Enophthalmos

H7_ENOPHTHALMOS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H05.4 Hospital discharge: ICD-9 — 3765 Cause of death: ICD-10 — H05.4 Cause of death: ICD-9 — 3765 2 out of 7 registries used, show all original rules.	18
4. Check minimum number of events None	18
5. Include endpoints None	18
6. Filter based on genotype QC (FinnGen only)	18

Control definitions (FinnGen only)

Control exclude: H7_LIDLACRIMALORBIT

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H05
Name in latin: Enophthalmus

NAME	H7_ENOPHTHALMOS
CONTROL_EXCLUDE	H7_LIDLACRIMALORBIT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H054
HD_ICD_9	3765
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H054
COD_ICD_9	3765
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Enophthalmos based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	185	106	77
Only index persons	162	100	62
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	49.37	50.70	47.14
Only index persons	45.04	49.36	38.06

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	18	10	8
Unadjusted period prevalence (%)	0.00	0.00	0.00
Median age at first event (years)	54.38	53.10	55.98

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

4.51

1.74

1.0

1.4

—

(36304419) Bacteria [Presence] in Urine

2.70

1.03

1.8

2.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.00

0.86

0.0

1.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.02

0.78

1.7

2.4

—

(3033658) Prothrombin time (PT) actual/Normal

2.17

0.75

4.0

2.4

83.6

91.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.08

0.72

1.6

1.4

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

1.99

0.69

1.8

1.7

1.2

1.4

mmol/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

2.17

0.67

3.0

3.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.00

0.64

0.0

11.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.80

0.60

2.3

3.1

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

136

0.51

0.59

2.5

3.9

1.3

mmol/l

0.00

122

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

133

0.56

0.57

3.7

4.3

1.9

1.8

mu/l

0.17

119

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

105

0.57

0.49

2.8

2.2

109.9

40.0

u/l

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

112

0.61

0.49

3.1

3.9

15.8

15.1

pmol/l

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.77

0.47

1.6

2.0

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.43

0.0

1.7

—

(42870588) Differential panel, method unspecified - Blood

1.74

0.42

4.5

5.5

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

139

0.77

0.24

2.9

4.3

4.9

4.8

mmol/l

0.18

127

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

139

0.77

0.24

3.3

4.7

2.9

2.8

mmol/l

0.12

126

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

130

0.77

0.23

2.3

3.8

5.8

5.9

mmol/l

0.24

117

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.22

0.0

1.4

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.22

0.0

1.0

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.22

0.0

1.5

—

(3000494) Fungus identified in Specimen by Culture

0.00

0.22

0.0

1.4

—

(40761535) Cells panel - Urine sediment

0.00

0.22

0.0

5.2

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.22

0.0

2.8

—

50.2

—

(3008898) HLA-B27 [Presence]

0.00

0.22

0.0

1.1

—

(3019225) pH of Specimen

0.00

0.22

0.0

3.0

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

0.00

0.22

0.0

9.6

—

122.3

—

(4010399)

0.00

0.22

0.0

1.2

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

0.00

0.22

0.0

5.3

—

33.6

—

(3016502) Oxygen saturation in Arterial blood

0.00

0.21

0.0

9.1

—

93.7

—

(3017181) Myelocytes/100 leukocytes in Blood

0.00

0.21

0.0

4.3

—

1.4

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

0.70

0.21

6.7

8.7

4.4

4.2

e9/l

—

(3044889) 12 lead EKG panel

1.40

0.21

2.8

3.3

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

138

0.79

0.11

3.0

4.3

1.4

1.5

mmol/l

0.18

126

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

0.84

0.09

3.3

4.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

0.80

0.09

6.0

4.2

—

(3020630) Protein [Mass/volume] in Serum or Plasma

0.00

0.0

8.8

—

68.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3022313) Gas panel - Capillary blood

0.00

0.0

3.8

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.0

2.0

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

0.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

0.00

0.0

6.8

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.2

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

1.2

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

0.00

0.0

2.7

—

0.3

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.0

14.0

—

0.9

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

2.8

—

(3009343) pH of Capillary blood

0.00

0.0

3.4

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.3

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.0

1.6

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

34.3

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

0.89

0.00

4.6

4.0

15.0

9.7

umol/l

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

2.0

—

(3019060) Gas panel - Arterial blood

0.00

0.0

4.3

—

(3013115) Eosinophils [#/volume] in Blood

1.02

0.00

4.7

5.8

0.2

e9/l

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

2.2

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.0

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

0.00

0.0

3.1

—

0.7

—

(3015171) Extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.2

—

(3021589) Normoblasts [#/volume] in Blood

0.91

0.00

10.0

9.4

0.0

e9/l

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.0

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

1.6

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.2

—

(3001604) Monocytes [#/volume] in Blood

1.07

0.00

4.7

5.9

0.7

0.5

e9/l

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

0.00

0.0

3.0

—

2.5

—

(3006315) Basophils [#/volume] in Blood

1.10

0.00

4.7

6.0

0.0

e9/l

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3014007) Fractional oxyhemoglobin in Arterial blood

0.00

0.0

3.0

—

89.7

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

11.4

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.0

1.4

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

0.00

0.0

6.0

—

(3015736) pH of Urine

1.03

0.00

2.4

4.0

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

3.2

—

(4034850)

0.00

0.0

27.3

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

1.8

—

1.2

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

1.8

—

7.9

—

(3043409) Potassium [Moles/volume] in Arterial blood

0.00

0.0

3.0

—

3.9

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.2

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

0.00

0.0

3.0

—

25.0

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.2

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.0

1.4

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.2

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.2

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.0

1.8

—

(3025941) Bacteria identified in Stool by Culture

0.00

0.0

1.0

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.2

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3020891) Body temperature

0.00

0.0

5.0

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.0

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

0.00

0.0

3.4

—

5.2

—

(40768443) Skin Pathology biopsy report

0.00

0.0

1.4

—

(3019198) Lymphocytes [#/volume] in Blood

0.95

0.00

4.7

5.6

2.2

1.9

e9/l

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

1.09

0.00

2.4

1.7

56.0

50.1

u/l

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_ENOPHTHALMOS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_ENOPHTHALMOS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H7_ENOPHTHALMOS – Enophthalmos

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Enophthalmos

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints