Acquired atrophy of ovary and fallopian tube

N14_ATROPHOV

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N83.3
  • Cause of death: ICD-10 N83.3

2 out of 7 registries used, show all original rules.

104

4. Check minimum number of events

None

104

5. Include endpoints

None

104

6. Filter based on genotype QC (FinnGen only)

104

Control definitions (FinnGen only)

Control exclude
N14_FEMALEGENNONINF

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N83
Name in latin
Atrophia acquisita ovarii et tubae uterinae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 567 567 -
Only index persons 554 554 -
Unadjusted period prevalence (%)
Whole population 0.02 0.02 -
Only index persons 0.02 0.02 -
Median age at first event (years)
Whole population - 41.06 -
Only index persons - 40.51 -

-FinnGen-

Key figures

All Female Male
Number of individuals 104 104 -
Unadjusted period prevalence (%) 0.04 0.04 -
Median age at first event (years) 41.20 41.20 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
90
Matched controls
900
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N83.3
ICD-10 Finland
Acquired atrophy of ovary and fallopian tube
+∞
129.6
90
*
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
100.8
38.2
40
7
N80.3
ICD-10 Finland
Endometriosis of pelvic peritoneum
+∞
24.0
22
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
10.0
21.9
57
132
N80.1
ICD-10 Finland
Endometriosis of ovary
+∞
18.3
17
*
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
17.7
14.7
23
17
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
6.4
13.4
42
108
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
81.8
13.0
14
*
N80.9
ICD-10 Finland
Endometriosis, unspecified
+∞
11.7
11
*
JAL21
NOMESCO Finland
Laparoscopic excision or destruction of lesion of peritoneum
+∞
11.7
11
*
N92.0
ICD-10 Finland
Excessive and frequent menstruation with regular cycle
32.7
11.1
14
5
N84.0
ICD-10 Finland
Polyp of corpus uteri
123.8
10.7
11
*
N97.9
ICD-10 Finland
Female infertility, unspecified
+∞
10.6
10
*
LCA06
NOMESCO Finland
Biopsy of endometrium
10.6
9.9
19
22
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
4.3
9.8
50
201
N80.0
ICD-10 Finland
Endometriosis of uterus
111.2
9.6
10
*
LAC01
NOMESCO Finland
Laparoscopic excision of ovarian cyst
+∞
9.5
9
*
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
8.3
9.0
20
30
N95.0
ICD-10 Finland
Postmenopausal bleeding
30.9
8.7
11
*
JAH01
NOMESCO Finland
Laparoscopy
12.4
7.6
13
12
SPAT1254
SPAT
Administration of medicine
5.7
7.6
22
48
N83.0
ICD-10 Finland
Follicular cyst of ovary
87.0
7.5
8
*
N83.1
ICD-10 Finland
Corpus luteum cyst
+∞
7.4
7
*
N95.1
ICD-10 Finland
Menopausal and female climacteric states
+∞
7.4
7
*
N83.8
ICD-10 Finland
Other noninflammatory disorders of ovary, fallopian tube and broad ligament
+∞
7.4
7
*
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
6.4
7.3
19
36
J02AC01
ATC
fluconazole; systemic
3.4
7.2
60
331
UJF32
NOMESCO Finland
Coloscopy
3.8
7.0
35
128
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.7
6.6
34
128
ULC02
NOMESCO Finland
Hysteroscopy
15.8
6.6
10
7
LAF01
NOMESCO Finland
Laparoscopic unilateral salpingo-oophorectomy
74.9
6.5
7
*
L02AE02
ATC
leuprorelin; implant, parenteral
28.9
6.3
8
*
LBF01
NOMESCO Finland
Laparoscopic perfusion of Fallopian tube
+∞
6.3
6
*
N81.2
ICD-10 Finland
Incomplete uterovaginal prolapse
+∞
6.3
6
*
N73.6
ICD-10 Finland
Female pelvic peritoneal adhesions
+∞
6.3
6
*
LCB25
NOMESCO Finland
Hysteroscopic excision of lesion
+∞
6.3
6
*
N80.5
ICD-10 Finland
Endometriosis of intestine
+∞
6.3
6
*
LAF11
NOMESCO Finland
Laparoscopic bilateral salpingo-oophorectomy
11.2
6.2
11
11

Mortality – FinRegistry

Association

Association between endpoint N14_ATROPHOV and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_ATROPHOV.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: N14_ATROPHOV – Acquired atrophy of ovary and fallopian tube

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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