Fibrothorax

J10_FIBROTHORAX

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — J94.1 Cause of death: ICD-10 — J94.1 2 out of 7 registries used, show all original rules.	72
4. Check minimum number of events None	72
5. Include endpoints None	72
6. Filter based on genotype QC (FinnGen only)	70

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

NAME	J10_FIBROTHORAX
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	J941
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	J941
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Fibrothorax based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	70	16	54
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	69.58	67.39	70.23

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
72: Matched controls
720

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

J94.1

ICD-10 Finland

Fibrothorax

+∞

103.5

J84.1

ICD-10 Finland

Other interstitial pulmonary diseases with fibrosis

45.9

30.3

H02AB06

ATC

prednisolone; systemic

8.5

13.2

266

UGC12

NOMESCO Finland

Flexible bronchoscopy

7.4

12.8

R03BB04

ATC

tiotropium bromide; inhalant

5.7

11.3

J96.1

ICD-10 Finland

Chronic respiratory failure

13.7

10.5

GD1DD

NOMESCO Finland

High resolution CT examination of lungs

9.4

10.0

J84.9

ICD-10 Finland

Interstitial pulmonary disease, unspecified

16.8

9.7

R03AK06

ATC

salmeterol and fluticasone; inhalant

4.7

8.9

J45.9

ICD-10 Finland

Asthma, unspecified

4.4

7.8

J84.8

ICD-10 Finland

Other specified interstitial pulmonary diseases

25.3

6.9

GD1BD

NOMESCO Finland

Thorax extensive CT-examination

6.8

R03BA01

ATC

beclometasone; inhalant

4.4

6.6

R03AC02

ATC

salbutamol; inhalant

3.8

6.6

279

M05BA04

ATC

alendronic acid; oral

6.2

6.4

R91

ICD-10 Finland

Abnormal findings on diagnostic imaging of lung

4.1

6.3

L04AX01

ATC

azathioprine; systemic

16.9

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3003396) Base excess in Arterial blood by calculation

2.74

3.05

18.6

5.1

1.52

0.52

mmol/l

0.22

(3019060) Gas panel - Arterial blood

3.02

2.80

2.1

3.5

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.42

2.71

27.5

4.0

27.89

23.82

mmol/l

1.54

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

4.36

2.65

2.0

2.8

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

3.00

2.60

3.7

3.1

121.02

212.99

ng/l

0.54

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.62

2.25

36.9

6.9

—

(3023419) Bacteria identified in Sputum by Culture

4.79

1.97

4.2

2.6

—

(40760892) CBC W Ordered Manual Differential panel - Blood

219

1.83

1.68

12.4

6.1

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

3.75

1.64

5.8

4.6

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.63

1.54

3.2

2.1

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

2.66

1.49

1.1

1.2

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

467

0.57

1.49

4.7

5.1

6.34

6.22

mmol/l

0.17

413

(3021901) Oxygen saturation in Capillary blood

3.28

1.46

4.0

2.3

—

(3022621) pH of Urine by Test strip

2.30

1.39

2.4

3.0

—

(3000494) Fungus identified in Specimen by Culture

2.21

1.29

4.2

1.6

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

449

0.60

1.27

7.6

6.6

45.06

42.24

mmol/mol

0.75

413

(3023368) Bacteria identified in Blood by Culture

181

1.68

1.22

6.8

4.6

—

(3022313) Gas panel - Capillary blood

2.47

1.16

6.1

3.2

—

(3009542) Hematocrit [Volume Fraction] of Blood

518

0.61

1.14

49.0

26.2

38.27

38.76

0.15

476

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

2.07

1.13

1.5

1.9

2.13

1.45

—

(3022145) Colonoscopy Study observation

2.09

1.08

1.2

1.4

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

504

0.64

1.02

34.8

21.1

84.00

90.06

umol/l

0.92

504

(3000991) Gas panel - Venous blood

1.91

1.01

34.8

6.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.95

0.98

4.8

4.0

—

(36304419) Bacteria [Presence] in Urine

146

1.62

0.97

4.2

2.9

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.88

0.96

2.5

2.0

—

(3005719) IgG [Mass/volume] in Serum or Plasma

2.09

0.89

2.3

3.2

9.45

9.35

g/l

—

(3000492) Spirometry study

1.87

0.88

4.0

1.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.65

0.84

3.5

1.9

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.73

0.77

3.5

1.7

—

(3028026) IgM [Mass/volume] in Serum or Plasma

2.16

0.76

2.0

1.5

1.01

1.02

g/l

—

(4200892) Spirometry reversibility

1.83

0.74

3.4

1.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.70

0.73

3.5

1.8

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

1.62

0.72

4.2

2.9

1.13

0.58

e6/l

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.74

0.71

43.1

7.0

93.60

94.10

—

(3026782) Osmolality of Urine

130

1.51

0.70

2.3

3.2

586.92

574.86

mosm/kgh2o

0.12

108

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

1.58

0.66

4.2

2.7

0.57

0.93

e6/l

—

(3003694) ABO and Rh group [Type] in Blood

111

0.59

0.64

1.1

1.2

—

(3030467) Casts [#/volume] in Urine by Automated count

151

1.45

0.63

4.3

3.0

0.32

0.42

e6/l

0.12

122

(3002032) Base excess in Venous blood by calculation

1.65

0.62

2.1

3.2

4.37

1.45

mmol/l

—

(40761511) CBC panel - Blood by Automated count

475

0.72

0.61

22.8

17.9

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.73

0.58

2.2

1.5

—

(3013512) EKG study

164

0.68

0.53

4.3

4.8

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

226

0.73

0.49

2.6

2.2

81.78

90.58

pmol/l

—

122

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

305

0.77

0.43

5.0

5.2

2.24

2.50

ug/l

0.18

263

(40761536) Microorganisms panel - Urine sediment

1.60

0.43

2.6

4.6

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

209

1.30

0.42

4.2

3.2

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.41

0.0

1.2

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.41

0.0

1.3

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

1.42

0.41

7.4

2.6

0.79

0.83

mmol/l

0.89

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.46

0.40

1.2

—

(3002582) Erythrocytes [#/volume] in Urine

182

1.30

0.39

4.4

3.3

10.13

434.19

e6/l

0.70

150

(3042936) Bacteria identified in Isolate by Culture

0.68

0.35

4.8

1.8

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.36

0.35

1.3

1.9

—

(3041096) Erythrocytes [Presence] in Urine by Automated

129

1.31

0.34

2.7

4.1

—

(3031040) Bacteria [#/volume] in Urine by Automated count

345

1.21

0.29

4.5

4.9

—

5480.00

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

233

0.80

0.29

5.0

2.7

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

105

1.29

0.27

7.5

3.1

989.77

199.32

ng/l

0.46

(3018095) Leukocytes [#/volume] in Urine

200

1.22

0.27

5.6

3.8

2.95

117.51

e6/l

1.67

161

(3011397) Hemoglobin [Presence] in Urine by Test strip

116

1.26

0.24

3.3

4.7

—

(3048689) Calprotectin [Mass/mass] in Stool

1.27

0.23

3.0

2.5

125.20

276.22

ug/g

—

(40768804) Tissue Pathology biopsy report

175

0.82

0.22

2.0

2.3

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.0

—

30.04

—

(1002224) Polysomnography panel

0.00

0.21

0.0

1.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.30

0.21

1.3

1.6

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.21

0.0

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.20

0.0

1.2

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.20

0.0

1.2

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.20

0.0

1.4

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.20

0.0

1.2

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.20

0.0

1.4

—

(1761868) Lipid panel - Serum or Plasma

121

0.80

0.19

3.0

3.6

—

(3026493) Urate [Moles/volume] in Serum or Plasma

129

1.21

0.19

3.7

3.2

386.78

6315.02

umol/l

—

105

(40758558) Short blood count panel - Blood

129

1.21

0.19

6.2

5.3

—

(3026008) Bacteria identified in Urine by Culture

181

0.85

0.16

2.9

3.2

—

(3012516) Albumin [Mass/volume] in Urine

161

1.16

0.14

3.4

2.8

56.50

95.07

mg/l

0.42

111

(3044889) 12 lead EKG panel

341

0.89

0.14

5.3

4.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

127

0.84

0.13

6.1

2.6

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

239

0.89

0.13

4.1

4.4

21.37

22.05

0.08

123

(3020682) Albumin/Creatinine [Ratio] in Urine

173

1.13

0.12

4.2

3.4

11.74

16.12

mg/mmol

0.19

113

(3035350) Ketones [Presence] in Urine by Test strip

235

1.10

0.09

3.6

4.7

0.00

estimate

—

(3044640) Blood type and Crossmatch panel - Blood

173

0.90

0.07

4.9

2.8

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

192

1.06

0.02

2.9

5.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

343

1.04

0.01

4.8

4.6

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

219

1.01

0.00

3.7

2.3

—

(3022217) INR in Platelet poor plasma by Coagulation assay

295

1.03

0.00

14.3

20.1

1.21

1.40

inr

0.56

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

5.0

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

2.3

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

3.3

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

2.3

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.1

—

316.07

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.5

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

1.7

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

2.3

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

664.57

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.6

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

-0.00

0.0

1.8

—

(40768806) Pleura Pathology biopsy report

0.00

-0.00

0.0

1.1

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

-0.00

0.0

1.0

—

10.52

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

3.2

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

3.4

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

3.0

—

2.18

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.2

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

0.76

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.6

—

(3002256) Pathology report gross observation

1.00

-0.00

1.0

1.3

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

-0.00

0.0

5.7

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

-0.00

0.0

1.4

—

1.49

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3045716) Anion gap in Serum or Plasma

0.00

-0.00

0.0

2.2

—

7.18

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

-0.00

0.0

3.6

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

4.9

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

0.86

-0.00

5.0

2.5

3.68

6.57

ug/l

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

-0.00

0.0

2.4

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.6

—

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: J10_FIBROTHORAX – Fibrothorax

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).

≡ Risteys

R13

FinnGen R12 + FinRegistry

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Fibrothorax

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Fibrothorax (J10_FIBROTHORAX)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints