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This is a non-core endpoint: only basic statistics are computed.

See its core counterpart CD2_INSITU_ORAL_EXALLC for full statistics.

Carcinoma in situ of oral cavity, oesophagus and stomach

CD2_INSITU_ORAL

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D00
  • Cause of death: ICD-10 D00

2 out of 7 registries used, show all original rules.

131

4. Check minimum number of events

None

131

5. Include endpoints

187

6. Filter based on genotype QC (FinnGen only)

187

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D00-D09
Name in latin
Carcinoma in situ cavitatis oris, oesophagi sive ventriculi

Similar endpoints

List of similar endpoints to Carcinoma in situ of oral cavity, oesophagus and stomach based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 187 57 130
Unadjusted period prevalence (%) 0.05 0.02 0.06
Median age at first event (years) 69.05 70.30 68.50

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
169
Matched controls
1690
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D00.2
ICD-10 Finland
Carcinoma in situ: Stomach
+∞
23.5
22
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.5
23.3
95
320
D00.1
ICD-10 Finland
Carcinoma in situ: Oesophagus
+∞
22.4
21
*
C15.5
ICD-10 Finland
Malignant neoplasm: Lower third of oesophagus
112.7
19.0
20
*
D00.00
ICD-10 Finland
Cancer in situ on the lip red border
+∞
18.0
17
*
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
20.2
17.6
26
15
130
Kela drug reimbursment
Malignant tumour
6.0
15.2
45
96
C15.9
ICD-10 Finland
Malignant neoplasm: Oesophagus, unspecified
+∞
14.8
14
*
JCA45
NOMESCO Finland
Endoscopic mucosal or submucosal resection in oesophagus
163.5
14.7
15
*
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
21.6
14.7
21
11
K22.7
ICD-10 Finland
Barrett oesophagus
21.6
14.7
21
11
D00.06
ICD-10 Finland
Cancer in situ in another part of the tongue
+∞
13.7
13
*
C02.11
ICD-10 Finland
Malignant neoplasm of border of tongue
151.6
13.7
14
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
43.9
13.4
16
*
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
18.7
13.4
20
12
D00.09
ICD-10 Finland
Unspecified cancer in situ in oral cavity and throat
+∞
12.7
12
*
JCF12
NOMESCO Finland
Endoscopic insertion of prosthetic tube into oesphagus
139.9
12.6
13
*
EKA10
NOMESCO Finland
Biopsy of cheek
23.4
12.3
17
8
8140/3-C16.0
ICD-O-3
Adenocarcinoma, NOS, of cardia, NOS
+∞
11.6
11
*
D13.0
ICD-10 Finland
Benign neoplasm: Oesophagus
128.3
11.6
12
*
JCA52
NOMESCO Finland
Other endoscopic procedure using diathermy or heat in oesophagus
128.3
11.6
12
*
WX002
NOMESCO Finland
Sedation and analgesia
3.8
11.0
53
182
WX402
NOMESCO Finland
General anaesthesia
4.5
10.8
41
113
C15.3
ICD-10 Finland
Malignant neoplasm: Upper third of oesophagus
+∞
10.5
10
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
34.9
10.5
13
*
EJB10
NOMESCO Finland
Excision of lesion of apex or body of tongue
34.9
10.5
13
*
EJB30
NOMESCO Finland
Excision of lesion of floor of mouth
105.6
9.5
10
*
K13.28
ICD-10 Finland
Other leukoplakia or disorder of epithelium of the palate or tongue
105.6
9.5
10
*
D00.04
ICD-10 Finland
In situ cancer of the floor of the mouth
+∞
9.5
9
*
C159, 8148, 2
ICD-O-3
NA
+∞
9.5
9
*
UJD02
NOMESCO Finland
Gastroscopy
5.5
9.2
27
56
A03FA01
ATC
metoclopramide; systemic, rectal
3.4
9.1
50
187
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
29.2
8.6
11
*
ECA20
NOMESCO Finland
Biopsy of gingiva
29.2
8.6
11
*
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
9.3
8.5
17
20
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
35.2
8.2
10
*
C16.9
ICD-10 Finland
Malignant neoplasm: Stomach, unspecified
35.2
8.2
10
*
TEA00
NOMESCO Finland
Biopsy of lip
23.4
8.1
11
5
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.8
8.1
67
325
JCA55
NOMESCO Finland
Endoscopic dilatation of oesophagus
16.0
7.8
12
8
UJC12
NOMESCO Finland
Flexible oesophagoscopy
19.5
7.7
11
6
N02AA05
ATC
oxycodone; systemic
3.1
7.6
46
182
107
Kela drug reimbursment
Pernicious anaemia
8.3
7.6
16
21
C15.4
ICD-10 Finland
Malignant neoplasm: Middle third of oesophagus
83.6
7.5
8
*
C16.09
ICD-10 Finland
Malignant tumor of cardiac or other unspecified carcinoma
83.6
7.5
8
*
C03.0
ICD-10 Finland
Malignant neoplasm: Upper gum
+∞
7.3
7
*
D00.01
ICD-10 Finland
In situ cancer of the mucous membrane of the cheek
+∞
7.3
7
*
EAA10
NOMESCO Finland
Excision of lesion of lip
21.1
7.2
10
5
D37.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Stomach
21.1
7.2
10
5
K13.78
ICD-10 Finland
Other change in the oral mucosa
10.7
7.2
13
13
EP1AE
NOMESCO Finland
Neck ultrasound examination
6.0
7.2
19
35
SBA00
NOMESCO Finland
Microbiological examinations
9.9
6.9
13
14
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
3.8
6.9
29
87
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
41.8
6.8
8
*
XJD02
NOMESCO Finland
Peroral endoscopic ultrasonography
23.6
6.7
9
*
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
4.5
6.7
23
57
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
5.0
6.5
20
44
8140/3-C16.9
ICD-O-3
Adenocarcinoma, NOS, of stomach, NOS
72.4
6.5
7
*
JCC12
NOMESCO Finland
Thoracoscopic or laparoscopic partial oesophagectomy
72.4
6.5
7
*
R4190
NOMESCO Finland
Nutritional therapy
8.7
6.5
13
16
B03BA03
ATC
hydroxocobalamin; parenteral
4.1
6.3
24
66
JN4BD
NOMESCO Finland
Extensive body CT
3.4
6.3
30
100
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
27.8
6.3
8
*
C03.1
ICD-10 Finland
Malignant neoplasm: Lower gum
+∞
6.3
6
*
C06.0
ICD-10 Finland
Malignant neoplasm: Cheek mucosa
+∞
6.3
6
*
D00.05
ICD-10 Finland
In situ cancer of the pharyngeal part of the tongue
+∞
6.3
6
*
EAA30
NOMESCO Finland
Partial excision of lower lip
+∞
6.3
6
*
EDB00
NOMESCO Finland
Partial excision of mandible
+∞
6.3
6
*
C160, 8148, 2
ICD-O-3
NA
+∞
6.3
6
*

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_ORAL – Carcinoma in situ of oral cavity, oesophagus and stomach

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).