info icon

This is a non-core endpoint: only basic statistics are computed.

Other recurrent vertebral subluxation

M13_VERTEBSUBLUX

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M43.5
  • Cause of death: ICD-10 M43.5

2 out of 7 registries used, show all original rules.

42

4. Check minimum number of events

None

42

5. Include endpoints

None

42

6. Filter based on genotype QC (FinnGen only)

42

Control definitions (FinnGen only)

Control exclude
M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M43
Name in latin
Alia subluxatio vertebralis recurrens

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 199 123 76
Only index persons 173 107 66
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population - 54.85 54.56
Only index persons 52.67 53.18 51.84

-FinnGen-

Key figures

All Female Male
Number of individuals 42 30 12
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 57.83 59.20 54.40

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3021440) Promyelocytes/100 leukocytes in Blood
14
22
9.05
9.18
6.4
4.9
%
0.4
0.4
—
5
8
(3017181) Myelocytes/100 leukocytes in Blood
14
26
7.58
7.86
6.5
4.6
%
0.8
1.1
—
5
11
(3018418) pH of Serum or Plasma
25
90
5.39
6.83
5.8
3.9
ph
7.4
7.4
1.33
12
15
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
16
39
6.01
6.81
5.7
3.1
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
14
31
6.27
6.55
13.6
3.1
—
—
—
0
0
(3029937) Albumin [Presence] in Urine by Test strip
23
87
4.63
5.69
11.3
3.6
estimate
0.0
0.0
0.00
15
32
(3032080) INR in Blood by Coagulation assay
30
145
4.74
5.24
12.8
8.3
inr
1.2
1.3
0.54
18
49
(3035350) Ketones [Presence] in Urine by Test strip
30
154
4.32
4.62
9.1
3.8
estimate
0.0
0.0
0.00
15
33
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
31
163
4.44
4.61
9.7
5.7
mmol/l
1.2
1.2
0.79
23
130
(40760892) CBC W Ordered Manual Differential panel - Blood
20
80
3.86
4.37
7.2
4.7
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
12
34
4.54
4.12
2.5
1.5
—
—
—
0
0
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
28
148
3.68
3.90
3.1
2.2
nmol/l
91.9
79.0
1.17
28
123
(3021601) Nitrite [Presence] in Urine by Test strip
29
159
3.66
3.77
9.7
5.4
estimate
0.0
0.0
0.00
16
33
(3045414) Leukocytes [Presence] in Urine
7
9
9.04
3.71
1.3
1.3
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
12
37
4.14
3.67
5.8
2.3
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
29
161
3.59
3.65
9.3
3.8
estimate
0.0
0.0
0.00
15
31
(1616796) Gas panel - Central venous blood
6
6
11.37
3.61
8.7
1.7
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
21
98
3.29
3.47
11.6
3.8
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
22
107
3.22
3.37
10.5
4.5
—
—
—
0
0
(3022145) Colonoscopy Study observation
11
35
3.90
3.20
1.3
1.4
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
34
230
3.50
3.03
9.9
4.4
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
8
18
5.22
2.96
1.9
3.2
—
—
—
0
0
(3003338) MCHC [Mass/volume]
18
283
0.36
2.58
34.1
16.8
g/l
326.7
330.8
0.51
18
283
(3007164) IgA [Mass/volume] in Serum or Plasma
14
60
3.00
2.55
1.3
1.5
g/l
2.4
2.4
—
9
42
(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum
15
68
2.88
2.47
1.5
1.2
u/ml
0.6
0.6
—
7
19
(40768797) Stomach Pathology biopsy report
10
37
3.23
2.29
1.5
1.2
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
22
128
2.51
2.18
11.9
3.8
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
19
104
2.51
2.13
3.5
2.3
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
9
33
3.19
2.08
2.1
1.4
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
15
74
2.60
2.07
8.8
3.0
—
—
—
0
0
(40761535) Cells panel - Urine sediment
6
18
3.71
1.82
3.0
3.9
—
—
—
0
0
(3019309) Folate [Moles/volume] in Red Blood Cells
14
71
2.46
1.80
2.0
1.7
nmol/l
1919.0
1078.9
—
9
45
(3030467) Casts [#/volume] in Urine by Automated count
14
73
2.38
1.69
5.5
3.1
e6/l
0.3
0.4
0.11
14
55
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
5
14
3.90
1.66
3.4
2.8
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
22
142
2.15
1.59
2.3
1.8
pmol/l
88.2
104.0
—
9
59
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
23
152
2.13
1.55
6.9
3.9
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
13
68
2.32
1.54
5.7
3.0
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
9
41
2.51
1.48
2.2
1.8
—
—
—
0
0
(3044889) 12 lead EKG panel
31
233
2.26
1.47
5.7
3.8
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
6
24
2.74
1.35
2.3
1.3
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
19
123
1.99
1.30
6.1
3.2
—
—
—
0
0
(3015736) pH of Urine
19
123
1.99
1.30
7.1
3.5
—
—
—
0
0
(3000991) Gas panel - Venous blood
5
20
2.69
1.18
10.6
7.0
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
16
102
1.92
1.12
5.7
3.2
—
—
—
0
0
(3013512) EKG study
18
120
1.88
1.10
3.6
3.8
—
—
—
0
0
(3002385) Erythrocyte distribution width [Ratio]
34
284
2.03
1.09
34.9
15.6
%
14.5
13.8
1.15
34
279
(40758558) Short blood count panel - Blood
13
79
1.93
1.03
6.8
8.3
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
0
30
0.00
1.02
0.0
1.5
—
—
—
0
0
(3022217) INR in Platelet poor plasma by Coagulation assay
8
46
1.91
0.89
26.4
24.3
—
1.4
—
0
10
(3019832) Treponema pallidum Ab [Presence] in Serum
0
24
0.00
0.82
0.0
2.0
—
—
—
0
0
(3023520) Reticulocytes [#/volume] in Blood
5
23
2.33
0.79
2.0
2.7
e9/l
57.9
73.4
—
5
17
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
5
24
2.22
0.77
2.6
1.4
—
—
—
0
0
(3002256) Pathology report gross observation
7
44
1.71
0.69
1.6
1.2
—
—
—
0
0
(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma
8
49
1.78
0.67
2.8
2.0
mmol/l
2.4
2.5
—
8
44
(46235355) HIV 1 and 2 tests - Meaningful Use set
8
52
1.66
0.64
1.5
2.1
—
—
—
0
0
(3001019) Free T4 and TSH panel - Serum or Plasma
0
21
0.00
0.62
0.0
2.0
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
6
34
1.89
0.62
1.3
1.5
—
—
—
0
0
(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum
0
23
0.00
0.60
0.0
2.3
—
—
—
0
0
(3024561) Albumin [Mass/volume] in Serum or Plasma
18
140
1.50
0.55
7.3
3.0
g/l
31.3
35.6
1.90
18
126
(3009542) Hematocrit [Volume Fraction] of Blood
28
317
0.65
0.54
21.5
13.7
%
39.5
40.0
0.16
16
213
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
6
40
1.58
0.54
4.5
3.1
e6/l
2.0
3.5
—
6
20
(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting
37
340
1.74
0.52
4.3
4.2
mmol/l
1.3
1.2
0.25
32
295
(40768804) Tissue Pathology biopsy report
18
142
1.47
0.50
2.9
2.1
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
18
144
1.44
0.46
2.9
2.7
—
—
—
0
0
(4035726)
5
31
1.69
0.45
1.2
1.4
—
—
—
0
0
(3003396) Base excess in Arterial blood by calculation
5
32
1.64
0.44
8.0
6.0
mmol/l
1.6
0.9
—
5
23
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
24
205
1.40
0.41
2.0
3.0
—
—
—
0
0
(3004716) Salmonella sp identified in Stool by Organism specific culture
0
18
0.00
0.41
0.0
1.5
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
6
46
1.35
0.35
1.3
1.7
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
10
75
1.44
0.34
3.4
2.5
—
—
—
0
0
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
7
52
1.41
0.33
1.4
1.5
—
—
—
0
0
(1761482) Bacteria [#/volume] in Urine by Culture
0
11
0.00
0.21
0.0
5.3
—
—
—
0
0
(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma
0
13
0.00
0.21
0.0
1.7
—
—
—
0
0
(3019473) Protein [Mass/volume] in Cerebral spinal fluid
0
13
0.00
0.21
0.0
1.2
—
404.7
—
0
13
(3049717) Cytology report of Urine Cyto stain
0
14
0.00
0.20
0.0
3.1
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
8
94
0.82
0.15
1.9
1.6
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
5
62
0.78
0.09
1.4
1.6
—
—
—
0
0
(3019150) Specific gravity of Urine by Refractometry
7
66
1.07
0.08
7.3
4.1
—
1.0
—
0
11
(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.5
—
16.2
—
0
6
(3004616) Nuclear Ab [Presence] in Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
(3023410) Appearance of Cerebral spinal fluid
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3050129) First trimester maternal screen panel - Serum or Plasma
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3051611) Lipemic interference index of Serum or Plasma
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
(21494434) Karyotype in Bone marrow
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(4146454)
0
5
0.00
0.00
0.0
4.0
—
—
—
0
0
(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(42529406) Shigella sp [Presence] in Stool by Culture
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3006418) Campylobacter sp identified in Tissue by Organism specific culture
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
(3048929) Epstein Barr virus Ab [Presence] in Serum
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3002523) Influenza virus A Ag [Presence] in Specimen
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3016018) Differential panel - Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma
6
61
0.98
0.00
5.0
4.6
%
33.7
30.7
—
6
33
(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3003740) Influenza virus B Ag [Presence] in Specimen
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3023420) DNA double strand Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
(3014765) Yersinia sp identified in Stool by Organism specific culture
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3025130) Human papilloma virus identified in Specimen
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(4268621)
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
(3044290) Cell count panel - Cerebral spinal fluid
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
(3039162) Centromere protein B Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint M13_VERTEBSUBLUX and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_VERTEBSUBLUX.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: M13_VERTEBSUBLUX – Other recurrent vertebral subluxation

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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