Other specified and unspecified disorders of iris and ciliary body

H7_IRISCILIARYNAS

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H21.8, H21.9, H22.8* Hospital discharge: ICD-9 — 364[8-9] Cause of death: ICD-10 — H21.8, H21.9, H22.8* Cause of death: ICD-9 — 364[8-9] 2 out of 7 registries used, show all original rules.	149
4. Check minimum number of events None	149
5. Include endpoints None	149
6. Filter based on genotype QC (FinnGen only)	139

Control definitions (FinnGen only)

Control exclude: H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	H7_IRISCILIARYNAS
CONTROL_EXCLUDE	H7_SCLERACORNEA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H21[8-9]\|H228
HD_ICD_9	364[8-9]
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H21[8-9]\|H228
COD_ICD_9	364[8-9]
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other specified and unspecified disorders of iris and ciliary body based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	973	537	432
Only index persons	839	470	369
Unadjusted period prevalence (%)
Whole population	0.01	0.02	0.01
Only index persons	0.02	0.02	0.01
Median age at first event (years)
Whole population	54.03	56.06	51.59
Only index persons	53.90	55.91	51.36

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	139	89	50
Unadjusted period prevalence (%)	0.03	0.03	0.02
Median age at first event (years)	52.83	53.77	51.17

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
149: Matched controls
1490

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H21.9

ICD-10 Finland

Disorder of iris and ciliary body, unspecified

+∞

79.4

H21.8

ICD-10 Finland

Other specified disorders of iris and ciliary body

+∞

75.6

H20.0

ICD-10 Finland

Acute and subacute iridocyclitis

178.5

28.8

XCK10

NOMESCO Finland

Photography of fundus of eye

8.0

25.8

S01ED51

ATC

timolol, combinations; ophthalmic

9.2

25.4

H20.1

ICD-10 Finland

Chronic iridocyclitis

+∞

20.3

Z01.0

ICD-10 Finland

Examination of eyes and vision

4.8

17.7

153

CK2S4

NOMESCO Finland

Plain photography of ocular fundus

8.7

17.5

114

Kela drug reimbursment

Glaucoma

6.4

15.1

H40.5

ICD-10 Finland

Glaucoma secondary to other eye disorders

59.3

14.1

CH2S4

NOMESCO Finland

Photography of iris

+∞

13.8

S01EA05

ATC

brimonidine; ophthalmic

31.7

13.3

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

5.0

12.7

D31.4

ICD-10 Finland

Benign neoplasm: Ciliary body

+∞

12.7

H20.9

ICD-10 Finland

Iridocyclitis, unspecified

+∞

11.6

L01BA01

ATC

methotrexate; systemic

13.4

11.2

H26.2

ICD-10 Finland

Complicated cataract

20.6

10.5

S01ED01

ATC

timolol; ophthalmic

12.6

9.8

XCW99

NOMESCO Finland

Other investigative procedure of eye

4.4

9.7

Z96.1

ICD-10 Finland

Presence of intraocular lens

3.8

9.6

107

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

13.6

9.6

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

13.6

9.6

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

5.4

9.1

L04AB04

ATC

adalimumab; parenteral

25.9

9.1

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

3.9

8.9

S01EC01

ATC

acetazolamide; systemic

12.7

8.8

3648X

ICD-9 Finland

Disorders of iris and ciliary body, Other disorders of iris and ciliary body

+∞

8.4

WX140

NOMESCO Finland

Parabulbar anesthesy

7.0

8.4

XCK00

NOMESCO Finland

Perimetry

5.3

8.4

L04AX03

ATC

methotrexate; systemic

3.9

7.8

L04AA13

ATC

[U] leflunomide

14.4

7.5

XCH00

NOMESCO Finland

Eye pressure measurement

7.5

6.7

WX100

NOMESCO Finland

Conjunctival surface anesthesia

3.4

6.7

S01BA04

ATC

prednisolone; ophthalmic

15.2

6.5

M08.3

ICD-10 Finland

Juvenile polyarthritis (seronegative)

72.8

6.5

M08.4

ICD-10 Finland

Pauciarticular juvenile arthritis

72.8

6.5

WX704

NOMESCO Finland

Intubation

4.3

6.4

H21.3

ICD-10 Finland

Cyst of iris, ciliary body and anterior chamber

+∞

6.3

M08.0

ICD-10 Finland

Juvenile rheumatoid arthritis

+∞

6.3

H40.4

ICD-10 Finland

Glaucoma secondary to eye inflammation

+∞

6.3

L04AA17

ATC

[U] adalimumab

+∞

6.3

CJB10

NOMESCO Finland

Laser discission of secondary cataract

4.0

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40760892) CBC W Ordered Manual Differential panel - Blood

546

2.23

5.44

8.1

6.2

—

(3021788) Differential panel - Synovial fluid

10.55

5.10

1.3

1.6

—

(3037522) Nuclear Ab [Titer] in Serum

146

2.42

4.18

1.5

1.3

730.67

714.29

titre

0.01

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

8.09

3.60

1.0

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.97

3.55

1.4

1.3

—

(3013115) Eosinophils [#/volume] in Blood

604

1.84

3.32

8.1

5.6

0.21

0.18

e9/l

0.82

546

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

135

2.22

3.15

2.2

2.6

5.30

8.89

umol/l

0.76

121

(3024561) Albumin [Mass/volume] in Serum or Plasma

462

1.82

3.14

5.0

4.4

35.12

35.86

g/l

0.46

437

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

482

1.80

3.09

2.3

2.4

81.57

77.45

nmol/l

0.51

436

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

609

1.77

2.94

5.1

6.4

11.24

10.64

umol/l

0.18

580

(3013826) Glucose [Moles/volume] in Serum or Plasma

687

1.78

2.93

3.4

4.3

6.72

6.52

mmol/l

0.27

637

(3001122) Ferritin [Mass/volume] in Serum or Plasma

518

1.75

2.86

2.9

2.6

96.85

98.69

ug/l

0.05

478

(40760888) Immunoglobulin light chains.free panel - Serum

4.39

2.72

1.9

7.9

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

294

1.82

2.70

2.3

3.3

2126.64

920.80

ng/l

0.48

251

(3004588) Protein electrophoresis panel - Serum or Plasma

2.66

2.62

3.3

3.7

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

704

1.70

2.54

10.7

8.8

4.21

3.94

e9/l

0.61

620

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.49

2.48

1.7

1.2

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

251

1.81

2.47

2.3

2.1

2.31

3.08

mg/l

2.21

219

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

3.48

2.43

1.2

—

(3035637) Corticotropin [Mass/volume] in Plasma

5.16

2.42

1.0

1.8

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

3.17

2.41

1.3

1.4

—

2.69

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

3.17

2.41

1.3

1.4

—

3.61

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

4.27

2.39

1.6

1.2

—

(3019150) Specific gravity of Urine by Refractometry

253

1.73

2.14

4.6

3.8

1.02

kg/l

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

157

1.88

2.11

1.4

1.6

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.52

2.08

1.4

1.5

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

126

1109

1.88

2.08

5.0

4.6

1.75

1.88

mu/l

0.74

119

1028

(3015377) Calcium [Moles/volume] in Serum or Plasma

385

1.63

2.08

4.1

3.0

2.34

2.36

mmol/l

0.57

341

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

214

1.76

2.06

1.4

1.7

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.62

2.06

1.4

1.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

264

1.70

2.06

1.6

1.9

—

(3048689) Calprotectin [Mass/mass] in Stool

159

1.85

2.03

2.0

1.9

80.54

79.37

ug/g

0.02

123

(42529406) Shigella sp [Presence] in Stool by Culture

2.56

1.98

1.4

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.56

1.98

1.4

1.2

—

(3025941) Bacteria identified in Stool by Culture

2.20

1.94

1.1

1.2

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

795

1.58

1.91

3.6

2.9

57.43

42.49

u/l

0.54

759

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

3.29

1.90

1.0

1.2

—

(3042936) Bacteria identified in Isolate by Culture

147

1.84

1.89

2.6

1.8

—

(3023368) Bacteria identified in Blood by Culture

279

1.65

1.87

3.8

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

157

1.79

1.81

1.5

2.2

—

(3019225) pH of Specimen

2.03

1.78

3.4

4.6

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

133

1210

1.92

1.70

17.7

13.9

3.93

3.95

mmol/l

0.45

127

1173

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

3.24

1.68

1.0

1.8

—

(3005719) IgG [Mass/volume] in Serum or Plasma

2.05

1.66

4.9

3.3

11.02

9.62

g/l

0.64

(40761535) Cells panel - Urine sediment

2.05

1.66

4.2

3.6

—

(3037121) Protein [Mass/volume] in Urine

2.48

1.65

1.3

4.5

0.12

0.17

g/l

—

(3000764) Benzodiazepines [Presence] in Urine

2.17

1.65

1.4

—

(3027008) Opiates [Presence] in Urine

2.17

1.65

1.4

—

(3028300) Cannabinoids [Presence] in Urine

2.17

1.65

1.5

1.4

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

253

1.62

1.65

1.4

2.0

0.57

0.91

mg/l

1.23

196

(3027944) Amphetamines [Presence] in Urine

2.13

1.59

1.4

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

126

1136

1.71

1.56

4.6

4.1

6.04

5.86

mmol/l

0.54

116

1053

(3009508) Creatinine [Moles/volume] in Urine

346

1.52

2.7

2.9

8.75

8.23

mmol/l

0.30

292

(3022217) INR in Platelet poor plasma by Coagulation assay

514

1.47

1.48

7.8

11.2

1.13

1.21

inr

0.35

168

(3016879) Cocaine [Presence] in Urine

2.12

1.48

1.4

—

(40758558) Short blood count panel - Blood

304

1.53

1.46

7.0

7.2

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

209

1.61

1.46

3.0

3.5

43.48

223.64

ng/l

1.56

150

(3022145) Colonoscopy Study observation

120

1.77

1.43

1.3

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

538

1.45

1.39

6.2

6.0

1.23

1.22

mmol/l

0.28

468

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

178

1.63

1.39

1.5

2.3

—

(3008898) HLA-B27 [Presence]

2.21

1.37

1.3

1.0

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

114

1.76

1.36

1.6

2.2

448.63

365.63

nmol/l

1.08

104

(40761511) CBC panel - Blood by Automated count

136

1267

1.84

1.29

17.1

11.3

—

(3000492) Spirometry study

101

1.77

1.26

1.4

1.5

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.23

1.23

3.4

2.7

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.23

1.23

2.4

2.1

—

(3035350) Ketones [Presence] in Urine by Test strip

587

1.40

1.21

4.6

3.6

0.00

estimate

-0.00

119

(3026008) Bacteria identified in Urine by Culture

353

1.44

1.19

2.9

—

(3013707) Erythrocyte sedimentation rate by Westergren method

101

891

1.41

1.16

7.0

3.8

13.10

10.42

mm/h

1.21

818

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

103

913

1.42

1.14

4.2

4.0

15.11

14.70

pmol/l

0.82

839

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.06

1.14

1.5

1.4

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

1.89

1.12

1.3

—

55.60

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

2.32

1.12

1.4

1.7

—

(3026493) Urate [Moles/volume] in Serum or Plasma

267

1.46

1.11

2.0

3.0

343.29

6131.41

umol/l

1.31

226

(3005322) IgE [Units/volume] in Serum or Plasma

1.83

1.11

1.4

1.2

52.42

157.23

u/ml

2.06

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

127

1175

1.55

1.08

5.1

4.6

2.68

2.75

mmol/l

0.40

119

1097

(3021589) Normoblasts [#/volume] in Blood

548

1.37

1.07

10.9

8.3

0.00

e9/l

0.50

448

(3020682) Albumin/Creatinine [Ratio] in Urine

324

1.41

1.05

3.6

3.5

10.83

8.41

mg/mmol

0.10

202

(3013512) EKG study

306

1.42

1.04

3.0

3.4

—

(3021960) Folate [Moles/volume] in Serum or Plasma

270

1.44

1.04

1.7

1.5

16.51

22.13

nmol/l

2.17

230

(3009214) Lutropin [Units/volume] in Serum or Plasma

2.11

1.04

1.4

1.7

12.20

11.48

u/l

—

(3002523) Influenza virus A Ag [Presence] in Specimen

2.32

1.04

1.0

1.1

—

(3003740) Influenza virus B Ag [Presence] in Specimen

2.32

1.04

1.0

1.1

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.05

1.01

1.1

1.3

—

(3044640) Blood type and Crossmatch panel - Blood

346

1.39

0.98

2.0

2.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

452

1.34

0.93

5.0

3.6

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

214

1.44

0.92

1.2

14.34

27.48

iu/ml

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

129

1209

1.50

0.89

18.4

12.2

23.69

23.15

mg/l

0.06

113

914

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

541

1.32

0.89

2.4

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

417

1.34

0.89

2.1

1.9

96.03

97.62

pmol/l

0.06

205

(3009542) Hematocrit [Volume Fraction] of Blood

141

1352

1.80

0.88

24.7

18.0

40.18

40.32

0.16

132

1275

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.65

0.88

1.6

1.3

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

124

1157

1.43

0.85

4.7

4.2

4.61

4.66

mmol/l

0.20

114

1081

(3021601) Nitrite [Presence] in Urine by Test strip

584

1.30

0.83

5.9

5.0

0.00

estimate

-0.00

110

(40768797) Stomach Pathology biopsy report

157

1.47

0.82

1.2

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

412

1.32

0.82

3.4

3.6

17.76

38.40

ng/l

1.14

277

(3029937) Albumin [Presence] in Urine by Test strip

301

1.35

0.81

6.1

3.9

0.00

estimate

-0.00

108

(3021387) Prolactin [Units/volume] in Serum or Plasma

1.70

0.80

1.5

175.00

314.72

mu/l

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

265

1.37

0.80

4.7

3.6

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.80

0.0

3.0

—

7.26

—

(3009261) Glucose [Presence] in Urine by Test strip

597

1.29

0.79

4.7

3.6

0.00

0.03

estimate

0.50

107

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.78

0.0

2.9

—

1.41

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.74

0.77

1.2

1.4

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.71

0.76

1.0

1.1

—

(3002256) Pathology report gross observation

144

1.45

0.72

1.1

1.2

—

(3012516) Albumin [Mass/volume] in Urine

307

1.32

0.71

3.0

75.88

256.65

mg/l

0.41

198

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

1.70

0.69

2.0

1.3

44.86

33.52

nmol/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

824

1.27

0.69

6.6

4.1

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

1.81

0.67

1.0

1.4

—

(3014051) Protein [Presence] in Urine by Test strip

1.81

0.67

2.0

1.9

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

136

0.64

7.7

5.3

101.22

103.81

mmol/l

—

136

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

122

1152

1.33

0.62

4.8

4.1

1.48

1.49

mmol/l

0.03

112

1071

(4200892) Spirometry reversibility

1.50

0.60

1.1

1.4

—

(4094501) Cardiovascular stress test using bicycle ergometer

1.74

0.58

1.2

1.1

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.48

0.57

1.8

1.6

20.13

21.48

iu/l

—

(3019309) Folate [Moles/volume] in Red Blood Cells

179

1.34

0.55

1.5

1.6

1358.24

1133.31

nmol/l

0.40

136

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.53

0.55

2.3

5.2

22.79

24.98

mmol/l

—

(1761868) Lipid panel - Serum or Plasma

467

0.80

0.52

3.3

2.6

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

127

1.38

0.52

10.3

8.4

—

(3022948) Iron [Moles/volume] in Serum or Plasma

163

1.34

0.52

2.2

2.0

14.84

15.39

umol/l

0.09

148

(3045414) Leukocytes [Presence] in Urine

1.58

0.49

1.7

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

248

1.26

0.48

2.0

2.1

—

(3003694) ABO and Rh group [Type] in Blood

352

1.23

0.47

1.4

1.5

—

(3044889) 12 lead EKG panel

825

1.20

0.46

3.8

3.6

—

(3007164) IgA [Mass/volume] in Serum or Plasma

287

1.24

0.46

1.6

1.5

2.28

2.44

g/l

0.21

163

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.42

0.45

2.6

8.8

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

129

0.68

0.45

2.2

1.6

—

(3028707) Methadone [Presence] in Urine by Screen method

1.63

0.43

1.8

1.6

—

(4034850) Laboratory test

1.63

0.43

12.2

10.3

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.45

0.43

2.3

1.5

—

(3000330) Specific gravity of Urine by Test strip

1.40

0.42

1.8

2.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

839

1.18

0.42

2.9

3.3

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.40

0.41

2.9

2.4

6.05

5.56

ug/l

0.06

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

2.3

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.41

0.0

3.9

—

81.58

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

5.4

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.41

0.0

2.5

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.41

0.0

2.5

—

106.76

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.41

0.0

2.5

—

3.86

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.40

0.0

1.4

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.39

0.0

1.2

—

6.29

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

1.40

0.38

1.4

1.3

—

(36304419) Bacteria [Presence] in Urine

332

1.19

0.37

2.2

3.1

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.34

0.37

1.3

1.6

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

156

0.75

0.36

1.4

1.5

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.63

0.36

1.0

1.7

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.48

0.36

1.3

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

111

1061

1.18

0.35

7.3

5.2

41.43

39.35

mmol/mol

1.19

102

996

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

422

1.17

0.33

2.8

3.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

119

1.29

0.33

1.7

1.5

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.38

0.33

1.2

1.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

156

1.25

0.33

1.4

1.6

—

(3011288) Drugs identified in Urine by Screen method

1.29

0.32

1.7

1.9

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

116

1116

1.18

0.31

4.3

3.7

1.29

1.24

mmol/l

0.40

105

1031

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

121

1.27

0.30

1.7

1.5

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.31

0.28

4.2

6.6

1.24

1.43

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.31

0.28

4.3

7.0

0.61

0.67

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

207

1.19

0.27

1.3

1.07

2.86

u/ml

—

(3022621) pH of Urine by Test strip

1.32

0.27

2.0

2.4

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

116

1121

1.16

0.27

15.4

11.5

84.41

84.19

ml/min/173m2

0.03

102

908

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

123

1.24

0.26

1.7

1.6

—

(3019060) Gas panel - Arterial blood

1.27

0.26

3.2

4.9

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

114

1.25

0.26

1.4

1.8

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

266

1.16

0.25

1.4

1.6

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

1.29

0.25

1.5

2.6

77.22

67.75

ml/min/173m2

—

(36660697) Celiac disease serology panel - Serum

115

1.24

0.24

1.5

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

106

1.25

0.24

2.0

3.0

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.36

0.24

1.4

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.29

0.23

1.4

1.1

—

(3030467) Casts [#/volume] in Urine by Automated count

337

1.13

0.22

2.2

3.2

0.55

0.33

e6/l

0.19

249

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.25

0.21

3.5

1.24

1.23

mmol/l

0.25

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

1.80

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

2.0

—

72.50

—

(3007368) IgG [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

26.36

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.21

0.0

1.3

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.21

0.0

1.0

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.21

0.0

2.0

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.27

0.21

1.9

1.4

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.0

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.5

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

186

0.84

0.20

2.1

3.0

0.88

2.09

e6/l

—

103

(3018095) Leukocytes [#/volume] in Urine

446

1.11

0.20

3.1

3.8

92.16

57.46

e6/l

0.20

307

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.20

0.0

1.1

—

(3014037) CD3+CD4+ (T4 helper) cells/100 cells in Blood

0.00

0.20

0.0

2.6

—

51.83

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

2.1

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

2.1

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.20

0.0

1.1

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

2.1

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

1.21

0.20

1.3

1.6

—

(21494755) Public health laboratory ask at order entry panel

122

0.81

0.20

1.1

1.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

175

1.17

0.20

1.8

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.25

0.19

1.4

1.5

—

(3000494) Fungus identified in Specimen by Culture

138

1.18

0.18

1.4

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.17

0.18

4.7

7.4

91.43

95.06

—

(3002582) Erythrocytes [#/volume] in Urine

374

1.10

0.15

2.3

3.3

19.84

208.44

e6/l

0.55

283

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.78

0.15

1.4

1.3

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.81

0.14

1.3

1.8

—

(3012544) pH of Venous blood

107

0.83

0.13

10.8

3.1

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

169

0.87

0.13

3.8

2.5

0.51

0.61

ug/l

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

200

0.89

0.13

2.1

2.8

0.85

0.78

e6/l

—

117

(3041096) Erythrocytes [Presence] in Urine by Automated

338

1.09

0.12

4.3

3.2

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

193

1.10

0.10

1.1

1.4

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

1.11

0.10

1.4

1.5

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

1.11

0.10

1.4

1.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

1.11

0.10

1.4

1.5

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

1.11

0.10

1.4

1.5

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.07

0.09

3.4

1.8

—

(40768804) Tissue Pathology biopsy report

480

0.94

0.09

1.8

2.0

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

302

1.08

0.09

1.7

1.6

1.29

1.33

mmol/l

0.10

252

(3022313) Gas panel - Capillary blood

1.14

0.09

1.7

2.9

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.83

0.08

1.2

1.8

—

(3018418) pH of Serum or Plasma

343

1.07

0.08

4.1

3.9

7.41

7.40

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

234

0.93

0.07

5.5

4.0

18.39

20.91

—

(3000991) Gas panel - Venous blood

0.87

0.07

5.8

5.3

—

(4035726) Immunohistochemistry procedure

107

0.93

0.02

1.5

1.3

—

(40761536) Microorganisms panel - Urine sediment

106

1.04

0.00

8.0

3.5

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

325

1.02

0.00

1.4

1.3

0.69

1.48

u/ml

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

1.62

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

2.2

—

(3033306) Mononuclear cells/100 leukocytes in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

-0.00

0.0

1.0

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

1.1

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

-0.00

0.0

1.0

—

176.60

—

(3009343) pH of Capillary blood

0.97

-0.00

1.6

3.2

—

7.43

—

(3002619) Bacteria identified in Specimen by Culture

0.00

-0.00

0.0

1.2

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.3

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3045716) Anion gap in Serum or Plasma

0.00

-0.00

0.0

2.0

—

8.40

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

-0.00

0.0

1.1

—

(3018658) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

2.3

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

-0.00

0.0

1.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.3

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

-0.00

0.0

1.0

—

(3004446) Plasmodium sp identified in Blood by Light microscopy

0.00

-0.00

0.0

3.0

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

28.20

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

-0.00

0.0

1.4

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.94

-0.00

2.8

2.2

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

0.82

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

2.3

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

-0.00

0.0

1.2

—

(3028433) Virus identified in Specimen by Culture

0.00

-0.00

0.0

1.7

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

3.2

—

102.00

—

(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture

0.00

-0.00

0.0

2.8

—

(3048402) Erythrocytes [#/area] in Urine sediment by Automated count

0.00

-0.00

0.0

1.0

—

0.80

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

-0.00

0.0

1.2

—

35.72

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3016038) Potassium [Moles/volume] in Urine

0.00

-0.00

0.0

1.0

—

25.14

—

(3011648) Oxygen content in Venous blood

0.00

-0.00

0.0

1.0

—

10.33

—

(42869547) Procollagen type III.N-terminal propeptide [Mass/volume] in Serum

0.00

-0.00

0.0

1.0

—

10.67

—

(1002224) Polysomnography panel

0.91

-0.00

1.0

1.1

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(40765096) Chromosome analysis panel by Banding

0.00

-0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

3.2

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.0

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

-0.00

0.0

1.0

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

-0.00

0.0

1.8

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.3

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_IRISCILIARYNAS and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_IRISCILIARYNAS	1.164 [0.86, 1.58]	0.327
Birth year	0.998 [0.99, 1.01]	0.68

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 413 females with H7_IRISCILIARYNAS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_IRISCILIARYNAS.

N-year risk	Females	Males
1	0.096%	No data
5	0.77%	No data
10	1.895%	No data
15	3.663%	No data
20	6.734%	No data

Relationships between endpoints

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Index endpoint: H7_IRISCILIARYNAS – Other specified and unspecified disorders of iris and ciliary body

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other specified and unspecified disorders of iris and ciliary body

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints