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Other disorders of iris and ciliary body

DOID EFO Endpoint Browser PheWeb

H7_OTHIRISCILIARY

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H21
  • Cause of death: ICD-10 — H21

2 out of 7 registries used, show all original rules.

931

4. Check minimum number of events

None

931

5. Include endpoints

969

6. Filter based on genotype QC (FinnGen only)

969

Control definitions (FinnGen only)

Control exclude
H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H15-H22
Name in latin
Aliae morbositates iridis et corporis ciliaris

Similar endpoints

↥

List of similar endpoints to Other disorders of iris and ciliary body based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8294 3671 4583
Only index persons 7402 3293 4109
Unadjusted period prevalence (%)
Whole population 0.12 0.11 0.13
Only index persons 0.14 0.12 0.16
Median age at first event (years)
Whole population 59.12 67.82 52.08
Only index persons 58.27 67.07 51.23

-FinnGen-

Key figures

All Female Male
Number of individuals 969 467 502
Unadjusted period prevalence (%) 0.19 0.16 0.22
Median age at first event (years) 63.02 62.57 63.43

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
861
Matched controls
8608
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H21.0
ICD-10 Finland
Hyphaema
+∞
323.0
422
*
H21.1
ICD-10 Finland
Other vascular disorders of iris and ciliary body
+∞
222.9
204
*
S01ED51
ATC
timolol, combinations; ophthalmic
19.5
215.2
351
293
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
595.6
154.9
149
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
141.1
154.3
161
14
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
24.8
110.5
159
78
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
108.7
102
*
S01EC01
ATC
acetazolamide; systemic
27.6
103.6
144
62
114
Kela drug reimbursment
Glaucoma
8.6
101.6
245
381
H43.1
ICD-10 Finland
Vitreous haemorrhage
24.7
100.8
145
70
WX140
NOMESCO Finland
Parabulbar anesthesy
14.1
93.7
167
144
Z96.1
ICD-10 Finland
Presence of intraocular lens
6.5
93.6
284
609
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
4.5
92.2
489
1938
S01EE01
ATC
latanoprost; ophthalmic
9.0
81.9
187
258
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.5
78.9
230
455
CKC12
NOMESCO Finland
Photocoagulation of retina
12.0
74.4
142
139
S01ED01
ATC
timolol; ophthalmic
11.3
69.5
137
142
XCK10
NOMESCO Finland
Photography of fundus of eye
6.0
69.1
213
445
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
6.7
67.9
190
349
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
9.0
65.4
147
193
S05.1
ICD-10 Finland
Contusion of eyeball and orbital tissues
24.4
61.5
88
40
S01EA03
ATC
apraclonidine; ophthalmic
29.7
59.9
81
30
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.5
59.9
403
1748
H21.9
ICD-10 Finland
Disorder of iris and ciliary body, unspecified
+∞
59.0
56
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.4
59.0
255
757
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
163.9
58.7
61
*
S01EC04
ATC
brinzolamide; ophthalmic
10.8
58.1
116
122
H21.8
ICD-10 Finland
Other specified disorders of iris and ciliary body
+∞
55.8
53
*
H16.0
ICD-10 Finland
Corneal ulcer
28.4
53.5
73
28
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.0
51.2
442
2215
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
60.9
49.1
57
10
H21.3
ICD-10 Finland
Cyst of iris, ciliary body and anterior chamber
+∞
48.4
46
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
13.6
47.5
84
68
CKD40
NOMESCO Finland
Endophotocoagulation of retina
24.9
47.4
67
29
H21.5
ICD-10 Finland
Other adhesions and disruptions of iris and ciliary body
+∞
47.3
45
*
XCD10
NOMESCO Finland
Electrophysiological examination of eye
11.8
46.1
87
81
H3603, E113
ICD-10 Finland
NA
27.7
45.3
62
24
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
6.6
44.0
120
206
CKC20
NOMESCO Finland
Cryopexy of undetached retina
99.3
43.2
47
5
S01EC54
ATC
brinzolamide, combinations; ophthalmic
23.8
42.0
60
27
CKC15
NOMESCO Finland
Panretinal photocoagulation
24.8
41.1
58
25
XCK00
NOMESCO Finland
Perimetry
5.6
41.0
128
260
H25.1
ICD-10 Finland
Senile nuclear cataract
2.9
40.1
317
1434
S01EC03
ATC
dorzolamide; ophthalmic
13.8
35.7
62
48
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
16.9
35.6
57
36
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
187.6
35.0
36
*
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
99.3
35.0
38
*
H40.0
ICD-10 Finland
Glaucoma suspect
4.6
34.6
128
312
H3603, E103
ICD-10 Finland
NA
20.8
34.3
51
26
S01EE03
ATC
bimatoprost; ophthalmic
9.7
33.7
70
78
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.2
33.2
136
365
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
22.0
33.0
48
23
WX100
NOMESCO Finland
Conjunctival surface anesthesia
3.8
32.1
152
464
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
9.7
31.9
66
73
H26.2
ICD-10 Finland
Complicated cataract
19.5
31.7
48
26
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
8.0
31.5
73
98
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
16.0
30.7
50
33
CKC10
NOMESCO Finland
Local photocoagulation of retina
12.1
30.5
56
49
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
8.1
30.4
70
93
H26.4
ICD-10 Finland
After-cataract
3.8
30.1
139
414
H21.2
ICD-10 Finland
Degeneration of iris and ciliary body
+∞
29.3
28
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
7.8
28.0
66
91
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
44.1
27.9
34
8
A10AE04
ATC
insulin glargine; parenteral
3.7
27.9
133
406
ZXA00
NOMESCO Finland
Right side
2.5
27.9
285
1433
WX002
NOMESCO Finland
Sedation and analgesia
2.7
27.7
223
980
H34.8
ICD-10 Finland
Other retinal vascular occlusions
8.6
26.8
59
73
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
3.8
26.5
121
356
S01BC03
ATC
diclofenac; ophthalmic
9.0
26.2
56
66
CHC05
NOMESCO Finland
Iridotomy
11.0
26.1
50
48
S01EE05
ATC
tafluprost; ophthalmic
7.4
25.9
63
91
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
15.2
25.4
42
29
XCH00
NOMESCO Finland
Eye pressure measurement
5.4
25.4
79
158
S01EX03
ATC
NA
7.6
25.2
60
84
CKD15
NOMESCO Finland
Injection of vitreous substitute
30.1
24.2
32
11
S01BC05
ATC
ketorolac; ophthalmic
4.9
23.8
80
175
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.7
23.7
109
321
ZXA05
NOMESCO Finland
Left side
2.4
23.6
260
1337
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
+∞
23.0
22
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
6.9
22.9
58
89
H3601, E113
ICD-10 Finland
NA
11.9
22.4
41
36
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
24.7
22.3
31
13
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
5.3
22.2
70
142
ZXA10
NOMESCO Finland
Bilateral
2.5
22.1
204
955
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
16.5
22.0
35
22
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
118.0
21.7
23
*
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
18.0
21.5
33
19
A10AA02
ATC
NA
5.0
21.1
69
146
H40.9
ICD-10 Finland
Glaucoma, unspecified
8.5
20.9
46
57
CH2S4
NOMESCO Finland
Photography of iris
78.8
20.8
23
*
CKD20
NOMESCO Finland
Removal of vitreous body substitute
20.7
20.5
30
15
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
6.2
20.3
55
93
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
9.7
20.3
41
44
T89
ICPC
Diabetes insulin dependent
5.2
20.2
64
131
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
4.1
20.0
81
213
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
4.5
20.0
73
174
S01EE04
ATC
travoprost; ophthalmic
8.0
19.8
45
59
A10AA01
ATC
NA
6.0
19.3
54
95
Z3229
NOMESCO Finland
Other healthcare associate professional
3.2
19.0
108
373
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
30.8
18.4
24
8
S01FA04
ATC
cyclopentolate; ophthalmic
17.0
17.9
28
17
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
5.2
17.9
56
113
H36.01
ICD-10 Finland
Diabetic maculopathy
10.7
17.8
34
33
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
24.6
17.4
24
10
ZXD05
NOMESCO Finland
Urgent procedure
2.0
17.4
280
1662
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
5.9
17.2
48
85
A10AE05
ATC
insulin detemir; parenteral
3.7
17.0
77
224
CHF15
NOMESCO Finland
Cryotherapy of ciliary body
64.7
16.8
19
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.9
16.7
55
118
CHD99
NOMESCO Finland
Other filtering operation
91.9
16.6
18
*
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
18.4
16.5
25
14
XCD20
NOMESCO Finland
Photoangiography of eye
7.1
16.4
40
59
WX142
NOMESCO Finland
Sub-tenon anesthesy
15.7
16.3
26
17
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
17.1
16.1
25
15
H04.10
ICD-10 Finland
Dry eye syndrome
3.0
15.9
97
352
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
5.1
15.5
49
101
CKD60
NOMESCO Finland
Anterior vitrectomy
15.1
15.4
25
17
H3601, E103
ICD-10 Finland
NA
11.5
15.3
28
25
TCG10
NOMESCO Finland
Removal of sutures from cornea
23.9
15.2
21
9
S05.9
ICD-10 Finland
Injury of eye and orbit, unspecified
12.1
15.1
27
23
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
5.9
15.1
42
74
H26.02
ICD-10 Finland
Presenil cataract
5.9
15.1
42
74
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
5.0
15.0
48
100
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
7.4
14.9
35
49
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.7
14.8
107
429
CS494
NOMESCO Finland
Other visual field testing
6.7
14.8
37
57
H40.20
ICD-10 Finland
Acute glaucoma with closed ventricular angle
18.8
14.7
22
12
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.7
14.7
110
449
S01FA02
ATC
scopolamine; ophthalmic
21.5
14.7
21
10
103
Kela drug reimbursment
Diabetes, insulin-treated
2.0
14.7
245
1458
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
+∞
14.6
14
*
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
81.5
14.6
16
*
H27.1
ICD-10 Finland
Dislocation of lens
36.7
14.5
18
5
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
14.5
358
2442
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
7.6
14.3
33
45
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
4.3
14.3
53
129
S01FA01
ATC
atropine; ophthalmic
22.7
14.3
20
9
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.9
14.1
87
318
H40.3
ICD-10 Finland
Glaucoma secondary to eye trauma
54.3
13.8
16
*
H40.8
ICD-10 Finland
Other glaucoma
54.3
13.8
16
*
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
9.3
13.8
28
31
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
13.7
311
2055
H30.2
ICD-10 Finland
Posterior cyclitis
76.4
13.6
15
*
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
5.0
13.6
43
89
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
5.8
13.6
38
68
H21.4
ICD-10 Finland
Pupillary membranes
+∞
13.6
13
*
H26.3
ICD-10 Finland
Drug-induced cataract
18.6
13.4
20
11
AA1AD
NOMESCO Finland
CT of head and brain
1.9
13.4
218
1279
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.0
13.2
208
1204
H02AB06
ATC
prednisolone; systemic
1.7
13.1
373
2633
Z3231
NOMESCO Finland
Registered nurse
1.9
12.9
244
1509
H16.9
ICD-10 Finland
Keratitis, unspecified
50.8
12.9
15
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
3.7
12.8
56
159
W22
ICD-10 Finland
Striking against or struck by other object(s)
3.1
12.8
73
253
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
7.2
12.7
30
43
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
5.4
12.5
37
71
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
+∞
12.5
12
*
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
24.7
12.5
17
7
CG2T4
NOMESCO Finland
Topography assessment of cornea
20.4
12.5
18
9
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.3
12.5
62
195
H20.8
ICD-10 Finland
Other iridocyclitis
131.9
12.5
13
*
H3600, E113
ICD-10 Finland
NA
8.6
12.3
26
31
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.2
12.3
66
220
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
11.3
12.1
22
20
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
9.5
12.0
24
26
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.4
11.9
58
180
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
10.7
11.8
22
21
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
5.0
11.7
37
77
H04AA01
ATC
glucagon; nasal, parenteral
5.0
11.7
37
77
L04AB04
ATC
adalimumab; parenteral
6.6
11.6
29
45
D31.4
ICD-10 Finland
Benign neoplasm: Ciliary body
65.9
11.6
13
*
H57.1
ICD-10 Finland
Ocular pain
4.9
11.6
37
78
3644A
ICD-9 Finland
Disorders of iris and ciliary body, Vascular disorders of iris and ciliary body
+∞
11.5
11
*
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
11.5
11
*
J01FF01
ATC
clindamycin; systemic
1.8
11.4
227
1421
H53.1
ICD-10 Finland
Subjective visual disturbances
3.0
11.4
65
226
C08CA01
ATC
amlodipine; oral
1.7
11.3
298
2032
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.6
11.2
81
326
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
11.2
260
1707
H3600, E103
ICD-10 Finland
NA
8.2
11.1
24
30
A02BC02
ATC
pantoprazole; systemic
1.6
10.9
505
4004
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
5.7
10.8
30
54
CG2S4
NOMESCO Finland
Photography of cornea
28.4
10.7
14
5
H34.1
ICD-10 Finland
Central retinal artery occlusion
13.1
10.7
18
14
NHQ40
NOMESCO Finland
Amputation of toe
5.4
10.7
31
59
J01DB01
ATC
cefalexin; oral
1.7
10.6
653
5576
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.1
10.6
124
635
W44
ICD-10 Finland
Foreign body entering into or through eye or natural orifice
6.7
10.6
26
40
C03CA01
ATC
furosemide; systemic
1.7
10.5
266
1788
H18.8
ICD-10 Finland
Other specified disorders of cornea
111.3
10.4
11
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.6
10.4
76
308
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
8.3
10.4
22
27
C10AA05
ATC
atorvastatin; oral
1.7
10.3
299
2081
L04AA17
ATC
[U] adalimumab; parenteral
19.1
10.3
15
8
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
6.0
10.2
27
46
L04AA01
ATC
[U] ciclosporin; systemic
6.0
10.2
27
46
TK800
NOMESCO Finland
Hemodialysis
5.2
10.1
30
59
CD2S4
NOMESCO Finland
Photography of eye
14.8
10.0
16
11
SPAT1262
SPAT
Handing over of treatment supplies
1.9
9.9
153
872
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
4.8
9.9
32
69
H26.1
ICD-10 Finland
Traumatic cataract
16.9
9.9
15
9
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.8
9.9
202
1265
J01MA12
ATC
levofloxacin; systemic
1.9
9.8
152
867
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
5.1
9.8
30
61
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.7
9.7
263
1792
Z2221
NOMESCO Finland
Medical doctor
1.7
9.7
224
1455
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
11.5
9.6
17
15
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.8
9.6
180
1098
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
7.3
9.5
22
31
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
9.4
9
*
H22.1*M45
ICD-10 Finland
Iridocyclitis in ankylosing spondylitis
+∞
9.4
9
*
L04AB06
ATC
golimumab; parenteral
12.5
9.4
16
13
Z49.1
ICD-10 Finland
Extracorporeal dialysis
7.0
9.4
22
32
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
4.6
9.3
31
69
ZX198
NOMESCO Finland
Other local administration
7.4
9.3
21
29
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
9.2
171
1037
TCF00
NOMESCO Finland
Subconjunctival therapeutic injection
37.1
9.0
11
*
H54.4
ICD-10 Finland
Blindness, monocular
18.8
8.9
13
7
ZXE00
NOMESCO Finland
One hour or less
1.6
8.8
306
2212
S05.0
ICD-10 Finland
Injury of conjunctiva and corneal abrasion without mention of foreign body
5.2
8.8
26
51
I50.9
ICD-10 Finland
Heart failure, unspecified
1.9
8.8
133
750
ZXD20
NOMESCO Finland
Day surgery
2.1
8.8
107
557
A10AE06
ATC
insulin degludec; parenteral
3.9
8.7
34
89
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.9
8.7
54
197
H44.5
ICD-10 Finland
Degenerated conditions of globe
50.5
8.7
10
*
CKD95
NOMESCO Finland
Extended combined vitectomy and lens procedure through pars plana
27.8
8.5
11
*
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
27.8
8.5
11
*
L04AB05
ATC
certolizumab pegol; parenteral
20.3
8.5
12
6
H3603, E107
ICD-10 Finland
NA
90.9
8.4
9
*
C07AB07
ATC
bisoprolol; oral
1.5
8.4
376
2887
L04AD01
ATC
ciclosporin; systemic
5.1
8.4
25
50
C09AA02
ATC
enalapril; systemic
1.8
8.4
168
1043
A10AD05
ATC
insulin aspart; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
4.7
8.4
27
59
3648X
ICD-9 Finland
Disorders of iris and ciliary body, Other disorders of iris and ciliary body
+∞
8.3
8
*
H221, M084
ICD-10 Finland
NA
+∞
8.3
8
*
H18.6
ICD-10 Finland
Keratoconus
+∞
8.3
8
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.6
8.3
60
242
S01AD03
ATC
aciclovir; ophthalmic
3.6
8.3
36
104
H54.7
ICD-10 Finland
Unspecified visual loss
14.6
8.2
13
9
1LA05
NOMESCO Finland
NA
14.6
8.2
13
9
H43.8
ICD-10 Finland
Other disorders of vitreous body
2.3
8.2
73
328
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
8.2
8.1
17
21
S01EB01
ATC
pilocarpine; ophthalmic
8.2
8.1
17
21
Z49.2
ICD-10 Finland
Other dialysis
11.8
8.1
14
12
B01AC04
ATC
clopidogrel; oral
1.8
8.0
138
814
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
5.2
7.9
23
45
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.8
7.9
135
796
M45
ICD-10 Finland
Ankylosing spondylitis
5.8
7.9
21
37
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.6
7.8
54
213
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.0
7.8
104
559
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
9.5
7.8
15
16
A11CC03
ATC
alfacalcidol; systemic
4.2
7.7
28
69
CHD00
NOMESCO Finland
Laser trabeculoplasty
5.3
7.7
22
42
CK2K4
NOMESCO Finland
Red-free imaging of ocular fundus
45.4
7.7
9
*
CHW99
NOMESCO Finland
Other operation on anterior chamber, anterior chamber angle, iris or ciliary body
45.4
7.7
9
*
Z2446
NOMESCO Finland
Social worker
2.4
7.7
62
266
N02BE01
ATC
paracetamol; systemic, rectal
1.6
7.6
688
6125
XCH05
NOMESCO Finland
Eye pressure longterm registration
8.1
7.6
16
20
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.3
7.6
72
333
H53.9
ICD-10 Finland
Visual disturbance, unspecified
3.5
7.6
34
101
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
9.0
7.6
15
17
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
2.6
7.5
52
206
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
3.3
7.5
35
108
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.1
7.5
83
416
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
6.5
7.4
18
28
RJ521
NOMESCO Finland
NA
80.8
7.4
8
*
R3120
NOMESCO Finland
Training in mobility skills
80.8
7.4
8
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
4.0
7.4
28
72
127
Kela drug reimbursment
Transplant complication
6.0
7.4
19
32
E10
ICD-10 Finland
Type 1 diabetes mellitus
4.2
7.3
26
63
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.8
7.3
125
733
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
6.9
7.3
17
25
CGG60
NOMESCO Finland
Reinforcement of sclera using graft
+∞
7.3
7
*
H221, M083
ICD-10 Finland
NA
+∞
7.3
7
*
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
+∞
7.3
7
*
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
5.2
7.3
21
41
S18
ICPC
Laceration/cut
1.5
7.3
317
2395
F28
ICPC
Limited function/disability (F)
15.9
7.2
11
7
I10
ICD-10 Finland
Essential (primary) hypertension
1.5
7.2
450
3667
A07EC01
ATC
sulfasalazine; oral, rectal
2.3
7.2
65
298
H33.4
ICD-10 Finland
Traction detachment of retina
30.3
7.2
9
*
CKD50
NOMESCO Finland
Endodiathermy of retina
30.3
7.2
9
*
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
20.2
7.1
10
5
H36.00
ICD-10 Finland
Diabetic background retinopathy
5.1
7.1
21
42
R1220
NOMESCO Finland
Psychological examination of need and possibilities to rehabilitation
8.0
7.1
15
19
M01CB01
ATC
sodium aurothiomalate; parenteral
6.1
7.1
18
30
F99
ICPC
Eye/adnexa disease other
12.1
7.1
12
10
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
3.8
7.0
28
76
S01ED02
ATC
betaxolol; ophthalmic
5.5
6.9
19
35
I50.0
ICD-10 Finland
Congestive heart failure
2.1
6.9
77
385
F05
ICPC
Visual disturbance other
3.6
6.9
29
82
B05DA
ATC
Isotonic solutions
9.4
6.8
13
14
L04AA06
ATC
mycophenolic acid; systemic
5.4
6.8
19
36
CJF45
NOMESCO Finland
Removal and implantation of artificial lens in anterior chamber with iridectomy or iridotomy
16.8
6.8
10
6
C09AA05
ATC
ramipril; oral
1.6
6.7
200
1377
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
4.5
6.7
22
50
H15.1
ICD-10 Finland
Episcleritis
22.7
6.7
9
*
SPAT1009
SPAT
Measurement of intraocular pressure
4.7
6.6
21
46
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
3.8
6.6
26
70
N18.8
ICD-10 Finland
Other chronic renal failure
3.4
6.6
30
91
R53
ICD-10 Finland
Malaise and fatigue
1.6
6.5
163
1071
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.2
6.5
62
289
CWW99
NOMESCO Finland
Other reoperation on eye and adjacent structures
70.4
6.4
7
*
CL2L4
NOMESCO Finland
Wide-field fundus photography for diabetic retinopathy screening
70.4
6.4
7
*
CKD99
NOMESCO Finland
Other intraoclular operations on vitreous body and retina
70.4
6.4
7
*
H16.2
ICD-10 Finland
Keratoconjunctivitis
70.4
6.4
7
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
7.5
6.4
14
19
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.6
6.4
179
1211
2504B
ICD-9 Finland
Diabetes mellitus, Diabetes with renal manifestations[DIABETES MELLITUS CUM COMPLICATIONE OCULI ,TYYPPI I]
14.4
6.4
10
7
H27.0
ICD-10 Finland
Aphakia
14.4
6.4
10
7
CA1AD
NOMESCO Finland
Orbita CT
14.4
6.4
10
7
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
9.3
6.3
12
13
R51.80
ICD-10 Finland
Headache
1.8
6.3
106
619
H36.02
ICD-10 Finland
Preproliferative diabetic retinopathy
18.2
6.3
9
5
N02AX02
ATC
tramadol; systemic, rectal
1.5
6.3
308
2369
J01CA04
ATC
amoxicillin; systemic
1.5
6.3
629
5567
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
6.3
6
*
3641A
ICD-9 Finland
Disorders of iris and ciliary body, Chronic iridocyclitis
+∞
6.3
6
*
CHB60
NOMESCO Finland
Anterior synechiolysis
+∞
6.3
6
*
TCA15
NOMESCO Finland
Retrobulbar therapeutic injection into orbit
+∞
6.3
6
*
M08.9
ICD-10 Finland
Juvenile arthritis, unspecified
26.9
6.2
8
*
H28.0*E10.3
ICD-10 Finland
Other specified diabetes mellitus - Diabetic cataract
26.9
6.2
8
*
N18.0
ICD-10 Finland
End-stage renal disease
5.1
6.2
18
36
H25.8
ICD-10 Finland
Other senile cataract
1.8
6.2
97
555
AN1
HP
Coronary angiography
1.8
6.2
100
575
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.6
6.2
41
161
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
1.8
6.1
96
547
A28
ICPC
Limited function/disability NOS
1.7
6.1
126
783
J05AB01
ATC
aciclovir; systemic
1.6
6.1
149
973
H25.0
ICD-10 Finland
Senile incipient cataract
2.3
6.1
53
240
B05DB
ATC
Hypertonic solutions
10.1
6.0
11
11
Z3226
NOMESCO Finland
Physiotherapist
1.7
6.0
141
912
L28
ICPC
Limited function/disability (L)
1.7
6.0
130
821
B03XA02
ATC
darbepoetin alfa; parenteral
3.8
6.0
23
61
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
5.6
6.0
16
29
A10AA03
ATC
NA
5.6
6.0
16
29

Mortality – FinRegistry

↥

Association

Association between endpoint H7_OTHIRISCILIARY and mortality.

Females

Parameter HR [95% CI] p-value
H7_OTHIRISCILIARY 1.36 [1.18, 1.57] < 0.001
Birth year 0.992 [0.98, 1.0] 0.081

During the follow-up period (1.1.1998 — 31.12.2019), 834 out of 2998 females with H7_OTHIRISCILIARY died.

Males

Parameter HR [95% CI] p-value
H7_OTHIRISCILIARY 1.515 [1.29, 1.78] < 0.001
Birth year 0.989 [0.98, 1.0] 0.024

During the follow-up period (1.1.1998 — 31.12.2019), 774 out of 3638 males with H7_OTHIRISCILIARY died.

Mortality risk

Mortality risk for people of age

years, who have H7_OTHIRISCILIARY.

N-year risk Females Males
1 0.073% 0.389%
5 0.65% 1.978%
10 1.761% 4.879%
15 3.416% 9.112%
20 6.018% 15.387%

Relationships between endpoints

↥

Index endpoint: H7_OTHIRISCILIARY – Other disorders of iris and ciliary body

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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