Noninflammatory disorders of female genital tract

N14_FEMALEGENNONINF

Uterine Inversion: A complication of obstetric labor in which the corpus of the uterus is forced completely or partially through the uterine cervix. This can occur during the late stages of labor and is associated with immediate postpartum hemorrhage.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N80-N98
  • Cause of death: ICD-10 N80-N98

2 out of 7 registries used, show all original rules.

126197

4. Check minimum number of events

None

126197

5. Include endpoints

157507

6. Filter based on genotype QC (FinnGen only)

157507

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 157507 157507 -
Unadjusted period prevalence (%) 53.69 53.69 -
Median age at first event (years) 42.30 42.30 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
414
Matched controls
2562
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
18.1
47.3
85
36
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
10.8
40.5
91
65
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
38.0
33.6
49
9
N94.4
ICD-10 Finland
Primary dysmenorrhoea
7.2
28.9
82
85
N91.1
ICD-10 Finland
Secondary amenorrhoea
21.7
28.2
47
15
N92.0
ICD-10 Finland
Excessive and frequent menstruation with regular cycle
10.8
24.7
54
35
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
17.0
22.3
40
16
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
11.3
21.7
46
28
N92.2
ICD-10 Finland
Excessive menstruation at puberty
14.3
19.9
38
18
N92.5
ICD-10 Finland
Other specified irregular menstruation
11.0
19.6
42
26
B02AA02
ATC
tranexamic acid; systemic
7.3
18.6
50
47
TLC00
NOMESCO Finland
Insertion of intrauterine device
13.4
18.5
36
18
N94.5
ICD-10 Finland
Secondary dysmenorrhoea
15.8
17.0
31
13
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
8.2
15.8
39
32
N80.3
ICD-10 Finland
Endometriosis of pelvic peritoneum
+∞
15.6
18
*
N80.9
ICD-10 Finland
Endometriosis, unspecified
+∞
14.7
17
*
N91.0
ICD-10 Finland
Primary amenorrhoea
116.1
14.3
18
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.9
13.3
97
244
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
89.4
11.0
14
*
LC2DE
NOMESCO Finland
Demanding ultrsound examination of uterus, parametrium and lower part of abdomen with speciel methods
15.3
10.6
19
8
N94.6
ICD-10 Finland
Dysmenorrhoea, unspecified
4.6
9.8
37
54
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
9.7
151
553
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
3.0
8.8
55
123
127
Kela drug reimbursment
Transplant complication
12.1
8.7
17
9
H02AB09
ATC
hydrocortisone; systemic
4.7
8.7
31
43
A02BC05
ATC
esomeprazole; systemic
3.1
8.6
51
110
N80
ICD-10 Finland
Endometriosis
+∞
8.6
10
*
J02AC01
ATC
fluconazole; systemic
2.7
8.5
63
157
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.4
8.5
86
256
N94.1
ICD-10 Finland
Dyspareunia
8.1
8.4
20
16
N93.9
ICD-10 Finland
Abnormal uterine and vaginal bleeding, unspecified
20.7
8.1
13
*
62301
ICD-8 Finland
Uterovaginal prolapse, Cystocele alia
+∞
7.7
9
*
N90.8
ICD-10 Finland
Other specified noninflammatory disorders of vulva and perineum
63.2
7.6
10
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
7.5
76
224
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
3.2
7.3
40
82
N02BE01
ATC
paracetamol; systemic, rectal
1.8
7.3
191
824
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
5.0
6.9
23
30
M01AE01
ATC
ibuprofen; systemic, rectal
1.7
6.8
228
1055
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.1
6.6
37
78
Z94.0
ICD-10 Finland
Kidney transplant status
12.7
6.4
12
6
P01AB01
ATC
metronidazole; oral, rectal
2.8
6.4
44
106
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
8.9
6.4
14
10
ZX120
NOMESCO Finland
Intravenous
3.4
6.3
31
59
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
21.1
6.3
10
*
M54.5
ICD-10 Finland
Low back pain
2.3
6.3
65
195
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.1
6.2
81
267
D06
ICPC
Abdominal pain localized other
2.5
6.2
52
139
137
Kela drug reimbursment
Uraemia requiring dialysis
28.4
6.1
9
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.9
6.0
95
340
N83.5
ICD-10 Finland
Torsion of ovary, ovarian pedicle and fallopian tube
+∞
6.0
7
*
JAL21
NOMESCO Finland
Laparoscopic excision or destruction of lesion of peritoneum
+∞
6.0
7
*
6271A
ICD-9 Finland
Menopausal and postmenopausal disorders, Postmenopausal bleeding
+∞
6.0
7
*

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: N14_FEMALEGENNONINF – Noninflammatory disorders of female genital tract

GWS hits: 10

This endpoint is excluded (different definition than used in FinnGen).