Degeneration of iris and ciliary body

H7_DEGENIRISCILIARY

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H21.2 Hospital discharge: ICD-9 — 3645 Cause of death: ICD-10 — H21.2 Cause of death: ICD-9 — 3645 2 out of 7 registries used, show all original rules.	32
4. Check minimum number of events None	32
5. Include endpoints None	32
6. Filter based on genotype QC (FinnGen only)	32

Control definitions (FinnGen only)

Control exclude: H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H21
Name in latin: Degenerationes iridis et corporis ciliaris

NAME	H7_DEGENIRISCILIARY
CONTROL_EXCLUDE	H7_SCLERACORNEA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H212
HD_ICD_9	3645
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H212
COD_ICD_9	3645
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Degeneration of iris and ciliary body based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	221	123	97
Only index persons	191	110	81
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	53.12	53.73	52.05
Only index persons	50.89	51.70	49.78

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	32	21	11
Unadjusted period prevalence (%)	0.01	0.01	0.00
Median age at first event (years)	53.44	45.48	68.65

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

3.95

2.81

1.7

2.2

—

(3001019) Free T4 and TSH panel - Serum or Plasma

6.42

2.67

1.0

2.3

—

(3023368) Bacteria identified in Blood by Culture

3.23

2.44

4.0

4.6

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

5.16

2.02

2.0

1.8

—

(42870588) Differential panel, method unspecified - Blood

2.78

2.02

7.2

5.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.60

1.93

2.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.60

1.93

2.0

2.3

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

3.09

1.81

1.4

2.0

—

(3019060) Gas panel - Arterial blood

4.34

1.78

3.4

3.0

—

(3032080) INR in Blood by Coagulation assay

2.56

1.74

9.9

4.4

1.3

1.1

inr

—

(3013115) Eosinophils [#/volume] in Blood

116

2.26

1.37

7.4

6.0

0.2

e9/l

0.40

108

(3001604) Monocytes [#/volume] in Blood

108

2.22

1.33

7.8

6.0

0.7

0.6

e9/l

0.69

(3006315) Basophils [#/volume] in Blood

109

2.19

1.29

7.8

6.0

0.0

e9/l

0.33

101

(3013650) Neutrophils [#/volume] in Blood by Automated count

138

2.20

1.26

9.1

9.9

3.9

4.1

e9/l

0.09

129

(3019198) Lymphocytes [#/volume] in Blood

111

2.13

1.22

7.8

6.0

2.0

1.8

e9/l

0.26

105

(3022096) Basophils/100 leukocytes in Blood

102

2.14

1.22

8.1

5.5

0.6

0.00

(3019069) Monocytes/100 leukocytes in Blood

105

2.05

1.10

8.3

6.1

9.1

8.7

0.26

(3018677) aPTT in Platelet poor plasma by Coagulation assay

2.50

1.07

3.6

1.5

39.6

29.6

—

(3006504) Eosinophils/100 leukocytes in Blood

106

2.02

1.07

8.1

5.6

2.5

2.8

0.25

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.19

1.06

2.1

1.3

—

(3002030) Lymphocytes/100 leukocytes in Blood

107

1.99

1.03

8.3

5.8

25.7

27.5

0.31

100

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.96

0.96

2.8

4.0

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

227

2.21

0.83

6.0

4.9

2.0

1.8

mu/l

0.66

210

(3019150) Specific gravity of Urine by Refractometry

1.84

0.82

2.7

4.7

—

1.0

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.38

0.80

1.2

1.7

—

(3018010) Neutrophils/100 leukocytes in Blood

105

1.81

0.80

8.4

5.6

57.7

57.3

0.06

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

1.81

0.79

8.6

4.6

1.2

mmol/l

0.00

(3015736) pH of Urine

1.81

0.79

4.1

3.5

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

1.76

0.78

1.7

1.5

1.2

1.5

mmol/l

—

(3002385) Erythrocyte distribution width [Ratio]

210

1.87

0.76

23.1

14.7

13.5

13.4

0.09

203

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.09

0.74

1.2

2.0

—

(3013707) Erythrocyte sedimentation rate by Westergren method

186

1.84

0.73

4.4

3.5

10.8

9.8

mm/h

0.23

170

(40760892) CBC W Ordered Manual Differential panel - Blood

1.88

0.70

2.8

4.9

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

1.74

0.67

6.5

3.3

22.2

30.3

u/l

1.51

(3017732) Neutrophils [#/volume] in Blood

0.00

0.62

0.0

2.6

—

4.6

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.88

0.62

1.8

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.00

0.62

0.0

13.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.75

0.61

3.2

3.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

192

1.70

0.60

3.2

3.6

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

1.63

0.55

1.8

1.7

108.9

96.7

pmol/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.61

0.52

3.9

3.0

—

(3000850) Epithelial cells [#/volume] in Urine

1.51

0.49

2.6

2.3

8.5

5.4

e6/l

—

(40758558) Short blood count panel - Blood

1.57

0.46

9.3

7.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.47

0.45

3.7

3.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.47

0.45

1.9

1.8

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.00

0.42

0.0

1.1

—

(36304419) Bacteria [Presence] in Urine

1.54

0.41

4.3

2.7

—

(3042936) Bacteria identified in Isolate by Culture

1.46

0.40

2.4

2.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

161

1.44

0.37

6.1

4.0

—

(3044889) 12 lead EKG panel

162

1.43

0.35

5.5

3.2

—

(3021960) Folate [Moles/volume] in Serum or Plasma

1.44

0.34

1.6

29.9

20.3

nmol/l

—

(3044640) Blood type and Crossmatch panel - Blood

1.45

0.34

2.0

1.9

—

(3033658) Prothrombin time (PT) actual/Normal

1.41

0.32

3.4

3.5

103.5

95.9

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

186

1.38

0.28

11.1

7.3

66.2

76.7

u/l

1.43

172

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

218

1.40

0.26

5.5

4.6

40.2

38.9

mmol/mol

0.24

207

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

119

1.31

0.23

5.2

3.4

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.22

0.0

4.5

—

50.8

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.22

0.0

1.0

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.22

0.0

1.2

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.22

0.0

2.4

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

0.00

0.22

0.0

4.5

—

24.3

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.21

0.0

1.5

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.5

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.5

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

(3003694) ABO and Rh group [Type] in Blood

0.74

0.17

2.0

1.6

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.16

0.09

1.5

1.3

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

1.11

0.09

2.2

3.6

1.1

2.1

ug/l

—

(3013512) EKG study

1.12

0.09

2.0

4.0

—

(3009542) Hematocrit [Volume Fraction] of Blood

232

1.14

0.08

23.0

13.5

39.7

40.0

0.11

184

(1761868) Lipid panel - Serum or Plasma

102

0.84

0.07

2.3

2.8

—

(40768804) Tissue Pathology biopsy report

0.87

0.07

1.9

—

(3021589) Normoblasts [#/volume] in Blood

104

0.94

0.00

13.1

7.8

0.0

e9/l

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

185

1.07

0.00

3.4

2.8

37.0

45.3

u/l

0.36

178

(3026008) Bacteria identified in Urine by Culture

0.89

0.00

1.2

3.0

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.6

—

(3024980) IgG subclass 4 [Mass/volume] in Serum

0.00

0.0

1.6

—

0.3

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

3.0

—

180.5

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

0.96

0.00

2.5

2.0

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.5

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

0.00

0.0

1.7

—

3.5

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3047826) Mullerian inhibiting substance [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

3.7

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.1

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.3

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

48.5

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.0

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

0.00

0.0

1.4

—

93.7

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.5

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.1

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

3.0

—

4.2

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

2.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_DEGENIRISCILIARY and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_DEGENIRISCILIARY.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H7_DEGENIRISCILIARY – Degeneration of iris and ciliary body

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Degeneration of iris and ciliary body

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints