Benign neoplasm: Penis

CD2_BENIGN_PENIS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only males

226837

2. Check conditions

None

226837

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D29.0&
  • Hospital discharge: ICD-9 2221
  • Hospital discharge: ICD-8 2221
  • Cause of death: ICD-10 D29.0&
  • Cause of death: ICD-9 2221
  • Cause of death: ICD-8 2221

2 out of 7 registries used, show all original rules.

68

4. Check minimum number of events

None

68

5. Include endpoints

None

68

6. Filter based on genotype QC (FinnGen only)

68

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D29
Name in latin
Neoplasma benignum penis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 661 - 661
Only index persons 598 - 598
Unadjusted period prevalence (%)
Whole population 0.02 - 0.02
Only index persons 0.02 - 0.02
Median age at first event (years)
Whole population - - 37.45
Only index persons - - 35.65

-FinnGen-

Key figures

All Female Male
Number of individuals 68 - 68
Unadjusted period prevalence (%) 0.03 - 0.03
Median age at first event (years) 44.10 - 44.10

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
65
Matched controls
650
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D29.0
ICD-10 Finland
Benign neoplasm: Penis
+∞
59.9
48
*
22210
ICD-8 Finland
Benign neoplasm of male genital organs, Penis
+∞
15.2
14
*
KGB00
NOMESCO Finland
Biopsy of penis
+∞
14.0
13
*
N47
ICD-10 Finland
Redundant prepuce, phimosis and paraphimosis
18.6
11.3
17
12
KGH10
NOMESCO Finland
Operation for phimosis
14.4
8.0
13
11
WX240
NOMESCO Finland
Penis blockade
77.1
6.6
7
*
C60.9
ICD-10 Finland
Malignant neoplasm: Penis, unspecified
+∞
6.3
6
*
C60.1
ICD-10 Finland
Malignant neoplasm: Glans penis
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
12
47
2.89
2.42
2.1
2.1
0.2
0.2
g/l
0.11
12
41
7
19
3.98
2.21
3.0
4.4
—
—
—
0
0
7
22
3.42
1.94
3.4
3.6
—
—
—
0
0
23
137
2.03
1.87
4.0
3.2
—
—
—
0
0
8
30
2.88
1.79
1.8
3.9
26.5
24.6
mmol/l
—
8
30
29
191
1.90
1.75
2.0
1.9
108.8
92.1
pmol/l
0.73
20
105
7
28
2.67
1.49
4.0
4.0
—
—
—
0
0
12
60
2.21
1.49
1.3
1.3
—
—
—
0
0
11
54
2.24
1.42
2.1
3.7
2.3
1.6
mmol/l
0.26
11
38
11
55
2.19
1.36
2.1
4.0
—
—
—
0
0
12
63
2.10
1.32
1.3
1.6
—
—
—
0
0
8
35
2.45
1.32
1.8
3.1
143.9
127.5
g/l
—
8
35
14
80
1.94
1.24
7.9
7.0
1.0
1.0
mmol/l
0.06
14
75
34
256
1.66
1.20
4.2
3.3
0.0
0.0
estimate
—
7
49
43
345
1.67
1.18
7.2
3.6
—
—
—
0
0
26
184
1.67
1.16
7.9
6.2
—
—
—
0
0
12
67
1.96
1.13
1.9
1.9
—
—
—
0
0
7
34
2.18
1.06
1.9
6.9
24.2
24.6
mmol/l
—
7
34
20
135
1.68
1.05
1.2
1.3
—
—
—
0
0
14
86
1.79
1.00
1.4
2.0
—
—
—
0
0
33
259
1.53
0.92
5.8
4.4
0.0
0.0
estimate
—
7
49
10
57
1.88
0.89
1.1
1.4
—
341.5
titre
—
0
13
16
106
1.67
0.89
4.4
2.7
—
—
—
0
0
33
261
1.51
0.88
4.3
3.3
0.0
0.0
estimate
—
7
47
8
46
1.84
0.86
2.0
1.9
—
—
—
0
0
52
456
1.60
0.83
23.5
18.7
13.9
13.7
%
0.36
52
446
17
117
1.60
0.82
3.9
5.2
—
—
—
0
0
0
26
0.00
0.80
0.0
9.7
—
—
—
0
0
22
163
1.52
0.78
5.0
4.5
11.2
13.1
mg/mmol
0.08
14
116
29
228
1.47
0.77
4.4
8.2
1.1
1.3
inr
—
10
65
7
39
1.88
0.75
2.3
1.5
—
—
—
0
0
5
27
1.92
0.70
12.4
30.7
—
—
—
0
0
30
243
1.42
0.67
11.2
10.9
0.0
0.0
e9/l
0.50
25
194
0
20
0.00
0.61
0.0
1.4
—
—
—
0
0
0
21
0.00
0.61
0.0
2.7
—
395.8
—
0
16
8
53
1.58
0.61
8.5
9.8
—
—
—
0
0
54
490
1.50
0.61
21.3
16.4
41.4
41.4
%
0.01
36
371
6
34
1.84
0.60
2.7
2.2
1.7
1.6
%
—
6
34
20
153
1.44
0.59
3.8
3.7
90.1
447.0
mg/l
0.49
14
115
0
23
0.00
0.59
0.0
1.2
—
—
—
0
0
12
83
1.54
0.56
1.2
2.5
—
—
—
0
0
6
38
1.63
0.56
1.5
1.4
—
—
—
0
0
60
565
1.53
0.51
20.0
14.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.9
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
296.0
—
0
11
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
12
156
0.72
0.40
2.2
2.7
412.3
9638.6
umol/l
1.05
12
132
26
222
1.28
0.37
2.5
2.9
0.4
0.7
ug/l
3.44
18
150
20
166
1.29
0.35
2.0
2.6
—
—
—
0
0
18
149
1.28
0.32
6.8
4.3
—
—
—
0
0
18
149
1.28
0.32
3.8
3.0
—
—
—
0
0
16
132
1.28
0.29
10.4
7.2
—
—
—
0
0
8
66
1.24
0.28
1.8
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
62.3
—
0
10
0
10
0.00
0.21
0.0
4.0
—
—
—
0
0
21
185
1.20
0.21
2.4
2.0
—
—
—
0
0
6
48
1.27
0.21
8.5
4.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
7
62
1.14
0.18
1.1
1.4
—
—
—
0
0
10
84
1.22
0.15
3.6
2.3
11.8
13.9
umol/l
—
10
74
5
43
1.18
0.10
5.2
3.0
—
7.4
—
0
5
5
43
1.18
0.10
2.6
4.5
—
—
—
0
0
16
146
1.13
0.09
5.2
3.5
0.0
0.0
estimate
—
7
41
11
123
0.87
0.09
4.3
3.2
—
—
—
0
0
57
558
1.13
0.07
23.7
17.3
139.7
139.5
mmol/l
0.24
57
548
39
377
1.08
0.06
3.8
4.0
—
—
—
0
0
22
209
1.08
0.05
3.7
2.7
—
—
—
0
0
54
550
0.91
0.05
21.0
14.4
23.8
26.4
mg/l
0.19
47
431
24
231
1.06
0.03
5.8
3.8
86.5
64.7
ng/l
0.16
17
159
57
562
1.09
0.03
23.9
17.4
4.1
4.0
mmol/l
0.25
57
552
16
153
1.06
0.01
5.5
5.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
4.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
5
54
0.92
0.00
5.2
2.4
261.8
113.7
ug/g
—
5
46
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
12.9
—
650.9
—
0
8
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
6
61
0.98
0.00
1.7
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
2.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_PENIS and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_PENIS 1.07 [0.79, 1.44] 0.656
Birth year 0.988 [0.98, 1.0] 0.013

During the follow-up period (1.1.1998 — 31.12.2019), 74 out of 444 males with CD2_BENIGN_PENIS died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_PENIS.

N-year risk Females Males
1 No data 0.182%
5 No data 1.191%
10 No data 3.334%
15 No data 6.002%
20 No data 10.271%

Relationships between endpoints

Index endpoint: CD2_BENIGN_PENIS – Benign neoplasm: Penis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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