Cyst of iris, ciliary body and anterior chamber

H7_CYSTIRIS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H21.3
  • Hospital discharge: ICD-9 3646
  • Cause of death: ICD-10 H21.3
  • Cause of death: ICD-9 3646

2 out of 7 registries used, show all original rules.

62

4. Check minimum number of events

None

62

5. Include endpoints

None

62

6. Filter based on genotype QC (FinnGen only)

61

Control definitions (FinnGen only)

Control exclude
H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H21
Name in latin
Cysta iridis, corporis ciliaris sive camerae anterioris

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 405 229 175
Only index persons 363 217 146
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.00
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 45.34 47.89 41.99
Only index persons 47.84 48.18 47.34

-FinnGen-

Key figures

All Female Male
Number of individuals 61 42 19
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 49.51 51.88 44.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
62
Matched controls
620
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H21.3
ICD-10 Finland
Cyst of iris, ciliary body and anterior chamber
+∞
81.4
59
*
XCD10
NOMESCO Finland
Electrophysiological examination of eye
99.4
26.8
28
5
D31.4
ICD-10 Finland
Benign neoplasm: Ciliary body
+∞
10.7
10
*
XCK10
NOMESCO Finland
Photography of fundus of eye
7.7
7.7
18
31
CD2S4
NOMESCO Finland
Photography of eye
+∞
7.4
7
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
45
349
2.06
1.72
3.9
3.8
—
—
—
0
0
48
393
1.98
1.41
4.8
4.0
15.35
14.90
pmol/l
0.65
43
358
27
192
1.72
1.22
2.0
1.9
89.43
100.91
pmol/l
0.44
13
86
17
107
1.81
1.15
2.1
3.1
—
—
—
0
0
19
128
1.70
1.02
2.5
2.9
0.32
0.29
e6/l
0.05
14
91
22
157
1.62
0.94
2.2
2.2
—
—
—
0
0
6
30
2.10
0.89
3.3
6.1
26.00
25.43
mmol/l
—
6
30
29
224
1.55
0.89
1.7
1.9
—
—
—
0
0
57
524
2.09
0.87
14.6
14.2
3.96
3.95
mmol/l
0.07
57
505
57
524
2.09
0.87
14.3
14.2
139.98
139.75
mmol/l
0.34
57
506
0
25
0.00
0.81
0.0
1.2
—
—
—
0
0
0
25
0.00
0.81
0.0
1.1
—
—
—
0
0
0
25
0.00
0.81
0.0
1.2
—
—
—
0
0
0
26
0.00
0.80
0.0
1.2
—
—
—
0
0
5
24
2.17
0.76
2.4
3.7
26.52
24.36
mmol/l
—
5
24
17
120
1.57
0.75
2.0
3.4
24.16
28.47
mg/l
—
8
77
5
25
2.08
0.74
2.4
3.2
—
—
—
0
0
5
25
2.08
0.74
1.4
2.6
150.60
136.40
g/l
—
5
25
9
58
1.64
0.74
1.4
1.3
—
—
—
0
0
40
340
1.50
0.74
4.1
3.7
—
—
—
0
0
5
27
1.92
0.70
1.2
1.2
—
—
—
0
0
6
100
0.56
0.69
1.5
1.9
—
—
—
0
0
51
459
1.63
0.69
20.2
16.2
14.85
14.57
%
0.14
51
454
5
29
1.79
0.65
1.0
1.1
—
—
—
0
0
54
495
1.70
0.62
4.3
4.2
5.55
5.80
mmol/l
1.58
47
455
18
134
1.48
0.62
2.5
2.7
—
—
—
0
0
5
87
0.54
0.62
1.8
1.5
—
—
—
0
0
8
53
1.58
0.61
1.1
1.2
—
—
—
0
0
0
21
0.00
0.61
0.0
1.1
—
—
—
0
0
0
22
0.00
0.60
0.0
3.5
—
0.13
—
0
9
0
23
0.00
0.59
0.0
1.2
—
—
—
0
0
17
129
1.44
0.53
1.5
3.0
373.33
5460.48
umol/l
0.78
12
108
10
140
0.66
0.50
3.2
3.7
—
—
—
0
0
7
46
1.59
0.50
1.1
1.3
—
—
—
0
0
17
131
1.41
0.49
3.1
4.0
3.73
5.58
mg/mmol
—
9
84
21
169
1.37
0.47
3.1
3.5
2.41
49.71
e6/l
1.65
14
115
15
115
1.40
0.44
2.8
2.2
2.19
2.92
mg/l
—
8
102
0
15
0.00
0.42
0.0
1.1
—
—
—
0
0
12
89
1.43
0.41
1.8
2.5
563.50
543.26
mosm/kgh2o
0.14
12
76
0
16
0.00
0.41
0.0
2.2
—
—
—
0
0
0
17
0.00
0.41
0.0
3.5
—
—
—
0
0
0
17
0.00
0.41
0.0
1.4
—
—
—
0
0
5
36
1.42
0.39
3.4
2.5
4.34
4.64
kpa
—
5
36
9
70
1.33
0.39
3.4
2.0
2.34
2.51
g/l
—
9
63
10
73
1.44
0.37
3.0
2.1
13.70
15.40
umol/l
—
10
68
55
521
1.49
0.34
13.7
13.0
18.14
21.28
mg/l
0.50
43
395
18
149
1.29
0.33
2.6
2.9
11.60
478.68
e6/l
0.54
13
112
17
142
1.27
0.28
2.1
3.0
8.88
8.06
mmol/l
0.20
12
116
9
74
1.25
0.27
1.7
1.8
—
—
—
0
0
36
330
1.22
0.26
4.2
4.0
—
28.30
—
0
10
16
135
1.25
0.24
9.1
7.7
—
—
—
0
0
5
38
1.34
0.24
3.4
7.1
—
—
—
0
0
23
203
1.21
0.24
2.7
2.6
—
—
—
0
0
5
41
1.24
0.22
2.4
2.5
—
—
—
0
0
5
41
1.24
0.22
3.8
2.9
—
—
—
0
0
5
42
1.21
0.22
3.8
2.9
2.02
3.14
mmol/l
—
5
31
0
12
0.00
0.21
0.0
1.3
—
8.23
—
0
7
0
13
0.00
0.21
0.0
3.2
—
3.86
—
0
13
18
158
1.20
0.19
2.3
2.5
—
—
—
0
0
7
61
1.17
0.18
2.1
1.3
—
—
—
0
0
6
78
0.74
0.16
1.3
1.3
—
—
—
0
0
17
152
1.16
0.14
1.9
3.3
—
—
—
0
0
16
143
1.16
0.13
1.8
1.5
—
—
—
0
0
11
126
0.85
0.12
3.5
4.2
—
—
—
0
0
5
43
1.18
0.10
3.8
2.9
5.84
5.87
kpa
—
5
43
29
274
1.11
0.10
9.6
5.6
0.04
0.04
e9/l
0.35
23
244
6
53
1.15
0.09
2.7
6.6
103.50
103.62
mmol/l
—
6
53
12
133
0.88
0.08
1.5
1.3
—
0.64
—
0
29
7
65
1.09
0.08
1.3
2.3
—
—
—
0
0
27
260
1.07
0.04
9.9
6.1
—
—
—
0
0
10
93
1.09
0.02
1.7
2.6
3.17
4.41
e6/l
—
10
84
18
179
1.01
0.00
3.5
3.3
28.33
47.70
ng/l
—
9
113
32
319
1.01
0.00
11.7
10.1
3.14
3.90
e9/l
2.12
25
279
28
275
1.03
0.00
9.7
5.5
0.55
0.56
e9/l
0.11
23
245
6
64
0.93
0.00
2.5
3.8
1.20
1.11
mmol/l
—
6
57
6
61
0.98
0.00
1.2
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
49.50
—
0
6
0
9
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.3
—
19.22
—
0
9
0
8
0.00
-0.00
0.0
1.1
—
240.38
—
0
8
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.0
—
89.74
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
7.18
—
0
5
0
5
0.00
-0.00
0.0
3.0
—
5.25
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
29.48
—
0
5
0
5
0.00
-0.00
0.0
3.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.3
—
3.90
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.1
—
5.63
—
0
9
0
7
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.3
—
104.29
—
0
7
0
9
0.00
-0.00
0.0
2.1
—
31.78
—
0
9
8
86
0.92
-0.00
1.5
2.9
0.83
0.82
mmol/l
—
8
80
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
63
0.95
-0.00
1.5
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
17.80
—
0
5
0
7
0.00
-0.00
0.0
3.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.1
—
65.22
—
0
9

Mortality – FinRegistry

Association

Association between endpoint H7_CYSTIRIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_CYSTIRIS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: H7_CYSTIRIS – Cyst of iris, ciliary body and anterior chamber

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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