Polyclonal hypergammaglobulinaemia

D3_POLYCLOHYPERGAMMA

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D89.0 Hospital discharge: ICD-9 — 2730A Hospital discharge: ICD-8 — 28790 Cause of death: ICD-10 — D89.0 Cause of death: ICD-9 — 2730A Cause of death: ICD-8 — 28790 2 out of 7 registries used, show all original rules.	38
4. Check minimum number of events None	38
5. Include endpoints None	38
6. Filter based on genotype QC (FinnGen only)	38

Control definitions (FinnGen only)

Control exclude: D3_IMMUNEMECHANISM

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D89
Name in latin: Hypergammaglobulinaemia polyclonalis

NAME	D3_POLYCLOHYPERGAMMA
CONTROL_EXCLUDE	D3_IMMUNEMECHANISM
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D890
HD_ICD_9	2730A
HD_ICD_8	28790
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D890
COD_ICD_9	2730A
COD_ICD_8	28790
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Polyclonal hypergammaglobulinaemia based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	293	131	156
Only index persons	226	111	115
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	59.57	60.32	58.32
Only index persons	56.72	57.87	55.60

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	38	17	21
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	53.84	47.20	59.21

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3022948) Iron [Moles/volume] in Serum or Plasma

5.34

5.86

6.6

3.5

10.8

14.4

umol/l

1.40

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

13.87

4.47

1.7

1.3

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

13.87

4.47

1.7

1.3

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

136

4.40

4.34

12.9

5.4

34.9

35.7

g/l

0.26

131

(42870588) Differential panel, method unspecified - Blood

113

4.05

4.20

15.7

4.5

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

13.86

3.90

1.0

1.8

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

13.86

3.90

1.0

1.4

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

117

3.45

3.37

6.8

3.0

122.3

138.9

ug/l

0.23

105

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

3.89

3.10

3.8

1.6

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

4.79

3.00

2.3

1.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

3.51

2.99

3.3

1.5

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

5.03

2.86

3.1

1.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

3.67

2.86

3.9

1.4

—

(36304419) Bacteria [Presence] in Urine

3.09

2.86

6.6

3.3

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

6.88

2.81

2.0

1.3

11.0

11.2

mg/l

—

(3000991) Gas panel - Venous blood

3.76

2.76

25.2

9.1

—

(3023368) Bacteria identified in Blood by Culture

3.03

2.74

7.0

5.0

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

4.79

2.49

1.4

1.1

—

(3018010) Neutrophils/100 leukocytes in Blood

152

2.88

2.42

18.2

5.1

58.3

58.5

0.02

140

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

2.88

2.29

7.6

3.4

0.7

e6/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.77

2.27

3.3

2.4

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

4.27

2.27

20.6

9.9

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

3.48

2.25

17.4

9.9

119.1

122.5

g/l

—

(3042936) Bacteria identified in Isolate by Culture

2.96

2.08

4.6

1.7

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

4.24

2.02

2.0

1.4

—

(40758558) Short blood count panel - Blood

2.53

1.97

10.6

8.1

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

2.67

1.93

8.1

3.5

0.3

2.8

e6/l

—

(3020682) Albumin/Creatinine [Ratio] in Urine

110

2.45

1.90

9.5

4.2

16.9

13.6

mg/mmol

0.15

(3032080) INR in Blood by Coagulation assay

139

2.38

1.78

6.8

7.3

1.0

1.2

inr

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

2.50

1.78

4.4

2.2

3.4

3.1

mg/l

0.25

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

124

2.29

1.66

4.4

2.7

65.0

76.4

nmol/l

1.48

105

(3007853) Bacteria identified in Skin by Aerobe culture

2.79

1.65

2.1

1.8

—

(4010399)

3.19

1.57

1.5

1.2

—

(3026008) Bacteria identified in Urine by Culture

2.30

1.56

3.9

3.5

—

(3044640) Blood type and Crossmatch panel - Blood

103

2.18

1.45

3.4

2.4

—

(1761868) Lipid panel - Serum or Plasma

110

0.37

1.43

3.8

2.8

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

104

2.15

1.41

5.4

2.6

24.4

28.1

u/l

0.97

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

131

2.11

1.39

9.1

3.3

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

192

2.12

1.28

14.3

4.6

7.4

6.7

mmol/l

0.70

175

(3019832) Treponema pallidum Ab [Presence] in Serum

2.87

1.25

2.0

1.5

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.72

1.19

27.8

8.5

23.0

25.4

mmol/l

—

(3002032) Base excess in Venous blood by calculation

2.20

1.17

13.9

5.4

-0.2

2.2

mmol/l

—

(3037522) Nuclear Ab [Titer] in Serum

2.25

1.14

1.8

1.5

—

858.5

—

(3019060) Gas panel - Arterial blood

2.58

1.12

2.4

6.5

—

(3022145) Colonoscopy Study observation

2.37

1.12

1.4

1.2

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.19

1.12

2.7

1.6

—

(3002256) Pathology report gross observation

2.29

1.09

1.1

1.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.29

1.09

2.9

1.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

219

2.06

1.09

11.5

4.7

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

122

1.90

1.07

3.0

2.1

86.8

99.1

pmol/l

0.68

(3004588) Protein electrophoresis panel - Serum or Plasma

2.46

1.06

14.0

2.8

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.09

1.00

2.7

1.7

—

(3012544) pH of Venous blood

2.14

0.96

13.9

5.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.89

0.93

6.0

3.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.93

0.89

1.6

1.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

176

1.78

0.88

2.6

2.7

—

(40768804) Tissue Pathology biopsy report

123

1.69

0.76

2.2

1.9

—

(3019225) pH of Specimen

2.06

0.73

12.0

3.5

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

1.70

0.72

1.6

1.7

2.0

1.4

mmol/l

1.24

(3022621) pH of Urine by Test strip

1.98

0.71

3.2

2.3

—

(4035726)

1.76

0.63

3.0

1.2

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.62

0.0

1.2

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.62

0.0

1.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.59

0.54

5.2

3.2

—

(40768797) Stomach Pathology biopsy report

1.68

0.53

1.6

1.3

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

1.61

0.50

1.6

1.8

1.4

1.2

mg/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.70

0.45

1.4

1.1

—

(3013707) Erythrocyte sedimentation rate by Westergren method

236

1.50

0.44

8.6

4.1

19.3

13.0

mm/h

0.74

217

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

185

1.45

0.44

11.0

7.3

8.9

10.3

umol/l

0.90

180

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.42

0.0

1.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.41

0.0

1.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

129

0.69

0.36

11.1

3.9

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

127

0.71

0.32

3.6

2.9

26.8

36.6

ng/l

—

(3021960) Folate [Moles/volume] in Serum or Plasma

1.30

0.28

2.3

1.7

20.7

20.9

nmol/l

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

106

1.34

0.28

4.5

3.0

73.4

56.0

u/l

1.04

100

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.40

0.25

4.2

3.5

3.6

6.3

umol/l

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.22

0.0

1.6

—

(4034850)

0.00

0.21

0.0

11.3

—

(3003694) ABO and Rh group [Type] in Blood

1.32

0.21

2.1

1.3

—

(3002385) Erythrocyte distribution width [Ratio]

270

0.78

0.21

60.0

18.5

14.2

13.8

0.61

263

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

152

1.21

0.16

7.4

4.0

—

(3044889) 12 lead EKG panel

226

0.84

0.13

7.8

3.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

0.84

0.07

11.1

3.8

—

(3013512) EKG study

102

0.85

0.07

4.3

3.6

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

111

1.12

0.04

2.9

4.6

16.6

21.3

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

145

0.95

0.00

3.9

5.4

1.6

4.2

ug/l

0.58

123

(3009542) Hematocrit [Volume Fraction] of Blood

284

0.95

0.00

53.8

16.6

38.3

39.2

0.25

201

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3025547) Thyroglobulin Ab [Units/volume] in Serum or Plasma

0.00

0.0

3.0

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.2

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.4

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(44790049)

0.00

0.0

2.0

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(44790048)

0.00

0.0

2.0

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(4146454)

0.00

0.0

3.2

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

6.0

—

10.2

—

(44806118)

0.00

0.0

2.0

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

2.6

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

2.2

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.6

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.00

0.00

16.6

6.0

—

(44790047)

0.00

0.0

2.0

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.0

2.9

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

3.6

—

64.0

—

(3011648) Oxygen content in Venous blood

0.00

0.0

2.5

—

11.8

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

4.4

—

3.8

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.0

1.0

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint D3_POLYCLOHYPERGAMMA and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_POLYCLOHYPERGAMMA.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: D3_POLYCLOHYPERGAMMA – Polyclonal hypergammaglobulinaemia

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Polyclonal hypergammaglobulinaemia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints