This is a non-core endpoint: only basic statistics are computed.

Wrist or foot drop (acquired)

M13_WRISTFOOTDROP

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M21.3 Cause of death: ICD-10 — M21.3 2 out of 7 registries used, show all original rules.	16
4. Check minimum number of events None	16
5. Include endpoints None	16
6. Filter based on genotype QC (FinnGen only)	16

Control definitions (FinnGen only)

Control exclude: M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M21
Name in latin: Deformitas [acquisita] carpi sive tarsi pendens

NAME	M13_WRISTFOOTDROP
CONTROL_EXCLUDE	M13_ARTHROPATHIES
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M213
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M213
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Wrist or foot drop (acquired) based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	151	84	67
Only index persons	145	80	65
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	-	52.97	55.99
Only index persons	54.49	53.28	55.99

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	16	8	8
Unadjusted period prevalence (%)	0.00	0.00	0.00
Median age at first event (years)	51.61	56.40	46.81

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3042936) Bacteria identified in Isolate by Culture

3.34

1.32

3.2

1.6

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

3.15

1.25

1.4

1.8

mg/l

1.4

1.6

—

(3013512) EKG study

2.39

1.01

2.8

4.4

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

0.47

0.71

6.2

9.2

e9/l

4.1

4.0

—

(40761511) CBC panel - Blood by Automated count

141

+∞

0.65

17.4

14.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

1.85

0.55

5.3

3.3

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

1.81

0.48

2.0

1.2

—

2.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.00

0.44

0.0

1.4

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

145

+∞

0.44

18.1

17.2

umol/l

76.1

79.2

0.21

145

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.43

0.0

1.6

—

(3000991) Gas panel - Venous blood

0.00

0.43

0.0

2.9

—

(3022217) INR in Platelet poor plasma by Coagulation assay

0.00

0.43

0.0

24.9

—

(3044640) Blood type and Crossmatch panel - Blood

1.74

0.43

3.0

2.2

—

(3012544) pH of Venous blood

0.00

0.42

0.0

3.0

—

(42870588) Differential panel, method unspecified - Blood

1.68

0.42

2.5

5.1

—

(3009542) Hematocrit [Volume Fraction] of Blood

121

0.71

0.26

14.7

13.1

42.4

40.5

—

(3023368) Bacteria identified in Blood by Culture

1.36

0.25

4.4

2.9

—

(1761868) Lipid panel - Serum or Plasma

1.44

0.24

4.0

2.7

—

(3013115) Eosinophils [#/volume] in Blood

0.68

0.22

8.6

5.1

e9/l

0.2

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.22

0.0

1.7

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.22

0.0

4.3

—

0.9

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

0.00

0.22

0.0

1.4

—

53.2

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.22

0.0

4.3

—

0.7

—

(3026008) Bacteria identified in Urine by Culture

1.28

0.11

2.0

3.5

—

(40768804) Tissue Pathology biopsy report

1.28

0.11

5.3

2.0

—

(3015736) pH of Urine

1.24

0.11

7.0

4.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.29

0.10

2.3

3.2

—

(3021589) Normoblasts [#/volume] in Blood

1.23

0.10

6.1

7.6

e9/l

0.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

1.33

0.10

5.6

4.4

—

(3044889) 12 lead EKG panel

0.78

0.10

3.3

4.8

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

0.00

0.0

1.3

—

(3025941) Bacteria identified in Stool by Culture

0.00

0.0

1.4

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.0

2.2

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.0

2.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

0.94

0.00

8.4

4.6

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.4

—

(3022096) Basophils/100 leukocytes in Blood

0.89

0.00

5.4

5.7

0.5

0.7

—

(1616796) Gas panel - Central venous blood

0.00

0.0

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

1.13

0.00

2.6

3.0

—

(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.4

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.0

1.2

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

46.0

—

(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay

0.00

0.0

2.0

—

0.5

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.2

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.0

1.3

—

(3006504) Eosinophils/100 leukocytes in Blood

0.84

0.00

8.8

5.6

3.1

3.2

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.0

1.2

—

167.0

—

(3004588) Protein electrophoresis panel - Serum or Plasma

0.00

0.0

1.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.0

2.7

—

(3036489) Thrombin time

0.00

0.0

1.5

—

21.0

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.0

5.3

—

(4094501)

0.00

0.0

1.2

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

0.86

0.00

23.8

4.7

mmol/l

1.3

1.2

—

(3009214) Lutropin [Units/volume] in Serum or Plasma

0.00

0.0

2.8

—

9.7

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.0

4.6

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_WRISTFOOTDROP and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_WRISTFOOTDROP.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: M13_WRISTFOOTDROP – Wrist or foot drop (acquired)

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Wrist or foot drop (acquired)

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints