Agent resistant to penicillin and related antibiotics

U22_AGENT_RESISTANT_PENICILLIN_RELATED_ANTIBI

No definition available.

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — U80 Cause of death: ICD-10 — U80 2 out of 7 registries used, show all original rules.	11
4. Check minimum number of events None	11
5. Include endpoints None	11
6. Filter based on genotype QC (FinnGen only)	11

Control definitions (FinnGen only)

Control exclude: U22_BACTERIAL_AGENTS_RESISTANT_ANTIBI

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: U8

NAME	U22_AGENT_RESISTANT_PENICILLIN_RELATED_ANTIBI
CONTROL_EXCLUDE	U22_BACTERIAL_AGENTS_RESISTANT_ANTIBI
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	U80
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	U80
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Agent resistant to penicillin and related antibiotics based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	91	46	45
Only index persons	87	43	44
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	-	54.59	63.17
Only index persons	61.47	59.63	63.26

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	11	9	-
Unadjusted period prevalence (%)	0.00	0.00	-
Median age at first event (years)	65.14	62.47	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

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(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

9.04

2.51

1.6

1.0

—

(3023368) Bacteria identified in Blood by Culture

3.31

1.12

3.2

2.8

—

(3026008) Bacteria identified in Urine by Culture

2.90

1.01

5.5

3.9

—

(3013512) EKG study

2.11

0.52

2.6

5.6

—

(3007164) IgA [Mass/volume] in Serum or Plasma

0.00

0.45

0.0

1.5

—

1.9

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.78

0.30

7.4

4.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

1.57

0.29

7.4

4.7

—

(3002385) Erythrocyte distribution width [Ratio]

0.58

0.28

22.4

22.2

13.8

14.4

—

(3022217) INR in Platelet poor plasma by Coagulation assay

0.00

0.22

0.0

9.7

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

0.00

0.22

0.0

2.2

—

30.5

—

(3021601) Nitrite [Presence] in Urine by Test strip

1.40

0.13

12.0

7.7

—

0.0

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

0.74

0.13

4.7

6.0

48.2

41.9

mmol/mol

—

(3018010) Neutrophils/100 leukocytes in Blood

1.30

0.12

15.0

6.9

53.5

59.3

—

(3002030) Lymphocytes/100 leukocytes in Blood

1.20

0.12

15.2

6.7

30.9

26.6

—

(3019198) Lymphocytes [#/volume] in Blood

1.20

0.12

15.0

7.1

1.6

1.9

e9/l

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.0

5.8

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

229.0

—

(3002256) Pathology report gross observation

0.00

0.0

1.2

—

(3000494) Fungus identified in Specimen by Culture

0.00

0.0

1.2

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

0.00

0.0

6.6

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.2

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.1

—

(3003338) MCHC [Mass/volume]

0.86

0.00

24.7

19.1

320.5

331.3

g/l

—

(3023520) Reticulocytes [#/volume] in Blood

0.00

0.0

1.7

—

66.3

—

(3020779) Urea [Moles/volume] in Serum or Plasma

0.00

0.0

12.7

—

13.5

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

0.00

0.0

1.1

—

(3005322) IgE [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

226.5

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.6

—

(36660697) Celiac disease serology panel - Serum

0.00

0.0

1.1

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.00

0.0

2.9

—

(4010399)

0.00

0.0

1.5

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

0.96

0.00

24.2

9.0

3.1

4.6

e9/l

—

Mortality – FinRegistry

↥

Association

Association between endpoint U22_AGENT_RESISTANT_PENICILLIN_RELATED_ANTIBI and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have U22_AGENT_RESISTANT_PENICILLIN_RELATED_ANTIBI.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: U22_AGENT_RESISTANT_PENICILLIN_RELATED_ANTIBI – Agent resistant to penicillin and related antibiotics

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Agent resistant to penicillin and related antibiotics

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints