Risteys · L12_DRUGPHOTOX

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L56.0# Cause of death: ICD-10 — L56.0# 2 out of 7 registries used, show all original rules.	29
4. Check minimum number of events None	29
5. Include endpoints None	29
6. Filter based on genotype QC (FinnGen only)	29

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	168	107	61
Only index persons	158	102	56
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	-	59.14	49.52
Only index persons	55.22	58.97	48.39

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	29	19	10
Unadjusted period prevalence (%)	0.01	0.01	0.00
Median age at first event (years)	58.49	59.15	57.25

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3020891) Body temperature

17.80

6.05

4.1

2.3

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

14.77

4.53

1.4

1.3

1.2

g/l

—

(3026008) Bacteria identified in Urine by Culture

4.72

4.05

3.1

2.8

—

(3006315) Basophils [#/volume] in Blood

108

5.27

4.03

14.8

5.7

0.0

e9/l

0.69

(3001604) Monocytes [#/volume] in Blood

109

5.19

4.00

14.7

5.6

0.5

0.6

e9/l

0.84

(3013115) Eosinophils [#/volume] in Blood

113

4.90

3.61

16.1

6.2

0.2

e9/l

0.74

(40760892) CBC W Ordered Manual Differential panel - Blood

4.10

3.24

13.3

4.9

—

(3014007) Fractional oxyhemoglobin in Arterial blood

7.28

3.23

8.1

14.0

93.9

90.0

—

(3019060) Gas panel - Arterial blood

6.06

3.18

4.1

5.8

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

135

4.38

3.11

27.7

9.5

3.8

4.1

e9/l

0.39

114

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

6.70

3.08

7.9

13.1

1.1

2.1

—

(42870588) Differential panel, method unspecified - Blood

3.73

2.97

17.5

5.4

—

(3018405) Lactate [Moles/volume] in Arterial blood

9.71

2.86

2.0

1.7

0.8

0.9

mmol/l

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

9.71

2.86

2.2

1.5

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

7.22

2.85

1.2

6.2

25.9

24.5

mmol/l

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

6.54

2.69

2.0

2.4

37.1

48.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

4.35

2.67

2.0

1.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

3.56

2.59

1.3

77.8

31.1

iu/ml

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

5.98

2.54

1.2

5.8

142.8

124.5

g/l

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

5.98

2.54

9.0

13.9

0.7

0.8

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

7.25

2.47

4.0

2.5

—

(3016502) Oxygen saturation in Arterial blood

4.19

2.39

7.5

11.2

95.9

92.7

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

3.26

2.37

4.9

2.8

74.1

74.6

nmol/l

0.03

(3002173) Hemoglobin [Mass/volume] in Arterial blood

4.50

2.32

8.4

13.4

119.6

115.5

g/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

150

3.57

2.26

8.5

4.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

4.74

2.16

1.8

1.2

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

5.78

2.16

2.0

2.1

1.2

1.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

3.41

1.97

1.8

1.6

—

(3002032) Base excess in Venous blood by calculation

3.67

1.94

1.6

4.9

3.1

mmol/l

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

3.67

1.94

7.4

6.0

—

(3019069) Monocytes/100 leukocytes in Blood

105

2.88

1.94

21.1

6.3

7.5

8.3

0.54

(3023368) Bacteria identified in Blood by Culture

2.87

1.91

5.2

4.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

2.78

1.87

8.1

3.4

—

(3012544) pH of Venous blood

3.51

1.86

2.0

4.8

—

(40761535) Cells panel - Urine sediment

3.92

1.85

5.8

3.2

—

(3018010) Neutrophils/100 leukocytes in Blood

108

2.76

1.80

18.0

5.6

61.1

57.7

0.72

(40758558) Short blood count panel - Blood

2.76

1.78

11.2

6.5

—

(3000991) Gas panel - Venous blood

3.70

1.76

8.0

11.1

—

(3029937) Albumin [Presence] in Urine by Test strip

2.76

1.74

9.7

3.7

0.0

estimate

—

(3002030) Lymphocytes/100 leukocytes in Blood

110

2.68

1.70

19.9

5.9

25.2

26.1

0.17

(3015736) pH of Urine

2.58

1.62

7.4

3.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

3.79

1.59

1.8

1.7

—

(3006504) Eosinophils/100 leukocytes in Blood

104

2.53

1.56

20.5

5.8

3.4

2.3

1.43

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

145

2.62

1.51

2.5

3.0

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.85

1.50

1.6

1.5

—

(3035350) Ketones [Presence] in Urine by Test strip

107

2.42

1.43

8.8

3.4

0.0

estimate

—

(3000492) Spirometry study

3.13

1.34

2.0

1.3

—

(3013512) EKG study

2.40

1.34

6.3

3.6

—

(3021601) Nitrite [Presence] in Urine by Test strip

111

2.28

1.27

10.7

4.5

0.0

estimate

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

2.96

1.27

2.2

2.4

17.6

2.6

ug/l

—

(3022096) Basophils/100 leukocytes in Blood

102

2.27

1.27

20.6

5.7

1.1

0.6

5.57

(3000494) Fungus identified in Specimen by Culture

2.75

1.22

4.9

1.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.47

1.15

2.3

1.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

2.17

1.15

4.6

4.5

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

2.17

1.12

7.4

3.0

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

2.11

1.07

2.9

2.3

86.5

90.2

pmol/l

—

(3026493) Urate [Moles/volume] in Serum or Plasma

2.12

1.00

6.4

2.4

376.4

345.4

umol/l

0.52

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.07

0.94

10.1

3.6

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.92

0.79

6.3

2.9

—

(3044640) Blood type and Crossmatch panel - Blood

1.88

0.76

2.8

2.4

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

1.87

0.67

2.6

3.9

—

21.3

—

(3000850) Epithelial cells [#/volume] in Urine

1.74

0.67

4.3

2.4

5.5

5.0

e6/l

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.63

0.0

1.8

—

(3022621) pH of Urine by Test strip

0.00

0.63

0.0

2.4

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.63

0.0

1.5

—

(3002582) Erythrocytes [#/volume] in Urine

1.72

0.59

5.4

3.3

10.8

41.2

e6/l

1.14

(3042936) Bacteria identified in Isolate by Culture

1.78

0.55

3.4

1.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.74

0.46

1.6

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.54

0.39

4.5

1.7

—

(3044889) 12 lead EKG panel

163

1.48

0.35

7.6

3.2

—

(3003694) ABO and Rh group [Type] in Blood

1.53

0.35

1.9

1.2

—

(36304419) Bacteria [Presence] in Urine

1.41

0.30

6.1

3.1

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.22

0.0

4.4

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.22

0.0

2.0

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

0.00

0.22

0.0

4.8

—

104.8

—

(1002224) Polysomnography panel

0.00

0.22

0.0

1.1

—

(40768793) Breast Pathology biopsy report

0.00

0.21

0.0

1.5

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.21

0.0

1.2

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.33

0.20

3.6

2.2

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

0.00

0.20

0.0

2.7

—

0.0

—

(3009542) Hematocrit [Volume Fraction] of Blood

214

0.79

0.18

28.3

15.5

39.3

39.4

0.03

155

(1761868) Lipid panel - Serum or Plasma

0.77

0.17

2.9

3.1

—

(40768804) Tissue Pathology biopsy report

1.03

0.00

2.0

2.1

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.0

1.1

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.1

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

2.5

—

(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.0

2.3

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.1

—

(4094501)

0.00

0.0

1.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.00

0.0

1.5

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

4.7

—

19.5

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

3.7

—

95.5

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.0

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

-0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_DRUGPHOTOX and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_DRUGPHOTOX.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_DRUGPHOTOX – Drug phototoxic response

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	L12_DRUGPHOTOX
CONTROL_EXCLUDE	L12_RADIATIONRELATEDSKIN
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L560
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L560
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Drug phototoxic response

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints