No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1594 |
4. Check minimum number of eventsNone |
1594 |
5. Include endpoints |
1692 |
6. Filter based on genotype QC (FinnGen only) |
1692 |
Control definitions (FinnGen only)
- Control exclude
- H7_LIDLACRIMALORBIT
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorders of orbit
based on the number of shared cases.
Similar with more cases:
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11521 | 7147 | 4305 |
| Only index persons | 10492 | 6687 | 3805 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.17 | 0.20 | 0.12 |
| Only index persons | 0.21 | 0.25 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 48.52 | 51.10 | 44.14 |
| Only index persons | 48.17 | 50.74 | 43.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1692 | 1195 | 497 |
| Unadjusted period prevalence (%) | 0.35 | 0.41 | 0.22 |
| Median age at first event (years) | 52.21 | 51.71 | 53.40 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1495
- Matched controls
- 14948
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
38.2
323.0
439
161
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
11751.9
323.0
677
*
H03BB01
ATC
carbimazole; oral
44.3
323.0
663
264
H05.2
ICD-10 Finland
Exophthalmic conditions
+∞
323.0
322
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
86.2
323.0
729
163
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
2819.9
265.6
249
*
H03AA01
ATC
levothyroxine sodium; systemic
6.3
220.5
801
2327
H062, E050
ICD-10 Finland
NA
+∞
208.3
195
*
BAA60
NOMESCO Finland
Total thyroidectomy
24.1
198.1
289
147
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
4.9
178.8
950
3922
H05.0
ICD-10 Finland
Acute inflammation of orbit
+∞
176.6
166
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
27.5
146.9
205
86
104
Kela drug reimbursment
Thyroid insufficiency
7.7
137.4
353
579
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
186.8
131.9
136
8
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
80.6
130.2
146
20
H04.10
ICD-10 Finland
Dry eye syndrome
8.7
105.1
242
325
H53.2
ICD-10 Finland
Diplopia
14.6
102.9
179
138
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
37.0
100.3
129
38
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.1
88.4
413
1284
H05.1
ICD-10 Finland
Chronic inflammatory disorders of orbit
+∞
84.2
80
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.0
82.7
678
3216
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
29.6
81.1
110
40
H05.9
ICD-10 Finland
Disorder of orbit, unspecified
+∞
79.9
76
*
C07AA05
ATC
propranolol; systemic
3.4
77.6
469
1775
H50.2
ICD-10 Finland
Vertical strabismus
41.7
75.1
94
24
H02.3
ICD-10 Finland
Blepharochalasis
55.5
75.1
89
17
H02AB06
ATC
prednisolone; systemic
2.7
74.4
851
4869
XCK00
NOMESCO Finland
Perimetry
6.0
72.3
215
407
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.5
71.7
287
755
H05.8
ICD-10 Finland
Other disorders of orbit
+∞
71.4
68
*
H02.4
ICD-10 Finland
Ptosis of eyelid
40.3
58.1
73
19
CA1AD
NOMESCO Finland
Orbita CT
200.9
56.4
58
*
CAC30
NOMESCO Finland
Decompression of orbit to sinuses
+∞
54.5
52
*
H00.03
ICD-10 Finland
Preseptal cellulite in the eyelid
461.2
45.5
45
*
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
67.2
45.4
52
8
A02BC02
ATC
pantoprazole; systemic
2.2
45.1
1019
7338
CAA30
NOMESCO Finland
Biopsy of orbit
439.9
43.4
43
*
ZXA10
NOMESCO Finland
Bilateral
2.6
38.6
322
1411
CAC44
NOMESCO Finland
Combined decompression of orbit
365.8
36.1
36
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.1
36.1
528
3045
CEC00
NOMESCO Finland
Recession of extraocular muscle
38.6
35.7
45
12
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
+∞
35.6
34
*
H57.1
ICD-10 Finland
Ocular pain
6.5
35.3
95
155
H02AB07
ATC
prednisone; oral
2.7
34.5
273
1154
H50.6
ICD-10 Finland
Mechanical strabismus
+∞
34.5
33
*
ZX120
NOMESCO Finland
Intravenous
3.1
34.5
209
746
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.0
33.7
145
395
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
5.5
33.2
102
197
H01.0
ICD-10 Finland
Blepharitis
4.8
31.9
111
246
XCK10
NOMESCO Finland
Photography of fundus of eye
3.0
31.4
196
711
3760A
ICD-9 Finland
Disorders of the orbit, Acute inflammation of orbit
+∞
31.4
30
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
31.0
442
2486
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
9.9
30.5
62
65
XCD10
NOMESCO Finland
Electrophysiological examination of eye
6.7
30.2
79
124
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
30.1
574
3613
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
30.0
346
1766
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
30.8
29.5
39
13
H02.5
ICD-10 Finland
Other disorders affecting eyelid function
+∞
29.3
28
*
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
8.3
29.0
65
81
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
28.8
637
4218
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
28.3
604
3939
CAC20
NOMESCO Finland
Lateral decompression of orbit
+∞
28.2
27
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.7
27.0
126
367
H50.0
ICD-10 Finland
Convergent concomitant strabismus
17.3
26.7
42
25
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
142.6
26.7
28
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.1
26.4
159
559
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.5
26.4
229
1006
CBK00
NOMESCO Finland
Myotomy or resection of tarsal muscle or levator muscle of eyelid for correction of retraction
+∞
26.1
25
*
CAB00
NOMESCO Finland
Anterior orbitotomy with excision of lesion
+∞
26.1
25
*
CA1DG
NOMESCO Finland
Eye and orbita very extensive MRI examination with high intensity magnet
61.2
26.0
30
5
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
5.4
26.0
80
155
Z3231
NOMESCO Finland
Registered nurse
2.0
25.9
433
2564
H50.8
ICD-10 Finland
Other specified strabismus
50.9
25.3
30
6
CBB10
NOMESCO Finland
Excision of redundant skin of eyelid
59.1
25.1
29
5
E03.89
ICD-10 Finland
Other specified hypothyroidism
4.3
25.0
97
240
T85
ICPC
Hyperthyroidism/thyrotoxicosis
17.4
24.9
39
23
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.7
24.8
185
745
D31.6
ICD-10 Finland
Benign neoplasm: Orbit, unspecified
91.6
24.7
27
*
CA1BD
NOMESCO Finland
Extensive orbita CT
132.2
24.7
26
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
5.2
24.4
77
154
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
42.1
23.7
29
7
WF099
NOMESCO Finland
Other radiotherapy
16.5
23.2
37
23
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
18.8
23.1
35
19
C07AB07
ATC
bisoprolol; oral
1.7
22.5
640
4487
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.9
22.4
143
524
WX002
NOMESCO Finland
Sedation and analgesia
2.0
20.9
301
1662
H05.5
ICD-10 Finland
Retained (old) foreign body following penetrating wound of orbit
+∞
20.9
20
*
CBB20
NOMESCO Finland
Correction of lax skin of eyelid and resection of herniated fat
212.8
20.6
21
*
CBB11
NOMESCO Finland
Resection of lax skin in upper eyelid
111.6
20.6
22
*
T86
ICPC
Hypothyroidism/myxoedema
3.7
20.4
93
266
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
27.5
20.1
27
10
2AB04
NOMESCO Finland
NA
23.7
20.0
28
12
UDH02
NOMESCO Finland
Rhinopharyngoscopy
3.0
19.1
115
405
E05.5
ICD-10 Finland
Thyroid crisis or storm
192.3
18.6
19
*
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
3.0
18.4
109
378
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.9
17.8
75
201
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
18.3
17.8
27
15
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
10.5
17.7
34
33
S01GX01
ATC
cromoglicic acid; ophthalmic
1.9
17.6
305
1790
AA1AD
NOMESCO Finland
CT of head and brain
1.9
17.3
309
1836
CS494
NOMESCO Finland
Other visual field testing
5.2
16.8
52
103
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
64.1
16.8
19
*
3763A
ICD-9 Finland
Disorders of the orbit, Other exophthalmic conditions
+∞
16.7
16
*
H05.4
ICD-10 Finland
Enophthalmos
+∞
16.7
16
*
E03
ICD-10 Finland
Other hypothyroidism
2.8
16.6
110
412
CA1BM
NOMESCO Finland
Eye and orbita MRI examination with 3 Tesla magnet
91.1
16.6
18
*
CBB21
NOMESCO Finland
Correction of lax skin and resection of herniated fat in upper eyelid
91.1
16.6
18
*
CEW99
NOMESCO Finland
Other operation on extraocular muscle
40.5
16.3
20
5
ZXE00
NOMESCO Finland
One hour or less
1.6
16.3
576
4178
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
2.9
16.3
100
358
Z3229
NOMESCO Finland
Other healthcare associate professional
2.4
16.1
139
604
N05CF01
ATC
zopiclone; oral
1.7
15.8
452
3091
H02.1
ICD-10 Finland
Ectropion of eyelid
60.7
15.8
18
*
CEC90
NOMESCO Finland
Total transposition of extraocular muscle or muscles
161.6
15.5
16
*
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
9.1
15.5
32
36
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
4.2
15.3
58
142
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
5.9
15.2
42
73
J01DB01
ATC
cefalexin; oral
1.7
15.0
1174
10279
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.7
14.8
326
2058
CE2W4
NOMESCO Finland
Eye movement mapping
32.0
14.8
19
6
UDM02
NOMESCO Finland
Sinoscopy
4.6
14.8
51
114
R51.80
ICD-10 Finland
Headache
1.9
14.7
218
1205
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
2.9
14.6
91
329
TCC40
NOMESCO Finland
Closure of lacrimal canaliculus with plug
+∞
14.6
14
*
CAA00
NOMESCO Finland
Puncture of orbital abscess
+∞
14.6
14
*
CB9S4
NOMESCO Finland
Photography of eyelids and eyebrows
80.9
14.6
16
*
F29
ICPC
Eye symptom/complaint other
2.4
14.3
122
528
N02BE01
ATC
paracetamol; systemic, rectal
1.7
14.2
1231
10968
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
42.9
14.1
17
*
WX402
NOMESCO Finland
General anaesthesia
1.8
14.0
249
1468
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
12.8
13.9
24
19
WX110
NOMESCO Finland
Local anesthesy
1.5
13.6
970
8173
3762A
ICD-9 Finland
Disorders of the orbit, Endocrine exophthalmos
+∞
13.6
13
*
ZXA00
NOMESCO Finland
Right side
1.7
13.5
369
2472
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
2.6
13.5
99
394
H02.8
ICD-10 Finland
Other specified disorders of eyelid
34.4
13.5
17
5
1XC02
NOMESCO Finland
NA
8.6
13.3
28
33
Z3226
NOMESCO Finland
Physiotherapist
1.8
13.2
265
1622
H50.1
ICD-10 Finland
Divergent concomitant strabismus
10.1
13.0
25
25
N02AX02
ATC
tramadol; systemic, rectal
1.5
13.0
556
4162
A11CC03
ATC
alfacalcidol; systemic
4.4
12.9
46
107
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
9.8
12.7
25
26
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
4.4
12.7
45
104
WX140
NOMESCO Finland
Parabulbar anesthesy
3.2
12.7
66
212
Z2221
NOMESCO Finland
Medical doctor
1.6
12.7
393
2716
2420A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic diffuse goitre
32.3
12.6
16
5
H02AB09
ATC
hydrocortisone; systemic
4.0
12.5
49
125
ZXA05
NOMESCO Finland
Left side
1.6
12.5
338
2255
WF002
NOMESCO Finland
Radical radiotherapy
2.9
12.4
73
256
ZXE20
NOMESCO Finland
More than three and less than five hours
1.9
12.3
190
1060
E05.89
ICD-10 Finland
Other thyrotoxicosis
14.5
12.3
20
14
S01ED01
ATC
timolol; ophthalmic
3.6
12.2
55
158
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.8
12.1
215
1263
A02BC01
ATC
omeprazole; systemic
1.6
12.0
372
2565
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
4.3
11.9
43
102
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
16.5
11.7
18
11
CD2S4
NOMESCO Finland
Photography of eye
16.5
11.7
18
11
H02.9
ICD-10 Finland
Disorder of eyelid, unspecified
30.3
11.6
15
5
ZXD20
NOMESCO Finland
Day surgery
1.9
11.6
190
1082
H44.5
ICD-10 Finland
Degenerated conditions of globe
65.5
11.6
13
*
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
6.5
11.6
29
45
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
4.7
11.5
38
82
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
8.7
11.5
24
28
CBJ40
NOMESCO Finland
Resection of levator muscle of eyelid
+∞
11.5
11
*
36907
ICD-8 Finland
Other inflammatory diseases of eye, Morbi inflammatori orbitae alii
+∞
11.5
11
*
CAW99
NOMESCO Finland
Other operation on orbit
+∞
11.5
11
*
36900
ICD-8 Finland
Other inflammatory diseases of eye, Abscessus orbitae
+∞
11.5
11
*
A02BC05
ATC
esomeprazole; systemic
1.5
11.4
553
4222
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
35.3
11.3
14
*
H10.4
ICD-10 Finland
Chronic conjunctivitis
12.8
11.1
19
15
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.5
11.1
757
6184
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.0
11.1
147
778
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
11.1
154
827
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.1
11.1
132
669
114
Kela drug reimbursment
Glaucoma
2.2
11.0
111
521
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.5
11.0
394
2807
106
Kela drug reimbursment
Hypoparathyroidism
12.0
10.8
19
16
N07BA03
ATC
varenicline; oral
2.6
10.8
79
315
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.2
10.7
116
562
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
8.0
10.6
23
29
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.0
10.5
61
212
CCD60
NOMESCO Finland
Transnasal dacryocystorhinostomy
110.8
10.4
11
*
H04.0
ICD-10 Finland
Dacryoadenitis
110.8
10.4
11
*
CBD99
NOMESCO Finland
Other plastic reconstruction of eyelid
+∞
10.4
10
*
CBH30
NOMESCO Finland
Tarsorraphy
+∞
10.4
10
*
H03BA02
ATC
propylthiouracil; oral
32.8
10.3
13
*
XCH00
NOMESCO Finland
Eye pressure measurement
2.8
10.3
64
231
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.1
10.3
120
602
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
10.2
304
2065
H04.3
ICD-10 Finland
Acute and unspecified inflammation of lacrimal passages
23.5
10.2
14
6
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
4.9
10.2
32
66
S18
ICPC
Laceration/cut
1.5
10.1
518
3979
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
6.5
10.0
25
39
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
10.0
362
2575
S01ED51
ATC
timolol, combinations; ophthalmic
2.3
10.0
95
437
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
4.1
10.0
37
91
XX3DW
NOMESCO Finland
Time consuming IT work
1.9
9.9
145
792
H00.1
ICD-10 Finland
Chalazion
4.3
9.8
35
83
S01EE01
ATC
latanoprost; ophthalmic
2.4
9.7
82
355
R4110
NOMESCO Finland
Physiotherapy
1.5
9.7
351
2495
TCC10
NOMESCO Finland
Probing of lacrimal canaliculus/duct
55.3
9.7
11
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
9.6
170
993
H40.0
ICD-10 Finland
Glaucoma suspect
2.1
9.6
104
506
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
2.3
9.6
87
391
CBJ30
NOMESCO Finland
Plastic repair of levator aponeurosis of eyelid
+∞
9.4
9
*
CBN99
NOMESCO Finland
Other operation on eyelid for malposition
+∞
9.4
9
*
CBF10
NOMESCO Finland
Shortening of canthal ligaments and tarsal plate for ectropion
+∞
9.4
9
*
CA1CD
NOMESCO Finland
Very extensive orbita CT
+∞
9.4
9
*
CAE10
NOMESCO Finland
Revision and secondary implant in orbit
+∞
9.4
9
*
S01KA02
ATC
hypromellose; ophthalmic
4.1
9.4
35
87
CBB00
NOMESCO Finland
Excision of chalazion
21.8
9.4
13
6
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
9.3
546
4287
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
9.6
9.3
18
19
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.5
9.3
314
2198
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
3.8
9.2
37
98
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.7
9.1
180
1091
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
9.0
199
1244
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
10.1
9.0
17
17
J31.0
ICD-10 Finland
Chronic rhinitis
2.0
8.9
106
538
A11CC02
ATC
dihydrotachysterol; oral
12.6
8.9
15
12
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.5
8.8
438
3322
H10.5
ICD-10 Finland
Blepharoconjunctivitis
4.6
8.8
29
64
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.0
8.7
106
543
E83.51
ICD-10 Finland
Hypocalcemia
8.3
8.6
18
22
N06AX11
ATC
mirtazapine; oral
1.5
8.6
415
3129
J32.1
ICD-10 Finland
Chronic frontal sinusitis
11.6
8.6
15
13
R01AD09
ATC
mometasone; nasal
1.4
8.6
610
4940
H01CB02
ATC
octreotide; parenteral
16.4
8.6
13
8
R03BB04
ATC
tiotropium bromide; inhalant
1.9
8.5
119
641
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
8.5
200
1272
J01.4
ICD-10 Finland
Acute pansinusitis
7.4
8.4
19
26
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.1
8.4
97
484
CBA10
NOMESCO Finland
Biopsy of eyelid
6.7
8.4
20
30
CAB10
NOMESCO Finland
Lateral orbitotomy with excision of lesion
+∞
8.3
8
*
H05.3
ICD-10 Finland
Deformity of orbit
+∞
8.3
8
*
36902
ICD-8 Finland
Other inflammatory diseases of eye, Tenonitis
+∞
8.3
8
*
3761A
ICD-9 Finland
Disorders of the orbit, Chronic inflammatory disorders of orbit
+∞
8.3
8
*
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
1.9
8.3
129
723
S01EC04
ATC
brinzolamide; ophthalmic
2.9
8.3
49
175
EBA00
NOMESCO Finland
Extraction of tooth
1.4
8.2
415
3155
R03AC02
ATC
salbutamol; inhalant
1.4
8.1
707
5910
H16.0
ICD-10 Finland
Corneal ulcer
2.6
8.1
59
236
N03AX16
ATC
pregabalin; oral
1.5
8.1
297
2107
H02AB04
ATC
methylprednisolone; systemic
1.6
8.0
194
1243
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
5.9
8.0
21
36
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
7.9
644
5314
N03AX12
ATC
gabapentin; oral
1.6
7.8
189
1210
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
4.9
7.8
24
50
F01
ICPC
Eye pain
2.9
7.8
45
158
R74
ICPC
Upper respiratory infection acute
1.4
7.8
365
2730
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
7.7
603
4936
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
7.7
219
1465
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
7.6
458
3584
ZX050
NOMESCO Finland
Stereotactic radiotherapy
8.1
7.6
16
20
D31.0
ICD-10 Finland
Benign neoplasm: Conjunctiva
7.2
7.5
17
24
CBG00
NOMESCO Finland
Epilation of cilia by electrolysis
80.5
7.4
8
*
TCC30
NOMESCO Finland
Intubation of lacrimal canaliculus/duct
80.5
7.4
8
*
CCA10
NOMESCO Finland
Biopsy of lacrimal gland
80.5
7.4
8
*
CBJ50
NOMESCO Finland
Operation for ptosis of eyebrow
80.5
7.4
8
*
CFC00
NOMESCO Finland
Excision of lesion of conjunctiva
13.4
7.4
12
9
M01AE03
ATC
ketoprofen; systemic, rectal
1.4
7.3
482
3824
M25.5
ICD-10 Finland
Pain in joint
1.4
7.3
362
2726
CAE00
NOMESCO Finland
Removal of implant from orbit
+∞
7.3
7
*
3112
FHL
Orbitotomy (includes biopsy and removal of local tumor or foreign object)
+∞
7.3
7
*
CEA00
NOMESCO Finland
Biopsy of extraocular muscle
+∞
7.3
7
*
CCD50
NOMESCO Finland
Dacryocystorhinostomy with insertion of tube
+∞
7.3
7
*
CBK99
NOMESCO Finland
Other operation for retraction of eyelid
+∞
7.3
7
*
E50.0
ICD-10 Finland
Vitamin A deficiency with conjunctival xerosis
+∞
7.3
7
*
J01FF01
ATC
clindamycin; systemic
1.4
7.3
345
2579
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
7.3
954
8452
R06AE07
ATC
cetirizine; oral
1.4
7.2
583
4783
S05.1
ICD-10 Finland
Contusion of eyeball and orbital tissues
4.7
7.2
23
50
H50.52
ICD-10 Finland
Exophoria
4.8
7.2
22
46
H02.2
ICD-10 Finland
Lagophthalmos
30.2
7.1
9
*
G44.2
ICD-10 Finland
Tension-type headache
1.6
7.1
173
1113
H53.8
ICD-10 Finland
Other visual disturbances
5.1
7.1
21
42
S01XA18
ATC
ciclosporin; ophthalmic
12.1
7.1
12
10
Z01.7
ICD-10 Finland
Laboratory examination
1.7
7.1
139
842
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
7.1
199
1328
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
8.8
7.0
14
16
H11.1
ICD-10 Finland
Conjunctival degenerations and deposits
7.0
7.0
16
23
H52.2
ICD-10 Finland
Astigmatism
4.0
7.0
26
66
ZX090
NOMESCO Finland
Other technic of radiotherapy
2.6
6.9
46
178
DPA30
NOMESCO Finland
Sphenotomy
5.5
6.9
19
35
DPA25
NOMESCO Finland
Trephine of frontal sinus through nose
5.5
6.9
19
35
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.6
6.8
167
1074
DM1BD
NOMESCO Finland
Extensive CT of paranasal sinuses and face area
8.3
6.8
14
17
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.3
6.8
57
248
CS2P4
NOMESCO Finland
Optic nerve head imaging
9.4
6.8
13
14
M79.6
ICD-10 Finland
Pain in limb
1.4
6.8
440
3478
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
40.2
6.8
8
*
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
16.8
6.7
10
6
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.4
6.7
55
238
M54.5
ICD-10 Finland
Low back pain
1.4
6.7
405
3159
S01EE05
ATC
tafluprost; ophthalmic
2.7
6.7
44
169
A02BC03
ATC
lansoprazole; oral
1.4
6.7
373
2870
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
3.2
6.6
32
101
R53
ICD-10 Finland
Malaise and fatigue
1.5
6.6
246
1749
S01AA01
ATC
chloramphenicol; ophthalmic (antibiotics)
2.2
6.6
64
299
J45.9
ICD-10 Finland
Asthma, unspecified
1.5
6.6
221
1534
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.5
6.6
236
1661
H11.4
ICD-10 Finland
Other conjunctival vascular disorders and cysts
8.7
6.6
13
15
R07.4
ICD-10 Finland
Chest pain, unspecified
1.4
6.5
309
2301
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
6.5
242
1716
CDC00
NOMESCO Finland
Enucleation of eye
70.1
6.4
7
*
H04.19
ICD-10 Finland
Other disorders of lacrimal gland
70.1
6.4
7
*
CA1DM
NOMESCO Finland
Eye and orbita very extensive MRI examination with 3 Tesla magnet
70.1
6.4
7
*
CFD10
NOMESCO Finland
Repair of conjunctiva
70.1
6.4
7
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.5
6.4
237
1683
C03CA01
ATC
furosemide; systemic
1.4
6.4
296
2198
J02AC01
ATC
fluconazole; systemic
1.3
6.4
554
4573
H40.9
ICD-10 Finland
Glaucoma, unspecified
3.8
6.4
25
67
N05BA01
ATC
diazepam; systemic, rectal
1.6
6.4
168
1101
BAA25
NOMESCO Finland
Bilateral partial excision of thyroid gland
9.3
6.3
12
13
R01AD12
ATC
fluticasone furoate; nasal
1.4
6.3
384
2995
H54.4
ICD-10 Finland
Blindness, monocular
18.1
6.3
9
5
K02.1
ICD-10 Finland
Caries of dentine
1.3
6.3
749
6473
CDC10
NOMESCO Finland
Enucleation of eye with insertion of prosthesis
+∞
6.3
6
*
CBF99
NOMESCO Finland
Other operation for ectropion
+∞
6.3
6
*
3119
FHL
Other measure in this category
+∞
6.3
6
*
CAB50
NOMESCO Finland
Orbitotomy with removal of foreign body
+∞
6.3
6
*
H01.80
ICD-10 Finland
Prolonged inflammation in the edge of the eyelid
26.8
6.2
8
*
Z97.0
ICD-10 Finland
Presence of artificial eye
26.8
6.2
8
*
H16.9
ICD-10 Finland
Keratitis, unspecified
4.1
6.2
22
54
S01GX09
ATC
olopatadine; ophthalmic
2.6
6.1
41
160
J01FA10
ATC
azithromycin; systemic
1.3
6.1
795
6943
H04.2
ICD-10 Finland
Epiphora
12.6
6.1
10
8
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.5
6.1
194
1332
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
2.8
6.1
36
131
H50.30
ICD-10 Finland
Intermittent esotropy
8.6
6.1
12
14
Mortality – FinRegistry
↥Association
Association between endpoint H7_ORBIT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ORBIT | 1.329 [1.18, 1.49] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.125 |
During the follow-up period (1.1.1998 — 31.12.2019), 737 out of 5877 females with H7_ORBIT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ORBIT | 1.431 [1.24, 1.65] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.018 |
During the follow-up period (1.1.1998 — 31.12.2019), 575 out of 3310 males with H7_ORBIT died.
Mortality risk
Mortality risk for people of age
years, who have H7_ORBIT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.149% | 0.331% |
| 5 | 0.859% | 1.848% |
| 10 | 1.888% | 4.304% |
| 15 | 3.475% | 8.147% |
| 20 | 6.072% | 13.883% |
Relationships between endpoints
↥Index endpoint: H7_ORBIT – Disorders of orbit
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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