phototoxic dermatitis: a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous. In rare cases the victims die.
Other and unspecified acute skin changes due to ultraviolet radiation
DOID EFO Endpoint Browser PheWeb
L12_OTHACUSKINSUNNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
954 |
4. Check minimum number of eventsNone |
954 |
5. Include endpointsNone |
954 |
6. Filter based on genotype QC (FinnGen only) |
954 |
Control definitions (FinnGen only)
- Control exclude
- L12_RADIATIONRELATEDSKIN
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified acute skin changes due to ultraviolet radiation
based on the number of shared cases.
Similar with more cases:
- Other acute skin changes due to ultraviolet radiation
- Radiation-related disorders of the skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9789 | 4557 | 5076 |
| Only index persons | 6433 | 3241 | 3192 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.13 | 0.14 |
| Only index persons | 0.12 | 0.12 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 44.43 | 47.31 | 41.57 |
| Only index persons | 35.57 | 39.46 | 31.63 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 954 | 426 | 528 |
| Unadjusted period prevalence (%) | 0.19 | 0.15 | 0.23 |
| Median age at first event (years) | 38.16 | 38.10 | 38.21 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 871
- Matched controls
- 8708
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
69282
ICD-8 Finland
Other eczema and dermatitis, E microbis
+∞
323.0
458
*
L56.8
ICD-10 Finland
Other specified acute skin changes due to ultraviolet radiation
+∞
197.6
182
*
69288
ICD-8 Finland
Other eczema and dermatitis, E causis alii definitis
+∞
88.0
83
*
L57.0
ICD-10 Finland
Actinic keratosis
13.8
79.9
143
122
L56.9
ICD-10 Finland
Acute skin change due to ultraviolet radiation, unspecified
273.0
74.6
75
*
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
32.9
61.5
81
27
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
6.4
60.0
173
326
69283
ICD-8 Finland
Other eczema and dermatitis, Dysidroticum (pompholyx)
+∞
54.8
52
*
TQW99
NOMESCO Finland
Other minor procedure on skin
10.3
52.8
108
118
D07AB08
ATC
desonide; topical
4.6
46.3
179
463
E0000UV
ATC
NA
2.7
40.4
413
2187
ZXC20
NOMESCO Finland
Use of chemical agents
13.6
38.7
68
54
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
31.1
37.8
50
17
D07AC01
ATC
betamethasone; topical
2.6
37.5
384
2009
D07AB02
ATC
hydrocortisone butyrate; topical
2.7
34.7
316
1529
69280
ICD-8 Finland
Other eczema and dermatitis, E radiatione solari
+∞
34.6
33
*
E000001
ATC
NA
2.8
30.9
239
1035
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.0
30.1
199
777
D07AC13
ATC
mometasone; topical
2.5
30.0
313
1603
L57.8
ICD-10 Finland
Other skin changes due to chronic exposure to nonionizing radiation
257.1
24.8
25
*
ZXC10
NOMESCO Finland
Use of laser
8.6
23.7
52
64
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.4
23.6
125
412
R06AE07
ATC
cetirizine; oral
2.1
22.2
382
2384
L20.0
ICD-10 Finland
Besnier prurigo
5.2
21.6
69
142
L56.4
ICD-10 Finland
Polymorphous light eruption
+∞
20.9
20
*
69240
ICD-8 Finland
Other eczema and dermatitis, Due to other chemicals
38.2
20.9
26
7
N05BB01
ATC
hydroxyzine; systemic
3.7
20.6
93
269
69299
ICD-8 Finland
Other eczema and dermatitis, Due to other and unspecified cause
23.0
20.5
29
13
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.6
19.9
95
288
E000002
ATC
NA
2.9
19.5
128
487
D07AA02
ATC
hydrocortisone; topical
2.6
18.6
145
611
EAA10
NOMESCO Finland
Excision of lesion of lip
10.1
18.3
36
37
D07AD01
ATC
clobetasol; topical
2.5
18.0
161
733
69200
ICD-8 Finland
Other eczema and dermatitis, Due to detergents
53.7
18.0
21
*
D04.0
ICD-10 Finland
Carcinoma in situ: Skin of lip
+∞
17.8
17
*
ZXC50
NOMESCO Finland
Cryotherapy
11.0
17.1
32
30
H02AB06
ATC
prednisolone; systemic
1.9
16.9
423
2942
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
11.4
16.8
31
28
C44.02
ICD-10 Finland
Spinocellular carcinoma of the lip skin
91.8
16.6
18
*
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
13.2
15.7
27
21
EAA30
NOMESCO Finland
Partial excision of lower lip
162.8
15.5
16
*
6929B
ICD-9 Finland
Contact dermatitis and other eczema, Unspecified cause[ECZEMA INFECTIOSUM]
29.2
15.2
20
7
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.5
14.2
122
541
E000003
ATC
NA
3.9
14.1
59
161
XQ802
NOMESCO Finland
Epicutan test
4.6
13.8
48
110
L30.3
ICD-10 Finland
Infective dermatitis
4.2
13.1
49
121
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
8.6
12.3
26
31
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
4.8
12.3
40
86
68600
ICD-8 Finland
Other local infections of skin and subcutaneous tissue, Pyoderma
47.3
11.9
14
*
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
9.8
11.8
23
24
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.7
11.7
51
145
6929X
ICD-9 Finland
Contact dermatitis and other eczema, Unspecified cause[DERMATITITIS ARTEFACTA NUD]
65.8
11.6
13
*
E000007
ATC
NA
3.3
11.2
57
183
D07XC01
ATC
betamethasone, combinations; topical
2.1
11.2
126
635
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
9.7
10.8
21
22
69230
ICD-8 Finland
Other eczema and dermatitis, Due to drugs
60.7
10.6
12
*
XQ800
NOMESCO Finland
Prick test
3.0
10.6
61
213
H02AB07
ATC
prednisone; oral
2.0
10.6
145
789
J01DB01
ATC
cefalexin; oral
1.7
10.5
653
5565
D11AH01
ATC
tacrolimus; topical
14.4
10.5
17
12
D07BC01
ATC
betamethasone and antiseptics; topical
2.0
10.0
128
679
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
16.9
9.9
15
9
D04.6
ICD-10 Finland
Carcinoma in situ: Skin of upper limb, including shoulder
26.3
9.8
13
5
D02AX
ATC
Other emollients and protectives
4.2
9.7
36
89
ZQZ00
NOMESCO Finland
Treatment of several skin areas
13.6
9.7
16
12
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.4
9.5
79
344
69009
ICD-8 Finland
Seborrhoeic dermatitis, Unspecified
101.1
9.4
10
*
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
101.1
9.4
10
*
QAA50
NOMESCO Finland
Cryotherapy of skin of head or neck
17.8
9.4
14
8
11006
ICD-8 Finland
Dermatophytosis, Pedis
30.4
9.4
12
*
D07CC01
ATC
betamethasone and antibiotics; topical
2.0
9.0
122
660
E000006
ATC
NA
2.4
8.5
71
311
70908
ICD-8 Finland
Other diseases of skin, Alii definiti
90.9
8.4
9
*
TQW80
NOMESCO Finland
Local dermatologic skincare
4.1
8.3
31
78
J01FF01
ATC
clindamycin; systemic
1.6
8.2
222
1499
R06.0
ICD-10 Finland
Dyspnoea
1.7
8.2
215
1442
D07XB05
ATC
dexamethasone, combinations; topical
3.9
8.1
32
85
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
2.7
8.0
54
208
J01AA04
ATC
lymecycline; systemic
2.1
8.0
95
489
R03AC03
ATC
terbutaline; inhalant
1.9
7.8
113
628
A46
ICD-10 Finland
Erysipelas
1.8
7.7
135
803
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
2.8
7.5
46
170
J01AA07
ATC
tetracycline; systemic
1.9
7.5
109
603
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
7.5
142
863
P01BA02
ATC
hydroxychloroquine; oral
2.3
7.5
65
291
R03AC02
ATC
salbutamol; inhalant
1.5
7.3
398
3149
ZXC15
NOMESCO Finland
Use of photodynamic technique
11.0
7.3
13
12
6927X
ICD-9 Finland
Contact dermatitis and other eczema, Due to solar radiation[DERMATITIS PHOTOTOXICA NUD]
+∞
7.3
7
*
69830
ICD-8 Finland
Pruritus and related conditions, Lichenification and lichen simplex chronicus
+∞
7.3
7
*
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.6
7.1
195
1316
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
7.1
133
806
D06BX01
ATC
metronidazole; topical
2.1
7.1
84
430
D05BB02
ATC
acitretin; oral
3.7
7.0
29
81
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.7
7.0
169
1104
L23.0
ICD-10 Finland
Allergic contact dermatitis due to metals
7.6
6.9
15
20
L40.0
ICD-10 Finland
Psoriasis vulgaris
2.8
6.9
44
165
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
6.8
241
1728
XQ848
NOMESCO Finland
Dermatological photography
4.1
6.8
25
63
N02AX02
ATC
tramadol; systemic, rectal
1.5
6.7
346
2697
J01DA01
ATC
[U] cefalexin; systemic
1.4
6.5
505
4254
D07AC14
ATC
methylprednisolone aceponate; topical
2.6
6.5
46
185
D07AB01
ATC
clobetasone; topical
3.2
6.5
31
98
8070/3-C44.0
ICD-O-3
Squamous cell carcinoma, NOS, of skin of lip, NOS
70.3
6.4
7
*
6929A
ICD-9 Finland
Contact dermatitis and other eczema, Unspecified cause[ECZEMA NUMMULARE]
70.3
6.4
7
*
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
6.4
150
971
S18
ICPC
Laceration/cut
1.5
6.3
317
2450
T78.4
ICD-10 Finland
Allergy, unspecified
2.8
6.3
37
134
30300
ICD-8 Finland
Alcoholism, Episodic excessive drinking
4.8
6.2
19
40
D06AX01
ATC
fusidic acid; topical (antibiotics for topical use)
2.0
6.2
78
409
C44.30
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face without histology
5.8
6.2
16
28
L30.0
ICD-10 Finland
Nummular dermatitis
2.9
6.1
35
123
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.2
6.0
60
289
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
529
4165
1.61
11.44
11.0
9.0
4.1
4.2
e9/l
0.43
473
3630
453
3562
1.52
9.01
6.9
6.0
1.2
1.2
mmol/l
1.06
417
3206
193
1266
1.66
8.37
3.0
3.3
0.8
0.8
mmol/l
1.28
180
1179
476
3877
1.45
7.42
7.1
6.8
1.2
1.2
mmol/l
0.35
419
3257
425
3389
1.46
7.40
5.8
4.9
34.7
34.9
g/l
0.29
402
3140
273
1995
1.52
7.35
2.5
2.2
3.0
3.1
mg/l
0.42
231
1672
102
581
1.85
7.24
1.9
1.7
—
—
—
0
0
73
373
2.04
7.13
1.4
1.2
830.8
185.9
u/ml
1.25
66
339
625
5398
1.46
6.90
4.5
4.1
15.8
13.5
mm/h
2.44
582
4918
373
2938
1.44
6.76
2.5
2.2
79.1
78.2
nmol/l
0.25
330
2568
375
2962
1.44
6.67
3.4
2.7
177.6
153.5
ug/l
0.75
346
2668
167
1118
1.60
6.58
3.1
2.4
2.3
2.3
g/l
0.30
157
1026
247
1815
1.49
6.35
2.8
2.4
—
—
—
0
0
157
1052
1.59
6.14
3.3
2.4
21.0
22.3
%
0.53
141
891
266
2005
1.45
5.95
2.9
2.7
2013.0
8198.9
umol/l
2.47
224
1708
654
5773
1.42
5.85
10.1
7.7
81.9
80.4
u/l
0.35
623
5393
112
698
1.69
5.84
2.5
2.3
42.8
32.1
u/l
0.85
92
586
478
4004
1.39
5.82
7.3
6.4
11.1
11.9
umol/l
0.82
455
3790
43
195
2.26
5.71
1.7
1.6
0.1
31.7
iu/ml
0.49
12
38
188
1337
1.51
5.60
2.1
1.9
—
—
—
0
0
195
1398
1.50
5.59
1.3
1.2
2.4
1.5
u/ml
0.37
42
373
142
954
1.57
5.47
1.9
1.8
—
—
—
0
0
529
4563
1.36
5.08
5.3
4.9
6.9
6.8
mmol/l
0.26
504
4286
172
1226
1.49
5.04
3.1
2.4
12.0
12.5
umol/l
0.49
162
1123
393
3252
1.35
4.89
2.2
2.1
93.3
94.1
pmol/l
0.13
198
1684
114
753
1.58
4.72
2.2
2.2
0.2
0.2
g/l
0.11
101
691
139
961
1.52
4.70
1.9
1.9
—
—
—
0
0
441
3733
1.34
4.64
2.7
2.5
—
—
—
0
0
299
2393
1.36
4.54
3.3
3.1
7.6
7.4
mmol/l
0.24
265
1969
559
4915
1.33
4.45
6.0
4.7
27.4
3337.6
e6/l
—
7
86
296
2379
1.35
4.34
2.3
2.1
240.1
232.3
u/l
0.05
278
2231
36
171
2.15
4.33
1.4
1.2
2.1
2.7
u/ml
—
6
23
36
174
2.11
4.16
1.4
1.2
2.9
8.8
u/ml
—
5
31
147
1055
1.47
4.14
6.6
5.3
1.0
1.0
mmol/l
0.13
140
963
40
203
2.01
4.07
1.8
1.9
6453.6
16202.2
e6/l
1.56
30
152
29
130
2.27
4.02
1.4
1.2
35.4
33.8
u/ml
—
6
10
135
962
1.47
3.94
5.8
7.7
5.1
5.1
kpa
0.04
127
920
135
963
1.47
3.92
5.8
7.7
11.6
11.9
kpa
0.24
127
923
201
1542
1.38
3.90
4.2
4.0
719.8
362.7
ng/l
0.27
172
1280
64
385
1.71
3.85
3.5
3.3
24.2
24.4
mmol/l
0.09
52
348
95
636
1.55
3.74
2.6
2.1
390.9
367.9
nmol/l
0.43
90
576
133
961
1.45
3.62
5.9
7.7
0.6
1.4
mmol/l
1.07
100
753
17
62
2.77
3.60
1.1
1.1
2.1
3.3
u/ml
—
7
26
309
2558
1.31
3.58
3.1
3.0
1914.5
1696.0
ng/l
0.34
271
2193
111
777
1.49
3.55
3.1
3.3
2.0
2.2
mmol/l
0.25
88
619
77
498
1.59
3.52
3.9
3.5
1.2
2.0
mmol/l
0.90
60
372
42
229
1.87
3.51
1.4
1.4
—
—
—
0
0
68
430
1.63
3.41
6.6
9.3
23.8
24.6
mmol/l
1.10
63
403
177
1359
1.37
3.40
3.1
2.8
0.8
1.1
e6/l
1.42
99
786
32
161
2.02
3.38
1.8
1.4
—
—
—
0
0
32
161
2.02
3.38
1.8
1.4
—
—
—
0
0
298
2483
1.29
3.23
4.2
3.9
13.7
8.2
mg/mmol
0.73
205
1570
17
66
2.60
3.22
2.0
2.5
—
—
—
0
0
123
899
1.42
3.15
4.2
3.8
243.2
256.7
u/l
0.53
110
842
38
209
1.85
3.12
2.1
1.9
—
—
—
0
0
206
1641
1.33
3.10
1.9
1.8
1106.6
1194.9
nmol/l
0.76
157
1207
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
48
285
1.72
3.07
2.8
2.7
0.3
0.4
u/ml
1.19
34
163
266
2201
1.29
3.02
3.9
3.2
0.4
0.6
e6/l
1.04
202
1682
199
1585
1.32
2.99
1.7
1.6
1.4
1.2
mg/l
0.30
157
1231
48
289
1.70
2.93
2.4
2.9
—
—
—
0
0
333
2844
1.26
2.90
4.0
3.3
—
—
—
0
0
76
514
1.52
2.90
7.1
8.8
93.1
94.0
%
0.40
76
509
59
377
1.60
2.88
1.6
1.7
1.7
1.6
g/l
0.35
43
328
6
9
6.70
2.87
1.0
1.0
—
—
—
0
0
33
179
1.87
2.85
1.6
1.6
—
—
—
0
0
10
31
3.25
2.78
1.0
1.0
—
—
—
0
0
398
3485
1.24
2.76
4.6
4.2
—
—
—
0
0
362
3138
1.25
2.74
4.2
3.9
39.4
56.9
ng/l
0.56
258
2348
75
513
1.50
2.72
7.1
8.7
0.7
0.7
%
0.20
75
508
285
2406
1.26
2.71
3.1
2.6
55.5
56.4
u/l
0.19
260
2215
35
197
1.81
2.71
1.1
1.2
—
—
—
0
0
308
2625
1.26
2.70
3.6
3.5
2.3
2.4
mmol/l
0.10
256
2257
38
222
1.74
2.61
2.0
2.6
0.0
0.0
g/l
0.00
32
203
503
4536
1.23
2.59
3.6
3.2
64.4
55.3
u/l
0.96
471
4175
35
200
1.78
2.59
1.1
1.2
—
—
—
0
0
23
114
2.04
2.58
1.3
1.4
112.0
106.0
u/ml
—
5
18
38
223
1.73
2.57
2.0
2.6
0.0
0.0
g/l
0.00
32
203
100
734
1.40
2.53
2.3
2.5
6.7
7.1
ug/l
0.10
80
635
84
598
1.44
2.51
4.0
3.5
103.1
89.7
ng/l
0.57
72
512
232
1929
1.27
2.49
1.6
1.6
19.2
20.8
nmol/l
1.04
204
1613
23
116
2.01
2.47
1.3
1.2
—
—
—
0
0
47
296
1.62
2.46
1.9
2.5
3.1
3.2
g/l
0.42
37
229
42
257
1.66
2.46
3.3
3.6
39.9
80.5
mg/l
0.92
33
209
74
517
1.47
2.45
6.6
8.6
1.4
1.4
%
0.01
74
512
42
258
1.66
2.43
3.3
3.6
39.3
43.0
mg/l
0.10
33
211
20
97
2.08
2.38
1.2
1.7
70.1
64.5
%
—
8
67
29
161
1.83
2.37
1.6
1.3
—
—
—
0
0
5
8
6.28
2.37
1.2
1.5
—
—
—
0
0
55
365
1.54
2.33
2.3
3.4
4.2
4.5
pmol/l
0.86
43
318
46
294
1.59
2.29
1.8
2.5
11.0
10.7
g/l
0.16
37
248
203
1677
1.27
2.29
3.0
2.6
4.9
4.9
e6/l
0.00
180
1485
19
92
2.09
2.28
1.6
1.3
—
—
—
0
0
19
92
2.09
2.28
1.6
1.3
—
—
—
0
0
19
92
2.09
2.28
1.6
1.3
—
—
—
0
0
71
500
1.45
2.27
1.4
1.5
—
—
—
0
0
582
5369
1.22
2.26
4.7
3.8
15.0
15.0
pmol/l
0.02
534
4788
160
1285
1.29
2.25
3.3
3.0
2.1
2.2
e6/l
0.03
85
718
19
93
2.06
2.22
1.6
1.3
—
—
—
0
0
19
93
2.06
2.22
1.6
1.3
—
—
—
0
0
19
93
2.06
2.22
1.6
1.3
—
—
—
0
0
5
9
5.58
2.21
2.0
1.1
—
—
—
0
0
5
9
5.58
2.21
1.0
1.1
—
—
—
0
0
5
9
5.58
2.21
1.0
1.1
—
—
—
0
0
272
2337
1.23
2.15
4.7
3.4
36.1
34.7
u/l
0.11
256
2215
91
678
1.38
2.14
2.1
2.9
65.9
66.6
g/l
0.32
79
612
115
891
1.33
2.10
3.8
2.8
10.0
9.1
umol/l
0.10
97
787
694
6536
1.23
2.10
5.4
4.7
6.0
2.1
mu/l
0.46
636
5868
38
237
1.63
2.10
2.1
2.6
0.0
0.0
g/l
0.50
32
217
40
253
1.61
2.10
2.0
2.5
36.5
37.2
g/l
0.26
32
213
755
7179
1.25
2.07
22.5
15.9
26.5
26.5
mg/l
0.00
654
5796
9
32
2.83
2.00
1.0
1.0
—
—
—
0
0
47
315
1.52
1.94
1.9
2.4
3.8
3.8
g/l
0.19
37
225
5
11
4.56
1.94
1.4
1.2
—
—
—
0
0
5
11
4.56
1.94
1.4
1.1
—
—
—
0
0
5
11
4.56
1.94
1.4
1.1
96.6
109.3
%
—
5
11
135
1084
1.29
1.92
1.3
1.2
18.5
15.5
u/ml
0.10
42
401
47
316
1.51
1.92
1.9
2.4
—
—
—
0
0
47
316
1.51
1.92
1.9
2.4
7.1
7.5
g/l
0.98
38
235
13
58
2.26
1.91
1.1
1.1
—
—
—
0
0
41
269
1.55
1.87
2.0
2.8
0.2
1.3
g/l
2.18
33
234
183
1529
1.24
1.87
4.0
3.1
2.5
2.5
mmol/l
0.71
155
1339
13
59
2.22
1.84
1.2
1.0
—
—
—
0
0
18
94
1.93
1.81
1.1
1.1
1.7
1.6
g/l
0.36
18
80
36
232
1.57
1.78
1.7
1.6
—
—
—
0
0
392
3540
1.18
1.77
4.4
3.8
0.0
0.0
estimate
0.00
71
667
68
500
1.39
1.76
2.0
1.7
—
—
—
0
0
18
96
1.89
1.71
2.1
2.3
45.0
23.9
mg/l
—
6
23
29
179
1.64
1.71
2.2
2.1
120.6
128.0
g/l
0.74
18
131
138
1132
1.26
1.66
29.1
25.4
1.5
1.4
inr
—
10
141
107
852
1.29
1.64
1.5
1.3
—
—
—
0
0
23
135
1.72
1.63
1.9
1.8
—
—
—
0
0
20
114
1.77
1.57
2.1
2.7
—
629.4
—
0
13
27
168
1.62
1.56
2.4
1.6
—
—
—
0
0
395
3600
1.17
1.54
4.4
3.8
0.0
0.0
estimate
0.80
70
650
37
250
1.50
1.52
1.4
1.2
—
—
—
0
0
42
292
1.46
1.51
1.3
1.3
—
—
—
0
0
15
79
1.91
1.50
2.9
2.3
—
—
—
0
0
16
87
1.85
1.46
3.8
3.7
—
—
—
0
0
136
1132
1.23
1.45
1.3
1.2
36.6
40.3
iu/ml
0.11
39
349
54
397
1.38
1.44
2.3
2.2
0.7
0.7
%
0.67
49
382
388
3547
1.16
1.43
5.8
5.1
0.0
0.0
estimate
0.00
72
667
7
29
2.42
1.39
3.9
4.1
—
—
—
0
0
29
191
1.53
1.36
1.8
1.7
—
—
—
0
0
10
47
2.14
1.34
1.1
1.3
—
—
—
0
0
10
47
2.14
1.34
1.1
1.3
—
—
—
0
0
707
6774
1.17
1.32
4.5
4.1
1.4
1.3
mmol/l
1.18
645
6090
0
41
0.00
1.31
0.0
1.0
—
1.1
—
0
23
28
185
1.53
1.30
1.8
1.7
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
5
18
2.79
1.28
1.0
2.8
183.4
131.6
%
—
5
18
16
92
1.75
1.25
1.3
1.9
—
—
—
0
0
8
36
2.23
1.24
3.0
1.5
—
—
—
0
0
8
36
2.23
1.24
3.0
1.5
—
—
—
0
0
8
36
2.23
1.24
3.0
1.5
—
—
—
0
0
8
36
2.23
1.24
3.0
1.5
—
—
—
0
0
5
19
2.64
1.21
1.8
1.3
—
—
—
0
0
20
124
1.63
1.21
1.4
1.3
—
—
—
0
0
76
607
1.27
1.19
2.9
2.8
59.2
62.9
ml/min/173m2
0.50
35
250
708
6808
1.15
1.17
7.1
6.2
41.3
40.6
mmol/mol
1.13
661
6238
13
72
1.82
1.15
1.5
1.3
—
—
—
0
0
5
20
2.51
1.15
1.6
1.2
0.9
2.7
mmol/l
—
5
20
107
893
1.22
1.15
3.1
4.1
3.5
27.8
ug/l
1.86
88
750
40
293
1.38
1.13
1.1
1.0
—
—
—
0
0
12
66
1.83
1.09
1.0
1.2
—
—
u/ml
—
0
0
11
59
1.87
1.07
1.2
1.1
—
—
—
0
0
54
419
1.31
1.07
2.4
3.3
25.1
25.2
mmol/l
0.08
54
407
22
145
1.53
1.06
1.4
1.3
—
—
—
0
0
25
173
1.46
0.98
2.8
2.7
14.8
16.1
%
0.65
13
91
35
258
1.37
0.98
4.4
4.0
3.9
3.9
mmol/l
0.13
35
238
7
36
1.95
0.97
1.1
2.4
610.7
1856.1
u/ml
—
7
36
40
302
1.34
0.97
1.7
2.0
45.6
38.8
u/l
0.88
34
261
58
462
1.27
0.96
5.3
7.3
24.7
25.0
mmol/l
0.33
58
457
42
320
1.33
0.96
4.9
3.6
151.6
12261.3
u/ml
0.78
36
271
724
7008
1.14
0.95
4.9
4.6
1.4
1.5
mmol/l
0.65
662
6341
9
51
1.77
0.94
1.1
1.1
—
—
—
0
0
9
51
1.77
0.94
1.1
1.1
—
—
—
0
0
50
393
1.29
0.92
1.3
1.2
44.4
113.9
iu/ml
2.24
13
150
9
52
1.74
0.92
1.1
1.1
—
—
—
0
0
9
52
1.74
0.92
1.1
1.1
—
—
—
0
0
9
52
1.74
0.92
1.1
1.1
—
—
—
0
0
40
305
1.33
0.92
1.6
1.5
—
—
—
0
0
6
28
2.15
0.91
3.7
1.5
—
—
—
0
0
6
28
2.15
0.91
3.7
1.6
—
—
—
0
0
6
28
2.15
0.91
3.7
1.5
—
—
—
0
0
704
6814
1.13
0.88
20.8
14.9
75.1
76.3
ml/min/173m2
0.77
592
5649
8
43
1.87
0.87
2.1
2.0
—
—
—
0
0
87
735
1.20
0.86
1.8
1.8
1.7
1.6
%
0.48
73
612
728
7064
1.13
0.86
5.0
4.6
4.5
4.6
mmol/l
1.17
676
6452
30
221
1.37
0.86
1.4
1.5
293.6
269.3
ug/g
0.31
21
126
37
282
1.32
0.86
2.4
1.6
—
—
—
0
0
744
7230
1.13
0.86
5.7
5.2
2.6
2.7
mmol/l
1.21
689
6550
12
72
1.68
0.85
2.3
1.6
—
—
—
0
0
8
46
1.75
0.82
1.3
1.7
—
—
—
0
0
8
46
1.75
0.82
1.3
1.7
—
—
—
0
0
20
138
1.46
0.82
1.7
1.4
—
—
—
0
0
6
32
1.88
0.82
1.5
1.1
—
—
—
0
0
8
47
1.71
0.80
2.0
3.1
74.9
103.9
nmol/l
—
8
47
781
7626
1.13
0.78
14.6
10.9
26.7
26.2
u/l
0.31
760
7325
17
115
1.49
0.77
1.1
1.5
—
—
—
0
0
42
333
1.27
0.76
1.6
1.6
—
—
—
0
0
14
91
1.55
0.75
2.1
1.7
—
—
—
0
0
22
159
1.39
0.73
1.4
1.2
—
—
—
0
0
38
476
0.79
0.71
1.6
1.8
—
—
—
0
0
111
978
1.15
0.70
9.3
7.6
—
—
—
0
0
174
1581
1.12
0.69
5.1
4.3
1.0
1.0
kg/l
0.09
17
239
39
311
1.26
0.69
2.9
1.7
—
—
—
0
0
607
5866
1.10
0.68
28.3
19.5
14.0
13.8
%
1.94
598
5727
775
7582
1.12
0.67
25.3
18.7
139.5
139.6
mmol/l
0.78
762
7378
12
78
1.55
0.65
2.3
1.6
—
—
—
0
0
7
44
1.60
0.65
2.3
1.6
—
—
—
0
0
14
95
1.48
0.64
1.1
1.1
2.0
6.5
u/ml
—
5
39
5
30
1.67
0.61
1.0
1.0
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
211
1954
1.10
0.60
5.0
4.1
0.0
0.0
estimate
0.50
65
642
48
400
1.21
0.59
2.9
3.7
49.6
46.5
%
0.38
48
393
8
52
1.54
0.59
2.0
1.6
0.9
1.0
g/l
—
8
52
775
7598
1.11
0.58
25.6
18.9
4.0
4.0
mmol/l
0.14
761
7384
8
55
1.46
0.56
1.0
1.4
—
—
—
0
0
10
65
1.54
0.55
2.6
1.5
—
—
—
0
0
10
65
1.54
0.55
2.6
1.5
—
—
—
0
0
10
65
1.54
0.55
2.6
1.5
—
—
—
0
0
184
1701
1.10
0.55
1.9
1.7
429.9
25673159.9
pmol/l
1.42
161
1375
16
116
1.39
0.54
1.3
1.7
—
—
—
0
0
13
182
0.71
0.54
1.3
1.2
—
—
—
0
0
723
7078
1.09
0.52
5.4
4.8
6.1
6.1
mmol/l
0.79
663
6346
6
41
1.47
0.50
1.3
1.2
—
—
—
0
0
6
41
1.47
0.50
1.5
1.7
11.0
19.4
nmol/l
—
6
36
25
198
1.27
0.50
3.5
2.8
8.0
7.8
kpa
0.33
25
179
26
207
1.26
0.50
1.6
1.5
—
—
—
0
0
105
949
1.12
0.49
4.5
4.7
32.3
32.3
%
0.00
77
612
13
93
1.40
0.48
1.1
1.2
1.4
1.8
u/ml
—
7
23
7
46
1.53
0.48
2.0
1.2
—
—
—
0
0
653
6377
1.08
0.48
25.1
17.2
39.0
39.2
%
0.22
454
4228
20
155
1.30
0.47
2.4
1.6
2.5
5.3
iu/l
—
7
43
12
86
1.40
0.44
1.4
1.4
—
—
—
0
0
5
31
1.62
0.43
1.0
1.3
—
—
—
0
0
5
32
1.57
0.42
1.8
1.7
32.5
53.0
ug/l
—
5
32
8
58
1.38
0.41
1.3
1.6
—
—
—
0
0
5
35
1.43
0.39
1.8
1.2
—
—
—
0
0
5
35
1.43
0.39
1.8
1.2
—
—
—
0
0
22
178
1.24
0.39
1.6
1.5
—
—
—
0
0
801
7906
1.08
0.38
32.3
23.3
133.1
134.3
g/l
1.29
793
7759
12
158
0.76
0.37
2.2
1.2
3.9
3.8
mmol/l
0.17
12
148
15
116
1.30
0.37
1.1
1.6
—
—
—
0
0
10
72
1.39
0.37
1.2
1.7
—
—
—
0
0
5
78
0.64
0.35
1.0
1.1
—
—
—
0
0
19
153
1.25
0.35
1.1
1.1
—
—
—
0
0
6
43
1.40
0.35
1.7
1.3
—
—
—
0
0
6
43
1.40
0.35
1.7
1.3
—
—
—
0
0
206
1961
1.06
0.32
1.6
1.7
1.4
1.4
mmol/l
0.03
185
1612
18
146
1.24
0.32
1.2
1.5
—
—
—
0
0
15
119
1.26
0.32
2.3
1.6
—
—
—
0
0
16
129
1.24
0.30
1.2
1.5
—
—
—
0
0
91
843
1.09
0.30
3.6
3.6
—
—
—
0
0
5
72
0.69
0.26
5.2
1.7
—
2.6
—
0
26
5
73
0.68
0.26
1.0
1.1
—
—
—
0
0
15
180
0.83
0.24
2.2
1.2
479.2
498.9
mg/l
0.08
15
169
230
2382
0.95
0.23
4.7
4.3
21.6
21.6
%
0.01
109
1164
5
38
1.32
0.23
1.6
2.3
—
—
—
0
0
13
106
1.23
0.23
1.8
1.5
—
—
—
0
0
83
778
1.07
0.22
1.6
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
6
51
1.18
0.19
1.8
2.5
—
—
—
0
0
9
83
1.09
0.14
1.0
1.1
—
—
—
0
0
15
134
1.12
0.11
1.6
2.9
4.1
4.4
e9/l
0.28
15
134
12
106
1.13
0.10
1.1
1.1
—
—
—
0
0
5
46
1.09
0.09
1.0
1.2
—
—
—
0
0
5
47
1.06
0.09
1.0
1.2
—
—
—
0
0
23
213
1.08
0.09
1.7
2.5
44.3
97.5
ug/min
—
10
120
13
116
1.12
0.09
1.1
1.1
—
—
—
0
0
67
649
1.03
0.07
4.8
3.9
1.2
1.2
mmol/l
0.38
61
561
294
2973
0.98
0.07
4.7
4.9
5.6
3.3
ug/l
0.50
260
2649
11
122
0.90
0.07
1.6
1.4
301.3
212.1
miu/ml
—
5
57
11
99
1.11
0.06
1.0
1.0
—
—
—
0
0
169
1711
0.99
0.05
3.4
3.0
0.6
0.8
ug/l
2.37
114
1143
15
140
1.07
0.04
1.7
3.3
53.4
58.2
%
0.55
15
140
276
2739
1.01
0.04
4.9
4.1
—
—
—
0
0
18
176
1.02
0.00
1.4
1.7
—
—
—
0
0
11
113
0.97
0.00
1.5
2.3
30.0
32.6
pg
1.06
11
113
17
173
0.98
0.00
6.1
3.9
19.2
30.2
mg/l
—
9
113
20
203
0.98
0.00
1.3
1.9
1.9
2.8
mg/l
0.55
12
150
16
159
1.01
0.00
1.8
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
6
59
1.02
0.00
1.3
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
5.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
9
89
1.01
0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
2.0
—
0.4
—
0
9
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_OTHACUSKINSUNNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHACUSKINSUNNAS | 0.923 [0.74, 1.15] | 0.471 |
| Birth year | 0.993 [0.98, 1.0] | 0.128 |
During the follow-up period (1.1.1998 — 31.12.2019), 134 out of 829 females with L12_OTHACUSKINSUNNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHACUSKINSUNNAS | 1.121 [0.91, 1.38] | 0.29 |
| Birth year | 0.983 [0.97, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 194 out of 643 males with L12_OTHACUSKINSUNNAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_OTHACUSKINSUNNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.089% | 0.185% |
| 5 | 0.486% | 1.079% |
| 10 | 1.204% | 2.838% |
| 15 | 2.335% | 5.413% |
| 20 | 4.209% | 9.097% |
Relationships between endpoints
↥Index endpoint: L12_OTHACUSKINSUNNAS – Other and unspecified acute skin changes due to ultraviolet radiation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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