phototoxic dermatitis: a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous. In rare cases the victims die.
Other and unspecified acute skin changes due to ultraviolet radiation
DOID EFO Endpoint Browser PheWeb
L12_OTHACUSKINSUNNAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
963 |
4. Check minimum number of eventsNone |
963 |
5. Include endpointsNone |
963 |
6. Filter based on genotype QC (FinnGen only) |
940 |
Control definitions (FinnGen only)
- Control exclude
- L12_RADIATIONRELATEDSKIN
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified acute skin changes due to ultraviolet radiation
based on the number of shared cases.
Similar with more cases:
- Other acute skin changes due to ultraviolet radiation
- Radiation-related disorders of the skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9789 | 4557 | 5076 |
| Only index persons | 6433 | 3241 | 3192 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.13 | 0.14 |
| Only index persons | 0.12 | 0.12 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 44.43 | 47.31 | 41.57 |
| Only index persons | 35.57 | 39.46 | 31.63 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 940 | 419 | 521 |
| Unadjusted period prevalence (%) | 0.20 | 0.15 | 0.24 |
| Median age at first event (years) | 38.58 | 38.85 | 38.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 963
- Matched controls
- 9630
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
69282
ICD-8 Finland
Other eczema and dermatitis, E microbis
+∞
307.7
484
*
L56.8
ICD-10 Finland
Other specified acute skin changes due to ultraviolet radiation
+∞
247.9
227
*
L57.0
ICD-10 Finland
Actinic keratosis
11.1
162.8
190
208
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
7.2
124.2
213
366
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
27.0
120.7
84
34
TQW99
NOMESCO Finland
Other minor procedure on skin
9.4
106.0
136
166
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
29.0
103.4
70
26
69288
ICD-8 Finland
Other eczema and dermatitis, E causis alii definitis
+∞
93.3
88
*
ZXC20
NOMESCO Finland
Use of chemical agents
15.0
92.3
84
61
L56.9
ICD-10 Finland
Acute skin change due to ultraviolet radiation, unspecified
241.8
87.0
88
*
D07AB08
ATC
desonide; topical
4.7
75.3
203
515
69283
ICD-8 Finland
Other eczema and dermatitis, Dysidroticum (pompholyx)
+∞
59.0
56
*
E0000UV, ,
ATC
2.9
57.1
489
2529
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
15.2
50.5
45
31
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.2
48.5
249
959
E000001, ,
ATC
3.1
48.4
265
1059
D07AC01
ATC
betamethasone; topical
2.6
46.7
443
2350
D07AB02
ATC
hydrocortisone butyrate; topical
2.7
46.1
366
1776
EAA10
NOMESCO Finland
Excision of lesion of lip
12.8
44.7
44
36
ZXC50
NOMESCO Finland
Cryotherapy
14.2
44.4
41
30
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.8
42.0
144
427
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
16.2
41.9
36
23
ZXC10
NOMESCO Finland
Use of laser
7.2
39.8
61
90
D07AC13
ATC
mometasone; topical
2.5
37.2
346
1778
69280
ICD-8 Finland
Other eczema and dermatitis, E radiatione solari
+∞
36.7
35
*
E000002, ,
ATC
3.4
35.8
143
467
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
12.2
32.7
33
28
R06AE07
ATC
cetirizine; oral
2.2
32.0
433
2576
L20.0
ICD-10 Finland
Besnier prurigo
4.4
31.2
82
199
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
11.8
30.2
31
27
D07AA02
ATC
hydrocortisone; topical
2.8
28.3
164
660
L30.3
ICD-10 Finland
Infective dermatitis
5.0
28.2
62
130
L57.8
ICD-10 Finland
Other skin changes due to chronic exposure to nonionizing radiation
103.1
27.8
30
*
N05BB01
ATC
hydroxyzine; systemic
3.5
25.8
93
283
D07AD01
ATC
clobetasol; topical
2.5
24.9
190
872
69200
ICD-8 Finland
Other eczema and dermatitis, Due to detergents
+∞
24.1
23
*
69299
ICD-8 Finland
Other eczema and dermatitis, Due to other and unspecified cause
38.7
24.0
30
8
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.1
23.9
106
366
69240
ICD-8 Finland
Other eczema and dermatitis, Due to other chemicals
46.2
22.5
27
6
H02AB06
ATC
prednisolone; systemic
1.9
21.4
495
3425
D07BC01
ATC
betamethasone and antiseptics; topical
2.5
20.8
147
648
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.5
20.3
145
641
XQ802
NOMESCO Finland
Epicutan test
4.3
19.8
52
126
D07XC01
ATC
betamethasone; topical
2.4
19.0
147
673
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
7.2
18.7
28
40
D04.0
ICD-10 Finland
Carcinoma in situ: Skin of lip
193.6
18.6
19
*
E000003, ,
ATC
3.6
18.3
61
176
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
4.4
18.2
46
108
6929B
ICD-9 Finland
Contact dermatitis and other eczema, Unspecified cause[ECZEMA INFECTIOSUM]
53.6
18.0
21
*
E000007, ,
ATC
3.5
17.6
63
190
H02AB07
ATC
prednisone; oral
2.2
16.4
164
835
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.5
16.0
56
167
C44.02
ICD-10 Finland
Spinocellular carcinoma of the lip skin
61.1
15.8
18
*
D02AX
ATC
Other emollients and protectives
4.2
15.3
41
101
EAA30
NOMESCO Finland
Partial excision of lower lip
32.3
14.8
19
6
XQ800
NOMESCO Finland
Prick test
2.9
14.8
73
267
E000006, ,
ATC
2.7
14.6
82
321
TQW80
NOMESCO Finland
Local dermatologic skincare
4.5
14.4
35
80
D04.6
ICD-10 Finland
Carcinoma in situ: Skin of upper limb, including shoulder
19.5
14.3
21
11
D11AH01
ATC
tacrolimus; topical
17.9
13.9
21
12
L56.4
ICD-10 Finland
Polymorphous light eruption
20.4
13.8
20
10
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
20.4
13.8
20
10
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.4
13.7
96
419
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
5.0
13.6
29
59
ZQZ00
NOMESCO Finland
Treatment of several skin areas
26.2
13.4
18
7
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.2
13.2
52
167
XQ848
NOMESCO Finland
Dermatological photography
4.4
13.2
33
77
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
2.7
13.0
72
280
68600
ICD-8 Finland
Other local infections of skin and subcutaneous tissue, Pyoderma
50.7
12.9
15
*
J01FF01
ATC
clindamycin; systemic
1.8
12.7
263
1697
D07CC01
ATC
betamethasone and antibiotics; topical
2.1
12.5
132
682
L30.0
ICD-10 Finland
Nummular dermatitis
3.2
12.3
48
153
D05BB02
ATC
acitretin; oral
4.0
12.2
35
91
69230
ICD-8 Finland
Other eczema and dermatitis, Due to drugs
121.4
11.4
12
*
11006
ICD-8 Finland
Dermatophytosis, Pedis
43.8
10.9
13
*
ZZR00
NOMESCO Finland
Flap of skin
3.9
10.7
31
81
J01DB01
ATC
cefalexin; oral
1.7
10.6
738
6352
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
2.6
10.5
62
249
L04AX01
ATC
azathioprine; systemic
3.1
10.2
42
139
S01GX01
ATC
cromoglicic acid; ophthalmic
1.8
10.2
155
907
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.7
10.0
218
1414
R06AX27
ATC
desloratadine; oral
1.7
9.9
209
1343
R03AC03
ATC
terbutaline; inhalant
1.9
9.9
130
724
D04.4
ICD-10 Finland
Carcinoma in situ: Skin of scalp and neck
26.3
9.8
13
5
6929X
ICD-9 Finland
Contact dermatitis and other eczema, Unspecified cause[DERMATITITIS ARTEFACTA NUD]
20.3
9.8
14
7
Z71.8
ICD-10 Finland
Other specified counselling
1.7
9.8
247
1665
S76
ICPC
Skin infection other
2.6
9.7
58
235
S29
ICPC
Skin symptom/complaint other
1.8
9.6
168
1024
A46
ICD-10 Finland
Erysipelas
1.8
9.5
156
933
30300
ICD-8 Finland
Alcoholism, Episodic excessive drinking
5.0
9.3
20
41
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.8
9.3
156
938
ZXC15
NOMESCO Finland
Use of photodynamic technique
10.8
9.3
17
16
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
3.0
9.3
40
136
D09AB01
ATC
zinc bandage without supplements; topical
4.0
9.2
26
67
Z3231
NOMESCO Finland
Registered nurse
1.6
9.1
258
1784
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.7
9.1
195
1258
D07XB05
ATC
dexamethasone; topical
3.3
9.0
34
107
D06BB10
ATC
imiquimod; topical
3.0
8.9
40
139
D04.2
ICD-10 Finland
Carcinoma in situ: Skin of ear and external auricular canal
24.3
8.9
12
5
Z2221
NOMESCO Finland
Medical doctor
1.6
8.9
245
1683
D05AX02
ATC
calcipotriol; topical
2.8
8.7
44
164
R03AK08
ATC
formoterol and beclometasone; inhalant
2.8
8.7
44
164
D06BX01
ATC
metronidazole; topical
2.0
8.7
96
504
R03BB04
ATC
tiotropium bromide; inhalant
1.8
8.7
126
725
J01AA04
ATC
lymecycline; systemic
1.9
8.5
104
565
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.2
8.5
74
355
T78.4
ICD-10 Finland
Allergy, unspecified
3.0
8.4
37
128
J01AA07
ATC
tetracycline; systemic
1.9
8.3
119
681
QAA50
NOMESCO Finland
Cryotherapy of skin of head or neck
10.9
8.3
15
14
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
8.2
173
1108
D06AX01
ATC
fusidic acid; topical
2.0
8.2
89
464
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
8.1
294
2146
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
22.2
8.0
11
5
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
2.9
8.0
36
126
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
7.7
280
2037
D04.7
ICD-10 Finland
Carcinoma in situ: Skin of lower limb, including hip
15.2
7.7
12
8
K13.09
ICD-10 Finland
Disease of the lips UNS
45.3
7.7
9
*
L71.8
ICD-10 Finland
Other rosacea
4.6
7.7
18
40
R06AX13
ATC
loratadine; oral
1.8
7.7
117
683
69009
ICD-8 Finland
Seborrhoeic dermatitis, Unspecified
25.2
7.6
10
*
S18
ICPC
Laceration/cut
1.5
7.6
399
3132
N06AX11
ATC
mirtazapine; oral
1.5
7.4
296
2194
J46
ICD-10 Finland
Status asthmaticus
3.1
7.3
29
94
R03AK07
ATC
formoterol and budesonide; inhalant
1.6
7.3
169
1106
6929A
ICD-9 Finland
Contact dermatitis and other eczema, Unspecified cause[ECZEMA NUMMULARE]
+∞
7.3
7
*
6927X
ICD-9 Finland
Contact dermatitis and other eczema, Due to solar radiation[DERMATITIS PHOTOTOXICA NUD]
+∞
7.3
7
*
XF400
NOMESCO Finland
ECG with 12 standard connections
1.6
7.3
167
1091
S01GX04
ATC
nedocromil; ophthalmic
4.3
7.2
18
42
70908
ICD-8 Finland
Other diseases of skin, Alii definiti
30.2
7.2
9
*
S21
ICPC
Skin texture symptom/complaint
1.8
7.1
118
705
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.5
7.1
225
1585
R06AE09
ATC
levocetirizine; oral
1.8
7.1
108
629
R06.0
ICD-10 Finland
Dyspnoea
1.5
7.1
257
1865
D07AB01
ATC
clobetasone; topical
2.7
7.1
36
135
D07AC14
ATC
methylprednisolone aceponate; topical
2.3
7.1
50
220
R03DC03
ATC
montelukast; oral
1.7
7.0
129
795
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
2.7
6.9
37
143
R03AC02
ATC
salbutamol; inhalant
1.4
6.8
464
3799
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
2.1
6.8
61
297
L26
ICD-10 Finland
Exfoliative dermatitis
16.8
6.8
10
6
C44.61
ICD-10 Finland
Basocellular carcinoma of the skin of the upper extremity including the shoulder
7.2
6.7
15
21
L20
ICD-10 Finland
Atopic dermatitis
4.1
6.6
18
45
R03BA02
ATC
budesonide; inhalant
1.6
6.6
155
1017
Z01.2
ICD-10 Finland
Dental examination
1.4
6.6
332
2568
M54.5
ICD-10 Finland
Low back pain
1.5
6.6
291
2195
R06AX22
ATC
ebastine; oral
1.7
6.5
132
835
D05AX52
ATC
calcipotriol, combinations; topical
2.3
6.5
49
222
J01MA12
ATC
levofloxacin; systemic
1.6
6.5
182
1248
69830
ICD-8 Finland
Pruritus and related conditions, Lichenification and lichen simplex chronicus
70.3
6.4
7
*
6924B
ICD-9 Finland
Contact dermatitis and other eczema, Due to other chemical products[DERMATITIS ARTEFACTA E METALLIS ALLERGICA]
70.3
6.4
7
*
J01FA01
ATC
erythromycin; systemic
1.8
6.4
99
580
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
6.4
139
895
P01BA02
ATC
hydroxychloroquine; oral
2.0
6.4
72
381
J01DA01
ATC
[U] cefalexin
1.4
6.4
554
4711
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
6.4
239
1743
N02AX02
ATC
tramadol; systemic, rectal
1.4
6.3
401
3228
Y1203, ,
ICD-8 Finland
+∞
6.3
6
*
C44.00
ICD-10 Finland
Malignant tumor of the lip skin without histology
+∞
6.3
6
*
6927A
ICD-9 Finland
Contact dermatitis and other eczema, Due to solar radiation[ERYTHEMA SOLARE]
+∞
6.3
6
*
6927F
ICD-9 Finland
Contact dermatitis and other eczema, Due to solar radiation[ERUPTIO POLYMORPHICA SOLARIS]
+∞
6.3
6
*
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
6.2
200
1414
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
5.8
6.2
16
28
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.3
6.1
44
195
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
6.1
423
3450
L04AB04
ATC
adalimumab; parenteral
3.8
6.1
18
48
Y1202
ICD-8 Finland
Skin tests, Allergy tests
12.6
6.1
10
8
6918B
ICD-9 Finland
Atopic dermatitis and related conditions, Other atopic dermatitis and related conditions[ECZEMA ATOPICUM]
10.1
6.0
11
11
N03AX16
ATC
[U] pregabalin
1.5
6.0
208
1489
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
535
4201
1.62
11.80
10.9
8.9
4.12
4.22
e9/l
0.47
479
3662
458
3594
1.52
9.24
6.9
6.0
1.21
1.21
mmol/l
0.94
426
3255
194
1273
1.66
8.40
2.9
3.3
0.84
0.82
mmol/l
1.30
182
1187
438
3454
1.49
8.35
7.5
5.8
26.29
26.83
%
0.46
416
3221
432
3399
1.49
8.32
7.4
5.6
57.90
57.76
%
0.08
412
3171
431
3417
1.47
7.84
5.9
4.8
34.74
34.92
g/l
0.25
408
3168
124
739
1.78
7.58
2.8
2.1
187.22
136.17
ug/g
1.00
99
585
480
3910
1.45
7.46
7.1
6.8
1.21
1.21
mmol/l
0.39
424
3316
632
5447
1.47
7.15
4.5
4.1
15.75
13.49
mm/h
2.33
589
4960
275
2022
1.50
7.14
2.5
2.2
2.95
3.13
mg/l
0.46
233
1691
378
2963
1.45
7.09
2.5
2.2
79.11
78.14
nmol/l
0.25
335
2583
102
587
1.83
7.00
1.9
1.6
—
—
—
0
0
380
2991
1.45
6.94
3.4
2.7
177.28
152.80
ug/l
0.78
351
2695
73
383
1.98
6.63
1.4
1.2
830.78
186.63
u/ml
1.25
66
347
168
1131
1.59
6.45
3.2
2.4
2.32
2.29
g/l
0.26
158
1039
249
1836
1.48
6.27
2.8
2.4
—
—
—
0
0
114
702
1.71
6.20
2.5
2.3
42.69
32.05
u/l
0.88
94
590
662
5829
1.43
6.14
10.0
7.7
81.53
80.43
u/l
0.24
631
5449
268
2017
1.46
6.04
2.9
2.7
1998.15
8295.95
umol/l
2.57
226
1734
158
1065
1.58
6.02
3.4
2.4
21.06
22.41
%
0.58
142
907
44
197
2.29
6.00
1.7
1.6
0.09
30.90
iu/ml
0.49
12
39
482
4034
1.39
5.91
7.3
6.4
11.05
11.89
umol/l
0.85
459
3824
143
959
1.58
5.55
1.9
1.8
—
—
—
0
0
189
1349
1.50
5.52
2.1
1.8
—
—
—
0
0
196
1413
1.49
5.45
1.3
1.2
2.43
1.54
u/ml
0.37
42
371
174
1239
1.49
5.12
3.2
2.4
12.02
12.64
umol/l
0.54
164
1145
534
4610
1.36
5.07
5.3
4.9
6.89
6.83
mmol/l
0.26
509
4335
397
3279
1.36
5.01
2.2
2.1
93.57
94.07
pmol/l
0.07
200
1692
140
966
1.53
4.78
1.9
1.9
—
—
—
0
0
566
4956
1.34
4.76
6.0
4.6
27.43
3299.25
e6/l
—
7
87
303
2417
1.37
4.71
3.4
3.1
7.57
7.43
mmol/l
0.22
269
1994
115
762
1.58
4.70
2.2
2.2
0.21
0.21
g/l
0.17
102
699
150
1063
1.49
4.50
6.7
5.3
1.04
1.02
mmol/l
0.22
143
970
445
3781
1.33
4.50
2.7
2.5
—
—
—
0
0
300
2404
1.36
4.50
2.3
2.1
238.28
232.05
u/l
0.04
282
2254
36
172
2.14
4.27
1.4
1.2
2.07
2.66
u/ml
—
6
23
204
1553
1.40
4.16
4.2
3.9
709.90
359.68
ng/l
0.27
175
1295
36
175
2.10
4.10
1.4
1.2
2.90
8.77
u/ml
—
5
31
136
967
1.47
4.01
5.8
7.7
5.11
5.12
kpa
0.03
128
925
136
968
1.47
3.99
5.8
7.7
11.67
11.89
kpa
0.20
128
928
40
205
1.99
3.97
1.8
1.9
6453.60
16444.95
e6/l
1.62
30
152
29
131
2.25
3.96
1.4
1.2
35.42
33.75
u/ml
—
6
10
451
3888
1.30
3.93
16.9
16.4
1.29
1.31
inr
0.18
108
1092
314
2579
1.32
3.89
3.1
3.0
1907.46
1698.55
ng/l
0.33
275
2212
96
643
1.55
3.76
2.5
2.0
390.66
369.43
nmol/l
0.39
91
582
17
61
2.82
3.70
1.1
1.1
1.88
3.36
u/ml
—
8
32
134
966
1.45
3.69
5.9
7.7
0.55
1.33
mmol/l
1.02
101
766
69
431
1.65
3.62
6.5
9.4
23.80
24.56
mmol/l
1.14
64
420
112
787
1.48
3.52
3.2
3.3
1.91
2.21
mmol/l
0.30
94
646
179
1371
1.38
3.49
3.1
2.8
0.76
1.15
e6/l
1.53
100
789
42
230
1.86
3.47
1.4
1.5
—
—
—
0
0
302
2506
1.30
3.40
4.1
3.7
13.45
8.24
mg/mmol
0.70
209
1583
39
210
1.89
3.40
1.9
1.9
—
—
—
0
0
77
504
1.57
3.36
3.9
3.6
1.18
1.93
mmol/l
0.85
60
375
125
909
1.43
3.29
4.2
3.9
242.87
255.91
u/l
0.51
112
853
339
2869
1.28
3.25
4.0
3.2
—
—
—
0
0
32
164
1.98
3.22
1.8
1.4
—
—
—
0
0
32
164
1.98
3.22
1.8
1.4
—
—
—
0
0
17
67
2.56
3.14
2.0
2.4
—
—
—
0
0
208
1656
1.33
3.13
1.9
1.8
1120.66
1194.53
nmol/l
0.59
159
1214
49
292
1.71
3.09
2.4
3.1
—
—
—
0
0
269
2222
1.29
3.09
3.9
3.2
0.38
0.57
e6/l
1.22
206
1707
201
1597
1.33
3.07
1.7
1.6
1.38
1.25
mg/l
0.29
158
1241
24
113
2.15
3.02
1.3
1.4
112.00
106.00
u/ml
—
5
18
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
48
287
1.71
3.00
2.8
2.6
0.29
0.35
u/ml
1.11
34
162
87
602
1.49
2.97
4.2
3.5
102.84
90.68
ng/l
0.52
75
515
60
382
1.61
2.96
1.6
1.7
1.67
1.57
g/l
0.38
44
333
36
199
1.84
2.93
1.1
1.2
—
—
—
0
0
289
2426
1.27
2.90
3.1
2.6
55.61
92.75
u/l
0.58
265
2237
313
2654
1.27
2.89
3.6
3.5
2.35
2.35
mmol/l
0.06
264
2303
366
3161
1.25
2.89
4.2
3.9
40.07
56.64
ng/l
0.53
263
2375
33
180
1.86
2.81
1.6
1.6
—
—
—
0
0
36
202
1.81
2.80
1.1
1.2
—
—
—
0
0
76
518
1.51
2.80
7.1
8.8
93.11
94.03
%
0.42
76
513
401
3513
1.24
2.76
3.0
2.7
—
—
—
0
0
289
2441
1.26
2.74
4.0
3.3
45.97
97.90
e6/l
0.84
222
1910
24
118
2.06
2.73
1.3
1.2
—
—
—
0
0
509
4579
1.24
2.73
3.6
3.2
64.00
55.35
u/l
0.89
476
4212
102
741
1.42
2.72
2.3
2.5
6.58
7.11
ug/l
0.14
82
641
6
10
6.03
2.70
1.0
1.3
—
—
—
0
0
75
517
1.49
2.63
7.1
8.7
0.66
0.68
%
0.16
75
512
235
1950
1.27
2.56
1.6
1.6
19.11
20.81
nmol/l
1.12
207
1631
10
31
3.25
2.52
1.0
1.0
—
—
—
0
0
38
225
1.72
2.50
2.0
2.6
0.00
0.00
g/l
-0.00
32
206
38
226
1.71
2.47
2.0
2.6
0.00
0.00
g/l
-0.00
32
206
206
1691
1.28
2.45
3.0
2.6
4.83
4.90
e6/l
0.02
186
1538
5
8
6.28
2.37
1.2
1.5
—
—
—
0
0
74
521
1.46
2.36
6.6
8.7
1.36
1.36
%
0.01
74
516
162
1297
1.30
2.33
3.4
3.0
2.11
2.21
e6/l
0.07
86
721
42
261
1.64
2.33
3.3
3.6
39.94
80.32
mg/l
0.94
33
213
139
1090
1.32
2.33
1.3
1.2
17.70
15.37
u/ml
0.08
44
405
20
98
2.06
2.33
1.2
1.7
70.13
64.97
%
—
8
67
47
301
1.59
2.32
1.9
2.5
2.99
3.04
g/l
0.13
39
266
42
262
1.63
2.30
3.3
3.6
39.30
43.12
mg/l
0.10
33
215
587
5414
1.22
2.28
4.7
3.8
14.97
14.98
pmol/l
0.03
539
4826
55
368
1.52
2.25
2.3
3.4
4.23
4.50
pmol/l
0.87
43
321
5
9
5.58
2.21
1.0
1.1
—
—
—
0
0
5
9
5.58
2.21
1.0
1.1
—
—
—
0
0
5
9
5.58
2.21
2.0
1.1
—
—
—
0
0
764
7252
1.26
2.21
22.3
15.9
26.47
26.56
mg/l
0.02
658
5842
125
973
1.33
2.21
2.4
2.5
1.80
1.80
%
0.02
110
856
71
503
1.44
2.20
1.4
1.5
—
—
—
0
0
188
1550
1.26
2.15
4.0
3.1
2.47
2.46
mmol/l
0.85
160
1358
46
299
1.57
2.15
1.8
2.4
10.93
10.75
g/l
0.07
38
263
703
6621
1.23
2.14
5.4
4.7
5.95
2.15
mu/l
0.46
645
5949
29
167
1.76
2.13
1.6
1.3
—
—
—
0
0
116
902
1.33
2.07
3.8
2.8
9.94
9.15
umol/l
0.09
98
796
91
683
1.37
2.05
2.1
2.9
65.93
66.62
g/l
0.33
79
616
273
2357
1.22
2.05
4.6
3.4
36.05
34.67
u/l
0.10
257
2235
38
240
1.61
2.01
2.1
2.6
0.00
0.02
g/l
0.50
32
220
40
257
1.58
1.98
2.0
2.5
36.54
37.33
g/l
0.30
32
222
19
98
1.96
1.96
1.6
1.3
—
—
—
0
0
19
98
1.96
1.96
1.6
1.3
—
—
—
0
0
19
98
1.96
1.96
1.6
1.3
—
—
—
0
0
5
11
4.56
1.94
1.4
1.1
96.60
109.27
%
—
5
11
19
99
1.94
1.91
1.6
1.3
—
—
—
0
0
19
99
1.94
1.91
1.6
1.3
—
—
—
0
0
19
99
1.94
1.91
1.6
1.3
—
—
—
0
0
398
3582
1.19
1.89
4.4
3.8
0.00
0.00
estimate
0.74
77
732
110
862
1.31
1.87
1.5
1.4
—
—
—
0
0
9
34
2.66
1.86
1.0
1.0
—
—
—
0
0
47
321
1.49
1.79
1.9
2.4
3.78
3.59
g/l
0.46
39
287
47
322
1.48
1.77
1.9
2.4
7.06
7.47
g/l
1.46
39
287
47
322
1.48
1.77
1.9
2.4
—
—
—
0
0
41
273
1.52
1.76
2.0
2.8
0.22
1.25
g/l
2.15
33
237
401
3629
1.18
1.76
4.3
3.8
0.00
0.01
estimate
0.80
70
655
13
61
2.15
1.72
1.1
1.1
—
—
—
0
0
5
13
3.86
1.71
1.4
1.2
—
—
—
0
0
20
111
1.82
1.69
2.1
2.6
—
629.38
—
0
13
68
504
1.38
1.69
2.0
1.6
—
—
—
0
0
13
62
2.11
1.66
1.2
1.0
—
—
—
0
0
36
237
1.54
1.64
1.7
1.6
—
—
—
0
0
139
1143
1.25
1.64
1.3
1.2
36.02
40.50
iu/ml
0.15
41
359
394
3578
1.17
1.63
5.7
5.1
0.00
0.00
estimate
-0.00
72
674
18
98
1.85
1.62
1.1
1.1
1.66
1.58
g/l
0.35
18
83
43
296
1.47
1.60
1.3
1.3
—
—
—
0
0
23
136
1.71
1.60
1.9
1.7
—
—
—
0
0
29
184
1.59
1.56
2.2
2.1
120.56
128.16
g/l
0.77
18
134
18
100
1.82
1.53
2.1
2.4
45.00
23.89
mg/l
—
6
24
27
170
1.61
1.50
2.4
1.6
—
—
—
0
0
12
58
2.08
1.49
1.2
1.1
—
—
—
0
0
16
87
1.85
1.46
3.8
3.7
—
—
—
0
0
37
254
1.47
1.42
1.4
1.3
—
—
—
0
0
715
6840
1.18
1.41
4.5
4.1
1.36
1.31
mmol/l
1.14
653
6145
15
81
1.87
1.40
2.9
2.5
—
—
—
0
0
7
29
2.42
1.39
3.9
4.1
—
—
—
0
0
29
191
1.53
1.36
1.8
1.7
—
—
—
0
0
10
47
2.14
1.34
1.1
1.3
—
—
—
0
0
10
47
2.14
1.34
1.1
1.3
—
—
—
0
0
78
615
1.29
1.32
2.8
2.7
59.23
63.07
ml/min/173m2
0.53
35
254
0
41
0.00
1.31
0.0
1.0
—
1.10
—
0
23
28
185
1.53
1.30
1.8
1.7
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
5
18
2.79
1.28
1.0
2.8
183.40
131.56
%
—
5
18
716
6870
1.16
1.28
7.1
6.1
41.29
40.64
mmol/mol
1.08
669
6291
16
92
1.75
1.25
1.3
1.9
—
—
—
0
0
8
37
2.17
1.21
3.0
1.5
—
—
—
0
0
8
37
2.17
1.21
3.0
1.5
—
—
—
0
0
41
298
1.39
1.20
1.0
1.0
—
—
—
0
0
13
71
1.84
1.19
1.5
1.3
—
—
—
0
0
60
465
1.31
1.18
5.2
7.3
24.63
25.00
mmol/l
0.41
60
460
108
901
1.22
1.16
3.1
4.2
3.46
27.61
ug/l
1.87
89
757
5
20
2.51
1.15
1.8
1.3
—
—
—
0
0
5
20
2.51
1.15
1.6
1.2
0.94
2.75
mmol/l
—
5
20
26
175
1.50
1.13
2.7
2.7
14.78
16.04
%
0.65
13
92
20
127
1.59
1.12
1.3
1.3
—
—
—
0
0
11
59
1.87
1.07
3.1
3.0
34.83
40.54
%
—
6
37
19
121
1.58
1.06
2.1
1.6
—
—
—
0
0
19
121
1.58
1.06
2.1
1.6
—
—
—
0
0
12
67
1.80
1.05
1.0
1.2
—
—
u/ml
—
0
0
41
307
1.35
1.03
1.6
1.5
—
—
—
0
0
54
422
1.30
1.02
2.4
3.3
25.13
25.22
mmol/l
0.07
54
410
732
7076
1.14
1.02
4.9
4.6
1.43
1.45
mmol/l
0.67
670
6403
7
36
1.95
0.97
1.1
2.4
610.71
1856.08
u/ml
—
7
36
40
302
1.34
0.97
1.7
2.0
45.64
38.72
u/l
0.90
34
260
35
259
1.36
0.96
4.4
4.0
3.95
3.93
mmol/l
0.07
35
254
22
149
1.49
0.96
1.4
1.3
—
—
—
0
0
736
7132
1.14
0.93
5.0
4.6
4.50
4.58
mmol/l
1.26
684
6515
752
7298
1.14
0.92
5.7
5.2
2.61
2.68
mmol/l
1.34
697
6613
9
52
1.74
0.92
1.1
1.1
—
—
—
0
0
9
52
1.74
0.92
1.1
1.1
—
—
—
0
0
713
6900
1.13
0.90
20.8
15.0
74.96
76.37
ml/min/173m2
0.95
601
5718
6
29
2.08
0.89
3.7
1.5
—
—
—
0
0
6
29
2.08
0.89
3.7
1.5
—
—
—
0
0
6
29
2.08
0.89
3.7
1.5
—
—
—
0
0
790
7699
1.15
0.88
14.6
10.8
26.64
26.14
u/l
0.30
768
7392
177
1583
1.14
0.87
5.0
4.2
1.02
1.02
kg/l
0.07
18
238
8
43
1.87
0.87
2.1
2.0
—
—
—
0
0
42
326
1.30
0.86
4.9
3.5
151.42
11996.69
u/ml
0.78
36
277
50
400
1.26
0.82
1.3
1.2
44.38
112.24
iu/ml
2.18
13
153
30
223
1.36
0.82
1.4
1.5
293.62
271.34
ug/g
0.27
21
129
8
46
1.75
0.82
2.0
3.1
74.88
103.98
nmol/l
—
8
46
8
46
1.75
0.82
1.3
1.7
—
—
—
0
0
8
46
1.75
0.82
1.3
1.7
—
—
—
0
0
6
32
1.88
0.82
1.5
1.1
—
—
—
0
0
12
73
1.65
0.82
2.3
1.6
—
—
—
0
0
37
286
1.31
0.79
2.4
1.6
—
—
—
0
0
20
139
1.45
0.79
1.7
1.5
—
—
—
0
0
87
742
1.19
0.79
1.8
1.8
1.70
1.59
%
0.47
73
615
643
6207
1.11
0.79
27.2
18.9
15.37
15.29
%
0.13
638
6087
784
7653
1.13
0.78
25.2
18.7
139.47
139.62
mmol/l
0.83
771
7444
215
1966
1.12
0.76
5.0
4.1
0.00
0.00
estimate
0.50
65
648
9
53
1.70
0.75
2.0
1.6
0.86
1.00
g/l
—
9
53
9
53
1.70
0.75
1.1
1.1
—
—
—
0
0
9
53
1.70
0.75
1.1
1.1
—
—
—
0
0
9
53
1.70
0.75
1.1
1.1
—
—
—
0
0
17
116
1.47
0.74
1.1
1.5
—
—
—
0
0
112
985
1.16
0.72
9.2
7.6
—
—
—
0
0
42
336
1.26
0.71
1.6
1.6
—
—
—
0
0
7
40
1.76
0.71
1.3
1.2
—
—
—
0
0
784
7669
1.12
0.69
25.6
18.8
4.00
4.00
mmol/l
0.14
770
7449
22
161
1.38
0.68
1.4
1.2
—
—
—
0
0
7
42
1.67
0.68
1.3
1.3
1.57
1.59
g/l
—
7
42
39
483
0.80
0.67
1.6
1.8
—
—
—
0
0
14
94
1.50
0.67
2.1
1.6
—
—
—
0
0
7
44
1.60
0.65
2.3
1.6
—
—
—
0
0
187
1715
1.11
0.64
1.9
1.7
428.76
29776928.01
pmol/l
1.66
164
1387
12
79
1.53
0.62
2.3
1.6
—
—
—
0
0
39
316
1.24
0.62
2.9
1.7
—
—
—
0
0
5
30
1.67
0.61
1.0
1.3
—
—
—
0
0
5
30
1.67
0.61
1.0
1.0
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
14
97
1.45
0.59
1.1
1.2
2.00
6.54
u/ml
—
5
39
19
140
1.36
0.58
2.1
2.0
64.89
58.92
%
0.52
19
140
8
54
1.49
0.57
1.0
1.3
—
—
—
0
0
13
184
0.70
0.57
1.3
1.2
—
—
—
0
0
731
7148
1.09
0.57
5.4
4.8
6.13
6.06
mmol/l
0.81
670
6402
16
116
1.39
0.54
1.3
1.7
—
—
—
0
0
48
406
1.19
0.52
2.9
3.7
49.59
46.67
%
0.35
48
399
10
66
1.52
0.52
2.6
1.5
—
—
—
0
0
10
66
1.52
0.52
2.6
1.5
—
—
—
0
0
10
66
1.52
0.52
2.6
1.5
—
—
—
0
0
6
41
1.47
0.50
1.5
1.7
11.03
19.43
nmol/l
—
6
35
7
46
1.53
0.48
2.0
1.2
—
—
—
0
0
810
7978
1.10
0.47
32.2
23.3
39.62
39.76
%
0.24
760
7397
26
209
1.25
0.47
1.6
1.5
—
—
—
0
0
810
7979
1.10
0.46
32.0
23.1
4.40
4.44
e12/l
1.58
797
7720
7
49
1.43
0.46
1.9
2.2
—
—
—
0
0
810
7981
1.09
0.45
32.2
23.3
133.14
134.24
g/l
1.22
802
7831
12
86
1.40
0.44
1.4
1.4
—
—
—
0
0
105
956
1.11
0.44
4.5
4.7
32.41
32.24
%
0.06
78
619
13
95
1.37
0.44
1.1
1.2
1.43
1.78
u/ml
—
7
23
20
157
1.28
0.43
2.4
1.6
2.47
5.24
iu/l
—
7
44
809
7975
1.09
0.43
32.1
23.2
245.45
244.68
e9/l
0.12
795
7746
5
32
1.57
0.42
1.8
1.7
32.48
53.01
ug/l
—
5
32
8
58
1.38
0.41
1.3
1.6
—
—
—
0
0
16
123
1.31
0.40
2.2
1.6
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
15
115
1.31
0.39
1.1
1.5
—
—
—
0
0
22
179
1.23
0.37
1.6
1.5
—
—
—
0
0
12
158
0.76
0.37
2.2
1.2
3.92
3.81
mmol/l
0.17
12
148
5
37
1.35
0.37
1.8
1.2
—
—
—
0
0
5
37
1.35
0.37
1.8
1.2
—
—
—
0
0
10
72
1.39
0.37
1.2
1.7
—
—
—
0
0
5
78
0.64
0.35
1.0
1.1
—
—
—
0
0
209
1986
1.07
0.34
1.6
1.7
1.37
1.37
mmol/l
0.03
187
1632
18
145
1.25
0.34
1.2
1.5
—
—
—
0
0
6
45
1.34
0.33
1.7
1.4
—
—
—
0
0
6
45
1.34
0.33
1.7
1.4
—
—
—
0
0
16
128
1.25
0.32
1.2
1.5
—
—
—
0
0
19
156
1.22
0.31
1.1
1.1
—
—
—
0
0
92
851
1.09
0.31
3.6
3.6
—
—
—
0
0
85
786
1.09
0.29
1.6
1.4
—
—
—
0
0
11
85
1.30
0.28
1.4
1.7
—
—
—
0
0
11
85
1.30
0.28
1.4
1.7
—
—
—
0
0
8
63
1.27
0.27
1.9
2.1
—
—
—
0
0
5
71
0.70
0.26
5.2
1.8
—
2.56
—
0
27
5
73
0.68
0.26
1.0
1.1
—
—
—
0
0
13
105
1.24
0.25
1.8
1.4
—
—
—
0
0
15
180
0.83
0.24
2.2
1.2
479.20
498.86
mg/l
0.08
15
169
10
78
1.29
0.24
1.1
1.2
7.63
7.44
mmol/l
—
10
67
5
40
1.25
0.22
1.6
2.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
13
108
1.21
0.20
1.1
1.1
—
—
—
0
0
233
2396
0.96
0.18
4.7
4.3
21.45
21.57
%
0.04
111
1165
9
80
1.13
0.15
1.2
1.4
198.67
345.43
pmol/l
—
9
72
9
83
1.09
0.14
1.0
1.1
—
—
—
0
0
24
217
1.11
0.14
1.6
2.4
41.94
96.76
ug/min
1.06
11
121
280
2755
1.02
0.10
4.9
4.1
—
—
—
0
0
5
46
1.09
0.09
1.0
1.2
—
—
—
0
0
5
47
1.06
0.09
1.0
1.2
—
—
—
0
0
68
656
1.04
0.09
4.8
3.8
1.23
1.22
mmol/l
0.37
62
566
6
55
1.09
0.09
1.3
1.5
—
—
—
0
0
11
123
0.89
0.08
1.6
1.4
301.26
217.88
miu/ml
—
5
59
11
98
1.12
0.07
1.0
1.0
—
—
—
0
0
15
137
1.10
0.07
1.6
2.9
4.07
4.42
e9/l
0.28
15
137
13
118
1.10
0.07
1.1
1.1
—
—
—
0
0
11
99
1.11
0.06
1.5
1.3
23792.40
104305.77
e6/l
—
5
56
19
178
1.07
0.05
1.5
1.7
—
—
—
0
0
298
2995
0.99
0.02
4.7
4.9
5.58
3.27
ug/l
0.51
263
2666
15
143
1.05
0.01
1.7
3.3
53.40
58.17
%
0.55
15
143
20
207
0.97
0.01
1.3
1.9
2.73
3.02
mg/l
0.09
13
157
171
1718
0.99
0.01
3.5
3.0
0.65
0.79
ug/l
1.93
115
1147
11
114
0.96
0.00
1.5
2.3
30.00
32.65
pg
1.07
11
114
16
162
0.99
0.00
1.8
1.4
—
—
—
0
0
17
175
0.97
0.00
6.1
3.9
19.19
29.88
mg/l
—
9
115
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
9
91
0.99
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.0
—
—
—
0
0
11
110
1.00
-0.00
1.5
1.3
1431.17
1531.64
e6/l
—
6
74
0
9
0.00
-0.00
0.0
2.0
—
0.44
—
0
9
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_OTHACUSKINSUNNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHACUSKINSUNNAS | 0.923 [0.74, 1.15] | 0.471 |
| Birth year | 0.993 [0.98, 1.0] | 0.128 |
During the follow-up period (1.1.1998 — 31.12.2019), 134 out of 829 females with L12_OTHACUSKINSUNNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHACUSKINSUNNAS | 1.121 [0.91, 1.38] | 0.29 |
| Birth year | 0.983 [0.97, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 194 out of 643 males with L12_OTHACUSKINSUNNAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_OTHACUSKINSUNNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.089% | 0.185% |
| 5 | 0.486% | 1.079% |
| 10 | 1.204% | 2.838% |
| 15 | 2.335% | 5.413% |
| 20 | 4.209% | 9.097% |
Relationships between endpoints
↥Index endpoint: L12_OTHACUSKINSUNNAS – Other and unspecified acute skin changes due to ultraviolet radiation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data