Other specified and unspecified disorders of iris and ciliary body

H7_IRISCILIARYNAS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H21.8, H21.9, H22.8* Hospital discharge: ICD-9 — 364[8-9] Cause of death: ICD-10 — H21.8, H21.9, H22.8* Cause of death: ICD-9 — 364[8-9] 2 out of 7 registries used, show all original rules.	142
4. Check minimum number of events None	142
5. Include endpoints None	142
6. Filter based on genotype QC (FinnGen only)	142

Control definitions (FinnGen only)

Control exclude: H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	H7_IRISCILIARYNAS
CONTROL_EXCLUDE	H7_SCLERACORNEA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H21[8-9]\|H228
HD_ICD_9	364[8-9]
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H21[8-9]\|H228
COD_ICD_9	364[8-9]
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other specified and unspecified disorders of iris and ciliary body based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	973	537	432
Only index persons	839	470	369
Unadjusted period prevalence (%)
Whole population	0.01	0.02	0.01
Only index persons	0.02	0.02	0.01
Median age at first event (years)
Whole population	54.03	56.06	51.59
Only index persons	53.90	55.91	51.36

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	142	91	51
Unadjusted period prevalence (%)	0.03	0.03	0.02
Median age at first event (years)	52.25	53.47	50.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
123: Matched controls
1228

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H21.9

ICD-10 Finland

Disorder of iris and ciliary body, unspecified

+∞

64.3

H21.8

ICD-10 Finland

Other specified disorders of iris and ciliary body

+∞

60.5

H20.0

ICD-10 Finland

Acute and subacute iridocyclitis

+∞

20.4

H20.1

ICD-10 Finland

Chronic iridocyclitis

+∞

13.8

XCK10

NOMESCO Finland

Photography of fundus of eye

6.8

12.8

H40.5

ICD-10 Finland

Glaucoma secondary to other eye disorders

+∞

12.7

S01ED51

ATC

timolol, combinations; ophthalmic

9.7

12.7

CK2S4

NOMESCO Finland

Plain photography of ocular fundus

12.3

10.7

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

15.1

10.0

CH2S4

NOMESCO Finland

Photography of iris

108.0

9.6

3648X

ICD-9 Finland

Disorders of iris and ciliary body, Other disorders of iris and ciliary body

+∞

8.4

S01EC01

ATC

acetazolamide; systemic

36.0

8.2

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

14.4

8.1

S01EA05

ATC

brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)

14.4

8.1

Z01.0

ICD-10 Finland

Examination of eyes and vision

4.0

7.7

104

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

14.6

7.6

D31.4

ICD-10 Finland

Benign neoplasm: Ciliary body

85.0

7.5

114

Kela drug reimbursment

Glaucoma

5.2

6.9

H26.2

ICD-10 Finland

Complicated cataract

18.0

6.9

Z96.1

ICD-10 Finland

Presence of intraocular lens

4.4

6.7

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

4.3

6.5

WX140

NOMESCO Finland

Parabulbar anesthesy

8.4

6.3

S01ED01

ATC

timolol; ophthalmic

8.4

6.3

H20.9

ICD-10 Finland

Iridocyclitis, unspecified

+∞

6.3

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

4.7

6.3

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

2.8

6.2

234

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(42870588) Differential panel, method unspecified - Blood

351

2.43

6.15

7.6

5.4

—

(3021788) Differential panel - Synovial fluid

10.57

5.10

1.3

1.6

—

(3037522) Nuclear Ab [Titer] in Serum

141

2.43

4.08

1.5

1.4

760.0

584.7

titre

0.18

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.09

3.77

1.4

1.2

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

126

2.30

3.28

2.2

2.6

5.5

8.7

umol/l

0.62

113

(3013826) Glucose [Moles/volume] in Serum or Plasma

655

1.85

3.10

3.4

4.3

6.7

6.5

mmol/l

0.25

608

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

7.77

3.08

1.0

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

442

1.82

3.00

5.0

4.3

35.1

35.9

g/l

0.47

417

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

582

1.81

2.98

5.2

6.1

11.2

10.6

umol/l

0.17

553

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

281

1.88

2.89

2.4

3.3

2177.2

945.7

ng/l

0.47

240

(40760888) Immunoglobulin light chains.free panel - Serum

4.64

2.84

1.9

8.3

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.63

2.72

1.7

1.2

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

4.54

2.51

1.6

1.2

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

463

1.70

2.43

2.4

80.5

77.3

nmol/l

0.35

417

(3035637) Corticotropin [Mass/volume] in Plasma

5.17

2.42

1.0

1.7

—

(3019150) Specific gravity of Urine by Refractometry

237

1.82

2.41

4.7

3.9

1.0

kg/l

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

246

1.81

2.39

1.6

1.9

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.60

2.35

3.5

3.8

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

121

1053

2.01

2.30

5.0

4.6

1.8

1.9

mu/l

0.67

115

980

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

200

1.85

2.29

1.4

1.7

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

146

1.96

2.26

1.4

1.6

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.64

2.25

1.4

1.5

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.75

2.24

1.4

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.69

2.15

1.4

1.2

—

(42529406) Shigella sp [Presence] in Stool by Culture

2.69

2.15

1.4

1.2

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

3.33

2.13

1.3

1.2

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

367

1.66

2.11

4.2

2.8

2.3

2.4

mmol/l

0.73

323

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

3.03

2.11

1.2

1.4

—

2.9

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

3.03

2.11

1.2

1.4

—

3.9

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

496

1.62

2.08

3.0

2.6

100.5

97.9

ug/l

0.07

457

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

3.62

2.08

1.0

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

2.28

1.84

1.4

1.5

—

(3028300) Cannabinoids [Presence] in Urine

2.28

1.84

1.5

—

(3027008) Opiates [Presence] in Urine

2.28

1.84

1.4

—

(3009508) Creatinine [Moles/volume] in Urine

325

1.61

1.83

2.8

2.9

8.8

8.2

mmol/l

0.32

272

(3005719) IgG [Mass/volume] in Serum or Plasma

2.15

1.83

4.9

3.3

11.0

9.7

g/l

0.58

(40761535) Cells panel - Urine sediment

2.15

1.83

4.3

3.7

—

(3034770) Mitochondria Ab [Titer] in Serum

2.86

1.82

1.4

1.2

—

(3048689) Calprotectin [Mass/mass] in Stool

157

1.80

1.82

2.0

83.1

80.5

ug/g

0.03

121

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

150

1.81

1.78

1.4

2.2

—

(3027944) Amphetamines [Presence] in Urine

2.25

1.78

1.4

1.5

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

757

1.56

1.75

3.7

2.9

59.1

42.1

u/l

0.60

721

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

120

1.88

1.74

4.8

4.3

34.8

32.2

0.42

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

242

1.65

1.73

2.4

2.1

2.4

3.1

mg/l

1.66

212

(3042936) Bacteria identified in Isolate by Culture

144

1.80

1.71

2.6

1.8

—

(3025941) Bacteria identified in Stool by Culture

2.14

1.71

1.1

1.2

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

201

1.69

1.70

3.0

3.4

43.5

225.8

ng/l

1.51

145

(3019225) pH of Specimen

2.02

1.67

3.4

4.0

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

245

1.63

1.65

1.4

2.0

0.6

0.9

mg/l

1.08

188

(3022145) Colonoscopy Study observation

115

1.86

1.63

1.3

—

(3016879) Cocaine [Presence] in Urine

2.21

1.60

1.4

1.5

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

110

1.84

1.52

1.6

2.2

448.6

358.3

nmol/l

1.22

101

(3023103) Potassium [Moles/volume] in Serum or Plasma

126

1152

1.83

1.48

18.3

13.8

3.9

4.0

mmol/l

0.53

120

1115

(40761511) CBC panel - Blood by Automated count

130

1202

1.96

1.43

17.4

11.2

—

(40758558) Short blood count panel - Blood

290

1.53

1.39

6.6

7.2

—

(3008898) HLA-B27 [Presence]

2.21

1.37

1.3

1.0

—

(3023368) Bacteria identified in Blood by Culture

265

1.54

1.36

4.0

3.8

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

119

1079

1.64

1.34

4.7

4.1

6.1

5.9

mmol/l

0.68

110

1005

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.43

1.31

2.4

2.1

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

2.84

1.29

1.0

1.4

—

(3013707) Erythrocyte sedimentation rate by Westergren method

848

1.45

1.25

6.9

3.8

13.3

10.6

mm/h

1.18

782

(3020682) Albumin/Creatinine [Ratio] in Urine

306

1.48

1.24

3.7

3.6

11.3

8.9

mg/mmol

0.10

191

(3013512) EKG study

289

1.48

1.22

3.1

3.3

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

203

1.54

1.18

1.2

14.3

28.1

iu/ml

—

(3026493) Urate [Moles/volume] in Serum or Plasma

256

1.49

1.16

2.0

2.9

340.7

6455.7

umol/l

1.31

214

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

516

1.40

1.14

6.5

5.8

1.2

mmol/l

0.13

448

(3021960) Folate [Moles/volume] in Serum or Plasma

257

1.48

1.14

1.7

1.5

16.5

22.4

nmol/l

2.33

219

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

171

1.56

1.12

1.5

2.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

276

1.46

1.11

4.4

5.0

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.83

1.11

1.4

1.2

52.4

157.2

u/ml

2.06

(3002523) Influenza virus A Ag [Presence] in Specimen

2.43

1.10

1.0

1.1

—

(3003740) Influenza virus B Ag [Presence] in Specimen

2.43

1.10

1.0

1.1

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

869

1.41

1.09

4.3

4.0

15.1

14.7

pmol/l

0.96

801

(3000492) Spirometry study

1.71

1.09

1.4

1.5

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.18

1.07

1.1

1.3

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.72

0.98

1.6

1.3

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.99

0.98

3.7

2.7

—

(3002256) Pathology report gross observation

134

1.57

0.98

1.1

1.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

422

1.37

0.97

5.2

3.7

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.94

0.95

1.4

1.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

396

1.36

0.93

2.1

1.9

96.0

98.5

pmol/l

0.10

195

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

2.19

0.92

1.5

1.6

—

(3035350) Ketones [Presence] in Urine by Test strip

550

1.34

0.91

4.7

3.6

0.0

estimate

—

107

(3044640) Blood type and Crossmatch panel - Blood

332

1.38

0.91

2.1

—

(3021589) Normoblasts [#/volume] in Blood

521

1.34

0.91

10.5

8.4

0.0

e9/l

0.50

424

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

120

1116

1.49

0.91

5.1

4.7

2.7

mmol/l

0.34

112

1043

(3012516) Albumin [Mass/volume] in Urine

289

1.38

0.86

3.1

3.0

79.3

275.1

mg/l

0.41

183

(3009214) Lutropin [Units/volume] in Serum or Plasma

1.98

0.85

1.5

1.7

12.7

12.2

u/l

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.80

0.0

3.1

—

7.4

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.80

0.0

1.3

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.80

0.0

1.3

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.79

0.0

2.9

—

1.4

—

(3029937) Albumin [Presence] in Urine by Test strip

284

1.36

0.79

6.3

4.0

0.0

estimate

—

103

(4094501)

1.80

0.77

1.2

1.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

512

1.30

0.77

3.9

—

(3026008) Bacteria identified in Urine by Culture

332

1.33

0.76

3.1

2.9

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

398

1.31

0.76

3.5

3.7

17.9

39.7

ng/l

1.15

264

(3011397) Hemoglobin [Presence] in Urine by Test strip

250

1.36

0.75

4.7

3.6

—

(3009542) Hematocrit [Volume Fraction] of Blood

116

1085

1.38

0.73

16.3

12.5

39.2

40.3

0.56

840

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

1.79

0.72

2.0

1.3

44.9

33.3

nmol/l

—

(40768797) Stomach Pathology biopsy report

153

1.44

0.72

1.2

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.59

0.71

2.3

5.4

22.8

24.9

mmol/l

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

1.96

0.71

1.0

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

119

1.49

0.71

10.3

8.6

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

117

1098

1.37

0.70

4.7

4.2

4.6

4.7

mmol/l

0.28

108

1028

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

122

1153

1.41

0.69

18.9

12.2

24.4

23.0

mg/l

0.16

106

873

(4034850)

1.75

0.64

12.2

10.8

—

(3021601) Nitrite [Presence] in Urine by Test strip

551

1.26

0.64

5.9

5.0

0.0

estimate

—

105

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

116

1092

1.34

0.63

4.8

4.1

1.5

mmol/l

0.10

107

1017

(3050129) First trimester maternal screen panel - Serum or Plasma

1.67

0.63

1.3

1.4

—

(3028707) Methadone [Presence] in Urine by Screen method

1.69

0.62

1.8

1.6

—

(3009261) Glucose [Presence] in Urine by Test strip

563

1.25

0.61

4.8

3.6

0.0

estimate

—

102

(3032080) INR in Blood by Coagulation assay

418

1.26

0.61

5.3

6.6

1.1

1.2

inr

0.25

136

(3022948) Iron [Moles/volume] in Serum or Plasma

159

1.38

0.59

2.2

2.1

14.8

15.4

umol/l

0.09

143

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.60

0.55

1.3

—

(3037467) Urinalysis macro (dipstick) panel - Urine

778

1.23

0.55

6.6

4.1

—

(3019309) Folate [Moles/volume] in Red Blood Cells

171

1.34

0.54

1.5

1.6

1404.1

1138.4

nmol/l

0.47

132

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.44

0.50

1.3

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

238

1.27

0.49

2.0

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.45

0.48

2.9

2.4

6.0

5.5

ug/l

0.06

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.48

0.47

2.6

8.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

103

1.40

0.47

1.4

1.9

—

(4010399)

1.43

0.46

1.1

1.4

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.42

0.45

1.9

1.6

22.2

21.3

iu/l

—

(3007164) IgA [Mass/volume] in Serum or Plasma

279

1.24

0.44

1.7

1.5

2.3

2.5

g/l

0.22

160

(3044889) 12 lead EKG panel

788

1.20

0.44

3.8

3.6

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.46

0.43

1.2

1.0

—

(3003694) ABO and Rh group [Type] in Blood

337

1.22

0.43

1.4

1.5

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

196

1.27

0.42

1.3

1.1

2.9

u/ml

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.41

0.0

3.9

—

81.6

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.41

0.0

2.6

—

106.9

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.41

0.0

2.6

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.41

0.0

2.6

—

3.9

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

5.1

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.41

0.0

1.4

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.33

0.40

4.3

6.7

1.2

1.5

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.33

0.40

4.3

7.1

0.6

0.7

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.44

0.39

1.4

1.3

—

(3019060) Gas panel - Arterial blood

1.39

0.39

3.2

4.8

—

(3019832) Treponema pallidum Ab [Presence] in Serum

143

1.30

0.39

1.3

1.6

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.39

0.0

1.2

—

6.3

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

178

0.76

0.37

2.1

2.9

0.6

2.2

e6/l

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

123

0.71

0.37

2.2

1.6

—

(1761868) Lipid panel - Serum or Plasma

441

0.84

0.37

3.3

2.6

—

(3045414) Leukocytes [Presence] in Urine

1.38

0.35

1.8

1.6

—

(3011288) Drugs identified in Urine by Screen method

1.35

0.34

1.7

1.9

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.35

0.33

3.5

3.7

1.2

mmol/l

0.23

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.36

0.31

2.4

1.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

261

1.19

0.31

1.4

1.6

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.31

0.31

1.0

1.1

—

(3000330) Specific gravity of Urine by Test strip

1.29

0.30

1.9

2.9

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

151

0.78

0.30

1.4

1.5

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

110

1059

1.17

0.29

4.3

3.8

1.3

1.2

mmol/l

0.50

100

984

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

1.32

0.29

1.5

2.6

77.2

68.2

ml/min/173m2

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.34

0.29

1.5

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

192

0.81

0.27

2.1

2.7

0.9

0.8

e6/l

—

111

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

110

1062

1.16

0.26

15.5

11.4

84.3

84.2

ml/min/173m2

0.01

855

(3022621) pH of Urine by Test strip

1.25

0.26

2.1

2.4

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

105

1013

1.14

0.24

7.5

5.2

41.6

39.4

mmol/mol

1.21

950

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

800

1.12

0.24

3.0

3.3

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.36

0.24

1.4

1.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

404

1.13

0.23

2.7

3.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

116

1.23

0.23

1.7

1.6

—

(36304419) Bacteria [Presence] in Urine

317

1.14

0.22

2.0

3.0

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

1.8

—

(3007368) IgG [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

26.4

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.21

0.0

1.3

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.0

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.21

0.0

2.0

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.4

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

1.26

0.20

1.5

1.6

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

2.2

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.20

0.0

1.1

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.20

0.0

1.1

—

(3022313) Gas panel - Capillary blood

1.23

0.20

1.7

2.6

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

118

1.21

0.20

1.7

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.20

0.18

4.7

7.5

91.4

95.0

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.70

0.17

1.0

1.6

—

(40768804) Tissue Pathology biopsy report

459

0.91

0.16

1.9

2.0

—

(21494755) Public health laboratory ask at order entry panel

119

0.83

0.16

1.1

1.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.16

0.16

2.0

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

102

1.19

0.15

2.1

3.1

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.78

0.15

1.3

1.7

—

(3007853) Bacteria identified in Skin by Aerobe culture

115

1.14

0.11

1.8

1.5

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

156

0.89

0.10

4.0

2.5

0.5

0.6

ug/l

—

(3000494) Fungus identified in Specimen by Culture

135

1.12

0.10

1.5

1.4

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

1.17

0.10

1.4

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

1.17

0.10

1.4

1.5

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

1.17

0.10

1.4

1.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

1.17

0.10

1.4

1.5

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.12

0.10

3.4

1.7

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.04

0.09

2.8

2.3

—

(3030467) Casts [#/volume] in Urine by Automated count

322

1.07

0.09

2.0

3.1

0.6

0.3

e6/l

0.21

237

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

166

1.10

0.08

1.9

1.8

—

(3009343) pH of Capillary blood

1.05

0.08

1.6

3.0

—

7.4

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.82

0.07

1.4

—

(3018095) Leukocytes [#/volume] in Urine

424

1.05

0.07

2.8

3.7

100.7

59.6

e6/l

0.22

292

(3012544) pH of Venous blood

104

0.86

0.06

10.8

3.2

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

213

0.93

0.06

6.0

3.7

17.7

20.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

317

1.05

0.05

4.5

3.2

—

(3002582) Erythrocytes [#/volume] in Urine

357

1.05

0.05

2.1

3.2

21.3

218.7

e6/l

0.55

269

(36660697) Celiac disease serology panel - Serum

113

1.07

0.02

1.6

1.3

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

317

0.97

0.01

1.4

1.3

0.7

1.5

u/ml

—

(4035726)

101

0.99

0.00

1.5

1.3

—

(40761536) Microorganisms panel - Urine sediment

101

0.99

0.00

8.7

3.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

184

0.98

0.00

1.2

1.4

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

291

1.00

0.00

1.7

1.6

1.3

mmol/l

0.11

245

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

0.0

1.0

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.7

—

(3020876) Protein [Mass/time] in 24 hour Urine

0.00

0.0

3.0

—

(3033306) Mononuclear cells/100 leukocytes in Cerebral spinal fluid

0.00

0.0

1.0

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.2

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

2.2

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.0

3.6

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(42869547) Procollagen type III.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

1.0

—

10.7

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3018418) pH of Serum or Plasma

330

1.00

0.00

4.4

3.9

7.4

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

0.8

—

(3048402) Erythrocytes [#/area] in Urine sediment by Automated count

0.00

0.0

1.0

—

0.8

—

(4027681)

0.00

0.0

1.4

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

2.6

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

0.0

1.0

—

176.6

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.0

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

3.2

—

102.0

—

(3002619) Bacteria identified in Specimen by Culture

0.00

0.0

1.2

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.8

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.2

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3004446) Plasmodium sp identified in Blood by Light microscopy

0.00

0.0

3.0

—

(3000991) Gas panel - Venous blood

0.89

0.00

5.8

5.4

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.1

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.2

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

28.2

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3045716) Anion gap in Serum or Plasma

0.00

0.0

2.0

—

8.4

—

(4281824)

0.00

0.0

1.0

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.2

—

35.7

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3011648) Oxygen content in Venous blood

0.00

0.0

1.0

—

10.3

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.1

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.3

—

(42869593) Oxyhemoglobin/Hemoglobin.total [Pure mass fraction] in Capillary blood

0.00

0.0

1.4

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.0

1.9

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.0

—

(3016038) Potassium [Moles/volume] in Urine

0.00

0.0

1.0

—

25.1

—

(1002224) Polysomnography panel

0.92

0.00

1.0

1.1

—

(3018658) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_IRISCILIARYNAS and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_IRISCILIARYNAS	1.164 [0.86, 1.58]	0.327
Birth year	0.998 [0.99, 1.01]	0.68

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 413 females with H7_IRISCILIARYNAS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_IRISCILIARYNAS.

N-year risk	Females	Males
1	0.096%	No data
5	0.77%	No data
10	1.895%	No data
15	3.663%	No data
20	6.734%	No data

Relationships between endpoints

↥

Index endpoint: H7_IRISCILIARYNAS – Other specified and unspecified disorders of iris and ciliary body

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other specified and unspecified disorders of iris and ciliary body

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints