Degeneration of iris and ciliary body

H7_DEGENIRISCILIARY

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H21.2 Hospital discharge: ICD-9 — 3645 Cause of death: ICD-10 — H21.2 Cause of death: ICD-9 — 3645 2 out of 7 registries used, show all original rules.	34
4. Check minimum number of events None	34
5. Include endpoints None	34
6. Filter based on genotype QC (FinnGen only)	31

Control definitions (FinnGen only)

Control exclude: H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H21
Name in latin: Degenerationes iridis et corporis ciliaris

NAME	H7_DEGENIRISCILIARY
CONTROL_EXCLUDE	H7_SCLERACORNEA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H212
HD_ICD_9	3645
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H212
COD_ICD_9	3645
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Degeneration of iris and ciliary body based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	221	123	97
Only index persons	191	110	81
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	53.12	53.73	52.05
Only index persons	50.89	51.70	49.78

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	31	20	11
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	54.10	46.10	68.65

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

3.61

2.47

1.7

2.2

—

(3001019) Free T4 and TSH panel - Serum or Plasma

4.95

2.26

1.0

2.1

—

(3023368) Bacteria identified in Blood by Culture

2.95

2.18

4.0

4.5

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

3.33

2.12

1.7

2.0

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

5.12

2.01

2.0

1.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.40

1.84

2.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.40

1.84

2.0

2.2

—

(3019060) Gas panel - Arterial blood

3.99

1.68

3.4

3.0

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

3.99

1.68

1.4

1.9

—

(40760892) CBC W Ordered Manual Differential panel - Blood

109

2.38

1.62

7.2

6.2

—

(3025941) Bacteria identified in Stool by Culture

3.71

1.58

1.2

1.3

—

(3022217) INR in Platelet poor plasma by Coagulation assay

101

2.10

1.23

17.7

10.0

1.27

1.07

inr

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.14

1.10

2.1

1.2

—

(3013115) Eosinophils [#/volume] in Blood

125

1.94

1.02

7.4

5.8

0.21

0.19

e9/l

0.28

116

(3001604) Monocytes [#/volume] in Blood

116

1.93

1.01

7.8

5.8

0.66

0.58

e9/l

0.67

107

(3006315) Basophils [#/volume] in Blood

117

1.91

0.98

7.8

5.7

0.04

e9/l

0.38

108

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

2.03

0.91

1.6

1.5

1.15

1.54

mmol/l

—

(3019198) Lymphocytes [#/volume] in Blood

119

1.86

0.91

7.8

5.8

1.96

1.85

e9/l

0.23

113

(3022096) Basophils/100 leukocytes in Blood

110

1.86

0.91

8.1

5.2

0.57

0.55

0.08

102

(3013650) Neutrophils [#/volume] in Blood by Automated count

148

1.85

0.90

9.0

9.5

3.95

4.12

e9/l

0.15

138

(3019069) Monocytes/100 leukocytes in Blood

113

1.79

0.81

8.3

5.8

9.07

8.60

0.31

106

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.81

0.81

2.8

3.9

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

2.37

0.80

3.6

1.5

39.60

29.71

—

(3006504) Eosinophils/100 leukocytes in Blood

114

1.76

0.78

8.1

5.4

2.52

2.92

0.33

107

(3019150) Specific gravity of Urine by Refractometry

1.75

0.78

2.7

4.5

—

1.01

—

(3002030) Lymphocytes/100 leukocytes in Blood

115

1.74

0.76

8.3

5.6

25.70

27.65

0.34

108

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.08

0.74

1.2

1.8

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.84

0.74

1.7

1.8

—

(3013707) Erythrocyte sedimentation rate by Westergren method

195

1.78

0.72

4.3

3.4

10.88

9.57

mm/h

0.32

179

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

1.75

0.72

6.1

3.3

21.54

29.84

u/l

1.70

(3019550) Sodium [Moles/volume] in Serum or Plasma

253

1.99

0.68

19.2

12.2

139.34

139.59

mmol/l

0.23

246

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.85

0.66

1.2

2.2

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

100

1.68

0.66

8.6

4.6

1.20

1.21

mmol/l

0.02

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

242

1.89

0.64

6.0

4.8

2.02

1.76

mu/l

0.76

225

(3002385) Erythrocyte distribution width [Ratio]

233

1.77

0.62

21.8

14.0

14.74

14.66

0.02

227

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.00

0.61

0.0

13.2

—

(3018010) Neutrophils/100 leukocytes in Blood

113

1.59

0.56

8.4

5.4

57.71

57.31

0.05

105

(3041096) Erythrocytes [Presence] in Urine by Automated

1.64

0.51

3.2

3.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.54

0.46

3.9

2.9

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

1.52

0.43

1.8

1.7

108.86

95.83

pmol/l

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.42

0.0

1.5

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.42

0.0

1.5

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.42

0.0

1.6

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.42

0.0

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

209

1.50

0.41

3.2

3.6

—

(36304419) Bacteria [Presence] in Urine

1.47

0.35

4.3

2.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

172

1.40

0.34

5.9

3.9

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

1.43

0.33

2.7

2.0

53.36

55.13

u/l

0.08

(3021960) Folate [Moles/volume] in Serum or Plasma

1.37

0.33

1.6

1.5

29.94

19.96

nmol/l

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

193

1.40

0.32

10.6

7.3

66.68

76.32

u/l

1.26

179

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.41

0.31

3.8

3.4

—

(40758558) Short blood count panel - Blood

1.41

0.31

9.3

7.0

—

(3033658) Prothrombin time (PT) actual/Normal

1.35

0.31

3.4

3.5

103.50

96.43

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.33

0.30

1.9

1.7

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

247

1.45

0.27

16.4

9.9

82.54

88.07

ml/min/173m2

0.46

208

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

127

1.32

0.26

2.7

2.1

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

229

1.35

0.25

5.7

4.5

40.07

38.97

mmol/mol

0.20

218

(3042936) Bacteria identified in Isolate by Culture

1.41

0.25

2.4

2.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.22

0.22

2.8

2.2

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.22

0.0

4.5

—

50.81

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.22

0.0

1.1

—

4.86

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.22

0.0

1.5

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.22

0.0

1.0

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.22

0.0

2.4

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

0.00

0.22

0.0

4.5

—

24.33

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.22

0.0

1.2

—

(3044889) 12 lead EKG panel

169

1.28

0.21

5.5

3.1

—

(3044640) Blood type and Crossmatch panel - Blood

1.31

0.21

2.0

1.8

—

(3003694) ABO and Rh group [Type] in Blood

0.82

0.16

1.9

1.6

—

(40768804) Tissue Pathology biopsy report

103

0.83

0.16

1.9

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

1.11

0.09

2.2

3.6

1.10

2.06

ug/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.09

0.09

1.5

1.3

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

281

1.22

0.09

15.0

9.3

23.86

26.41

u/l

0.59

274

(3013512) EKG study

1.12

0.09

2.0

4.0

—

(3021589) Normoblasts [#/volume] in Blood

108

0.90

0.03

13.1

7.6

0.00

e9/l

—

(1761868) Lipid panel - Serum or Plasma

108

0.90

0.03

2.2

2.7

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

196

1.05

0.00

3.3

2.9

36.40

44.71

u/l

0.39

189

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

48.52

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.0

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.0

2.0

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.0

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

0.00

0.0

1.4

—

93.71

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.6

—

(3024980) IgG subclass 4 [Mass/volume] in Serum

0.00

0.0

1.6

—

0.33

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

1.5

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3026008) Bacteria identified in Urine by Culture

1.02

-0.00

1.5

3.0

—

(3047826) Mullerian inhibiting substance [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

3.28

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

-0.00

0.0

1.1

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

-0.00

0.0

1.1

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

-0.00

0.0

1.3

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

-0.00

0.0

2.0

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

3.0

—

4.20

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

0.00

-0.00

0.0

5.0

—

22.98

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.00

-0.00

2.3

2.0

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.5

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

3.0

—

180.50

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.7

—

3.48

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

-0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_DEGENIRISCILIARY and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_DEGENIRISCILIARY.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H7_DEGENIRISCILIARY – Degeneration of iris and ciliary body

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Degeneration of iris and ciliary body

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints