Drug-induced tics and other tics of organic origin

DRUGADVERS_TICS_OTHER_TICS_ORGANIC_ORIGIN

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G25.6# 1 out of 7 registries used, show all original rules.	26
4. Check minimum number of events None	26
5. Include endpoints None	26
6. Filter based on genotype QC (FinnGen only)	26

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	DRUGADVERS_TICS_OTHER_TICS_ORGANIC_ORIGIN
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G256
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Drug-induced tics and other tics of organic origin based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	205	111	94
Only index persons	179	99	80
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	-	54.17	44.42
Only index persons	47.70	51.28	43.27

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	26	17	9
Unadjusted period prevalence (%)	0.01	0.01	0.00
Median age at first event (years)	46.61	42.15	55.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

206

0.31

2.14

8.1

4.8

43.1

38.4

mmol/mol

0.54

192

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

4.48

1.80

1.0

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

3.04

1.58

1.6

1.4

—

(36660697) Celiac disease serology panel - Serum

3.61

1.51

1.4

1.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.84

1.21

1.0

1.9

—

(3013512) EKG study

2.22

1.12

2.9

4.6

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

2.17

1.04

3.5

3.6

22.8

17.6

ng/l

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.82

0.0

1.3

—

(3037522) Nuclear Ab [Titer] in Serum

2.23

0.77

1.2

1.4

—

420.0

—

(3023368) Bacteria identified in Blood by Culture

1.85

0.74

3.7

4.4

—

(3009542) Hematocrit [Volume Fraction] of Blood

210

0.54

0.70

25.8

13.7

40.4

40.2

0.05

162

(40760892) CBC W Ordered Manual Differential panel - Blood

1.77

0.68

1.6

4.3

—

(3037467) Urinalysis macro (dipstick) panel - Urine

155

1.84

0.68

2.5

4.6

—

(3042936) Bacteria identified in Isolate by Culture

1.89

0.67

1.0

1.8

—

(3044889) 12 lead EKG panel

145

1.78

0.66

3.2

3.9

—

(42870588) Differential panel, method unspecified - Blood

1.80

0.65

6.0

7.3

—

(4035726)

0.00

0.63

0.0

1.1

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

241

+∞

0.63

11.5

13.8

75.2

73.0

umol/l

0.16

241

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.62

0.52

1.7

1.6

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.62

0.52

3.1

3.6

—

(3031040) Bacteria [#/volume] in Urine by Automated count

142

1.57

0.51

5.9

5.0

—

110.2

—

(3006504) Eosinophils/100 leukocytes in Blood

100

1.60

0.46

5.9

5.7

1.3

3.1

4.26

(3019069) Monocytes/100 leukocytes in Blood

100

1.60

0.46

6.1

6.0

8.7

8.1

0.20

(40768804) Tissue Pathology biopsy report

0.63

0.42

1.5

1.9

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

113

0.69

0.38

4.8

3.7

—

(3033658) Prothrombin time (PT) actual/Normal

1.43

0.37

1.8

4.2

97.2

88.4

—

(3015736) pH of Urine

1.51

0.36

2.9

3.5

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

1.49

0.35

2.5

4.2

33.9

35.7

g/l

0.67

(3022096) Basophils/100 leukocytes in Blood

1.46

0.32

6.3

5.7

0.3

0.7

2.20

(3044640) Blood type and Crossmatch panel - Blood

0.66

0.31

2.2

2.1

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

0.74

0.27

1.8

2.7

82.9

80.7

nmol/l

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.35

0.24

2.4

2.2

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.35

0.24

2.0

1.5

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

220

0.76

0.24

3.6

4.4

4.5

4.6

mmol/l

0.01

204

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

150

0.73

0.23

4.4

3.5

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.22

0.0

2.0

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.22

0.0

1.3

—

458.2

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

0.00

0.22

0.0

8.0

—

24.3

—

(40768793) Breast Pathology biopsy report

0.00

0.21

0.0

1.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.34

0.21

3.1

3.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.31

0.21

2.0

1.8

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

1.23

0.11

2.0

2.6

—

178.2

—

(36304419) Bacteria [Presence] in Urine

1.20

0.10

5.7

4.1

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

0.76

0.09

2.4

3.1

923.4

771.8

ng/l

—

(3003694) ABO and Rh group [Type] in Blood

1.08

0.08

1.8

1.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.15

0.08

2.9

3.5

—

(1761868) Lipid panel - Serum or Plasma

0.87

0.08

1.8

3.0

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

149

0.87

0.05

3.3

3.2

38.2

38.6

u/l

0.02

142

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

121

1.15

0.05

2.2

5.5

7.6

10.5

umol/l

2.05

114

(3019198) Lymphocytes [#/volume] in Blood

114

0.94

0.00

6.7

5.9

2.5

2.0

e9/l

0.80

103

(3013115) Eosinophils [#/volume] in Blood

112

0.97

0.00

13.8

6.1

0.1

0.2

e9/l

5.17

103

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.7

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

3.2

—

191.1

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

1.2

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

0.00

0.0

12.5

—

1.3

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

3.2

—

166.7

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

1.3

—

14.9

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3026008) Bacteria identified in Urine by Culture

0.98

0.00

3.4

2.8

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.0

6.0

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

1.1

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

8.0

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

2.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.00

0.00

5.4

4.0

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.2

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

16.3

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

0.00

0.0

1.3

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.0

2.0

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

2.0

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(40758558) Short blood count panel - Blood

1.04

0.00

23.5

10.0

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.0

1.1

—

0.3

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.2

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

1.02

0.00

2.7

1.9

52.4

53.4

u/l

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.0

2.4

—

2.5

—

(40768443) Skin Pathology biopsy report

0.00

0.0

1.0

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.0

2.4

—

(1002224) Polysomnography panel

0.00

0.0

1.0

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.0

3.7

—

1.0

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.0

3.7

—

0.7

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

0.00

0.0

10.6

—

24.9

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.0

1.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.89

0.00

2.0

1.7

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.0

1.2

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.8

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(4094501)

0.00

0.0

1.0

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.0

1.8

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

4.5

—

2.9

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

0.00

-0.00

0.0

4.8

—

(3000330) Specific gravity of Urine by Test strip

0.00

-0.00

0.0

5.1

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

47.4

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

-0.00

0.0

1.7

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

-0.00

0.0

1.1

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

-0.00

0.0

2.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint DRUGADVERS_TICS_OTHER_TICS_ORGANIC_ORIGIN and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have DRUGADVERS_TICS_OTHER_TICS_ORGANIC_ORIGIN.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: DRUGADVERS_TICS_OTHER_TICS_ORGANIC_ORIGIN – Drug-induced tics and other tics of organic origin

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Drug-induced tics and other tics of organic origin

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints