Carcinoma in situ of lip

CD2_INSITU_LIP

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions not C3_LIP	519930
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D00.00& Cause of death: ICD-10 — D00.00& Cancer registry: Topography ICD-O-3 — C00 Cancer registry: Morphology ICD-O-3 — ANY Cancer registry: Behaviour codes — 2 3 out of 7 registries used, show all original rules.	33
4. Check minimum number of events None	33
5. Include endpoints None	33
6. Filter based on genotype QC (FinnGen only)	33

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF9
Parent code in ICD-10: D00
Name in latin: Carcinoma in situ glandulae thyreoideae

NAME	CD2_INSITU_LIP
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS	!C3_LIP
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D0000
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D0000
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO	C00
CANC_TOPO_EXCL
CANC_MORPH	ANY
CANC_MORPH_EXCL
CANC_BEHAV	2

Similar endpoints

↥

List of similar endpoints to Carcinoma in situ of lip based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Carcinoma in situ of lip, excluding all cancers

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	33	10	23
Unadjusted period prevalence (%)	0.01	0.00	0.01
Median age at first event (years)	67.61	58.16	71.73

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40768804) Tissue Pathology biopsy report

3.37

2.85

2.8

2.3

—

(3002256) Pathology report gross observation

4.24

2.46

1.9

1.6

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

7.11

2.46

4.4

8.4

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

3.88

2.27

3.8

4.0

4.8

4.7

kpa

—

(3027801) Oxygen [Partial pressure] in Arterial blood

3.88

2.27

3.8

4.0

11.6

10.7

kpa

—

(3016502) Oxygen saturation in Arterial blood

3.88

2.27

4.0

4.2

92.0

94.9

—

(3000494) Fungus identified in Specimen by Culture

3.94

2.10

1.4

1.3

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

3.42

1.84

4.0

4.3

114.3

124.9

g/l

—

(3014007) Fractional oxyhemoglobin in Arterial blood

3.73

1.58

2.8

5.9

94.3

93.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.89

1.55

3.6

2.0

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

3.49

1.49

2.8

5.3

0.8

0.7

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

3.49

1.49

2.6

3.6

0.9

1.2

—

(3000991) Gas panel - Venous blood

3.27

1.41

4.0

6.2

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

2.82

1.37

5.0

1.7

45.7

4.2

umol/l

—

(3023368) Bacteria identified in Blood by Culture

2.29

1.35

9.2

4.1

—

(3026008) Bacteria identified in Urine by Culture

2.25

1.30

4.4

3.1

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.91

1.26

1.6

2.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.68

1.21

2.9

2.1

—

(3042936) Bacteria identified in Isolate by Culture

2.42

1.14

4.3

1.5

—

(3003694) ABO and Rh group [Type] in Blood

2.05

1.05

1.4

1.5

—

(40761511) CBC panel - Blood by Automated count

232

2.36

0.98

23.9

15.1

—

(3044640) Blood type and Crossmatch panel - Blood

2.04

0.97

3.7

2.2

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

100

1.92

0.95

3.1

4.7

39.0

42.2

ng/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

100

1.92

0.95

6.6

3.4

—

(3009542) Hematocrit [Volume Fraction] of Blood

181

1.89

0.84

35.8

18.2

34.6

39.0

0.57

111

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.38

0.80

1.4

1.7

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.17

0.76

7.8

9.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.84

0.74

3.6

2.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.92

0.69

1.8

2.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.79

0.68

3.0

1.9

—

(3019150) Specific gravity of Urine by Refractometry

1.79

0.68

5.1

4.3

—

1.0

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

233

1.87

0.65

35.0

19.7

106.8

85.8

umol/l

0.85

233

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

101

1.67

0.63

5.8

3.1

—

(3017181) Myelocytes/100 leukocytes in Blood

0.00

0.62

0.0

4.6

—

0.8

—

(3002385) Erythrocyte distribution width [Ratio]

180

1.67

0.60

37.8

20.5

14.0

13.9

0.07

173

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

1.63

0.57

2.0

2.4

77.7

74.4

nmol/l

0.18

(36304419) Bacteria [Presence] in Urine

1.54

0.43

4.7

2.9

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.00

0.42

0.0

1.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.42

0.0

1.6

—

(3013512) EKG study

0.59

0.42

3.4

5.6

—

(3025159) Blasts/100 leukocytes in Blood

0.00

0.42

0.0

4.6

—

1.6

—

(3002179) Metamyelocytes/100 leukocytes in Blood

0.00

0.41

0.0

4.5

—

0.8

—

(3021440) Promyelocytes/100 leukocytes in Blood

0.00

0.41

0.0

4.9

—

0.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

110

1.47

0.41

3.4

2.9

—

(42870588) Differential panel, method unspecified - Blood

1.48

0.35

6.1

5.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

153

1.39

0.32

6.2

4.6

—

(3041096) Erythrocytes [Presence] in Urine by Automated

0.63

0.30

4.4

3.7

—

(3044889) 12 lead EKG panel

149

1.29

0.22

5.7

4.3

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.22

0.0

3.4

—

4.7

—

(3012501) Base excess in Blood by calculation

0.00

0.22

0.0

3.4

—

2.8

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.22

0.0

1.3

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.22

0.0

3.4

—

8.6

—

(3010421) pH of Blood

0.00

0.22

0.0

3.7

—

7.4

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.22

0.0

1.1

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.22

0.0

1.5

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.22

0.0

1.0

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

0.00

0.22

0.0

1.0

—

26.2

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.22

0.0

1.2

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.27

0.21

5.3

4.3

—

(3000492) Spirometry study

0.00

0.21

0.0

1.7

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

0.71

0.19

1.2

1.4

2.0

1.3

mmol/l

—

(3000850) Epithelial cells [#/volume] in Urine

1.21

0.18

5.6

2.4

4.8

e6/l

—

(3015736) pH of Urine

1.29

0.18

5.0

3.8

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

106

1.21

0.12

2.0

2.2

116.4

89.7

pmol/l

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

1.08

0.10

1.2

1.6

1.4

0.8

mg/l

—

(3026493) Urate [Moles/volume] in Serum or Plasma

1.12

0.09

3.4

3.0

326.3

10976.7

umol/l

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

131

0.87

0.07

4.1

3.1

100.1

46.3

u/l

0.75

122

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.0

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.3

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.0

2.1

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

3.3

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

0.00

0.0

1.3

—

22.4

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.2

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

0.91

0.00

5.6

4.3

—

(4094501)

0.00

0.0

1.0

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(3025941) Bacteria identified in Stool by Culture

0.00

0.0

1.0

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.0

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.3

—

(3027456) Digoxin [Moles/volume] in Serum or Plasma

0.00

0.0

1.8

—

0.6

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(40758558) Short blood count panel - Blood

0.86

0.00

6.2

6.6

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.0

1.1

—

(3024980) IgG subclass 4 [Mass/volume] in Serum

0.00

0.0

1.0

—

0.7

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.4

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.1

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

4.6

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.4

—

(3026782) Osmolality of Urine

0.94

0.00

6.0

3.3

501.7

561.4

mosm/kgh2o

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: CD2_INSITU_LIP – Carcinoma in situ of lip

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Carcinoma in situ of lip

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Carcinoma in situ of lip (CD2_INSITU_LIP)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints