Acquired atrophy of ovary and fallopian tube

N14_ATROPHOV

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

only females

293218

2. Check conditions

None

293218

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N83.3
  • Cause of death: ICD-10 N83.3

2 out of 7 registries used, show all original rules.

105

4. Check minimum number of events

None

105

5. Include endpoints

None

105

6. Filter based on genotype QC (FinnGen only)

102

Control definitions (FinnGen only)

Control exclude
N14_FEMALEGENNONINF

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N83
Name in latin
Atrophia acquisita ovarii et tubae uterinae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 567 567 -
Only index persons 554 554 -
Unadjusted period prevalence (%)
Whole population 0.02 0.02 -
Only index persons 0.02 0.02 -
Median age at first event (years)
Whole population - 41.06 -
Only index persons - 40.51 -

-FinnGen-

Key figures

All Female Male
Number of individuals 102 102 -
Unadjusted period prevalence (%) 0.04 0.04 -
Median age at first event (years) 41.17 41.17 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
105
Matched controls
1050
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N83.3
ICD-10 Finland
Acquired atrophy of ovary and fallopian tube
+∞
151.4
105
*
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
121.6
49.9
51
8
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
9.8
31.3
68
166
N80.3
ICD-10 Finland
Endometriosis of pelvic peritoneum
+∞
25.0
23
*
N95.1
ICD-10 Finland
Menopausal and female climacteric states
+∞
19.4
18
*
N80.1
ICD-10 Finland
Endometriosis of ovary
214.8
18.1
18
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
5.5
16.8
50
149
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
13.9
14.5
25
23
JAL21
NOMESCO Finland
Laparoscopic excision or destruction of lesion of peritoneum
+∞
13.8
13
*
LCA06
NOMESCO Finland
Biopsy of endometrium
12.5
12.8
23
23
N80.9
ICD-10 Finland
Endometriosis, unspecified
146.8
12.7
13
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
4.3
12.4
60
249
N80.0
ICD-10 Finland
Endometriosis of uterus
+∞
11.7
11
*
UJF32
NOMESCO Finland
Coloscopy
4.4
11.3
39
125
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
5.9
10.8
22
45
LAC01
NOMESCO Finland
Laparoscopic excision of ovarian cyst
121.7
10.6
11
*
N84.0
ICD-10 Finland
Polyp of corpus uteri
121.7
10.6
11
*
N97.9
ICD-10 Finland
Female infertility, unspecified
29.3
10.1
13
5
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
17.7
9.3
14
9
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
5.6
9.0
19
40
SPAT1254
SPAT
Administration of medicine
5.0
9.0
22
53
N83.1
ICD-10 Finland
Corpus luteum cyst
97.6
8.5
9
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.6
8.5
39
149
N83.8
ICD-10 Finland
Other noninflammatory disorders of ovary, fallopian tube and broad ligament
+∞
8.4
8
*
LBF01
NOMESCO Finland
Laparoscopic perfusion of Fallopian tube
+∞
8.4
8
*
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
3.4
8.2
70
389
JAH01
NOMESCO Finland
Laparoscopy
12.2
8.1
14
13
J02AC01
ATC
fluconazole; systemic
3.3
7.9
68
376
JAP01
NOMESCO Finland
Laparoscopic freeing of adhesions in the peritoneal cavity
85.9
7.5
8
*
N95.2
ICD-10 Finland
Postmenopausal atrophic vaginitis
+∞
7.4
7
*
N83.0
ICD-10 Finland
Follicular cyst of ovary
32.5
7.3
9
*
LC2DE
NOMESCO Finland
Demanding ultrsound examination of uterus, parametrium and lower part of abdomen with speciel methods
11.2
7.3
13
13
N95.0
ICD-10 Finland
Postmenopausal bleeding
15.2
7.1
11
8
G03DC03
ATC
lynestrenol; oral
18.2
6.9
10
6
N81.2
ICD-10 Finland
Incomplete uterovaginal prolapse
42.9
6.9
8
*
L02AE02
ATC
leuprorelin; implant, parenteral
24.4
6.8
9
*
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
9.1
6.6
13
16
ULC02
NOMESCO Finland
Hysteroscopy
15.6
6.5
10
7
N73.6
ICD-10 Finland
Female pelvic peritoneal adhesions
74.2
6.5
7
*
N92.0
ICD-10 Finland
Excessive and frequent menstruation with regular cycle
7.9
6.5
14
20
N03AX16
ATC
[U] pregabalin
3.1
6.5
34
139
LAF01
NOMESCO Finland
Laparoscopic unilateral salpingo-oophorectomy
28.6
6.3
8
*
N81.6
ICD-10 Finland
Rectocele
28.6
6.3
8
*
TLW12
NOMESCO Finland
Insertion of frozen embryo
+∞
6.3
6
*
N80.5
ICD-10 Finland
Endometriosis of intestine
+∞
6.3
6
*
N97.8
ICD-10 Finland
Female infertility of other origin
+∞
6.3
6
*
SPAT1263
SPAT
Sampling
2.8
6.3
53
280
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
4.0
6.2
20
59
B02AA02
ATC
tranexamic acid; systemic
3.6
6.2
23
75

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
20
42
5.65
9.51
1.5
1.4
—
—
—
0
0
48
237
2.89
6.53
3.8
2.5
—
—
—
0
0
82
541
3.35
6.48
5.6
3.9
—
—
—
0
0
85
616
2.99
4.87
4.4
3.8
9.01
10.58
mm/h
0.78
80
576
57
344
2.44
4.79
2.0
1.7
—
—
—
0
0
60
374
2.41
4.64
7.1
4.1
0.00
0.00
estimate
—
9
75
60
379
2.36
4.44
5.2
3.1
0.00
0.00
estimate
—
10
75
32
153
2.57
4.38
6.2
3.3
1.02
1.02
kg/l
—
6
23
51
304
2.32
4.28
5.2
2.7
6.00
5.86
ph
—
5
18
52
313
2.31
4.26
10.7
9.3
1.00
1.16
inr
2.47
14
97
59
380
2.26
4.05
5.3
3.0
0.00
0.00
estimate
-0.00
11
83
41
236
2.21
3.62
2.1
2.0
—
—
—
0
0
97
833
3.16
3.16
5.8
4.5
1.59
1.85
mu/l
2.15
90
773
59
410
2.00
3.02
5.9
5.8
9.34
9.34
umol/l
0.00
59
392
8
17
5.00
2.98
2.0
1.2
53.38
89.88
pmol/l
—
8
17
86
692
2.34
2.90
4.9
4.0
14.78
14.41
pmol/l
0.77
80
640
5
6
8.67
2.78
2.4
1.8
—
—
—
0
0
10
29
3.70
2.77
6.1
3.7
—
—
—
0
0
57
400
1.93
2.76
5.1
5.7
0.05
0.04
e9/l
0.32
52
351
52
358
1.90
2.63
6.5
5.8
1.21
1.22
mmol/l
0.18
44
308
16
71
2.48
2.49
1.2
1.4
—
—
—
0
0
54
382
1.85
2.47
5.2
6.0
—
—
—
0
0
34
207
1.95
2.46
4.0
2.8
—
—
—
0
0
27
154
2.01
2.33
1.4
1.2
3.71
13.89
u/ml
1.00
12
59
98
874
2.82
2.32
17.9
10.6
18.48
20.21
mg/l
0.21
78
641
13
54
2.61
2.30
2.5
3.5
6.22
6.00
kpa
0.23
13
54
15
68
2.41
2.23
1.9
1.4
—
—
—
0
0
13
55
2.56
2.22
2.5
3.5
—
—
—
0
0
19
99
2.12
2.06
1.3
1.2
—
—
—
0
0
8
26
3.24
2.06
2.9
2.2
27.63
24.45
mmol/l
—
8
26
38
253
1.79
2.04
3.5
3.2
71.97
20.07
ng/l
0.40
18
159
27
162
1.90
2.00
1.4
1.2
7.68
24.40
iu/ml
1.21
11
48
93
814
2.25
1.91
4.3
3.9
5.90
5.80
mmol/l
0.13
84
758
28
179
1.77
1.69
3.8
3.7
—
—
—
0
0
40
283
1.67
1.68
2.3
2.0
94.36
94.90
pmol/l
0.02
16
139
7
25
2.92
1.68
3.1
2.0
0.70
0.60
%
—
7
25
27
173
1.75
1.61
2.0
1.8
1.62
0.95
mg/l
0.90
18
125
34
233
1.68
1.60
3.3
3.6
7.39
7.40
ph
—
7
40
11
51
2.29
1.57
7.8
7.4
—
—
—
0
0
87
761
1.84
1.53
5.1
4.6
38.13
38.78
mmol/mol
0.31
79
719
7
28
2.60
1.48
3.1
2.0
1.70
1.26
%
—
7
28
6
22
2.83
1.45
1.3
1.1
—
—
—
0
0
38
274
1.61
1.45
3.7
3.0
9.57
64.90
e6/l
2.96
31
181
95
860
2.10
1.42
4.2
3.8
5.00
4.94
mmol/l
0.21
88
803
27
180
1.67
1.39
5.9
3.0
—
—
—
0
0
5
17
3.03
1.37
8.2
4.3
—
—
—
0
0
9
43
2.19
1.34
2.7
2.2
7.31
4.35
kpa
—
9
43
30
210
1.60
1.28
6.4
3.4
0.00
0.00
estimate
—
10
77
8
36
2.32
1.27
2.8
2.3
—
—
—
0
0
30
211
1.59
1.25
3.0
2.7
—
—
—
0
0
29
204
1.58
1.21
1.2
1.2
0.53
1.74
u/ml
—
7
53
94
859
1.90
1.19
4.2
3.7
1.60
1.59
mmol/l
0.09
86
802
91
824
1.78
1.19
3.8
3.4
1.28
1.19
mmol/l
0.55
83
767
0
33
0.00
1.18
0.0
1.5
—
—
—
0
0
0
33
0.00
1.18
0.0
1.5
—
—
—
0
0
0
34
0.00
1.18
0.0
1.6
—
—
—
0
0
13
73
1.89
1.17
9.4
7.0
103.69
104.38
mmol/l
0.15
13
73
5
20
2.57
1.16
4.4
4.0
0.76
0.81
%
—
5
20
95
873
1.93
1.15
4.7
4.2
2.95
2.95
mmol/l
0.02
87
816
7
31
2.35
1.13
13.6
5.8
26.57
25.38
mmol/l
—
7
31
11
59
1.97
1.12
12.0
7.1
94.42
95.69
%
0.28
11
59
14
82
1.82
1.11
2.3
5.7
1.00
1.03
mmol/l
0.18
14
77
10
52
2.02
1.10
7.2
3.5
—
—
—
0
0
17
254
0.61
1.07
1.7
1.5
—
—
—
0
0
28
201
1.54
1.06
4.3
3.3
—
—
—
0
0
12
69
1.83
1.01
1.2
2.1
326.00
333.75
nmol/l
0.05
12
64
7
37
1.95
0.96
15.6
7.9
91.13
94.49
%
—
7
37
10
55
1.90
0.96
1.5
1.4
—
—
—
0
0
6
30
2.06
0.88
15.3
6.2
—
—
—
0
0
11
65
1.77
0.86
2.5
2.6
4.41
4.75
pmol/l
0.60
11
60
6
31
1.99
0.86
2.0
1.4
—
—
—
0
0
6
32
1.93
0.83
1.8
1.8
—
—
—
0
0
10
59
1.77
0.79
10.6
6.8
119.20
119.44
g/l
—
10
59
9
56
1.66
0.74
1.4
1.3
—
—
—
0
0
9
56
1.66
0.74
1.8
3.9
—
—
—
0
0
7
39
1.85
0.74
15.6
7.6
1.97
1.23
%
—
7
39
7
39
1.85
0.74
15.6
7.6
0.74
0.65
%
—
7
39
24
181
1.42
0.72
1.3
1.4
2.04
2.20
g/l
0.17
14
104
5
26
1.97
0.71
2.0
1.7
—
—
—
0
0
14
95
1.55
0.68
2.1
1.5
—
—
—
0
0
7
44
1.63
0.66
4.7
5.3
25.30
25.15
mmol/l
—
7
44
10
64
1.62
0.61
1.3
1.1
—
—
—
0
0
14
98
1.49
0.60
1.6
1.3
—
—
—
0
0
0
22
0.00
0.60
0.0
1.1
—
—
—
0
0
6
35
1.76
0.59
1.2
1.1
—
—
—
0
0
14
100
1.46
0.55
1.1
1.2
—
—
—
0
0
7
46
1.56
0.49
2.4
2.1
—
—
—
0
0
25
203
1.30
0.48
3.2
4.0
1.31
7.44
mg/mmol
1.49
14
125
61
553
1.25
0.47
4.0
3.2
—
—
—
0
0
14
104
1.40
0.46
1.4
1.7
—
—
—
0
0
42
367
1.24
0.45
7.6
7.6
0.00
0.00
e9/l
-0.00
34
298
5
31
1.64
0.43
1.8
4.3
24.80
25.41
mmol/l
—
5
31
5
31
1.64
0.43
1.4
1.5
169.00
287.04
mu/l
—
5
25
0
17
0.00
0.41
0.0
1.5
—
—
—
0
0
9
70
1.31
0.38
1.3
2.5
2.03
1.71
%
—
9
63
16
128
1.29
0.34
4.5
2.2
2.50
2.45
mmol/l
0.72
16
112
23
194
1.24
0.33
2.7
3.4
6.23
389.93
mg/l
0.54
12
121
7
52
1.37
0.32
2.1
3.7
1.21
1.25
mmol/l
—
7
45
10
78
1.31
0.25
1.2
1.5
—
—
—
0
0
13
107
1.25
0.23
1.6
2.4
13.43
13.57
umol/l
0.02
13
101
0
11
0.00
0.21
0.0
12.2
—
1945.91
—
0
11
0
11
0.00
0.21
0.0
10.4
—
961.91
—
0
11
0
10
0.00
0.21
0.0
1.0
—
11.39
—
0
10
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
3.1
—
43.83
—
0
6
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
2.7
—
—
—
0
0
8
67
1.21
0.17
5.4
3.2
—
—
—
0
0
81
786
1.13
0.16
23.3
14.2
330.49
330.73
g/l
0.09
81
780
9
106
0.84
0.13
1.2
1.4
—
—
—
0
0
21
191
1.12
0.13
2.0
1.8
—
—
—
0
0
12
106
1.15
0.10
1.9
1.9
—
—
—
0
0
10
112
0.88
0.07
1.6
1.8
—
—
—
0
0
24
226
1.08
0.07
5.8
7.3
—
—
—
0
0
33
340
0.96
0.03
2.8
2.5
—
—
—
0
0
16
167
0.95
0.01
1.9
1.6
—
—
—
0
0
10
104
0.96
0.00
1.5
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
-0.00
1.6
2.2
3.36
6.23
e9/l
—
5
46
5
52
0.96
-0.00
1.6
1.3
—
—
—
0
0
5
59
0.84
-0.00
1.2
1.2
—
32.65
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
31.60
—
0
5
0
7
0.00
-0.00
0.0
5.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
28.88
—
0
5
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
46.71
—
0
7
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
7
73
0.96
-0.00
1.6
1.3
—
—
—
0
0
5
49
1.02
-0.00
1.4
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
8.8
—
0.65
—
0
5

Mortality – FinRegistry

Association

Association between endpoint N14_ATROPHOV and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_ATROPHOV.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: N14_ATROPHOV – Acquired atrophy of ovary and fallopian tube

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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