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Carcinoma in situ of lip, oral cavity and pharynx

CD2_INSITU_LIPORALPHARYNX

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D00.0
  • Hospital discharge: ICD-9 2300
  • Cause of death: ICD-10 D00.0
  • Cause of death: ICD-9 2300

2 out of 7 registries used, show all original rules.

87

4. Check minimum number of events

None

87

5. Include endpoints

None

87

6. Filter based on genotype QC (FinnGen only)

87

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D00
Name in latin
Carcinoma in situ labii (oris)

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 87 29 58
Unadjusted period prevalence (%) 0.02 0.01 0.03
Median age at first event (years) 67.18 69.00 66.26

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
73
Matched controls
729
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
49.2
22.1
26
8
D00.00
ICD-10 Finland
Cancer in situ on the lip red border
+∞
18.5
17
*
D00.06
ICD-10 Finland
Cancer in situ in another part of the tongue
+∞
14.0
13
*
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
25.9
13.3
18
9
D00.09
ICD-10 Finland
Unspecified cancer in situ in oral cavity and throat
+∞
12.9
12
*
EJB10
NOMESCO Finland
Excision of lesion of apex or body of tongue
155.7
12.9
13
*
SBA00
NOMESCO Finland
Microbiological examinations
155.7
12.9
13
*
C02.11
ICD-10 Finland
Malignant neoplasm of border of tongue
77.8
12.0
13
*
EKA10
NOMESCO Finland
Biopsy of cheek
23.1
10.8
15
8
EJB30
NOMESCO Finland
Excision of lesion of floor of mouth
+∞
10.7
10
*
K13.28
ICD-10 Finland
Other leukoplakia or disorder of epithelium of the palate or tongue
+∞
10.7
10
*
TEA00
NOMESCO Finland
Biopsy of lip
63.8
9.9
11
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
13.4
9.9
17
16
D00.04
ICD-10 Finland
In situ cancer of the floor of the mouth
+∞
9.6
9
*
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
57.1
8.9
10
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
4.7
8.8
39
143
K13.78
ICD-10 Finland
Other change in the oral mucosa
23.5
8.8
12
6
ECA20
NOMESCO Finland
Biopsy of gingiva
31.8
8.8
11
*
SAA03
NOMESCO Finland
Extended examination of mouth
4.5
8.5
40
154
EAA10
NOMESCO Finland
Excision of lesion of lip
50.6
7.9
9
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
21.2
7.9
11
6
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
+∞
7.4
7
*
D00.01
ICD-10 Finland
In situ cancer of the mucous membrane of the cheek
+∞
7.4
7
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
19.0
7.0
10
6
A07AA02
ATC
nystatin; oral
7.6
7.0
16
26
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
14.1
6.8
11
9
C03.0
ICD-10 Finland
Malignant neoplasm: Upper gum
76.2
6.5
7
*
K13.29
ICD-10 Finland
Indefinite leukoplakia
76.2
6.5
7
*
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
29.5
6.4
8
*
C06.0
ICD-10 Finland
Malignant neoplasm: Cheek mucosa
+∞
6.3
6
*
D00.05
ICD-10 Finland
In situ cancer of the pharyngeal part of the tongue
+∞
6.3
6
*
EAA30
NOMESCO Finland
Partial excision of lower lip
+∞
6.3
6
*
C03.1
ICD-10 Finland
Malignant neoplasm: Lower gum
+∞
6.3
6
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
5.0
6.1
20
51

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
26
62
5.55
11.01
2.8
2.4
0.2
0.2
g/l
0.13
26
53
45
245
2.73
5.04
4.0
2.2
—
—
—
0
0
19
64
3.52
4.92
1.3
1.3
368.0
272.7
titre
—
5
11
21
78
3.23
4.66
1.8
1.3
—
—
—
0
0
19
67
3.35
4.57
1.6
1.3
—
—
—
0
0
21
83
3.02
4.18
1.9
1.4
—
—
—
0
0
50
310
2.44
4.00
7.3
6.0
0.6
0.6
e9/l
0.08
41
264
50
312
2.42
3.92
7.3
6.0
0.0
0.0
e9/l
0.08
41
267
16
57
3.21
3.76
6.4
10.1
—
—
—
0
0
9
244
0.30
3.74
3.4
3.0
—
—
—
0
0
50
318
2.35
3.68
7.3
6.1
1.8
1.8
e9/l
0.07
43
276
50
321
2.31
3.56
7.4
6.1
0.2
0.2
e9/l
1.13
43
274
21
92
2.69
3.44
6.9
8.2
0.5
1.6
mmol/l
0.71
16
71
23
109
2.51
3.21
1.6
1.8
28.5
29.4
s
0.52
23
103
44
277
2.19
3.19
2.2
2.0
86.0
92.8
pmol/l
0.48
24
139
35
202
2.23
3.13
3.7
2.6
—
—
—
0
0
6
8
7.95
3.10
1.5
1.0
—
—
—
0
0
23
113
2.41
2.96
2.9
1.7
—
—
—
0
0
44
287
2.08
2.82
6.5
6.0
59.9
59.3
%
0.11
39
266
17
76
2.54
2.65
3.2
2.8
19.5
8.8
umol/l
0.37
17
63
44
292
2.03
2.64
6.7
6.3
24.2
25.9
%
0.46
39
269
36
223
2.05
2.61
7.6
4.5
—
—
—
0
0
33
207
1.96
2.25
6.5
5.7
—
—
—
0
0
32
200
1.95
2.20
3.6
3.1
0.4
0.5
e6/l
0.13
26
149
31
195
1.92
2.08
3.6
3.1
—
—
—
0
0
9
33
2.92
2.00
1.3
1.8
—
—
—
0
0
25
148
1.97
1.98
1.3
1.4
—
—
—
0
0
26
157
1.94
1.95
10.0
6.3
—
—
—
0
0
14
66
2.34
1.94
5.1
4.4
—
—
—
0
0
10
40
2.69
1.91
9.5
7.7
—
—
—
0
0
50
377
1.77
1.80
13.3
10.0
4.4
4.4
e9/l
0.01
45
323
14
70
2.19
1.70
1.2
1.5
—
—
—
0
0
13
63
2.25
1.70
5.4
4.2
1.7
2.9
mmol/l
0.44
13
50
8
32
2.65
1.64
4.1
2.8
0.7
0.6
%
—
8
32
12
57
2.28
1.64
1.2
1.4
—
—
—
0
0
8
33
2.56
1.58
4.1
2.9
2.0
1.2
%
—
8
33
5
15
3.47
1.54
5.4
4.1
—
—
—
0
0
35
248
1.69
1.51
3.8
3.8
71.7
88.5
e6/l
0.11
26
185
9
38
2.52
1.51
2.2
2.0
—
—
—
0
0
75
655
2.05
1.50
31.5
16.3
40.8
25.0
mg/l
1.95
62
532
32
222
1.70
1.49
3.9
3.2
68.9
309.2
e6/l
0.40
27
174
16
90
1.95
1.45
1.4
1.6
—
—
—
0
0
6
24
2.61
1.33
4.8
3.3
21.7
36.5
mg/l
—
6
19
21
134
1.75
1.30
1.4
1.7
1205.2
1361.0
nmol/l
0.31
16
100
11
191
0.51
1.23
3.5
3.6
—
—
—
0
0
28
200
1.59
1.13
4.1
3.3
35.5
376.2
mg/l
0.57
22
133
17
106
1.75
1.13
2.6
2.3
15.8
21.9
%
1.26
12
94
7
32
2.29
1.11
6.7
3.3
—
—
—
0
0
7
32
2.29
1.11
3.6
4.2
—
—
—
0
0
9
45
2.11
1.09
6.2
3.1
129.6
129.4
g/l
—
9
45
40
316
1.49
1.01
7.7
10.6
1.0
1.3
inr
—
6
101
28
205
1.54
1.01
4.0
3.1
—
—
—
0
0
7
36
2.03
0.99
7.7
2.8
26.7
24.8
mmol/l
—
7
36
11
62
1.89
0.99
2.1
2.6
334.0
338.3
nmol/l
0.02
11
53
13
78
1.78
0.98
1.2
1.5
—
—
—
0
0
10
55
1.92
0.96
1.5
1.3
—
—
—
0
0
9
52
1.81
0.96
1.2
1.4
—
—
—
0
0
6
28
2.22
0.93
3.0
2.4
—
—
—
0
0
8
46
1.81
0.85
6.6
3.1
—
7.5
—
0
6
8
46
1.81
0.85
8.0
7.1
23.6
25.4
mmol/l
—
8
46
37
297
1.43
0.83
9.4
11.6
0.0
0.0
e9/l
0.79
29
253
5
24
2.15
0.76
2.4
1.7
—
—
—
0
0
28
217
1.43
0.75
4.5
4.0
4.0
11.5
mg/mmol
1.34
22
138
11
71
1.63
0.66
1.4
1.4
—
—
—
0
0
5
29
1.77
0.65
1.6
1.2
101.0
148.3
u/ml
—
5
24
50
438
1.33
0.61
5.6
4.7
—
—
—
0
0
8
54
1.53
0.59
6.3
2.5
10.4
9.2
g/l
—
8
44
0
23
0.00
0.59
0.0
1.0
—
—
—
0
0
9
59
1.59
0.57
11.9
4.4
—
—
—
0
0
9
60
1.56
0.56
7.1
3.7
—
—
—
0
0
61
554
1.34
0.55
34.7
16.5
36.0
40.6
%
1.83
40
360
7
45
1.60
0.50
1.9
1.8
1.3
1.2
g/l
—
7
37
20
157
1.36
0.49
4.7
4.0
—
—
—
0
0
17
215
0.74
0.46
6.9
4.6
—
—
—
0
0
5
33
1.55
0.42
6.0
4.0
—
—
—
0
0
51
462
1.25
0.42
5.2
4.3
—
—
—
0
0
35
304
1.25
0.41
4.7
4.5
21.0
49.1
ng/l
1.80
27
242
9
67
1.38
0.39
4.7
3.5
—
—
—
0
0
72
683
1.31
0.37
26.9
15.2
—
—
—
0
0
7
52
1.38
0.32
5.9
2.1
—
—
—
0
0
23
201
1.20
0.24
1.7
2.8
0.5
0.8
ug/l
1.26
14
135
5
39
1.30
0.23
2.0
3.2
0.3
0.1
e6/l
—
5
39
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
3.2
—
18.3
—
0
12
0
13
0.00
0.21
0.0
2.0
—
—
—
0
0
0
14
0.00
0.20
0.0
3.1
—
—
—
0
0
72
696
1.20
0.20
37.6
19.3
84.8
83.8
umol/l
0.11
72
696
13
150
0.84
0.16
6.4
5.9
—
—
—
0
0
9
82
1.11
0.15
3.3
4.5
5.5
137.7
ug/l
—
9
71
5
46
1.09
0.10
1.0
1.6
—
—
—
0
0
8
75
1.07
0.07
3.5
1.9
—
—
—
0
0
25
262
0.94
0.05
4.7
3.9
—
—
—
0
0
10
94
1.07
0.01
1.0
1.2
—
—
—
0
0
54
538
1.01
0.00
37.8
19.8
14.2
14.0
%
0.40
54
524
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.6
—
—
—
0
0
0
6
0.00
0.00
0.0
2.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
1.9
—
0
5
0
6
0.00
0.00
0.0
1.8
—
17.7
—
0
6
0
5
0.00
0.00
0.0
11.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
33.7
—
0
7
0
7
0.00
0.00
0.0
1.1
—
262.6
—
0
7
0
8
0.00
0.00
0.0
2.6
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_LIPORALPHARYNX – Carcinoma in situ of lip, oral cavity and pharynx

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).