGen only)	27

Control definitions (FinnGen only)

Control exclude: M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	M13_SOFTTISSUEINOTH
CONTROL_EXCLUDE	M13_SOFTTISSUE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M73
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M73
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Soft tissue disorders in diseases classified elsewhere based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	239	122	116
Only index persons	226	117	109
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	49.88	49.37	50.50
Only index persons	49.69	49.02	50.42

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	27	17	10
Unadjusted period prevalence (%)	0.01	0.01	0.00
Median age at first event (years)	52.54	52.57	52.48

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

7.43

5.66

8.4

3.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

4.90

3.88

9.8

2.7

—

(3015736) pH of Urine

4.67

3.67

8.4

2.6

—

(3019060) Gas panel - Arterial blood

8.17

3.04

3.3

6.3

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

5.50

2.68

4.3

12.5

119.4

116.4

g/l

—

(3041096) Erythrocytes [Presence] in Urine by Automated

3.70

2.62

3.2

3.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

4.86

2.44

1.4

1.9

—

(3042936) Bacteria identified in Isolate by Culture

3.97

2.43

3.2

1.4

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

4.10

2.32

1.3

1.6

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

3.05

2.01

5.8

2.8

26.8

30.9

u/l

0.60

(4010399)

4.22

1.96

2.5

1.7

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

4.84

1.91

5.4

9.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.56

1.87

1.3

1.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

3.56

1.87

12.6

5.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

3.13

1.68

5.1

4.5

—

(3000494) Fungus identified in Specimen by Culture

3.01

1.58

1.7

1.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.36

1.42

3.0

1.6

—

(3044889) 12 lead EKG panel

150

2.79

1.40

4.8

3.9

—

(3037467) Urinalysis macro (dipstick) panel - Urine

140

2.65

1.38

8.3

3.6

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.56

1.32

1.3

1.6

—

(4035726)

0.00

1.26

0.0

1.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

2.42

1.13

1.3

1.4

—

(40768797) Stomach Pathology biopsy report

2.55

1.08

1.2

1.6

—

(3026008) Bacteria identified in Urine by Culture

2.17

1.01

4.5

2.5

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.37

0.96

1.8

2.3

2.4

2.3

g/l

—

(42870588) Differential panel, method unspecified - Blood

2.00

0.85

7.1

3.8

—

(3023368) Bacteria identified in Blood by Culture

2.02

0.83

3.6

—

(3013707) Erythrocyte sedimentation rate by Westergren method

146

2.01

0.81

7.1

3.6

14.1

13.5

mm/h

0.08

127

(3007853) Bacteria identified in Skin by Aerobe culture

2.22

0.77

4.6

1.7

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.22

0.77

2.4

9.2

101.6

104.0

mmol/l

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

176

1.87

0.68

10.6

7.3

78.4

80.1

u/l

0.09

165

(3019225) pH of Specimen

0.00

0.63

0.0

4.0

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.63

0.0

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

126

1.66

0.53

3.1

2.7

—

(3002256) Pathology report gross observation

1.69

0.45

1.0

1.4

—

(3002385) Erythrocyte distribution width [Ratio]

194

1.72

0.43

26.5

15.9

14.1

13.8

0.39

187

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

1.52

0.42

7.2

3.2

13.2

53.2

ng/l

—

(3023520) Reticulocytes [#/volume] in Blood

0.00

0.41

0.0

1.4

—

80.3

—

(3026493) Urate [Moles/volume] in Serum or Plasma

1.64

0.40

3.7

2.8

313.8

7530.1

umol/l

—

(3018418) pH of Serum or Plasma

1.56

0.39

1.9

4.4

—

7.4

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

1.43

0.34

6.3

4.9

2.2

1.7

ug/l

—

(1761868) Lipid panel - Serum or Plasma

0.66

0.29

2.0

3.3

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

1.30

0.29

2.7

3.8

2.3

2.4

mmol/l

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.43

0.25

1.2

1.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

109

1.37

0.25

6.5

3.4

—

(3021960) Folate [Moles/volume] in Serum or Plasma

1.35

0.22

2.0

1.5

21.0

20.1

nmol/l

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.22

0.0

1.1

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.22

0.0

3.0

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.22

0.0

1.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.00

0.22

0.0

1.7

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3013512) EKG study

0.70

0.20

1.8

4.3

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

142

1.31

0.19

3.8

2.3

102.4

47.4

u/l

0.68

133

(3044640) Blood type and Crossmatch panel - Blood

0.79

0.18

2.6

1.9

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.16

0.09

4.1

3.0

—

(40768804) Tissue Pathology biopsy report

1.07

0.00

1.7

2.2

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

128

1.03

0.00

5.8

4.9

7.0

6.5

mmol/l

0.29

119

(3003694) ABO and Rh group [Type] in Blood

0.93

0.00

1.0

1.5

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(36304419) Bacteria [Presence] in Urine

0.98

0.00

3.8

3.1

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.2

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.0

1.0

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.0

1.0

—

(3027008) Opiates [Presence] in Urine

0.00

0.0

1.0

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.0

2.1

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.0

1.0

—

4.5

—

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

0.00

0.0

1.2

—

0.8

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

3.2

—

(3016879) Cocaine [Presence] in Urine

0.00

0.0

1.0

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

2.2

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.2

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.00

0.0

2.0

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

2.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.00

0.00

2.8

2.0

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.0

1.1

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

2.3

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

211

0.98

0.00

17.5

13.9

82.2

79.5

ml/min/173m2

0.27

179

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.0

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.0

3.0

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.0

1.0

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

0.00

0.0

2.2

—

4.0

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.3

—

169.0

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.0

1.0

—

10.3

—

(4034850)

0.00

0.0

5.9

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

0.00

0.0

2.2

—

431.5

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.0

2.8

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_SOFTTISSUEINOTH and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_SOFTTISSUEINOTH.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: M13_SOFTTISSUEINOTH – Soft tissue disorders in diseases classified elsewhere

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Soft tissue disorders in diseases classified elsewhere

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints