Benign neoplasm of mesothelial tissue

CD2_BENIGN_MESOTHELIAL

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D19 Cause of death: ICD-10 — D19 2 out of 7 registries used, show all original rules.	42
4. Check minimum number of events None	42
5. Include endpoints CD2_BENIGN_MESOTHELIAL_PLEURA CD2_BENIGN_MESOTHELIAL_PERITONEUM CD2_BENIGN_MESOTHELIAL_NOS	42
6. Filter based on genotype QC (FinnGen only)	42

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 2
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D10-D36
Name in latin: Neoplasma benignum mesotheliale

NAME	CD2_BENIGN_MESOTHELIAL
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	CD2_BENIGN_MESOTHELIAL_PLEURA\|CD2_BENIGN_MESOTHELIAL_PERITONEUM\|CD2_BENIGN_MESOTHELIAL_NOS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D19
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D19
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Benign neoplasm of mesothelial tissue based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	333	200	131
Only index persons	287	179	108
Unadjusted period prevalence (%)
Whole population	0.00	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	53.33	51.89	55.73
Only index persons	51.30	49.81	53.77

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	42	30	12
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	48.93	44.19	60.78

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3022145) Colonoscopy Study observation

3.79

2.86

1.3

1.4

—

(3042936) Bacteria identified in Isolate by Culture

2.82

1.97

1.5

2.0

—

(3019060) Gas panel - Arterial blood

3.00

1.49

2.2

4.3

—

(4035726)

2.50

1.17

1.6

1.2

—

(42870588) Differential panel, method unspecified - Blood

102

1.92

1.12

3.9

4.5

—

(3002256) Pathology report gross observation

2.11

1.09

1.3

1.2

—

(3000991) Gas panel - Venous blood

0.00

0.82

0.0

6.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.75

0.76

1.3

1.4

—

(3025941) Bacteria identified in Stool by Culture

1.96

0.71

1.0

1.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

162

1.59

0.70

4.6

4.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.70

0.69

1.8

2.3

—

(3006504) Eosinophils/100 leukocytes in Blood

153

1.59

0.68

4.0

4.9

1.95

2.74

1.17

141

(3041096) Erythrocytes [Presence] in Urine by Automated

1.64

0.68

3.2

3.5

—

(3019069) Monocytes/100 leukocytes in Blood

154

1.57

0.66

3.9

5.2

8.09

8.33

0.13

143

(3002385) Erythrocyte distribution width [Ratio]

290

1.64

0.65

15.5

15.6

13.17

13.58

1.57

284

(3018010) Neutrophils/100 leukocytes in Blood

155

1.55

0.64

3.7

4.9

54.91

56.76

0.26

146

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

127

1.57

0.63

3.1

4.2

—

(3022096) Basophils/100 leukocytes in Blood

147

1.53

0.60

4.1

4.8

0.52

0.66

0.60

134

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.60

0.0

1.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

110

1.57

0.60

2.5

3.1

—

(3019150) Specific gravity of Urine by Refractometry

1.65

0.56

1.7

5.1

—

1.02

—

(3003338) MCHC [Mass/volume]

293

1.59

0.54

14.1

16.8

333.24

331.53

g/l

0.66

293

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.59

0.51

2.4

1.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.59

0.51

1.6

1.5

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

272

1.53

0.50

3.2

4.0

15.01

14.52

pmol/l

0.58

248

(3009542) Hematocrit [Volume Fraction] of Blood

319

1.58

0.47

12.9

13.2

41.55

40.01

1.03

243

(36304419) Bacteria [Presence] in Urine

1.51

0.46

2.5

2.7

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

194

1.41

0.43

4.3

4.6

6.93

6.49

mmol/l

0.44

180

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.42

0.0

1.9

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.42

0.0

3.7

—

1.51

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.42

0.0

1.3

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

0.00

0.41

0.0

4.2

—

128.35

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.41

0.0

1.2

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

0.59

0.40

2.0

1.9

3.16

3.20

mg/l

—

(3002030) Lymphocytes/100 leukocytes in Blood

157

1.38

0.39

4.1

5.1

26.59

28.66

0.33

147

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.54

0.38

1.5

2.7

35.33

13.44

umol/l

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.50

0.37

2.3

1.6

—

(3026008) Bacteria identified in Urine by Culture

1.43

0.37

3.3

3.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

130

1.37

0.36

1.4

1.8

103.91

98.12

pmol/l

—

(3044889) 12 lead EKG panel

239

1.36

0.35

3.4

3.5

—

(1761868) Lipid panel - Serum or Plasma

123

1.34

0.31

2.6

2.7

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

0.65

0.29

1.6

3.8

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

328

1.40

0.26

4.2

4.5

1.66

1.92

mu/l

0.89

297

(3003694) ABO and Rh group [Type] in Blood

0.69

0.25

1.1

1.4

—

(3044640) Blood type and Crossmatch panel - Blood

118

1.28

0.23

1.9

2.2

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.3

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.21

0.0

1.3

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.21

0.0

1.3

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.21

0.0

3.2

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.21

0.0

1.3

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.21

0.0

1.2

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.21

0.0

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.21

0.0

1.2

—

(3037121) Protein [Mass/volume] in Urine

0.00

0.21

0.0

3.9

—

0.16

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.21

0.0

1.7

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

0.00

0.20

0.0

4.6

—

24.32

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.20

0.0

3.9

—

0.76

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.18

0.19

1.4

1.7

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.21

0.17

4.3

4.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

249

0.83

0.16

3.0

3.1

—

(3023368) Bacteria identified in Blood by Culture

1.25

0.15

8.7

3.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

236

1.15

0.10

4.7

4.3

—

(3013512) EKG study

1.18

0.09

2.7

3.9

—

(40758558) Short blood count panel - Blood

1.18

0.09

3.7

7.7

—

(40768804) Tissue Pathology biopsy report

160

1.10

0.05

3.0

1.9

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

119

0.90

0.04

2.1

3.3

19.27

29.68

u/l

2.60

112

(3001122) Ferritin [Mass/volume] in Serum or Plasma

153

0.97

0.00

2.3

2.7

71.44

88.30

ug/l

0.47

137

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

324

0.95

0.00

11.4

12.5

94.67

84.68

ml/min/173m2

1.99

262

(3015736) pH of Urine

126

1.05

0.00

1.9

3.8

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

(3010130) Cytomegalovirus IgG Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.1

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.9

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.1

—

(40768797) Stomach Pathology biopsy report

1.05

0.00

1.0

1.2

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3028626) Oxygen [Partial pressure] in Capillary blood

0.00

0.0

1.6

—

8.34

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

5.5

—

1.52

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.00

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.0

1.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.02

0.00

2.0

1.8

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.0

1.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.1

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.0

1.3

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.0

1.4

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

2.2

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

4.8

—

106.60

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.00

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.1

—

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.0

3.6

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.0

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.7

—

(4268621)

0.00

0.0

1.2

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

4.8

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

0.25

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

2.4

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.0

1.6

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

7.7

—

181.83

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.4

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.0

1.1

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.05

0.00

1.0

1.9

1.36

1.34

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

5.5

—

6.70

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.3

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.00

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.2

—

(1616796) Gas panel - Central venous blood

0.00

0.0

1.4

—

(3003181) Sodium [Moles/volume] in Urine

0.00

0.0

1.8

—

50.00

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

4.8

—

4.04

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

1.5

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.5

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.3

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

1.67

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.4

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.0

1.2

—

109.80

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.3

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.94

0.00

1.7

1.4

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3024928) Oxygen saturation in Venous blood

0.00

0.0

3.8

—

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_MESOTHELIAL and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_MESOTHELIAL.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_MESOTHELIAL – Benign neoplasm of mesothelial tissue

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Benign neoplasm of mesothelial tissue

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints