Other recurrent vertebral subluxation

M13_VERTEBSUBLUX

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M43.5 Cause of death: ICD-10 — M43.5 2 out of 7 registries used, show all original rules.	42
4. Check minimum number of events None	42
5. Include endpoints None	42
6. Filter based on genotype QC (FinnGen only)	42

Control definitions (FinnGen only)

Control exclude: M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M43
Name in latin: Alia subluxatio vertebralis recurrens

NAME	M13_VERTEBSUBLUX
CONTROL_EXCLUDE	M13_DORSOPATHY
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M435
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M435
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other recurrent vertebral subluxation based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	199	123	76
Only index persons	173	107	66
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	-	54.85	54.56
Only index persons	52.67	53.18	51.84

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	42	30	12
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	57.83	59.20	54.40

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3021440) Promyelocytes/100 leukocytes in Blood

9.05

9.18

6.4

4.9

0.4

—

(3017181) Myelocytes/100 leukocytes in Blood

7.58

7.86

6.5

4.6

0.8

1.1

—

(3018418) pH of Serum or Plasma

5.39

6.83

5.8

3.9

7.4

1.33

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

6.01

6.81

5.7

3.1

—

(40761536) Microorganisms panel - Urine sediment

6.27

6.55

13.6

3.1

—

(3029937) Albumin [Presence] in Urine by Test strip

4.63

5.69

11.3

3.6

0.0

estimate

0.00

(3032080) INR in Blood by Coagulation assay

145

4.74

5.24

12.8

8.3

1.2

1.3

inr

0.54

(3035350) Ketones [Presence] in Urine by Test strip

154

4.32

4.62

9.1

3.8

0.0

estimate

0.00

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

163

4.44

4.61

9.7

5.7

1.2

mmol/l

0.79

130

(40760892) CBC W Ordered Manual Differential panel - Blood

3.86

4.37

7.2

4.7

—

(3007853) Bacteria identified in Skin by Aerobe culture

4.54

4.12

2.5

1.5

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

148

3.68

3.90

3.1

2.2

91.9

79.0

nmol/l

1.17

123

(3021601) Nitrite [Presence] in Urine by Test strip

159

3.66

3.77

9.7

5.4

0.0

estimate

0.00

(3045414) Leukocytes [Presence] in Urine

9.04

3.71

1.3

—

(3042936) Bacteria identified in Isolate by Culture

4.14

3.67

5.8

2.3

—

(3009261) Glucose [Presence] in Urine by Test strip

161

3.59

3.65

9.3

3.8

0.0

estimate

0.00

(1616796) Gas panel - Central venous blood

11.37

3.61

8.7

1.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

3.29

3.47

11.6

3.8

—

(42870588) Differential panel, method unspecified - Blood

107

3.22

3.37

10.5

4.5

—

(3022145) Colonoscopy Study observation

3.90

3.20

1.3

1.4

—

(3037467) Urinalysis macro (dipstick) panel - Urine

230

3.50

3.03

9.9

4.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

5.22

2.96

1.9

3.2

—

(3003338) MCHC [Mass/volume]

283

0.36

2.58

34.1

16.8

326.7

330.8

g/l

0.51

283

(3007164) IgA [Mass/volume] in Serum or Plasma

3.00

2.55

1.3

1.5

2.4

g/l

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

2.88

2.47

1.5

1.2

0.6

u/ml

—

(40768797) Stomach Pathology biopsy report

3.23

2.29

1.5

1.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

128

2.51

2.18

11.9

3.8

—

(3044640) Blood type and Crossmatch panel - Blood

104

2.51

2.13

3.5

2.3

—

(3000494) Fungus identified in Specimen by Culture

3.19

2.08

2.1

1.4

—

(3023368) Bacteria identified in Blood by Culture

2.60

2.07

8.8

3.0

—

(40761535) Cells panel - Urine sediment

3.71

1.82

3.0

3.9

—

(3019309) Folate [Moles/volume] in Red Blood Cells

2.46

1.80

2.0

1.7

1919.0

1078.9

nmol/l

—

(3030467) Casts [#/volume] in Urine by Automated count

2.38

1.69

5.5

3.1

0.3

0.4

e6/l

0.11

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

3.90

1.66

3.4

2.8

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

142

2.15

1.59

2.3

1.8

88.2

104.0

pmol/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

152

2.13

1.55

6.9

3.9

—

(36304419) Bacteria [Presence] in Urine

2.32

1.54

5.7

3.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.51

1.48

2.2

1.8

—

(3044889) 12 lead EKG panel

233

2.26

1.47

5.7

3.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.74

1.35

2.3

1.3

—

(3026008) Bacteria identified in Urine by Culture

123

1.99

1.30

6.1

3.2

—

(3015736) pH of Urine

123

1.99

1.30

7.1

3.5

—

(3000991) Gas panel - Venous blood

2.69

1.18

10.6

7.0

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

102

1.92

1.12

5.7

3.2

—

(3013512) EKG study

120

1.88

1.10

3.6

3.8

—

(3002385) Erythrocyte distribution width [Ratio]

284

2.03

1.09

34.9

15.6

14.5

13.8

1.15

279

(40758558) Short blood count panel - Blood

1.93

1.03

6.8

8.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

1.02

0.0

1.5

—

(3022217) INR in Platelet poor plasma by Coagulation assay

1.91

0.89

26.4

24.3

—

1.4

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.00

0.82

0.0

2.0

—

(3023520) Reticulocytes [#/volume] in Blood

2.33

0.79

2.0

2.7

57.9

73.4

e9/l

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.22

0.77

2.6

1.4

—

(3002256) Pathology report gross observation

1.71

0.69

1.6

1.2

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

1.78

0.67

2.8

2.0

2.4

2.5

mmol/l

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.66

0.64

1.5

2.1

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.62

0.0

2.0

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.89

0.62

1.3

1.5

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.00

0.60

0.0

2.3

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

140

1.50

0.55

7.3

3.0

31.3

35.6

g/l

1.90

126

(3009542) Hematocrit [Volume Fraction] of Blood

317

0.65

0.54

21.5

13.7

39.5

40.0

0.16

213

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

1.58

0.54

4.5

3.1

2.0

3.5

e6/l

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

340

1.74

0.52

4.3

4.2

1.3

1.2

mmol/l

0.25

295

(40768804) Tissue Pathology biopsy report

142

1.47

0.50

2.9

2.1

—

(1761868) Lipid panel - Serum or Plasma

144

1.44

0.46

2.9

2.7

—

(4035726)

1.69

0.45

1.2

1.4

—

(3003396) Base excess in Arterial blood by calculation

1.64

0.44

8.0

6.0

1.6

0.9

mmol/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

205

1.40

0.41

2.0

3.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.41

0.0

1.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.35

0.35

1.3

1.7

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.44

0.34

3.4

2.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.41

0.33

1.4

1.5

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.21

0.0

5.3

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.5

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.21

0.0

1.5

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

404.7

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.20

0.0

3.1

—

(3003694) ABO and Rh group [Type] in Blood

0.82

0.15

1.9

1.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.78

0.09

1.4

1.6

—

(3019150) Specific gravity of Urine by Refractometry

1.07

0.08

7.3

4.1

—

1.0

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

1.5

—

16.2

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.0

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.7

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.3

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.0

1.0

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.8

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.7

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.3

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.7

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.4

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

2.7

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(4146454)

0.00

0.0

4.0

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.6

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.0

1.4

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.0

1.4

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

2.3

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.0

1.6

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.0

1.4

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.1

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.1

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.2

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

1.2

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

0.98

0.00

5.0

4.6

33.7

30.7

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

2.0

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.0

1.4

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

1.4

—

(4268621)

0.00

0.0

2.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.3

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.7

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

1.3

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_VERTEBSUBLUX and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_VERTEBSUBLUX.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: M13_VERTEBSUBLUX – Other recurrent vertebral subluxation

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other recurrent vertebral subluxation

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints