Malignant neoplasm of peripheral nerves and autonomic nervous system

C3_PERIPHERAL_NERVES_AUTONOMIC3_NERVESYSTEM

tumour of cranial and spinal nerves: ['A benign or malignant neoplasm arising from a peripheral nerve or the perineural sheaths.', 'Neoplasms which arise from peripheral nerve tissue. This includes NEUROFIBROMAS; SCHWANNOMAS; GRANULAR CELL TUMORS; and malignant peripheral NERVE SHEATH NEOPLASMS. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp1750-1)']

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Cause of death: ICD-10 — C47 Cause of death: ICD-9 — 1928 Cause of death: ICD-8 — 192[4-5] Cancer registry: Topography ICD-O-3 — C47 Cancer registry: Morphology ICD-O-3 — ANY Cancer registry: Behaviour codes — 3 2 out of 7 registries used, show all original rules.	44
4. Check minimum number of events None	44
5. Include endpoints None	44
6. Filter based on genotype QC (FinnGen only)	44

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF9

NAME	C3_PERIPHERAL_NERVES_AUTONOMIC3_NERVESYSTEM
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	C47
COD_ICD_9	1928
COD_ICD_8	192[4-5]
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO	C47
CANC_TOPO_EXCL
CANC_MORPH	ANY
CANC_MORPH_EXCL
CANC_BEHAV	3

Similar endpoints

↥

List of similar endpoints to Malignant neoplasm of peripheral nerves and autonomic nervous system based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	44	23	21
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	16.95	14.81	19.29

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3000991) Gas panel - Venous blood

4.88

3.94

7.7

9.8

—

(40768804) Tissue Pathology biopsy report

128

3.21

3.50

2.5

1.7

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

3.11

3.06

3.4

2.5

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

4.43

2.86

6.3

4.1

0.9

1.5

mmol/l

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

3.33

2.60

2.6

3.7

203.0

242.8

u/l

1.22

(3044640) Blood type and Crossmatch panel - Blood

104

2.69

2.54

3.6

2.4

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

4.68

2.47

6.7

7.5

—

(4035726)

3.63

2.39

1.4

1.2

—

(3002256) Pathology report gross observation

3.30

2.38

1.3

1.1

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.84

2.31

7.6

13.8

24.5

24.7

mmol/l

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

101

2.55

2.26

5.6

3.1

2.4

mmol/l

0.77

(3014007) Fractional oxyhemoglobin in Arterial blood

4.16

2.01

8.7

7.0

97.0

91.7

—

(3022096) Basophils/100 leukocytes in Blood

149

2.34

1.99

4.3

7.5

0.6

0.06

138

(3006504) Eosinophils/100 leukocytes in Blood

150

2.32

1.94

4.4

7.5

3.1

2.8

0.30

141

(3019069) Monocytes/100 leukocytes in Blood

151

2.30

1.90

4.5

7.7

8.3

0.41

143

(3002030) Lymphocytes/100 leukocytes in Blood

156

2.18

1.71

4.4

7.5

26.2

28.3

0.36

147

(3052851) Hemolysis interference index of Serum or Plasma

3.88

1.66

2.6

2.9

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.79

1.59

8.3

5.7

106.6

103.5

mmol/l

—

(3023368) Bacteria identified in Blood by Culture

2.22

1.56

5.1

4.5

—

(3018010) Neutrophils/100 leukocytes in Blood

153

2.05

1.49

4.5

7.3

57.3

58.2

0.11

145

(3013650) Neutrophils [#/volume] in Blood by Automated count

196

1.98

1.32

11.4

11.6

3.9

4.5

e9/l

0.95

168

(3012544) pH of Venous blood

2.58

1.18

5.6

7.7

—

(3019309) Folate [Moles/volume] in Red Blood Cells

2.15

1.12

1.4

1.6

463.8

1041.8

nmol/l

—

(3027945) Reticulocytes/100 erythrocytes in Blood

2.33

1.11

2.3

1.9

2.0

1.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

157

1.80

1.06

4.6

4.0

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

171

1.72

0.93

9.3

6.6

13.3

9.7

umol/l

0.93

163

(42870588) Differential panel, method unspecified - Blood

116

1.76

0.93

4.1

6.6

—

(3042936) Bacteria identified in Isolate by Culture

2.00

0.92

2.3

2.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

0.45

0.92

5.8

3.1

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

258

0.59

0.90

2.6

3.3

—

(40758558) Short blood count panel - Blood

1.74

0.82

10.1

7.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

127

0.55

0.80

4.9

3.8

—

(3037467) Urinalysis macro (dipstick) panel - Urine

236

1.67

0.79

6.3

4.4

—

(3024354) Oxygen [Partial pressure] in Venous blood

2.22

0.77

6.6

6.4

4.6

4.8

kpa

—

(3019225) pH of Specimen

2.12

0.75

2.8

4.6

—

(3013707) Erythrocyte sedimentation rate by Westergren method

240

1.61

0.70

3.0

4.0

8.2

10.2

mm/h

0.74

221

(4010399)

1.88

0.68

1.2

1.6

—

(3009542) Hematocrit [Volume Fraction] of Blood

309

1.65

0.65

25.3

13.7

40.7

40.8

0.04

236

(36660697) Celiac disease serology panel - Serum

1.75

0.63

1.2

—

(3000492) Spirometry study

1.75

0.63

1.2

1.4

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.62

0.0

1.4

—

(3008898) HLA-B27 [Presence]

0.00

0.62

0.0

1.1

—

(3021589) Normoblasts [#/volume] in Blood

157

1.50

0.58

7.1

10.3

0.0

e9/l

0.50

123

(1761868) Lipid panel - Serum or Plasma

116

0.62

0.55

2.5

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

107

1.45

0.44

5.0

4.0

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.63

0.44

2.2

3.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.53

0.44

2.2

7.8

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

1.58

0.43

4.0

3.6

31.0

35.3

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.42

0.0

1.3

—

129.0

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.42

0.0

1.6

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.42

0.0

2.9

—

1.3

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.42

0.0

1.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.53

0.42

2.8

1.9

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.53

0.42

3.2

2.2

40.2

22.3

u/l

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.41

0.0

1.5

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.9

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.41

0.0

2.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

0.61

0.40

1.8

—

(3009508) Creatinine [Moles/volume] in Urine

1.44

0.39

4.6

3.5

6.3

7.5

mmol/l

0.64

(3044889) 12 lead EKG panel

206

1.36

0.39

3.7

3.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

0.69

0.35

1.6

2.0

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

301

1.39

0.33

4.1

4.6

37.1

39.2

mmol/mol

0.67

278

(3026008) Bacteria identified in Urine by Culture

1.33

0.25

4.7

3.2

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.40

0.24

1.8

2.4

416.0

427.5

nmol/l

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.40

0.24

2.4

2.0

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.36

0.24

4.0

10.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.21

0.22

1.4

1.5

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.21

0.0

1.1

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.21

0.0

1.4

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.21

0.0

1.4

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.21

0.0

1.4

—

(3020891) Body temperature

0.00

0.21

0.0

6.1

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.30

0.21

1.3

1.5

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.20

0.0

1.6

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.20

0.0

1.2

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.20

0.0

1.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.27

0.19

2.4

2.0

—

(3013512) EKG study

1.28

0.19

3.0

4.1

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

362

1.36

0.17

25.6

15.3

78.1

75.9

umol/l

0.17

362

(36304419) Bacteria [Presence] in Urine

1.24

0.16

5.2

3.9

—

(3003694) ABO and Rh group [Type] in Blood

104

0.83

0.15

2.0

1.6

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.23

0.14

2.6

4.0

—

(40761511) CBC panel - Blood by Automated count

368

0.88

0.08

17.1

11.0

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

110

1.13

0.05

3.1

3.9

55.3

30.5

ng/l

—

(3015736) pH of Urine

142

0.98

0.00

4.4

3.7

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.0

2.7

—

8.8

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.84

0.00

1.6

1.7

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

3.7

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.0

2.7

—

5.0

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.0

1.1

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

1.8

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

3.0

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

0.0

1.2

—

21.0

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

3.0

—

4.0

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

3.0

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

40.9

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

4.4

—

58.4

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3006245) CD3-CD19+ cells/100 cells in Blood

0.00

0.0

3.4

—

1.8

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3024928) Oxygen saturation in Venous blood

0.00

0.0

3.7

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

3.0

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.2

—

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

0.00

0.0

1.5

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

3.0

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

1.8

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.0

1.2

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.0

1.3

—

1.8

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

0.00

0.0

1.0

—

0.5

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

4.7

—

22.2

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

3.0

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

3.0

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3043453) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum

0.00

0.0

1.2

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.0

1.2

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

0.93

0.00

1.1

1.3

—

1.2

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.2

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.0

2.8

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

3.0

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

1.4

—

4.2

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

0.0

1.2

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

3.0

—

104.4

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

-0.00

0.0

1.4

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.7

—

10.8

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

-0.00

0.0

1.6

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

-0.00

0.0

1.4

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.1

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: C3_PERIPHERAL_NERVES_AUTONOMIC3_NERVESYSTEM – Malignant neoplasm of peripheral nerves and autonomic nervous system

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Malignant neoplasm of peripheral nerves and autonomic nervous system

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Malignant neoplasm of peripheral nerves and autonomic nervous system (C3_PERIPHERAL_NERVES_AUTONOMIC3_NERVESYSTEM)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints