Duodenal ulcer - Acute with haemorrhage, drug-induced

DUODENAL_ULCER_ACUTE_W_HAEMORRHAGE

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ATC codes for adverse effects of Drugs — ANY Hospital discharge: ICD-10 — K26.0# 1 out of 7 registries used, show all original rules.	59
4. Check minimum number of events None	59
5. Include endpoints None	59
6. Filter based on genotype QC (FinnGen only)	59

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	DUODENAL_ULCER_ACUTE_W_HAEMORRHAGE
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC	ANY
HD_ICD_10	K260
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Duodenal ulcer - Acute with haemorrhage, drug-induced based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	59	15	44
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	54.39	48.66	56.35

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40768443) Skin Pathology biopsy report

4.83

1.97

1.4

1.1

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.37

1.05

2.0

2.5

0.9

0.8

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.93

1.02

9.8

5.7

102.7

103.2

mmol/l

—

(3024731) MCV [Entitic volume]

426

0.64

0.83

27.1

23.3

91.1

91.7

0.25

414

(3035941) MCH [Entitic mass]

426

0.64

0.83

27.2

23.2

30.3

30.5

0.25

414

(3000963) Hemoglobin [Mass/volume] in Blood

426

0.64

0.83

27.4

23.4

131.2

135.4

g/l

0.66

414

(3007461) Platelets [#/volume] in Blood

425

0.64

0.81

27.2

23.3

254.9

237.7

e9/l

0.53

407

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.27

0.78

2.0

2.5

1.4

1.2

—

(3012544) pH of Venous blood

1.89

0.75

2.1

3.6

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

252

1.47

0.70

5.4

4.4

6.7

6.9

mmol/l

0.28

240

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.62

0.69

1.5

2.3

—

(40761511) CBC panel - Blood by Automated count

400

0.68

0.66

18.9

16.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.62

0.65

4.7

5.0

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

188

1.46

0.64

3.2

4.3

21.0

64.3

ng/l

1.56

144

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

208

0.68

0.59

3.9

6.0

9.3

12.8

umol/l

1.26

200

(3000991) Gas panel - Venous blood

1.63

0.56

3.3

7.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

106

0.61

0.55

4.1

—

(3032080) INR in Blood by Coagulation assay

175

1.40

0.53

8.0

1.4

1.3

inr

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

411

0.72

0.51

19.6

19.5

87.0

87.6

umol/l

0.03

411

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.58

0.50

2.4

3.6

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

410

0.73

0.49

21.5

19.0

139.5

mmol/l

0.02

396

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.66

0.44

1.6

1.5

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

359

0.75

0.43

15.8

16.1

76.9

75.3

ml/min/173m2

0.17

294

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

270

0.75

0.43

2.5

3.8

14.8

15.1

pmol/l

0.13

244

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

156

0.71

0.42

6.5

4.3

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.42

0.0

1.4

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.42

0.0

2.0

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.41

0.0

1.3

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.50

0.41

1.4

1.6

308.2

422.3

nmol/l

—

(42870588) Differential panel, method unspecified - Blood

135

1.36

0.40

3.1

5.0

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

132

0.70

0.38

2.3

63.4

55.6

u/l

—

125

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

394

0.77

0.37

18.5

16.3

21.3

25.5

mg/l

0.52

323

(3002256) Pathology report gross observation

1.51

0.37

1.3

—

(3044640) Blood type and Crossmatch panel - Blood

120

1.33

0.33

1.9

2.4

—

(3009542) Hematocrit [Volume Fraction] of Blood

323

0.79

0.33

14.8

17.2

39.4

39.7

0.08

203

(3037467) Urinalysis macro (dipstick) panel - Urine

262

0.79

0.31

3.4

4.5

—

(3023368) Bacteria identified in Blood by Culture

126

0.75

0.28

6.2

4.5

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

0.66

0.28

6.8

3.4

0.8

mmol/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

154

0.79

0.23

4.5

2.9

—

(3022145) Colonoscopy Study observation

1.27

0.23

1.8

1.5

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.21

0.0

1.2

—

(3008898) HLA-B27 [Presence]

0.00

0.21

0.0

1.0

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.21

0.0

3.9

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.0

—

24.5

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.5

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

0.3

—

(3015171) Extractable nuclear Ab [Units/volume] in Serum

0.00

0.21

0.0

1.4

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

1.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.21

0.0

1.1

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.21

0.0

2.8

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.20

0.0

2.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

0.71

0.18

2.4

1.8

—

(40768804) Tissue Pathology biopsy report

131

1.19

0.15

1.9

2.2

—

(3021960) Folate [Moles/volume] in Serum or Plasma

104

0.84

0.14

1.2

1.6

20.6

18.6

nmol/l

—

(3044889) 12 lead EKG panel

287

0.88

0.13

3.9

4.4

—

(36304419) Bacteria [Presence] in Urine

115

0.84

0.12

3.0

2.7

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

182

1.14

0.12

2.0

2.6

—

(3026008) Bacteria identified in Urine by Culture

114

0.85

0.11

4.5

3.0

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.09

0.10

1.8

1.5

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.09

0.10

2.8

1.8

—

(40768797) Stomach Pathology biopsy report

1.12

0.09

1.7

1.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

186

1.11

0.08

2.9

3.9

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

1.04

0.07

3.4

2.9

2.5

mmol/l

—

(3003694) ABO and Rh group [Type] in Blood

1.06

0.07

1.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.03

0.07

5.9

3.8

—

(40758558) Short blood count panel - Blood

0.86

0.07

8.8

5.5

—

(1761868) Lipid panel - Serum or Plasma

124

0.95

0.00

3.4

3.1

—

(3013512) EKG study

126

1.03

0.00

4.1

4.5

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.0

—

(4024509)

0.00

0.0

1.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

1.6

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

1.2

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.6

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

5.7

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.4

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

2.6

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

2.2

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.4

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

4.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.0

1.1

—

2.0

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

3.6

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

3.6

—

106.6

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.7

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

2.1

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.2

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

2.3

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.3

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.1

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.0

1.1

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

2.3

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.5

—

214.7

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

1.3

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.0

1.6

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

2.3

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.7

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

2.0

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

2.4

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

1.7

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

2.7

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.0

1.0

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

0.0

1.5

—

27.0

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

2.1

—

(3042936) Bacteria identified in Isolate by Culture

0.93

0.00

3.6

1.8

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.4

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

5.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.1

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

0.97

0.00

4.2

2.5

8.0

9.2

ug/l

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(3003181) Sodium [Moles/volume] in Urine

0.00

0.0

1.8

—

57.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.02

0.00

2.4

1.6

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.3

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

1.3

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

3.6

—

4.1

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.0

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.99

0.00

35.6

9.5

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.0

1.1

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

↥

Index endpoint: DUODENAL_ULCER_ACUTE_W_HAEMORRHAGE – Duodenal ulcer - Acute with haemorrhage, drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Duodenal ulcer - Acute with haemorrhage, drug-induced

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Duodenal ulcer - Acute with haemorrhage, drug-induced (DUODENAL_ULCER_ACUTE_W_HAEMORRHAGE)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints