Risteys · N14_HABITABORT

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule only females	293373
2. Check conditions None	293373
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — N96 Cause of death: ICD-10 — N96 2 out of 7 registries used, show all original rules.	864
4. Check minimum number of events None	864
5. Include endpoints None	864
6. Filter based on genotype QC (FinnGen only)	864

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	4967	4967	-
Only index persons	4929	4929	-
Unadjusted period prevalence (%)
Whole population	0.14	0.14	-
Only index persons	0.18	0.18	-
Median age at first event (years)
Whole population	-	33.37	-
Only index persons	-	33.37	-

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	864	864	-
Unadjusted period prevalence (%)	0.29	0.29	-
Median age at first event (years)	33.78	33.78	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
779: Matched controls
7789

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

N96

ICD-10 Finland

Habitual aborter

+∞

323.0

779

O02.1

ICD-10 Finland

Missed abortion

36.1

323.0

549

482

O03.9

ICD-10 Finland

Spontaneous abortion, Complete or unspecified, without complication

22.7

244.1

384

320

N97.9

ICD-10 Finland

Female infertility, unspecified

132.5

189.7

198

LC2BE

NOMESCO Finland

Transvaginal ultrasound examination of uterus, parametria and lower abdomen

10.2

187.5

568

1628

Z32.1

ICD-10 Finland

Pregnancy confirmed

7.7

140.9

433

1090

Z35.1

ICD-10 Finland

Supervision of pregnancy with history of abortive outcome

64.1

137.9

159

O03.4

ICD-10 Finland

Spontaneous abortion, Incomplete, without complication

18.5

137.7

223

165

MA1AE

NOMESCO Finland

Ultrasound examination of early pregnancy (before 12. postmenstrual week)

7.2

133.9

434

1154

LC2AE

NOMESCO Finland

Ultrasound examination of uterus and parametria

10.3

130.4

291

428

O02.0

ICD-10 Finland

Blighted ovum and nonhydatidiform mole

13.6

123.8

230

232

LC2HE

NOMESCO Finland

Hystero-salpingography with ultrasound

54.4

101.1

120

Z35.0

ICD-10 Finland

Supervision of pregnancy with history of infertility

41.1

99.6

125

MBA00

NOMESCO Finland

Vacuum aspiration from uterus after delivery or abortion

14.2

93.5

167

147

O20.0

ICD-10 Finland

Threatened abortion

13.1

91.2

169

161

MBA40

NOMESCO Finland

Pharmacological evacuation of uterus after abortion

15.4

87.4

150

119

ULC02

NOMESCO Finland

Hysteroscopy

28.9

81.9

112

MBA05

NOMESCO Finland

Curettage of uterus after abortion

24.6

80.9

116

G03GA01

ATC

chorionic gonadotrophin; parenteral

14.2

77.0

136

114

N95.1

ICD-10 Finland

Menopausal and female climacteric states

+∞

74.2

MBA03

NOMESCO Finland

Curettage of uterus after delivery or abortion

9.4

72.5

160

208

Z32.0

ICD-10 Finland

Pregnancy, not (yet) confirmed

9.4

70.1

154

198

TLW00

NOMESCO Finland

Insemination

+∞

69.9

MBA96

NOMESCO Finland

Other removal of retained products of conception after delivery or abortion

10.3

68.3

142

165

LA2AE

NOMESCO Finland

Ultrasound examination of ovarian cyst

236.0

64.2

O03.1

ICD-10 Finland

Spontaneous abortion, Incomplete, complicated by delayed or excessive haemorrhage

12.4

62.6

117

109

N97.0

ICD-10 Finland

Female infertility associated with anovulation

333.0

61.3

LCA06

NOMESCO Finland

Biopsy of endometrium

12.8

60.8

112

101

TLW10

NOMESCO Finland

Transfer of fresh embryo

+∞

60.2

LAA10

NOMESCO Finland

Percutaneous or transvaginal puncture and recovery of oocyte

114.1

58.8

TLW12

NOMESCO Finland

Insertion of frozen embryo

600.1

57.4

H01CA02

ATC

nafarelin; nasal

24.0

57.1

N97.8

ICD-10 Finland

Female infertility of other origin

308.5

57.0

N83.2

ICD-10 Finland

Other and unspecified ovarian cysts

13.6

52.8

O20.9

ICD-10 Finland

Haemorrhage in early pregnancy, unspecified

7.7

51.5

127

192

G03GA05

ATC

follitropin alfa; parenteral

14.5

50.4

W82

ICPC

Abortion spontaneous

15.6

49.7

LX1AE

NOMESCO Finland

Gynecological ultrasound examination as part of clinical examination

4.4

47.7

196

547

W78

ICPC

Pregnancy

3.1

47.3

414

2106

LCB25

NOMESCO Finland

Hysteroscopic excision of lesion

39.7

47.0

LC2DE

NOMESCO Finland

Demanding ultrsound examination of uterus, parametrium and lower part of abdomen with speciel methods

10.0

43.1

G03GA06

ATC

follitropin beta; parenteral

13.8

41.7

O00.1

ICD-10 Finland

Tubal pregnancy

10.9

41.2

G03DA04

ATC

progesterone; systemic, rectal, vaginal

11.9

38.5

H01CC01

ATC

ganirelix; parenteral

11.2

38.4

N97.4

ICD-10 Finland

Female infertility associated with male factors

395.9

38.4

MA2AE

NOMESCO Finland

Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus

2.7

38.3

389

2078

XLD00

NOMESCO Finland

Sytologyspecimen from mouth of uterus

4.4

38.1

153

410

O03.3

ICD-10 Finland

Spontaneous abortion, Incomplete, with other and unspecified complications

31.3

37.8

G03GA02

ATC

human menopausal gonadotrophin; parenteral

12.8

37.1

Z09.0

ICD-10 Finland

Follow-up examination after surgery for other conditions

6.5

36.8

101

175

Z35.8

ICD-10 Finland

Supervision of other high-risk pregnancies

3.1

36.6

243

981

R10.3

ICD-10 Finland

Pain localized to other parts of lower abdomen

2.9

36.3

283

1271

N80.3

ICD-10 Finland

Endometriosis of pelvic peritoneum

373.8

36.3

ZXD05

NOMESCO Finland

Urgent procedure

2.7

36.3

367

1934

G03DB01

ATC

dydrogesterone; oral

3.3

36.1

212

782

O03.0

ICD-10 Finland

Spontaneous abortion, Incomplete, complicated by genital tract and pelvic infection

24.2

35.3

N84.0

ICD-10 Finland

Polyp of corpus uteri

68.3

34.3

G03CA03

ATC

estradiol; nasal, systemic, rectal, transdermal, vaginal

3.2

33.4

209

799

Z35.2

ICD-10 Finland

Supervision of pregnancy with other poor reproductive or obstetric history

6.2

32.0

160

B01AB05

ATC

enoxaparin; parenteral

3.0

30.8

210

849

LBE01

NOMESCO Finland

Laparoscopic salpingectomy

9.9

29.9

ZXE00

NOMESCO Finland

One hour or less

2.4

29.9

378

2177

N87.1

ICD-10 Finland

Moderate cervical dysplasia

+∞

29.4

O00.9

ICD-10 Finland

Ectopic pregnancy, unspecified

12.3

28.6

L02BG04

ATC

letrozole; oral

6.8

28.5

118

LAA06

NOMESCO Finland

Transvaginal puncture of ovarian cyst

+∞

28.3

LBF01

NOMESCO Finland

Laparoscopic perfusion of Fallopian tube

150.4

27.8

MA2DE

NOMESCO Finland

Detailed ultrasound examination of fetus including color doppler method

2.7

27.7

226

1013

R2110

NOMESCO Finland

Giving the first information

4.2

27.5

112

299

Z36.3

ICD-10 Finland

Antenatal screening for malformations using ultrasound and other physical methods

2.3

27.4

487

3264

XLA10

NOMESCO Finland

5.9

26.9

144

N92.6

ICD-10 Finland

Irregular menstruation, unspecified

5.2

25.6

175

O03.6

ICD-10 Finland

Spontaneous abortion, Complete or unspecified, complicated by delayed or excessive haemorrhage

11.3

24.9

B02AA02

ATC

tranexamic acid; systemic

3.2

24.8

148

537

Z35.9

ICD-10 Finland

Supervision of high-risk pregnancy, unspecified

4.0

24.4

104

289

JAH01

NOMESCO Finland

Laparoscopy

8.0

24.3

O03

ICD-10 Finland

Spontaneous abortion

12.2

24.2

Z31.5

ICD-10 Finland

Genetic counselling

3.8

23.9

108

315

Z09.8

ICD-10 Finland

Follow-up examination after other treatment for other conditions

5.4

23.9

152

N80.0

ICD-10 Finland

Endometriosis of uterus

89.6

23.8

SPAT1379

SPAT

Health check-up of pregnant person

2.3

23.6

284

1544

N92.0

ICD-10 Finland

Excessive and frequent menstruation with regular cycle

4.4

23.5

226

LCA10

NOMESCO Finland

Curettage of body of uterus

16.8

23.4

LA2HE

NOMESCO Finland

Repeated measurement of ovarian cyst

123.6

22.7

O47.0

ICD-10 Finland

False labour before 37 completed weeks of gestation

2.5

22.0

197

915

P01AB01

ATC

metronidazole; oral, rectal

2.2

22.0

344

2093

O26.2

ICD-10 Finland

Pregnancy care of habitual aborter

226.1

21.7

WX404

NOMESCO Finland

Intravenous generell anesthesy

2.6

21.4

176

777

O02.9

ICD-10 Finland

Abnormal product of conception, unspecified

25.0

21.0

N83.1

ICD-10 Finland

Corpus luteum cyst

49.4

20.3

N80.9

ICD-10 Finland

Endometriosis, unspecified

49.4

20.3

N97.1

ICD-10 Finland

Female infertility of tubal origin

+∞

19.9

N92.1

ICD-10 Finland

Excessive and frequent menstruation with irregular cycle

6.3

19.4

WX400

NOMESCO Finland

Inhalation anesthesy

4.7

19.4

156

N87.2

ICD-10 Finland

Severe cervical dysplasia, not elsewhere classified

+∞

18.8

Z39.2

ICD-10 Finland

Routine postpartum follow-up

2.1

18.8

303

1835

W03

ICPC

Antepartum bleeding

8.4

18.7

N97

ICD-10 Finland

Female infertility

22.4

18.3

SPAT1197

SPAT

Extensive health check-up of expecting family

2.0

17.9

309

1912

MCA10

NOMESCO Finland

Lower uterine segment caesarean section

2.2

17.7

215

1145

SPAT1317

SPAT

Planned health check-up monitoring, health check-up performed based on individual need

2.3

17.6

203

1053

D68.8

ICD-10 Finland

Other specified coagulation defects

11.9

17.1

TLC00

NOMESCO Finland

Insertion of intrauterine device

3.6

17.0

246

O03.5

ICD-10 Finland

Spontaneous abortion, Complete or unspecified, complicated by genital tract and pelvic infection

26.3

17.0

Z2221

NOMESCO Finland

Medical doctor

2.0

16.5

251

1468

N71.0

ICD-10 Finland

Acute inflammatory disease of uterus

4.1

16.5

168

N87.0

ICD-10 Finland

Mild cervical dysplasia

48.6

16.1

JAL21

NOMESCO Finland

Laparoscopic excision or destruction of lesion of peritoneum

61.3

15.8

N95.2

ICD-10 Finland

Postmenopausal atrophic vaginitis

+∞

15.7

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.9

15.6

298

1890

O35.8

ICD-10 Finland

Maternal care for other (suspected) fetal abnormality and damage

4.2

15.6

156

N80.4

ICD-10 Finland

Endometriosis of rectovaginal septum and vagina

163.1

15.5

Q51.2

ICD-10 Finland

Other doubling of uterus

38.9

15.4

N80.1

ICD-10 Finland

Endometriosis of ovary

38.9

15.4

LDC03

NOMESCO Finland

Conisation of cervix uteri using diathermy or laser

7.6

15.1

B01AB04

ATC

dalteparin; parenteral

5.4

15.1

O99.80

ICD-10 Finland

The fear of childbirth

2.6

15.0

120

514

WX408

NOMESCO Finland

General anesthesy, balanced

2.2

14.7

175

914

W84

ICPC

Pregnancy high risk

2.9

14.7

353

Q95.0

ICD-10 Finland

Balanced translocation and insertion in normal individual

+∞

14.6

LA2JE

NOMESCO Finland

Follow-up of menstrual cycle with repeated measurement of ovarian cyst

+∞

14.6

Q51.3

ICD-10 Finland

Bicornate uterus

81.7

14.6

N91.1

ICD-10 Finland

Secondary amenorrhoea

8.7

14.6

WX320

NOMESCO Finland

Spinalanesthesy

2.2

14.3

160

812

ULA02

NOMESCO Finland

Kolposcopy

2.8

14.0

382

O35.1

ICD-10 Finland

Maternal care for (suspected) chromosomal abnormality in fetus

3.8

13.9

168

N81.2

ICD-10 Finland

Incomplete uterovaginal prolapse

54.4

13.9

E28.2

ICD-10 Finland

Polycystic ovarian syndrome

6.0

13.6

N98.1

ICD-10 Finland

Hyperstimulation of ovaries

+∞

13.6

ZXD20

NOMESCO Finland

Day surgery

2.6

13.6

103

427

L02AE01

ATC

buserelin; implant, nasal, parenteral

18.6

13.4

Z34.9

ICD-10 Finland

Supervision of normal pregnancy, unspecified

1.9

13.3

228

1373

J02AC01

ATC

fluconazole; systemic

1.8

13.2

404

2955

SPAT1380

SPAT

Postpartum check-up

1.9

13.1

225

1356

N84.1

ICD-10 Finland

Polyp of cervix uteri

19.4

13.0

OAA11

SPAT

3.2

13.0

229

N02BE01

ATC

paracetamol; systemic, rectal

1.9

12.7

616

5185

Z36.0

ICD-10 Finland

Antenatal screening for chromosomal anomalies

2.3

12.6

119

555

MA5AE

NOMESCO Finland

Morphology ultrasound screening, weeks 18+0 to 21+6 of gestation

2.4

12.4

108

484

J01DB01

ATC

cefalexin; oral

1.9

12.3

633

5393

Z31.4

ICD-10 Finland

Procreative investigation and testing

14.6

12.3

MA2HE

NOMESCO Finland

Detailed morfological ultrasound examination of fetus

1.8

12.3

322

2226

WX602

NOMESCO Finland

Repeated or continuing anesthesia shots throug a catheter

2.1

12.2

148

772

Z34.8

ICD-10 Finland

Supervision of other normal pregnancy

1.8

12.1

292

1966

G01AA10

ATC

clindamycin; vaginal

2.0

12.0

176

997

G03GB02

ATC

clomifene; oral

5.4

11.9

Z09.9

ICD-10 Finland

Follow-up examination after unspecified treatment for other conditions

7.9

11.7

R87.6

ICD-10 Finland

Abnormal findings in specimens from female genital organs, abnormal cytological findings

2.5

11.6

431

Z31.2

ICD-10 Finland

In vitrofertilization

66.0

11.6

SPAT1196

SPAT

Monitoring of normal pregnancy

2.0

11.4

174

996

A02BC01

ATC

omeprazole; systemic

2.0

11.4

170

961

LCB98

NOMESCO Finland

Other transluminal endoscopic excision of lesion of uterus

35.6

11.3

Z71.2

ICD-10 Finland

Person consulting for explanation of investigation findings

1.9

11.2

180

1050

Z3232

NOMESCO Finland

Midwife

1.9

11.1

189

1126

O24.4

ICD-10 Finland

Diabetes mellitus arising in pregnancy

1.9

10.8

176

1030

W29

ICPC

Pregnancy symptom/complaint other

2.9

10.8

230

ZXD10

NOMESCO Finland

Scheduled procedure

1.8

10.5

242

1591

Z31.1

ICD-10 Finland

Artificial insemination

+∞

10.4

LEF13

NOMESCO Finland

Colpoperineoplasty and vaginal hysterectomy

+∞

10.4

O06.1

ICD-10 Finland

Unspecified abortion, incomplete, complicated by delayed or excessive haemorrhage

33.0

10.4

N92.4

ICD-10 Finland

Excessive bleeding in the premenopausal period

11.5

10.1

MA2JE

NOMESCO Finland

Ultrasound screening of fetal nuchal translucency

1.8

10.1

189

1161

O34.3

ICD-10 Finland

Maternal care for cervical incompetence

9.3

10.1

MA3AE

NOMESCO Finland

Combined first trimester screening

2.2

10.0

100

479

Z01.4

ICD-10 Finland

Gynaecological examination (general)(routine)

1.8

10.0

200

1253

O03.8

ICD-10 Finland

Spontaneous abortion, Complete or unspecified, with other and unspecified complications

17.0

9.9

Z87.5

ICD-10 Finland

Personal history of complications of pregnancy, childbirth and the puerperium

4.6

9.9

WZB00

NOMESCO Finland

Telephone receipt or other advice

1.7

9.8

246

1650

G03GA30

ATC

gonadotropins - combinations; systemic

20.3

9.8

WX306

NOMESCO Finland

Lumbar epidural anesthesy

2.0

9.7

125

666

LX1XE

NOMESCO Finland

Other gynecological ultrasound examination

5.3

9.6

MA2XE

NOMESCO Finland

Other obstetric ultrasound examination

2.0

9.4

134

745

O60

ICD-10 Finland

Preterm labour and delivery

2.8

9.4

220

H01CC02

ATC

cetrorelix; parenteral

22.0

9.4

ZXE10

NOMESCO Finland

More than one and less than three hours

1.7

9.1

206

1333

N95.0

ICD-10 Finland

Postmenopausal bleeding

8.7

8.8

LCA13

NOMESCO Finland

Curettage of cervix and body of uterus

10.9

8.8

N83.0

ICD-10 Finland

Follicular cyst of ovary

10.9

8.8

XMA22

NOMESCO Finland

General examination of pregnant woman

2.0

8.8

118

639

O82.0

ICD-10 Finland

Delivery by elective caesarean section

2.2

8.6

423

G43.1

ICD-10 Finland

Migraine with aura [classical migraine]

2.2

8.6

412

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

2.0

8.6

111

593

D25.9

ICD-10 Finland

Leiomyoma of uterus, unspecified

2.9

8.5

185

O32.1

ICD-10 Finland

Maternal care for breech presentation

2.2

8.5

443

N85.6

ICD-10 Finland

Intrauterine synechiae

+∞

8.3

LCA96

NOMESCO Finland

Other intrauterine operation

+∞

8.3

D25.0

ICD-10 Finland

Submucous leiomyoma of uterus

5.9

8.3

SPAT1189

SPAT

Other ultrasound examination during pregnancy

2.3

8.3

356

O34.2

ICD-10 Finland

Maternal care due to uterine scar from previous surgery

2.0

8.3

107

572

G02CB01

ATC

bromocriptine; systemic

3.9

8.1

LBC21

NOMESCO Finland

Laparoscopic salpingotomy and removal of products of conception

33.7

8.1

G43.9

ICD-10 Finland

Migraine, unspecified

2.3

8.1

345

A10BA02

ATC

metformin; oral

2.1

7.9

468

H03AA01

ATC

levothyroxine sodium; systemic

1.7

7.9

166

1045

J01AA02

ATC

doxycycline; systemic

1.6

7.9

534

4529

W15

ICPC

Infertility/subfertility female

8.6

7.8

O20

ICD-10 Finland

Haemorrhage in early pregnancy

8.6

7.8

N81.1

ICD-10 Finland

Cystocele

10.9

7.8

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

1.6

7.8

227

1570

MA4AT

NOMESCO Finland

Chorion biopsy with ultrasound guidance

5.1

7.8

MAB00

NOMESCO Finland

Cerclage of cervix of pregnant uterus

45.4

7.7

LDA20

NOMESCO Finland

Biopsy of vaginal cervix

2.4

7.7

286

MBW96

NOMESCO Finland

Other operation after delivery or abortion

13.5

7.4

WX402

NOMESCO Finland

General anaesthesia

1.9

7.3

111

628

LCA30

NOMESCO Finland

Transfer of oocyte or embryo to uterus in assisted fertilisation

+∞

7.3

TLW14

NOMESCO Finland

ICSI

+∞

7.3

LCG02

NOMESCO Finland

Hysteroscopic freeing of adhesions

+∞

7.3

N94.5

ICD-10 Finland

Secondary dysmenorrhoea

6.3

7.3

Z87.4

ICD-10 Finland

Personal history of diseases of the genitourinary system

5.9

7.3

MAA00

NOMESCO Finland

Amniocentesis

2.6

7.2

198

N81.6

ICD-10 Finland

Rectocele

7.4

7.2

O01.1

ICD-10 Finland

Incomplete and partial hydatidiform mole

30.3

7.2

SPAT1357

SPAT

Monitoring of problem during pregnancy

2.3

7.2

299

6310A

ICD-9 Finland

Other abnormal product of conception[OVUM ABORTIVUM]

5.1

7.1

Z63.7

ICD-10 Finland

Other stressful life events affecting family and household

4.1

7.1

TLW99

NOMESCO Finland

Other minor surgical procedure in gynaecology

5.7

7.1

A06AC01

ATC

ispaghula (psylla seeds); oral

1.9

7.0

110

629

Z71.8

ICD-10 Finland

Other specified counselling

1.6

7.0

199

1362

O99.1

ICD-10 Finland

Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium

4.5

7.0

R07.4

ICD-10 Finland

Chest pain, unspecified

1.9

7.0

546

OAA12

SPAT

3.2

7.0

114

Z35.5

ICD-10 Finland

Supervision of elderly primigravida

6.4

7.0

J01CA08

ATC

pivmecillinam; oral

1.5

6.9

376

2993

O99.89

ICD-10 Finland

Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium

2.8

6.9

156

A02BC05

ATC

esomeprazole; systemic

1.6

6.9

223

1576

O80.8

ICD-10 Finland

Other single spontaneous delivery

2.0

6.8

500

N93.9

ICD-10 Finland

Abnormal uterine and vaginal bleeding, unspecified

5.0

6.7

O82.10

ICD-10 Finland

Delivery by emergency caesarean section

1.9

6.7

102

577

N02AJ06

ATC

codeine and paracetamol; systemic

1.5

6.6

243

1768

LAC01

NOMESCO Finland

Laparoscopic excision of ovarian cyst

8.8

6.6

Z3226

NOMESCO Finland

Physiotherapist

1.8

6.5

104

602

LBF00

NOMESCO Finland

Perfusion of Fallopian tube

70.4

6.4

W85

ICPC

Gestational diabetes

2.0

6.4

456

L02AE02

ATC

leuprorelin; implant, parenteral

4.2

6.3

N91.4

ICD-10 Finland

Secondary oligomenorrhoea

18.2

6.3

Q51.8

ICD-10 Finland

Other congenital malformations of uterus and cervix

+∞

6.3

N80.89

ICD-10 Finland

Endometriosis with other specified or multiple localization

+∞

6.3

O99.2

ICD-10 Finland

Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium

2.8

6.2

136

O20.8

ICD-10 Finland

Other haemorrhage in early pregnancy

5.4

6.2

Z35

ICD-10 Finland

Supervision of high-risk pregnancy

3.6

6.2

O75.6

ICD-10 Finland

Delayed delivery after spontaneous or unspecified rupture of membranes

2.6

6.1

162

Z70.8

ICD-10 Finland

Other sex counselling

12.6

6.1

O35.2

ICD-10 Finland

Maternal care for (suspected) hereditary disease in fetus

8.7

6.1

WX307

NOMESCO Finland

Obstetric epidural analgesia

1.6

6.1

165

1115

O47.9

ICD-10 Finland

False labour, unspecified

2.7

6.0

139

Mortality – FinRegistry

↥

Association

Association between endpoint N14_HABITABORT and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_HABITABORT.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: N14_HABITABORT – Habitual aborter

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	N14_HABITABORT
CONTROL_EXCLUDE	N14_FEMALEGENNONINF
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	N96
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	N96
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Habitual aborter

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints