Risteys · G6_CNSPHLEB

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G08 Hospital discharge: ICD-9 — 325 Hospital discharge: ICD-8 — 321 Cause of death: ICD-10 — G08 Cause of death: ICD-9 — 325 Cause of death: ICD-8 — 321 2 out of 7 registries used, show all original rules.	19
4. Check minimum number of events None	19
5. Include endpoints None	19
6. Filter based on genotype QC (FinnGen only)	19

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	280	167	108
Only index persons	194	123	71
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	35.34	35.85	33.55
Only index persons	29.79	30.40	28.73

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	19	15	-
Unadjusted period prevalence (%)	0.00	0.01	-
Median age at first event (years)	30.39	29.95	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

4.94

2.68

1.6

1.4

—

(3044640) Blood type and Crossmatch panel - Blood

4.17

2.41

2.1

1.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

4.90

2.32

1.4

1.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

4.64

2.22

1.4

1.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

4.00

2.06

3.8

3.0

—

(3012516) Albumin [Mass/volume] in Urine

3.43

1.80

3.5

2.8

mg/l

33.0

62.7

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

3.57

1.77

1.1

2.0

—

(40758558) Short blood count panel - Blood

3.06

1.60

13.4

7.2

—

(3000494) Fungus identified in Specimen by Culture

3.38

1.38

1.2

1.6

—

(40768804) Tissue Pathology biopsy report

2.46

1.09

1.9

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.00

1.09

0.0

1.6

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

160

+∞

1.08

5.1

3.8

mmol/l

6.2

5.7

1.00

141

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

2.56

1.07

3.6

3.7

—

(3023368) Bacteria identified in Blood by Culture

2.40

0.87

2.4

5.7

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

2.16

0.82

19.8

12.9

e9/l

4.3

3.8

0.20

(3003694) ABO and Rh group [Type] in Blood

2.03

0.75

1.1

1.7

—

(3044889) 12 lead EKG panel

110

2.03

0.65

3.9

3.4

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

169

+∞

0.64

6.5

4.3

mmol/l

2.6

2.9

1.24

151

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.67

0.54

1.9

1.6

—

(42870588) Differential panel, method unspecified - Blood

1.69

0.52

12.4

5.1

—

(3002030) Lymphocytes/100 leukocytes in Blood

1.77

0.48

10.7

5.3

29.6

28.2

0.18

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

0.00

0.43

0.0

4.0

—

26.7

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.42

0.0

1.3

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

1.53

0.35

2.1

4.4

g/l

37.6

35.7

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.51

0.34

3.4

3.6

—

(3015736) pH of Urine

1.41

0.32

4.2

2.8

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

1.46

0.32

1.4

3.1

ug/l

119.9

87.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.30

0.24

4.8

5.2

—

(36304419) Bacteria [Presence] in Urine

1.29

0.22

7.7

2.9

—

(3026008) Bacteria identified in Urine by Culture

1.39

0.22

5.1

2.3

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.22

0.0

1.5

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

0.00

0.22

0.0

1.8

—

13.1

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.22

0.0

1.0

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.22

0.0

1.1

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.22

0.0

2.0

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

178

+∞

0.22

21.6

10.0

u/l

29.9

25.7

0.56

173

(3000492) Spirometry study

0.00

0.21

0.0

1.2

—

(3020779) Urea [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

10.1

—

8.6

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.21

0.0

1.2

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.21

0.0

1.6

—

(3018418) pH of Serum or Plasma

1.12

0.10

2.2

5.5

—

7.4

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

1.20

0.10

1.7

2.6

nmol/l

97.3

77.9

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.6

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.6

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

0.00

0.0

3.1

—

3.8

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.1

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.6

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.0

3.3

—

1.2

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.6

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

0.00

0.0

18.0

—

1.0

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.7

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.0

3.3

—

0.6

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

0.00

0.0

18.0

—

0.9

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.6

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.6

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

0.00

0.0

8.3

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

0.95

0.00

8.0

2.9

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

37.4

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.2

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(40761535) Cells panel - Urine sediment

0.00

0.0

4.6

—

(3019060) Gas panel - Arterial blood

0.00

0.0

2.1

—

(3022313) Gas panel - Capillary blood

0.00

0.0

1.0

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.4

—

(3010813) Leukocytes [#/volume] in Blood

184

+∞

0.00

33.5

19.5

e9/l

6.5

6.3

0.16

178

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.6

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.0

1.1

—

0.2

—

(3015171) Extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.0

1.1

—

1.1

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.2

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.3

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

0.83

0.00

1.4

3.1

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

129

1.02

0.00

4.0

3.2

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

1.2

—

(3020961) Endomysium IgA Ab [Titer] in Serum

0.00

0.0

1.2

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.2

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

0.00

0.0

4.4

—

166.0

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.2

—

(3014007) Fractional oxyhemoglobin in Arterial blood

0.00

0.0

20.7

—

94.1

—

(3026361) Erythrocytes [#/volume] in Blood

184

+∞

0.00

33.7

19.5

e12/l

4.6

4.5

0.54

178

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.1

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.2

—

0.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_CNSPHLEB and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have G6_CNSPHLEB.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: G6_CNSPHLEB – Intracranial and intraspinal phlebitis and thrombophlebitis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	G6_CNSPHLEB
CONTROL_EXCLUDE	G6_NEUINFL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G08
HD_ICD_9	325
HD_ICD_8	321
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G08
COD_ICD_9	325
COD_ICD_8	321
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Intracranial and intraspinal phlebitis and thrombophlebitis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints