Dysplastic lesion of the vulva of unknown severity

N14_VULVAL_DYSPLASIA_NOS

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule only females	293218
2. Check conditions None	293218
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — N90.3 Cause of death: ICD-10 — N90.3 2 out of 7 registries used, show all original rules.	55
4. Check minimum number of events None	55
5. Include endpoints None	55
6. Filter based on genotype QC (FinnGen only)	55

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze: DF7

NAME	N14_VULVAL_DYSPLASIA_NOS
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	N903
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	N903
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Dysplastic lesion of the vulva of unknown severity based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	290	290	-
Only index persons	280	280	-
Unadjusted period prevalence (%)
Whole population	0.01	0.01	-
Only index persons	0.01	0.01	-
Median age at first event (years)
Whole population	-	59.03	-
Only index persons	-	58.75	-

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	55	55	-
Unadjusted period prevalence (%)	0.02	0.02	-
Median age at first event (years)	57.34	57.34	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
55: Matched controls
550

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

N90.3

ICD-10 Finland

Dysplasia of vulva, unspecified

+∞

78.8

ULA02

NOMESCO Finland

Kolposcopy

58.9

51.7

LFB00

NOMESCO Finland

Biopsy of vulva or perineum

153.6

37.7

XLD00

NOMESCO Finland

Sytologyspecimen from mouth of uterus

15.4

24.5

N90.2

ICD-10 Finland

Severe vulvar dysplasia, not elsewhere classified

+∞

18.8

LFC00

NOMESCO Finland

Partial excision of vulva

+∞

18.8

D07AD01

ATC

clobetasol; topical

10.4

17.1

L90.0

ICD-10 Finland

Lichen sclerosus et atrophicus

16.8

10.2

LC2BE

NOMESCO Finland

Transvaginal ultrasound examination of uterus, parametria and lower abdomen

6.2

9.8

146

D07.1

ICD-10 Finland

Carcinoma in situ: Vulva

+∞

9.6

N90.0

ICD-10 Finland

Mild vulvar dysplasia

59.9

9.0

LFB10

NOMESCO Finland

Excision of lesion of vulva or perineum

52.8

8.0

LEB00

NOMESCO Finland

Biopsy of vagina

19.2

7.6

8077/2-C51.9

ICD-O-3

Squamous intraepithelial neoplasia, high grade of vulva, NOS

+∞

7.4

D06BB10

ATC

imiquimod; topical

10.2

6.8

R87.6

ICD-10 Finland

Abnormal findings in specimens from female genital organs, abnormal cytological findings

7.0

6.7

A63.0

ICD-10 Finland

Anogenital (venereal) warts

17.0

6.7

LFB20

NOMESCO Finland

Destruction of lesion of vulva or perineum

78.6

6.6

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3025130) Human papilloma virus identified in Specimen

34.17

13.46

1.9

2.1

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

6.83

6.33

2.4

1.7

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

102

3.94

5.80

4.3

3.6

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

3.39

3.96

3.4

2.4

1.65

1.13

e6/l

0.20

(40768804) Tissue Pathology biopsy report

205

2.95

3.61

4.3

2.1

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

146

2.87

3.58

1.9

1.4

—

(3023368) Bacteria identified in Blood by Culture

2.88

3.31

3.8

3.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

101

2.75

3.04

2.1

1.8

—

(36304419) Bacteria [Presence] in Urine

116

2.69

3.04

4.6

2.5

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

2.88

2.95

2.1

2.0

0.75

0.83

mmol/l

1.98

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

143

2.55

2.85

5.0

2.7

—

(3044640) Blood type and Crossmatch panel - Blood

145

2.50

2.75

2.4

1.8

—

(3030467) Casts [#/volume] in Urine by Automated count

114

2.55

2.71

4.8

2.6

0.33

0.61

e6/l

0.32

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

2.85

2.67

3.7

2.5

2.45

5.24

e6/l

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

108

2.53

2.61

1.7

1.3

12.16

30.28

iu/ml

—

(4035726) Immunohistochemistry procedure

2.99

2.46

1.3

—

(3002582) Erythrocytes [#/volume] in Urine

135

2.38

2.44

4.3

2.7

15.77

73.95

e6/l

0.77

105

(3048929) Epstein Barr virus Ab [Presence] in Serum

6.73

2.42

1.0

1.4

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

284

2.50

2.36

11.6

8.4

4.01

3.82

e9/l

0.24

257

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

5.98

2.26

1.0

1.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

2.94

2.24

1.6

1.7

—

(3031040) Bacteria [#/volume] in Urine by Automated count

333

2.61

2.15

5.7

4.4

—

111.00

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.73

2.12

1.4

1.3

—

(3018095) Leukocytes [#/volume] in Urine

159

2.20

2.11

5.4

3.4

17.74

85.52

e6/l

1.61

109

(40760892) CBC W Ordered Manual Differential panel - Blood

224

2.18

2.05

9.5

5.3

—

(3026493) Urate [Moles/volume] in Serum or Plasma

111

2.26

2.04

1.6

2.1

274.87

8766.70

umol/l

1.08

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

4.07

1.99

1.0

1.1

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

4.88

1.98

1.0

1.5

—

(3026782) Osmolality of Urine

2.38

1.92

4.5

2.5

455.60

502.22

mosm/kgh2o

0.38

(3052851) Hemolysis interference index of Serum or Plasma

4.46

1.86

4.6

4.3

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.19

1.79

1.3

2.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

338

2.25

1.67

5.7

4.2

—

(3000492) Spirometry study

2.75

1.67

1.5

1.4

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

2.55

1.66

3.0

3.9

217.90

245.34

u/l

—

(3002256) Pathology report gross observation

2.32

1.57

1.3

1.2

—

(40758558) Short blood count panel - Blood

130

2.00

1.57

6.2

6.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.28

1.52

1.8

1.6

—

(3042936) Bacteria identified in Isolate by Culture

2.28

1.52

2.2

1.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.16

1.51

1.4

1.6

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.34

1.50

1.4

—

(36660697) Celiac disease serology panel - Serum

2.49

1.48

1.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.49

1.48

1.8

1.6

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.42

1.45

1.8

1.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.61

1.44

1.4

1.3

—

(40768797) Stomach Pathology biopsy report

2.16

1.43

1.3

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.13

1.39

1.4

1.0

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

2.95

1.31

4.8

2.1

23.58

24.68

mmol/l

—

(3026008) Bacteria identified in Urine by Culture

174

1.80

1.27

3.2

2.7

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

113

1.88

1.26

1.8

1.3

54.10

15.30

u/ml

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

233

1.76

1.20

3.2

2.3

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.64

1.17

5.0

2.0

126.40

126.75

g/l

—

(40768443) Skin Pathology biopsy report

2.64

1.17

1.0

1.2

—

(40761535) Cells panel - Urine sediment

2.52

1.17

8.0

2.9

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

2.28

0.95

4.3

2.3

5.08

5.66

kpa

—

(3003338) MCHC [Mass/volume]

418

1.85

0.88

28.9

15.0

329.74

330.63

g/l

0.33

418

(3003694) ABO and Rh group [Type] in Blood

143

1.63

0.87

1.8

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

309

1.60

0.83

3.2

3.1

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.19

0.76

1.4

1.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.93

0.70

1.2

1.4

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.73

0.63

1.0

1.4

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

182

1.45

0.60

2.3

1.8

74.45

107.71

pmol/l

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.60

0.0

1.5

—

286.20

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

1.75

0.59

1.3

1.1

—

172.17

—

(3021589) Normoblasts [#/volume] in Blood

213

1.42

0.56

12.2

8.1

0.00

e9/l

-0.00

182

(3013512) EKG study

140

0.65

0.52

4.1

3.0

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

1.52

0.49

1.9

3.1

0.97

1.16

mmol/l

—

(3000494) Fungus identified in Specimen by Culture

1.53

0.46

1.6

1.3

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.62

0.43

1.0

1.2

—

(3012544) pH of Venous blood

1.62

0.43

2.6

2.2

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.42

0.0

4.9

—

18.32

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

0.00

0.40

0.0

1.6

—

7.77

—

(3022621) pH of Urine by Test strip

1.44

0.36

1.3

2.7

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.44

0.36

5.8

5.9

100.33

104.37

mmol/l

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.41

0.36

1.3

1.5

—

(3022217) INR in Platelet poor plasma by Coagulation assay

196

1.30

0.35

14.7

11.2

1.14

1.20

inr

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

139

1.32

0.34

3.2

1.8

127.06

136.27

u/l

0.06

131

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

198

1.28

0.32

6.7

3.7

—

(3044889) 12 lead EKG panel

342

1.25

0.26

5.7

3.4

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.21

0.22

1.2

1.4

—

(1761868) Lipid panel - Serum or Plasma

174

0.81

0.22

2.3

2.7

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.21

0.0

2.6

—

4.21

—

(4281824) Cell count and differential, peritoneal fluid

0.00

0.21

0.0

1.0

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.21

0.0

2.6

—

61.90

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

0.00

0.21

0.0

4.2

—

24.77

—

(3043409) Potassium [Moles/volume] in Arterial blood

0.00

0.21

0.0

4.9

—

3.83

—

(3022313) Gas panel - Capillary blood

0.00

0.21

0.0

4.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

109

1.25

0.21

1.4

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.21

0.0

4.1

—

1.40

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

173

0.82

0.20

9.1

3.1

11.79

20.00

ng/l

—

111

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.20

0.0

3.1

—

129.41

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.71

0.18

1.8

2.0

—

(3019309) Folate [Moles/volume] in Red Blood Cells

1.17

0.16

1.4

1.7

1865.44

1164.89

nmol/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.12

0.10

4.4

2.8

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

1.10

0.09

1.3

1.9

26.50

28.79

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.82

0.09

3.0

5.6

—

(3022145) Colonoscopy Study observation

1.05

0.08

1.9

1.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.15

0.07

1.8

1.7

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

458

1.18

0.07

18.9

10.8

84.03

82.92

ml/min/173m2

0.17

363

(3041096) Erythrocytes [Presence] in Urine by Automated

142

0.98

0.00

5.3

3.6

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

1.0

—

32.50

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

1.2

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.2

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

34.48

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

25.45

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.7

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

2.4

—

210.44

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.2

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

-0.00

0.0

1.2

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.1

—

(3020911) Cortisol [Moles/time] in 24 hour Urine

0.00

-0.00

0.0

1.4

—

59.40

—

(3011288) Drugs identified in Urine by Screen method

0.00

-0.00

0.0

1.3

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

96.68

—

(3023410) Appearance of Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(4146454) Self-monitoring of blood glucose

0.00

-0.00

0.0

2.8

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

(3023419) Bacteria identified in Sputum by Culture

0.00

-0.00

0.0

2.4

—

(3000012) Reticulocyte production index

0.00

-0.00

0.0

1.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

0.00

-0.00

0.0

2.0

—

105.22

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

1.2

—

94.00

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

2.6

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

1.8

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.1

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

-0.00

0.0

1.0

—

13.80

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

-0.00

0.0

3.1

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

2.6

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

3.6

—

Mortality – FinRegistry

↥

Association

Association between endpoint N14_VULVAL_DYSPLASIA_NOS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_VULVAL_DYSPLASIA_NOS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: N14_VULVAL_DYSPLASIA_NOS – Dysplastic lesion of the vulva of unknown severity

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Dysplastic lesion of the vulva of unknown severity

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints