Other acute skin changes due to ultraviolet radiation

L12_OTHACUSKINSUN

phototoxic dermatitis: a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous. In rare cases the victims die.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L56
  • Cause of death: ICD-10 L56

2 out of 7 registries used, show all original rules.

657

4. Check minimum number of events

None

657

5. Include endpoints

1325

6. Filter based on genotype QC (FinnGen only)

1325

Control definitions (FinnGen only)

Control exclude
L12_RADIATIONRELATEDSKIN

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L55-L59
Name in latin
Aliae commutationes acutae cutis e radiatione ultraviolacea

Similar endpoints

List of similar endpoints to Other acute skin changes due to ultraviolet radiation based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12305 6288 5855
Only index persons 8709 4853 3856
Unadjusted period prevalence (%)
Whole population 0.17 0.18 0.16
Only index persons 0.16 0.18 0.15
Median age at first event (years)
Whole population 44.15 46.17 41.73
Only index persons 37.54 41.00 33.18

-FinnGen-

Key figures

All Female Male
Number of individuals 1325 715 610
Unadjusted period prevalence (%) 0.26 0.24 0.27
Median age at first event (years) 41.04 41.23 40.81

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1208
Matched controls
12077
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
69282
ICD-8 Finland
Other eczema and dermatitis, E microbis
+∞
323.0
458
*
L56.4
ICD-10 Finland
Polymorphous light eruption
615.0
258.2
247
5
L56.8
ICD-10 Finland
Other specified acute skin changes due to ultraviolet radiation
2262.0
193.0
182
*
69288
ICD-8 Finland
Other eczema and dermatitis, E causis alii definitis
+∞
87.6
83
*
L57.0
ICD-10 Finland
Actinic keratosis
12.4
85.3
160
147
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
6.5
83.4
238
440
D07AB08
ATC
desonide; topical
5.3
80.0
275
636
L56.9
ICD-10 Finland
Acute skin change due to ultraviolet radiation, unspecified
401.7
76.7
76
*
D07AC01
ATC
betamethasone; topical
2.9
65.2
564
2764
E0000UV
ATC
NA
2.9
64.3
605
3119
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.6
61.5
336
1175
D07AB02
ATC
hydrocortisone butyrate; topical
2.9
56.0
465
2162
69283
ICD-8 Finland
Other eczema and dermatitis, Dysidroticum (pompholyx)
+∞
54.6
52
*
TQW99
NOMESCO Finland
Other minor procedure on skin
8.2
52.1
121
161
L56.3
ICD-10 Finland
Solar urticaria
+∞
51.4
49
*
E000001
ATC
NA
3.0
51.2
361
1489
D07AC13
ATC
mometasone; topical
2.7
49.2
464
2286
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
14.9
47.8
81
58
L56.2
ICD-10 Finland
Photocontact dermatitis [berloque dermatitis]
162.7
45.1
47
*
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
4.0
43.8
194
553
D07AA02
ATC
hydrocortisone; topical
3.3
41.0
239
845
R06AE07
ATC
cetirizine; oral
2.3
39.5
581
3499
XQ802
NOMESCO Finland
Epicutan test
5.6
37.1
113
218
ZXC20
NOMESCO Finland
Use of chemical agents
11.5
36.5
69
63
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
22.6
35.9
52
24
69280
ICD-8 Finland
Other eczema and dermatitis, E radiatione solari
+∞
34.5
33
*
H02AB06
ATC
prednisolone; systemic
2.1
32.6
630
4149
E000002
ATC
NA
3.1
31.8
193
695
L57.8
ICD-10 Finland
Other skin changes due to chronic exposure to nonionizing radiation
112.9
30.8
33
*
L20.0
ICD-10 Finland
Besnier prurigo
4.4
29.8
114
280
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.2
28.5
161
550
N05BB01
ATC
hydroxyzine; systemic
3.6
27.1
129
386
L56.0
ICD-10 Finland
Drug phototoxic response
+∞
26.1
25
*
P01BA02
ATC
hydroxychloroquine; oral
3.2
25.8
145
491
D07AD01
ATC
clobetasol; topical
2.4
24.7
234
1089
D07BC01
ATC
betamethasone and antiseptics; topical
2.5
22.2
191
838
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.5
21.5
188
835
69240
ICD-8 Finland
Other eczema and dermatitis, Due to other chemicals
44.2
21.5
26
6
XQ800
NOMESCO Finland
Prick test
3.2
21.1
115
381
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.2
19.9
77
192
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
9.6
19.7
40
43
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
13.0
19.0
33
26
69299
ICD-8 Finland
Other eczema and dermatitis, Due to other and unspecified cause
17.4
18.7
29
17
D07CC01
ATC
betamethasone and antibiotics; topical
2.3
18.7
182
849
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
4.8
18.5
62
134
E000003
ATC
NA
3.6
18.3
85
249
ZXC50
NOMESCO Finland
Cryotherapy
10.6
18.2
35
34
XQ848
NOMESCO Finland
Dermatological photography
7.0
17.8
44
65
L30.3
ICD-10 Finland
Infective dermatitis
4.0
17.5
71
185
69200
ICD-8 Finland
Other eczema and dermatitis, Due to detergents
42.6
17.3
21
5
TQW80
NOMESCO Finland
Local dermatologic skincare
5.1
17.2
54
109
ZXC10
NOMESCO Finland
Use of laser
5.2
17.0
53
106
R06AX27
ATC
desloratadine; oral
1.9
16.8
304
1832
XQ806
NOMESCO Finland
Minimal Erythema Dose (MED) test
+∞
16.7
16
*
D04.0
ICD-10 Finland
Carcinoma in situ: Skin of lip
172.2
16.5
17
*
D07XC01
ATC
betamethasone, combinations; topical
2.3
16.3
169
812
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
16.1
217
1166
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
8.0
16.1
36
46
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
11.8
16.1
29
25
C44.02
ICD-10 Finland
Spinocellular carcinoma of the lip skin
60.8
15.8
18
*
EAA10
NOMESCO Finland
Excision of lesion of lip
7.1
15.7
38
55
L93.0
ICD-10 Finland
Discoid lupus erythematosus
12.6
14.9
26
21
R06AX22
ATC
ebastine; oral
2.0
14.8
200
1077
6927F
ICD-9 Finland
Contact dermatitis and other eczema, Due to solar radiation[ERUPTIO POLYMORPHICA SOLARIS]
+∞
14.6
14
*
D02AX
ATC
Other emollients and protectives
4.1
14.1
55
139
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.8
14.0
276
1699
E000007
ATC
NA
2.9
13.9
85
305
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
8.1
13.6
30
38
L56.1
ICD-10 Finland
Drug photoallergic response
+∞
13.6
13
*
6929B
ICD-9 Finland
Contact dermatitis and other eczema, Unspecified cause[ECZEMA INFECTIOSUM]
18.4
13.4
20
11
D11AH01
ATC
tacrolimus; topical
12.3
13.1
23
19
L23.0
ICD-10 Finland
Allergic contact dermatitis due to metals
7.5
13.0
30
41
ZQZ00
NOMESCO Finland
Treatment of several skin areas
28.7
13.0
17
6
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
12.9
335
2237
R06AE09
ATC
levocetirizine; oral
2.0
12.8
168
889
H02AB07
ATC
prednisone; oral
1.9
12.6
192
1076
69230
ICD-8 Finland
Other eczema and dermatitis, Due to drugs
+∞
12.5
12
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.8
12.4
233
1408
E000006
ATC
NA
2.5
12.3
100
425
EAA30
NOMESCO Finland
Partial excision of lower lip
27.0
12.1
16
6
L23.3
ICD-10 Finland
Allergic contact dermatitis due to drugs in contact with skin
11.2
12.0
22
20
D07AC14
ATC
methylprednisolone aceponate; topical
2.9
12.0
71
251
D07XB05
ATC
dexamethasone, combinations; topical
3.9
11.9
49
131
J01DB01
ATC
cefalexin; oral
1.6
11.7
915
7962
L57.9
ICD-10 Finland
Skin changes due to chronic exposure to nonionizing radiation, unspecified
121.0
11.4
12
*
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
5.4
11.4
33
62
68600
ICD-8 Finland
Other local infections of skin and subcutaneous tissue, Pyoderma
35.4
11.3
14
*
D06BX01
ATC
metronidazole; topical
2.1
11.1
125
623
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.1
11.0
60
201
J01DA01
ATC
[U] cefalexin; systemic
1.5
10.9
719
5950
R03AC02
ATC
salbutamol; inhalant
1.5
10.9
578
4558
H04.10
ICD-10 Finland
Dry eye syndrome
2.2
10.9
114
548
T78.4
ICD-10 Finland
Allergy, unspecified
3.0
10.8
61
208
N02AX02
ATC
tramadol; systemic, rectal
1.5
10.7
483
3670
6929X
ICD-9 Finland
Contact dermatitis and other eczema, Unspecified cause[DERMATITITIS ARTEFACTA NUD]
18.0
10.7
16
9
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
8.1
10.6
23
29
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
9.3
10.5
21
23
QAA50
NOMESCO Finland
Cryotherapy of skin of head or neck
14.3
10.5
17
12
R06.0
ICD-10 Finland
Dyspnoea
1.6
10.4
285
1912
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.3
10.2
98
455
S18
ICPC
Laceration/cut
1.5
10.1
432
3234
11006
ICD-8 Finland
Dermatophytosis, Pedis
40.4
10.0
12
*
J01FF01
ATC
clindamycin; systemic
1.6
9.9
310
2149
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
16.8
9.9
15
9
D05BB02
ATC
acitretin; oral
3.8
9.8
40
107
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.3
9.8
93
430
M25.5
ICD-10 Finland
Pain in joint
1.6
9.5
297
2058
L71.8
ICD-10 Finland
Other rosacea
5.7
9.5
26
46
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.0
9.1
111
570
N03AX12
ATC
gabapentin; oral
1.8
8.8
165
986
R96
ICPC
Asthma
2.2
8.7
92
443
J01AA07
ATC
tetracycline; systemic
1.8
8.7
162
967
69009
ICD-8 Finland
Seborrhoeic dermatitis, Unspecified
50.3
8.7
10
*
70908
ICD-8 Finland
Other diseases of skin, Alii definiti
50.3
8.7
10
*
A46
ICD-10 Finland
Erysipelas
1.8
8.6
161
963
ZXC15
NOMESCO Finland
Use of photodynamic technique
11.7
8.6
15
13
L50.3
ICD-10 Finland
Dermatographic urticaria
4.9
8.4
26
54
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
8.4
469
3679
XQ815
NOMESCO Finland
Photoprovocation test
+∞
8.3
8
*
L17
ICPC
Foot/toe symptom/complaint
1.6
8.3
252
1727
R03AC03
ATC
terbutaline; inhalant
1.8
8.2
150
893
S29
ICPC
Skin symptom/complaint other
1.7
8.0
175
1097
L04AX01
ATC
azathioprine; systemic
2.6
8.0
55
216
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
7.9
363
2729
L50.8
ICD-10 Finland
Other urticaria
4.4
7.8
27
63
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
7.8
486
3876
A02BC03
ATC
lansoprazole; oral
1.5
7.7
329
2430
D02BB01
ATC
betacarotene; oral
15.1
7.7
12
8
M54.5
ICD-10 Finland
Low back pain
1.5
7.6
334
2483
L26
ICD-10 Finland
Exfoliative dermatitis
18.5
7.6
11
6
L23.9
ICD-10 Finland
Allergic contact dermatitis, unspecified cause
5.8
7.5
20
35
N03AX16
ATC
pregabalin; oral
1.5
7.5
248
1730
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.5
7.5
294
2132
J01AA04
ATC
lymecycline; systemic
1.8
7.5
138
822
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
2.4
7.4
59
251
D09AB01
ATC
zinc bandage without supplements; topical
3.5
7.4
32
92
D05AX52
ATC
calcipotriol, combinations; topical
2.4
7.4
63
276
L30.0
ICD-10 Finland
Nummular dermatitis
2.7
7.4
47
176
D04.6
ICD-10 Finland
Carcinoma in situ: Skin of upper limb, including shoulder
10.9
7.3
13
12
6927X
ICD-9 Finland
Contact dermatitis and other eczema, Due to solar radiation[DERMATITIS PHOTOTOXICA NUD]
+∞
7.3
7
*
C07AB07
ATC
bisoprolol; oral
1.4
7.1
517
4216
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
7.1
220
1512
D02AE01
ATC
carbamide; topical
2.1
7.0
79
395
L71.9
ICD-10 Finland
Rosacea, unspecified
3.6
6.9
29
82
S01GX01
ATC
cromoglicic acid; ophthalmic
1.6
6.9
194
1300
G47.3
ICD-10 Finland
Sleep apnoea
1.6
6.9
208
1420
D07AB01
ATC
clobetasone; topical
2.7
6.9
45
173
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.7
6.9
45
173
D11AX14
ATC
[U] tacrolimus; topical
8.3
6.8
14
17
H02AB04
ATC
methylprednisolone; systemic
1.7
6.8
158
1007
D06BB10
ATC
imiquimod; topical
2.9
6.8
39
136
L23.2
ICD-10 Finland
Allergic contact dermatitis due to cosmetics
5.1
6.8
20
40
R03BA05
ATC
fluticasone; inhalant
1.6
6.8
189
1265
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
2.3
6.8
60
270
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
6.8
171
1117
N06AX11
ATC
mirtazapine; oral
1.4
6.7
337
2564
R03AK07
ATC
formoterol and budesonide; inhalant
1.6
6.7
196
1326
Z01.2
ICD-10 Finland
Dental examination
1.4
6.6
392
3072
J01AA02
ATC
doxycycline; systemic
1.4
6.6
874
7853
UJF32
NOMESCO Finland
Coloscopy
1.5
6.5
266
1939
R06AX13
ATC
loratadine; oral
1.6
6.5
152
972
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.9
6.4
96
533
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.7
6.4
140
875
8070/3-C44.0
ICD-O-3
Squamous cell carcinoma, NOS, of skin of lip, NOS
70.2
6.4
7
*
J01MA12
ATC
levofloxacin; systemic
1.5
6.4
203
1398
N02BE01
ATC
paracetamol; systemic, rectal
1.4
6.4
952
8709
S87
ICPC
Dermatitis/atopic eczema
3.4
6.3
28
83
C03CA01
ATC
furosemide; systemic
1.4
6.3
330
2523
R03DC03
ATC
montelukast; oral
1.6
6.3
162
1058
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
11.1
6.3
11
10
L16
ICPC
Ankle symptom/complaint
1.8
6.3
99
563
N05BA01
ATC
diazepam; systemic, rectal
1.6
6.3
145
924
D04.2
ICD-10 Finland
Carcinoma in situ: Skin of ear and external auricular canal
18.1
6.3
9
5
WXQ24
NOMESCO Finland
UVB/UVA light therapy
+∞
6.3
6
*
Y1203
ICD-8 Finland
NA
+∞
6.3
6
*
J01FA06
ATC
roxithromycin; oral
1.4
6.2
428
3437
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
6.2
706
6144
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
1.9
6.2
81
431
30300
ICD-8 Finland
Alcoholism, Episodic excessive drinking
4.5
6.2
20
45
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.6
6.1
154
1005
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
4.1
6.1
22
55
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.6
6.1
140
890
XF400
NOMESCO Finland
ECG with 12 standard connections
1.6
6.0
181
1231
N05CF01
ATC
zopiclone; oral
1.4
6.0
349
2717
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.4
6.0
326
2507
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
3.5
6.0
26
76
I50.9
ICD-10 Finland
Heart failure, unspecified
1.6
6.0
156
1023
E66.01
ICD-10 Finland
Obesity due to excess calories
2.0
6.0
75
390
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
6.0
394
3131

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
124
404
3.28
30.60
1.4
1.2
—
—
—
0
0
258
1320
2.19
25.41
1.4
1.3
595.5
529.6
titre
0.24
62
282
26
6
44.12
21.45
1.2
1.0
—
—
—
0
0
101
372
2.86
20.06
1.2
1.2
0.7
1.0
u/ml
—
7
34
675
5125
1.65
17.35
7.4
5.5
0.0
0.0
e9/l
0.92
605
4437
694
5308
1.65
17.31
7.6
5.8
0.2
0.2
e9/l
1.33
630
4668
82
293
2.92
17.20
2.2
1.5
0.2
0.2
g/l
1.19
77
282
672
5105
1.64
17.17
7.4
5.5
0.6
0.6
e9/l
0.79
603
4412
678
5237
1.60
15.62
7.4
5.6
1.9
1.9
e9/l
0.63
615
4622
74
265
2.90
15.47
1.4
1.2
1.8
2.8
u/ml
1.25
18
30
750
5986
1.58
14.64
11.3
8.8
4.1
4.1
e9/l
0.05
675
5225
61
202
3.12
14.63
1.3
1.2
49.9
43.3
u/ml
0.10
17
18
44
123
3.67
13.75
1.3
1.2
38.5
57.1
u/ml
—
6
7
479
3493
1.58
13.52
7.5
5.4
—
—
—
0
0
601
4677
1.52
12.33
7.7
5.7
0.7
0.7
%
0.73
573
4354
613
4796
1.52
12.23
6.3
5.8
1.2
1.2
mmol/l
0.57
567
4342
613
4826
1.50
11.69
7.7
5.7
3.0
2.8
%
0.92
584
4490
613
4846
1.49
11.34
8.0
5.9
8.9
8.7
%
0.90
584
4530
614
4884
1.48
10.85
7.6
5.5
57.9
57.5
%
0.35
587
4559
893
7663
1.51
10.71
5.1
4.0
14.9
12.8
mm/h
3.10
839
7042
258
1701
1.64
10.70
3.1
3.2
0.8
0.8
mmol/l
0.60
242
1588
619
4961
1.46
10.37
7.8
5.8
26.8
27.4
%
0.72
589
4607
514
3983
1.47
10.18
2.7
2.0
—
—
—
0
0
545
4276
1.47
10.11
2.5
2.2
79.9
77.4
nmol/l
1.12
492
3794
115
610
1.97
9.92
1.4
1.2
570.1
172.1
u/ml
1.22
106
561
372
2713
1.52
9.87
2.6
2.1
3.0
3.0
mg/l
0.15
319
2281
186
1154
1.71
9.67
2.7
2.2
152.2
124.5
ug/g
0.63
145
922
645
5264
1.44
9.52
6.6
6.6
1.2
1.2
mmol/l
0.31
553
4436
670
5508
1.44
9.50
6.9
6.2
10.5
11.6
umol/l
1.93
639
5225
422
3216
1.46
8.82
2.2
2.1
202.8
221.3
u/l
0.20
399
3027
225
1506
1.60
8.65
2.7
2.3
2.3
2.3
g/l
0.16
211
1389
825
7116
1.42
8.53
5.3
4.3
—
—
—
0
0
555
4469
1.42
8.51
3.4
2.7
146.2
133.0
ug/l
0.54
518
4082
916
8065
1.44
8.36
9.8
7.4
79.1
79.3
u/l
0.05
875
7562
298
2151
1.50
8.10
1.3
1.2
1.8
1.6
u/ml
0.08
70
584
270
1910
1.52
8.08
1.4
1.4
2.5
2.5
g/l
0.07
147
1165
162
1018
1.67
7.99
1.7
1.5
—
—
—
0
0
83
426
2.01
7.89
1.1
1.4
—
8.6
—
0
8
559
4549
1.40
7.88
5.7
4.7
35.0
35.2
g/l
0.33
522
4227
407
3147
1.42
7.66
4.6
3.8
7.4
7.4
ph
0.27
78
600
207
1400
1.57
7.56
3.0
2.4
21.1
22.4
%
0.69
186
1185
348
2621
1.44
7.55
8.4
6.5
—
—
—
0
0
357
2708
1.44
7.43
3.0
2.6
1559.3
6587.0
umol/l
2.85
306
2327
184
1221
1.59
7.29
2.0
1.7
—
—
—
0
0
217
1505
1.53
7.06
1.7
1.7
—
—
—
0
0
235
1663
1.50
6.95
1.3
1.3
13.9
13.9
u/ml
0.00
83
636
792
6910
1.36
6.87
5.7
4.5
177.6
2772.2
e6/l
—
8
109
720
6213
1.35
6.58
5.0
4.9
6.8
6.7
mmol/l
0.22
681
5820
231
1653
1.48
6.44
2.8
2.4
12.2
12.8
umol/l
0.64
217
1510
54
255
2.17
6.43
2.0
1.8
6175.5
14171.0
e6/l
1.62
40
189
33
125
2.68
6.35
1.5
1.2
—
—
—
0
0
543
4534
1.33
6.01
11.7
9.5
0.0
0.0
e9/l
0.78
452
3713
150
994
1.57
5.96
2.2
2.2
0.2
0.2
g/l
0.03
135
922
376
2974
1.37
5.93
5.0
4.3
—
—
—
0
0
410
3298
1.35
5.78
2.9
2.5
52.6
56.0
u/l
1.64
379
3048
305
2342
1.39
5.74
4.3
3.6
—
—
—
0
0
146
972
1.56
5.69
2.9
2.3
39.4
36.9
u/l
0.17
119
819
324
2532
1.37
5.45
2.7
2.3
—
—
—
0
0
398
3211
1.34
5.44
3.2
3.0
7.6
7.5
mmol/l
0.19
349
2690
275
2094
1.40
5.41
1.9
1.7
1092.0
1195.3
nmol/l
1.18
214
1555
234
1741
1.42
5.25
1.4
1.3
41.8
35.1
iu/ml
0.31
76
548
32
132
2.46
5.23
1.8
1.7
58.9
62.9
%
0.19
15
88
520
4384
1.31
5.15
2.2
2.0
94.3
94.7
pmol/l
0.08
270
2256
392
3177
1.33
5.15
3.2
3.0
1703.1
1533.0
ng/l
0.32
341
2707
172
1217
1.47
5.04
1.6
1.4
—
—
—
0
0
137
938
1.51
4.72
2.6
2.1
366.2
374.8
nmol/l
0.18
128
854
171
1226
1.45
4.68
5.9
8.0
5.1
5.1
kpa
0.12
159
1174
171
1227
1.45
4.66
5.9
8.0
11.8
12.0
kpa
0.28
160
1177
510
4334
1.29
4.63
8.6
9.6
1.2
1.3
inr
0.34
132
1252
175
1264
1.44
4.61
1.6
1.6
—
—
—
0
0
374
3053
1.31
4.59
3.3
3.2
59.7
265.6
mg/l
2.62
251
1936
40
194
2.09
4.53
1.8
1.6
—
—
—
0
0
431
3594
1.30
4.50
3.5
3.4
2.3
2.4
mmol/l
0.17
361
3117
235
1796
1.37
4.48
3.1
2.7
0.9
1.1
e6/l
0.65
133
1012
169
1227
1.43
4.33
6.0
8.0
0.8
1.3
mmol/l
0.66
130
962
114
769
1.53
4.22
1.2
1.2
—
—
—
0
0
391
3243
1.29
4.21
4.2
3.9
11.1
7.8
mg/mmol
0.53
265
2043
187
1390
1.40
4.20
6.0
5.2
1.0
1.0
mmol/l
0.10
178
1278
263
2066
1.34
4.18
4.1
3.8
607.1
325.1
ng/l
0.25
205
1631
160
1162
1.43
4.10
1.4
1.3
—
—
—
0
0
171
1258
1.41
4.08
1.5
1.3
—
—
—
0
0
133
936
1.47
4.02
5.7
6.8
1.3
1.4
mmol/l
0.94
128
897
65
387
1.71
4.00
2.2
2.1
218.2
473.5
ug/l
1.12
59
363
35
170
2.09
3.98
1.2
1.4
—
—
—
0
0
576
5034
1.26
3.98
4.3
3.6
0.0
0.0
estimate
0.00
112
952
280
2236
1.32
3.96
4.9
4.5
—
—
—
0
0
140
1000
1.45
3.92
3.1
3.2
2.1
2.1
mmol/l
0.03
116
785
125
874
1.48
3.91
6.8
8.0
—
—
—
0
0
484
4154
1.26
3.89
4.1
3.8
34.2
51.2
ng/l
0.74
333
2932
439
3727
1.27
3.86
4.4
3.6
193.1
105.4
e6/l
0.24
314
2677
203
1552
1.36
3.84
2.1
2.1
—
—
—
0
0
356
2947
1.28
3.84
3.8
3.1
0.6
0.5
e6/l
0.08
272
2236
99
662
1.54
3.83
1.4
1.4
—
—
—
0
0
77
487
1.62
3.78
3.7
3.5
—
—
—
0
0
581
5107
1.25
3.74
4.3
3.6
0.0
0.0
estimate
0.80
110
933
98
658
1.53
3.73
7.0
9.5
93.1
94.0
%
0.46
98
653
106
724
1.50
3.73
1.5
1.4
—
—
—
0
0
31
148
2.12
3.70
1.1
1.1
1.0
2.1
u/ml
0.47
16
58
250
1989
1.32
3.62
3.7
3.0
2.5
2.5
mmol/l
0.53
210
1742
24
104
2.33
3.60
1.1
1.0
2.5
3.7
u/ml
0.25
12
36
572
5037
1.24
3.58
5.7
5.0
0.0
0.0
estimate
0.50
113
963
35
178
1.99
3.55
1.4
1.4
—
—
—
0
0
190
1456
1.36
3.55
1.3
1.2
—
—
—
0
0
1088
10302
1.31
3.55
20.7
14.8
23.3
25.0
mg/l
0.93
927
8230
857
7886
1.25
3.54
4.6
4.0
14.9
14.8
pmol/l
0.17
797
7144
66
409
1.65
3.53
3.8
3.8
24.6
24.9
mmol/l
0.46
61
383
50
287
1.77
3.52
1.1
1.2
—
—
—
0
0
25
113
2.24
3.43
1.4
1.4
19878.2
100187.7
e6/l
0.71
17
79
121
868
1.43
3.34
2.0
2.8
66.4
66.9
g/l
0.27
107
789
59
361
1.66
3.33
3.5
3.3
0.3
0.2
g/l
0.12
26
144
96
660
1.49
3.30
7.1
9.4
0.6
0.7
%
0.40
96
654
382
3241
1.25
3.29
4.1
3.1
—
—
—
0
0
126
914
1.42
3.28
2.2
2.4
6.6
6.6
ug/l
0.02
103
800
394
3357
1.25
3.27
2.7
2.4
—
—
—
0
0
275
2245
1.28
3.27
2.9
2.5
5.2
5.9
e6/l
0.31
243
1985
119
856
1.43
3.24
4.1
3.4
—
—
—
0
0
341
2863
1.26
3.21
3.8
3.1
—
—
—
0
0
96
665
1.48
3.19
6.7
9.3
1.4
1.3
%
0.31
96
659
43
244
1.79
3.18
2.5
3.7
—
—
—
0
0
97
676
1.47
3.13
3.9
3.4
7.4
7.4
ph
0.24
12
90
125
915
1.40
3.10
1.5
1.4
—
—
—
0
0
76
505
1.54
3.08
3.4
3.1
24.4
24.3
mmol/l
0.08
63
449
82
555
1.51
3.05
7.1
9.9
23.9
24.5
mmol/l
0.96
75
519
8
16
5.02
3.05
1.0
1.8
—
—
—
0
0
279
2306
1.27
2.99
1.8
1.7
1.2
1.1
mg/l
0.11
216
1768
305
2550
1.25
2.96
1.6
1.5
19.7
20.8
nmol/l
0.68
267
2152
101
720
1.44
2.91
4.3
5.6
—
—
—
0
0
109
788
1.42
2.91
4.2
3.9
0.4
0.5
%
0.45
20
191
377
3232
1.23
2.91
3.9
3.2
40.1
91.3
e6/l
1.18
295
2498
14
52
2.71
2.89
1.4
2.9
505.6
1406.6
u/ml
1.10
14
52
72
480
1.53
2.89
1.6
1.7
1.7
1.6
g/l
0.46
54
423
32
172
1.88
2.83
3.1
2.7
—
—
—
0
0
18
77
2.36
2.82
1.1
1.1
—
—
—
0
0
17
71
2.41
2.80
1.2
1.1
—
—
—
0
0
1000
9452
1.24
2.79
5.5
4.8
4.7
2.0
mu/l
0.46
928
8607
65
428
1.55
2.77
4.6
4.4
—
—
—
0
0
110
805
1.40
2.75
3.6
3.5
94.9
86.5
ng/l
0.42
95
699
81
560
1.48
2.75
1.3
1.2
—
—
—
0
0
19
85
2.25
2.71
1.0
1.2
—
—
—
0
0
52
327
1.61
2.69
3.0
3.4
39.8
72.1
mg/l
0.93
40
266
123
921
1.37
2.69
7.1
6.9
10.9
10.2
mmol/l
0.48
118
869
96
689
1.42
2.69
2.3
2.5
28.3
19.0
au/ml
—
5
31
52
328
1.61
2.66
3.0
3.4
36.4
39.8
mg/l
0.11
40
267
22
106
2.09
2.63
1.9
2.1
—
—
—
0
0
128
968
1.36
2.63
1.6
1.4
—
—
—
0
0
30
162
1.87
2.63
1.3
1.4
127.4
113.2
u/ml
—
7
29
25
127
1.99
2.61
1.1
1.0
0.2
1.8
u/ml
0.85
13
46
319
2719
1.23
2.57
4.8
3.9
0.0
0.0
estimate
0.88
105
931
24
121
2.00
2.56
1.1
1.0
0.6
2.4
u/ml
0.92
11
26
34
572
0.58
2.53
1.5
1.5
—
—
—
0
0
110
819
1.37
2.50
4.5
4.1
0.0
0.1
%
1.10
23
234
30
165
1.84
2.50
1.6
1.5
—
—
—
0
0
25
130
1.94
2.46
1.1
1.0
2.6
3.7
u/ml
0.18
15
58
154
1211
1.31
2.44
2.3
2.5
1.8
1.8
%
0.29
136
1068
20
96
2.10
2.43
1.6
1.4
28.0
31.8
%
—
9
61
154
1212
1.31
2.43
3.5
2.6
8.5
8.6
umol/l
0.02
132
1060
207
1696
1.26
2.38
3.3
2.9
2.7
2.3
e6/l
0.20
109
918
104
775
1.37
2.37
4.6
4.1
0.0
0.6
%
0.72
20
201
13
52
2.51
2.36
1.2
1.5
6.4
7.0
ug/l
0.17
13
41
86
621
1.41
2.36
1.8
1.8
1.6
1.5
g/l
0.03
77
573
104
777
1.37
2.33
3.1
2.7
10.9
10.8
g/l
0.09
98
713
49
316
1.57
2.32
3.8
3.4
—
—
—
0
0
98
728
1.37
2.28
2.1
2.4
—
—
—
0
0
43
270
1.61
2.28
1.1
1.2
—
—
—
0
0
25
135
1.87
2.23
2.2
2.6
—
—
—
0
0
47
304
1.57
2.21
1.4
1.5
297.1
287.2
ug/g
0.11
28
177
16
73
2.21
2.21
1.2
1.3
14.6
12.0
mmol/l
—
9
20
20
100
2.02
2.21
1.1
1.0
1.2
4.7
u/ml
1.22
12
35
113
870
1.33
2.10
4.5
4.0
1.0
0.9
%
0.09
25
258
17
82
2.09
2.07
1.1
1.0
0.1
0.4
u/ml
—
8
20
28
161
1.76
2.07
1.0
1.1
—
—
—
0
0
36
223
1.63
2.04
2.0
2.5
—
—
—
0
0
10
38
2.64
2.01
1.9
3.1
—
—
—
0
0
543
4947
1.17
2.01
4.3
4.1
—
—
—
0
0
50
337
1.50
1.99
1.8
2.3
37.0
37.8
g/l
0.40
41
290
1003
9588
1.19
1.99
6.7
5.8
40.9
40.0
mmol/mol
2.04
934
8845
48
323
1.50
1.93
3.7
4.1
3.9
3.9
mmol/l
0.02
48
298
69
499
1.40
1.92
2.6
2.3
0.7
0.7
%
0.41
64
478
311
2716
1.19
1.92
1.7
1.7
1.4
1.4
mmol/l
0.05
280
2277
23
128
1.81
1.90
1.2
1.2
—
—
—
0
0
82
612
1.36
1.89
3.1
3.5
4.3
4.5
pmol/l
0.97
66
538
249
2136
1.20
1.87
3.3
2.7
532.4
551.6
mosm/kgh2o
0.74
210
1828
116
915
1.29
1.84
4.0
2.9
183.7
210.6
ng/l
0.43
109
841
316
3573
0.85
1.80
2.9
2.9
—
—
—
0
0
36
232
1.57
1.77
2.2
2.1
120.8
129.4
g/l
1.26
23
169
257
2231
1.19
1.69
4.9
4.0
1.0
1.0
kg/l
0.24
32
338
71
529
1.36
1.68
2.6
3.3
25.6
25.2
mmol/l
0.42
71
512
6
19
3.17
1.66
1.0
1.1
—
—
—
0
0
13
63
2.07
1.60
3.5
3.5
—
—
—
0
0
1108
10744
1.19
1.58
22.9
17.1
4.0
4.0
mmol/l
0.06
1086
10431
76
579
1.33
1.58
8.6
10.9
—
—
—
0
0
71
536
1.34
1.57
2.4
2.4
—
—
—
0
0
28
176
1.60
1.55
1.3
1.2
285.6
292.1
u/ml
0.05
21
104
169
1423
1.22
1.55
29.1
24.2
1.5
1.4
inr
0.24
17
182
126
1029
1.25
1.54
4.6
4.0
—
—
—
0
0
8
33
2.43
1.54
1.0
1.1
—
—
—
0
0
5
15
3.34
1.52
1.0
1.1
—
—
—
0
0
26
162
1.62
1.50
1.2
1.0
—
—
—
0
0
137
1134
1.23
1.49
3.1
4.1
3.5
23.2
ug/l
1.91
112
944
18
101
1.79
1.49
3.4
3.5
—
—
—
0
0
1103
10707
1.18
1.47
18.2
14.0
—
—
—
0
0
1104
10719
1.18
1.46
22.8
16.9
139.5
139.6
mmol/l
1.04
1084
10421
7
28
2.51
1.45
1.3
1.1
—
—
—
0
0
34
228
1.50
1.45
1.7
1.5
—
—
—
0
0
25
157
1.60
1.41
1.2
1.1
—
—
—
0
0
10
46
2.18
1.40
2.5
2.7
—
—
—
0
0
12
60
2.01
1.38
1.4
1.6
14.3
19.2
nmol/l
1.95
12
54
10
47
2.14
1.34
1.0
1.0
—
—
—
0
0
22
137
1.62
1.30
1.3
1.2
—
—
—
0
0
1123
10943
1.17
1.29
14.3
10.4
26.0
26.0
u/l
0.00
1095
10542
15
84
1.79
1.27
1.2
1.4
—
—
—
0
0
6
25
2.41
1.24
1.0
1.1
—
—
—
0
0
6
25
2.41
1.24
1.0
1.1
—
—
—
0
0
6
25
2.41
1.24
1.0
1.1
—
—
—
0
0
775
7388
1.12
1.22
4.4
3.8
—
—
—
0
0
259
2311
1.15
1.22
1.9
1.7
36403929.0
32391849.9
pmol/l
0.04
228
1911
10
49
2.05
1.22
1.4
1.3
—
—
—
0
0
16
94
1.71
1.17
1.1
1.2
—
—
—
0
0
5
20
2.51
1.15
1.2
1.5
—
—
—
0
0
0
36
0.00
1.14
0.0
2.2
—
—
—
0
0
107
892
1.22
1.13
2.4
2.7
68.1
70.6
e9/l
0.34
81
688
84
683
1.25
1.12
6.4
7.9
24.8
24.5
mmol/l
0.32
79
641
47
354
1.34
1.11
1.7
1.6
—
—
—
0
0
84
687
1.24
1.07
1.3
1.2
81.2
144.0
iu/ml
1.42
27
270
23
153
1.51
1.06
1.2
1.2
2.3
6.9
u/ml
—
7
60
1063
10355
1.13
1.06
5.5
4.9
2.7
2.7
mmol/l
1.76
982
9486
34
247
1.39
1.02
1.6
3.1
28.8
34.7
umol/l
1.14
29
207
9
48
1.88
1.00
3.9
2.8
—
—
—
0
0
11
61
1.81
0.98
2.8
1.6
—
—
—
0
0
882
8518
1.11
0.98
25.3
17.9
13.9
13.8
%
1.04
869
8319
22
148
1.49
0.98
1.2
1.2
—
—
—
0
0
103
870
1.20
0.98
3.9
3.7
1.2
1.2
mmol/l
0.66
92
755
51
398
1.29
0.97
1.1
1.1
—
—
—
0
0
1032
10053
1.12
0.96
5.1
4.6
6.1
6.0
mmol/l
1.31
950
9098
10
54
1.86
0.96
1.2
1.4
129.7
146.7
nmol/l
—
10
54
9
51
1.77
0.94
1.0
1.1
—
—
—
0
0
1040
10140
1.12
0.94
4.9
4.4
4.6
4.6
mmol/l
1.94
965
9361
51
402
1.28
0.91
4.6
3.4
126.0
9698.4
u/ml
0.78
44
343
1000
9735
1.11
0.91
4.4
3.9
1.3
1.3
mmol/l
1.08
919
8861
11
63
1.75
0.90
1.8
1.9
4.8
3.5
ug/l
0.40
11
55
11
63
1.75
0.90
1.8
2.0
4.1
2.0
ug/l
1.09
11
54
6
29
2.07
0.89
1.3
1.3
—
—
—
0
0
49
386
1.28
0.89
1.4
1.3
21.2
31.1
iu/l
1.63
44
332
1032
10069
1.11
0.88
4.8
4.4
1.4
1.5
mmol/l
1.16
946
9220
15
95
1.59
0.87
4.4
3.8
58.4
52.4
%
—
9
70
6
30
2.00
0.87
2.2
1.8
—
—
—
0
0
22
153
1.45
0.86
2.8
2.4
4.3
31.9
u/ml
0.56
22
148
18
120
1.51
0.85
1.2
1.2
—
—
nmol/l
—
0
0
8
46
1.74
0.82
1.0
1.2
—
—
—
0
0
33
249
1.33
0.82
1.3
1.3
—
—
—
0
0
13
81
1.61
0.81
1.1
1.1
0.0
0.8
u/ml
—
6
36
42
331
1.28
0.78
12.8
9.7
—
—
—
0
0
17
115
1.48
0.77
1.8
1.4
282.2
278.7
mosm/kgh2o
0.26
11
83
5
24
2.09
0.74
1.6
1.3
0.9
2.2
mmol/l
—
5
24
30
228
1.32
0.73
1.7
2.0
3604.4
2790.2
u/l
0.14
12
88
9
56
1.61
0.72
4.0
2.8
—
—
—
0
0
9
56
1.61
0.72
21.3
16.9
—
—
—
0
0
16
110
1.46
0.68
3.8
4.2
—
—
—
0
0
15
102
1.48
0.67
2.1
2.2
—
—
—
0
0
14
94
1.49
0.67
1.1
1.1
—
—
—
0
0
55
458
1.21
0.66
2.5
1.8
—
—
—
0
0
13
190
0.68
0.65
1.5
1.7
—
—
—
0
0
18
247
0.73
0.64
3.4
3.3
7.2
7.7
mmol/l
0.41
18
242
76
655
1.17
0.63
1.3
1.2
—
—
—
0
0
16
112
1.43
0.63
1.1
1.6
—
—
—
0
0
5
30
1.67
0.61
1.0
1.0
—
—
—
0
0
13
88
1.48
0.60
2.1
1.3
—
—
—
0
0
80
696
1.16
0.60
1.8
1.5
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
20
148
1.36
0.60
4.2
2.6
—
—
—
0
0
42
345
1.22
0.59
1.0
1.1
—
—
—
0
0
11
72
1.53
0.59
1.5
1.5
11.7
13.3
umol/l
0.36
11
67
70
604
1.17
0.59
6.5
7.6
24.7
25.0
mmol/l
0.32
70
598
28
219
1.28
0.58
1.4
1.2
10.7
10.8
u/l
0.01
23
180
17
123
1.39
0.58
1.2
1.4
45.9
26.6
u/l
0.87
12
99
6
35
1.72
0.57
1.3
1.1
—
—
—
0
0
6
36
1.67
0.56
2.0
1.7
—
—
—
0
0
61
709
0.85
0.56
4.6
3.0
—
—
—
0
0
23
176
1.31
0.56
2.2
2.0
62.5
61.2
%
0.09
23
176
6
38
1.58
0.54
1.0
1.2
—
—
—
0
0
1156
11415
1.10
0.54
29.7
21.5
91.6
91.2
fl
1.79
1142
11230
14
99
1.42
0.54
1.1
1.2
—
—
—
0
0
20
261
0.76
0.54
3.3
3.2
1.7
1.6
mmol/l
0.21
20
256
1156
11416
1.10
0.53
29.7
21.4
30.4
30.3
pg
0.85
1142
11229
9
61
1.48
0.53
2.6
1.9
—
—
—
0
0
1156
11417
1.10
0.53
29.8
21.5
4.4
4.5
e12/l
0.92
1132
11080
9
62
1.45
0.53
2.2
2.8
—
—
—
0
0
1156
11420
1.10
0.51
30.0
21.6
133.7
134.3
g/l
0.77
1143
11229
6
40
1.50
0.51
2.0
1.8
—
—
—
0
0
1155
11410
1.10
0.51
29.9
21.5
252.1
249.5
e9/l
0.68
1130
11113
1156
11421
1.10
0.51
29.9
21.6
6.9
6.8
e9/l
0.83
1133
11083
11
75
1.47
0.50
2.2
1.9
—
40.7
—
0
9
11
75
1.47
0.50
1.3
1.1
—
—
—
0
0
24
189
1.27
0.49
1.6
1.3
57.4
64.9
mmol/l
0.37
19
152
14
101
1.39
0.49
1.0
1.1
—
—
—
0
0
7
108
0.65
0.48
1.6
1.4
—
—
—
0
0
20
154
1.30
0.48
1.2
1.1
—
12.4
—
0
10
26
208
1.26
0.48
3.4
3.2
4.1
4.3
e9/l
0.20
26
208
7
47
1.49
0.47
2.6
1.7
—
—
—
0
0
10
141
0.71
0.45
1.4
1.4
—
—
—
0
0
10
140
0.71
0.43
1.3
1.4
—
—
—
0
0
5
31
1.62
0.43
1.8
1.3
—
—
—
0
0
70
783
0.89
0.41
1.2
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
1.8
—
0
15
0
16
0.00
0.41
0.0
2.4
—
94.0
—
0
8
15
114
1.32
0.40
3.3
2.1
—
—
—
0
0
11
79
1.40
0.40
1.2
2.2
5.3
5.5
umol/l
—
5
54
97
884
1.10
0.40
4.9
3.8
—
—
—
0
0
7
104
0.67
0.39
1.3
1.7
—
—
—
0
0
5
35
1.43
0.39
2.2
2.5
25.0
18.7
ug/l
—
5
29
7
106
0.66
0.39
4.1
2.1
13.0
13.2
%
—
7
106
14
106
1.32
0.39
1.4
1.6
—
—
—
0
0
25
207
1.21
0.36
4.1
2.6
—
—
—
0
0
947
9328
1.05
0.36
22.6
15.8
39.5
39.4
%
0.15
666
6532
44
384
1.15
0.36
1.8
1.8
20.1
20.9
s
0.93
39
340
49
555
0.88
0.36
4.2
3.4
—
—
—
0
0
11
81
1.36
0.36
1.7
1.5
0.9
1.0
g/l
1.39
11
81
12
90
1.34
0.36
1.8
1.5
—
—
—
0
0
6
42
1.43
0.35
1.8
1.4
—
—
—
0
0
27
227
1.19
0.34
2.9
2.5
14.9
16.1
%
0.69
14
117
14
109
1.29
0.33
1.7
1.8
—
—
—
0
0
11
144
0.76
0.33
1.3
1.5
—
—
—
0
0
26
219
1.19
0.33
3.4
3.4
54.0
58.1
%
0.85
26
219
25
210
1.19
0.33
2.7
3.4
8.9
1744.0
u/ml
0.84
20
200
19
231
0.82
0.32
2.5
1.4
8.4
25.7
e6/l
0.60
14
183
19
231
0.82
0.32
2.5
1.5
299.1
929.0
e6/l
0.50
14
189
25
294
0.85
0.31
4.5
4.4
—
—
—
0
0
48
431
1.12
0.28
2.3
2.7
—
—
—
0
0
11
85
1.30
0.28
2.3
1.5
—
—
—
0
0
18
149
1.21
0.28
5.6
5.0
406.8
361.3
umol/l
0.55
13
132
30
261
1.15
0.28
1.4
1.3
284.6
226.1
miu/ml
0.29
14
121
103
1095
0.94
0.24
1.5
1.7
—
—
—
0
0
17
199
0.85
0.21
1.2
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
3.2
—
0
5
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
21
241
0.87
0.21
6.1
3.9
—
—
—
0
0
23
201
1.15
0.21
1.9
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
8
102
0.78
0.21
2.1
2.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
21
240
0.87
0.20
5.2
3.8
20.4
28.2
mg/l
0.55
11
163
47
510
0.92
0.20
1.4
1.7
—
—
—
0
0
29
261
1.11
0.18
2.6
1.9
2.6
4.8
iu/l
1.98
12
86
27
243
1.11
0.17
5.9
4.9
1.8
2.7
mmol/l
1.02
20
172
870
8620
1.03
0.17
28.1
19.0
331.5
332.0
g/l
0.86
862
8540
31
282
1.10
0.16
1.5
1.1
—
—
—
0
0
12
101
1.19
0.16
1.5
1.6
—
—
—
0
0
27
244
1.11
0.16
5.9
4.9
5.1
5.1
kpa
0.05
27
239
27
244
1.11
0.16
5.9
4.9
8.0
8.4
kpa
0.73
27
239
13
151
0.86
0.15
1.2
1.1
—
—
—
0
0
13
151
0.86
0.15
1.2
1.1
—
—
—
0
0
19
168
1.13
0.15
1.7
1.3
—
—
—
0
0
6
77
0.78
0.15
1.2
1.2
—
—
—
0
0
26
236
1.10
0.15
1.2
1.5
—
—
—
0
0
29
266
1.09
0.14
2.0
2.5
36.2
96.3
ug/min
1.34
13
151
79
826
0.95
0.13
1.3
1.4
—
—
—
0
0
13
113
1.15
0.13
1.8
1.6
—
—
—
0
0
13
113
1.15
0.13
1.8
1.6
—
—
—
0
0
13
113
1.15
0.13
1.8
1.6
—
—
—
0
0
13
113
1.15
0.13
1.8
1.6
—
—
—
0
0
11
127
0.87
0.12
1.5
1.3
1322.8
1557.1
e6/l
—
6
86
316
3106
1.02
0.12
4.4
3.9
—
—
—
0
0
18
164
1.10
0.09
1.3
1.9
—
—
—
0
0
13
116
1.12
0.09
1.2
1.1
—
—
—
0
0
5
48
1.04
0.09
1.0
1.1
177.3
235.1
iu/ml
—
5
48
6
57
1.05
0.08
1.8
2.4
1201.7
1870.9
ml
—
6
50
27
253
1.07
0.08
3.9
2.7
8.1
7.9
kpa
0.26
27
231
5
63
0.79
0.08
1.2
1.1
—
—
—
0
0
7
64
1.09
0.08
1.0
1.2
—
—
—
0
0
280
2765
1.02
0.07
3.8
3.3
—
—
—
0
0
16
147
1.09
0.07
1.1
1.2
—
—
—
0
0
7
81
0.86
0.07
1.4
1.2
29.3
36.9
mg/l
—
7
71
199
1960
1.02
0.07
3.3
3.0
0.6
0.8
ug/l
3.29
131
1296
9
101
0.89
0.06
1.7
1.4
—
—
—
0
0
14
151
0.93
0.05
2.6
2.7
—
—
—
0
0
71
695
1.02
0.04
2.4
3.1
3.6
4.1
e9/l
1.58
56
543
10
109
0.92
0.04
1.3
1.5
—
—
—
0
0
27
260
1.04
0.03
1.9
1.3
444.3
506.2
mg/l
0.56
27
245
24
231
1.04
0.02
1.8
1.2
3.9
3.8
mmol/l
0.29
24
217
276
2776
0.99
0.02
1.4
1.4
—
—
—
0
0
18
172
1.05
0.02
1.6
1.6
—
—
—
0
0
343
3415
1.01
0.02
4.7
4.8
5.0
3.2
ug/l
0.46
304
3050
26
252
1.03
0.02
1.3
1.5
—
—
—
0
0
26
253
1.03
0.01
1.3
1.5
—
—
—
0
0
19
184
1.03
0.00
1.2
1.2
—
—
—
0
0
26
254
1.02
0.00
1.3
1.5
—
—
—
0
0
27
276
0.98
0.00
1.2
1.1
—
—
—
0
0
20
196
1.02
0.00
1.3
1.5
—
—
—
0
0
13
131
0.99
0.00
1.2
1.3
—
—
—
0
0
11
113
0.97
0.00
1.4
1.1
—
—
—
0
0
16
163
0.98
0.00
4.7
3.7
0.5
1.4
%
1.45
11
137
67
667
1.00
0.00
2.2
2.1
11.8
12.4
nmol/l
0.28
60
584
25
245
1.02
0.00
3.3
2.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
8
89
0.90
0.00
1.1
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
5.3
—
—
—
0
0
8
80
1.00
0.00
1.4
1.8
9.8
11.0
%
—
8
80
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
15.4
—
0
5
5
54
0.93
0.00
2.0
3.1
—
—
—
0
0
0
5
0.00
0.00
0.0
16.6
—
229.4
—
0
5
12
120
1.00
0.00
1.3
1.3
—
—
—
0
0
9
92
0.98
0.00
1.2
1.2
—
—
—
0
0
6
64
0.94
0.00
2.3
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
167.8
—
0
6
9
99
0.91
0.00
2.4
2.5
—
—
—
0
0
7
78
0.90
0.00
1.3
1.1
188.9
243.8
mg/l
—
7
70
25
250
1.00
0.00
1.3
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint L12_OTHACUSKINSUN and mortality.

Females

Parameter HR [95% CI] p-value
L12_OTHACUSKINSUN 0.926 [0.79, 1.09] 0.361
Birth year 0.998 [0.99, 1.01] 0.614

During the follow-up period (1.1.1998 — 31.12.2019), 231 out of 2255 females with L12_OTHACUSKINSUN died.

Males

Parameter HR [95% CI] p-value
L12_OTHACUSKINSUN 1.147 [0.96, 1.37] 0.129
Birth year 0.99 [0.98, 1.0] 0.046

During the follow-up period (1.1.1998 — 31.12.2019), 282 out of 1251 males with L12_OTHACUSKINSUN died.

Mortality risk

Mortality risk for people of age

years, who have L12_OTHACUSKINSUN.

N-year risk Females Males
1 0.099% 0.216%
5 0.486% 1.37%
10 1.451% 3.59%
15 2.824% 6.989%
20 5.077% 12.099%

Relationships between endpoints

Index endpoint: L12_OTHACUSKINSUN – Other acute skin changes due to ultraviolet radiation

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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