Sequelae of complication of pregnancy, childbirth and the puerperium

O15_SEQUL_OF_COMPLIC

No definition available.

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule only females	293373
2. Check conditions None	293373
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — O94 Cause of death: ICD-10 — O94 2 out of 7 registries used, show all original rules.	16
4. Check minimum number of events None	16
5. Include endpoints None	16
6. Filter based on genotype QC (FinnGen only)	16

Control definitions (FinnGen only)

Control exclude: O15_OBSTET_NAS

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF3
Parent code in ICD-10: O94-O99

NAME	O15_SEQUL_OF_COMPLIC
CONTROL_EXCLUDE	O15_OBSTET_NAS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	O94
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	O94
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Sequelae of complication of pregnancy, childbirth and the puerperium based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	113	113	-
Only index persons	111	111	-
Unadjusted period prevalence (%)
Whole population	0.00	0.00	-
Only index persons	0.00	0.00	-
Median age at first event (years)
Whole population	-	32.18	-
Only index persons	-	32.23	-

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	16	16	-
Unadjusted period prevalence (%)	0.01	0.01	-
Median age at first event (years)	32.74	32.74	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

5.08

2.29

3.7

2.5

—

(3023511) Choriogonadotropin [Units/volume] in Urine

4.67

1.96

1.3

1.1

—

(3003694) ABO and Rh group [Type] in Blood

3.84

1.82

3.7

1.9

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

3.79

1.77

2.0

1.5

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

3.79

1.77

2.0

1.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

3.79

1.77

2.0

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

3.79

1.77

2.0

1.5

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

3.63

1.70

2.1

1.6

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

3.67

1.59

1.6

1.9

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

2.98

1.32

1.9

1.5

—

(3033658) Prothrombin time (PT) actual/Normal

2.98

1.18

3.0

2.8

102.4

93.3

—

(3005033) Fetal Nuchal fold Thickness US

2.83

1.12

2.0

1.5

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

2.83

1.12

2.0

1.5

—

(3044640) Blood type and Crossmatch panel - Blood

2.46

1.03

2.0

1.5

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

2.58

1.00

5.2

3.1

—

(36304419) Bacteria [Presence] in Urine

2.48

0.97

4.2

2.7

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.48

0.97

2.2

1.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.55

0.96

2.5

1.8

—

(3019832) Treponema pallidum Ab [Presence] in Serum

2.42

0.94

2.1

1.7

—

(3026008) Bacteria identified in Urine by Culture

2.40

0.88

2.4

1.8

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

136

+∞

0.88

5.5

4.2

—

(3020682) Albumin/Creatinine [Ratio] in Urine

0.00

0.87

0.0

4.6

—

20.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

2.32

0.86

3.0

2.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.69

0.85

1.6

1.4

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

2.56

0.83

2.0

1.5

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

2.19

0.79

3.8

2.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.25

0.72

3.1

1.9

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

2.08

0.71

7.4

3.4

—

(42870588) Differential panel, method unspecified - Blood

1.99

0.65

5.2

3.6

—

(3012516) Albumin [Mass/volume] in Urine

0.00

0.64

0.0

4.2

—

96.0

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.86

0.58

2.3

1.9

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.96

0.50

1.6

—

(3013512) EKG study

0.00

0.44

0.0

2.4

—

(40768804) Tissue Pathology biopsy report

1.57

0.38

1.9

1.6

—

(3003338) MCHC [Mass/volume]

120

0.73

0.25

12.8

10.5

331.4

332.6

g/l

0.16

120

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

0.00

0.22

0.0

2.8

—

18.6

—

(3015736) pH of Urine

1.18

0.10

2.5

2.4

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

1.35

0.10

2.6

3.2

4.9

5.8

mmol/l

3.78

(3013826) Glucose [Moles/volume] in Serum or Plasma

0.79

0.10

3.3

2.5

4.9

6.4

mmol/l

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

0.00

0.0

1.4

—

22.4

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

1.6

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

0.00

0.0

3.2

—

56.0

—

(3028026) IgM [Mass/volume] in Serum or Plasma

0.00

0.0

2.5

—

1.5

—

(3009343) pH of Capillary blood

0.00

0.0

2.4

—

(3023520) Reticulocytes [#/volume] in Blood

0.00

0.0

1.8

—

74.9

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.0

1.0

—

(3022313) Gas panel - Capillary blood

0.00

0.0

2.7

—

(3005719) IgG [Mass/volume] in Serum or Plasma

0.00

0.0

2.5

—

10.4

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.9

—

44.8

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3025941) Bacteria identified in Stool by Culture

0.00

0.0

1.0

—

(3022621) pH of Urine by Test strip

0.00

0.0

1.5

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

0.00

0.0

2.2

—

1.2

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

0.00

0.0

2.7

—

23.9

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

4.5

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.1

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.4

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.0

1.4

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

1.2

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.0

2.8

—

(3026725) Estradiol (E2) [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

0.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

0.89

0.00

2.6

2.1

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.0

1.2

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.0

1.8

—

(40761535) Cells panel - Urine sediment

0.00

0.0

3.4

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.0

1.5

—

Mortality – FinRegistry

↥

Association

Association between endpoint O15_SEQUL_OF_COMPLIC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_SEQUL_OF_COMPLIC.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: O15_SEQUL_OF_COMPLIC – Sequelae of complication of pregnancy, childbirth and the puerperium

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Sequelae of complication of pregnancy, childbirth and the puerperium

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints