No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditions
|
958 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
940 |
4. Check minimum number of eventsNone |
940 |
5. Include endpointsNone |
940 |
6. Filter based on genotype QC (FinnGen only) |
902 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Graves ophthalmopathy
based on the number of shared cases.
Similar with more cases:
- Disorders of lacrimal system and orbit in diseases classified elsewhere
- Disorders of orbit
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Disorders of eyelid, lacrimal system and orbit
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4440 | 3590 | 832 |
| Only index persons | 4309 | 3510 | 799 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.10 | 0.02 |
| Only index persons | 0.11 | 0.13 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 50.59 | 50.50 | 51.24 |
| Only index persons | 50.44 | 50.39 | 50.67 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 902 | 742 | 160 |
| Unadjusted period prevalence (%) | 0.23 | 0.26 | 0.07 |
| Median age at first event (years) | 51.63 | 51.12 | 53.99 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 940
- Matched controls
- 9400
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
104
Kela drug reimbursment
Thyroid insufficiency
14.5
307.7
372
405
BAA60
NOMESCO Finland
Total thyroidectomy
43.5
307.7
333
117
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
497.5
307.7
818
125
H03AA01
ATC
levothyroxine sodium; systemic
21.0
307.7
779
1763
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
42.6
307.7
254
81
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
86.4
307.7
500
122
H03BB01
ATC
carbimazole; oral
186.9
307.7
752
197
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
307.7
833
*
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
48.6
250.3
148
36
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
43.8
239.0
145
39
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
+∞
237.9
218
*
H062, E050,
ICD-10 Finland
+∞
235.6
216
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
55.2
157.6
90
18
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
7.0
154.4
739
3234
H50.2
ICD-10 Finland
Vertical strabismus
43.7
151.2
91
23
H53.2
ICD-10 Finland
Diplopia
12.5
145.0
153
144
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
173.3
130.1
134
9
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.9
124.4
590
2419
C07AA05
ATC
propranolol; systemic
4.5
109.5
418
1428
XCK00
NOMESCO Finland
Perimetry
7.0
95.4
161
269
H05.2
ICD-10 Finland
Exophthalmic conditions
182.0
95.2
98
6
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.0
84.3
217
534
T85
ICPC
Hyperthyroidism/thyrotoxicosis
25.0
73.0
52
22
H02AB06
ATC
prednisolone; systemic
3.1
61.4
603
3417
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
13.7
60.1
57
44
E03.89
ICD-10 Finland
Other specified hypothyroidism
6.3
60.0
108
190
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.2
58.4
133
291
ZX120
NOMESCO Finland
Intravenous
4.2
58.0
176
484
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.5
56.3
247
874
CAC30
NOMESCO Finland
Decompression of orbit to sinuses
+∞
53.7
51
*
T86
ICPC
Hypothyroidism/myxoedema
5.6
53.4
108
212
H50.0
ICD-10 Finland
Convergent concomitant strabismus
18.0
52.6
43
25
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.2
52.5
272
1060
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
10.0
52.1
61
65
CA1AD
NOMESCO Finland
Orbita CT
175.8
48.3
50
*
H50.6
ICD-10 Finland
Mechanical strabismus
+∞
44.1
42
*
XCD10
NOMESCO Finland
Electrophysiological examination of eye
8.0
43.7
61
81
CEC00
NOMESCO Finland
Recession of extraocular muscle
64.5
42.6
49
8
H04.10
ICD-10 Finland
Dry eye syndrome
3.2
42.1
199
726
E03
ICD-10 Finland
Other hypothyroidism
3.9
38.3
124
353
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
11.6
38.2
40
36
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
192.3
36.0
37
*
ZXA10
NOMESCO Finland
Bilateral
2.7
35.9
246
1091
CAC44
NOMESCO Finland
Combined decompression of orbit
360.1
35.2
35
*
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
8.1
35.1
48
62
H50.8
ICD-10 Finland
Other specified strabismus
128.2
34.9
37
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
33.9
266
1256
A02BC02
ATC
pantoprazole; systemic
2.6
32.4
723
5324
CAC20
NOMESCO Finland
Lateral decompression of orbit
+∞
30.4
29
*
C07AB07
ATC
bisoprolol; oral
2.2
29.1
485
3107
WF099
NOMESCO Finland
Other radiotherapy
27.1
28.6
39
15
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
4.6
28.6
71
165
L04AX03
ATC
methotrexate; systemic
2.9
28.3
149
570
CBK00
NOMESCO Finland
Myotomy or resection of tarsal muscle or levator muscle of eyelid for correction of retraction
+∞
27.2
26
*
H02AB07
ATC
prednisone; oral
2.6
26.5
184
810
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
40.0
25.0
31
8
CS494
NOMESCO Finland
Other visual field testing
5.3
24.5
50
98
H02.5
ICD-10 Finland
Other disorders affecting eyelid function
38.7
24.0
30
8
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
22.7
284
1597
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
123.0
22.7
24
*
XCK10
NOMESCO Finland
Photography of fundus of eye
2.9
22.7
116
435
A11CC03
ATC
alfacalcidol; systemic
6.0
22.4
40
69
2AB04, ,
NOMESCO Finland
39.7
21.8
27
7
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.2
21.8
60
151
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
28.8
21.0
28
10
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
5.0
21.0
46
96
Z3231
NOMESCO Finland
Registered nurse
2.0
20.5
287
1673
CEW99
NOMESCO Finland
Other operation on extraocular muscle
58.9
20.0
23
*
CA1BM
NOMESCO Finland
Eye and orbita MRI examination with 3 Tesla magnet
+∞
19.9
19
*
CEC90
NOMESCO Finland
Total transposition of extraocular muscle or muscles
+∞
19.9
19
*
N05CF01
ATC
zopiclone; oral
1.9
19.8
343
2148
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
19.7
380
2465
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
8.1
19.2
26
33
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
19.1
400
2657
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
28.5
18.8
25
9
E05.5
ICD-10 Finland
Thyroid crisis or storm
71.4
18.8
21
*
WX402
NOMESCO Finland
General anaesthesia
2.1
18.3
231
1289
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
18.2
431
2961
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.6
18.2
115
479
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
14.7
18.2
30
21
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
3.9
18.0
55
149
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
3.0
17.9
84
299
WF002
NOMESCO Finland
Radical radiotherapy
3.7
17.6
58
166
L04AA06
ATC
mycophenolic acid; systemic
5.8
17.4
32
57
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
14.2
17.4
29
21
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
5.4
17.1
34
65
E05.89
ICD-10 Finland
Other thyrotoxicosis
35.7
16.7
21
6
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
12.4
16.4
29
24
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.9
15.6
79
293
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.0
14.1
164
881
H02AB09
ATC
hydrocortisone; systemic
4.3
14.0
36
86
H57.1
ICD-10 Finland
Ocular pain
3.1
13.7
58
195
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
1.7
13.3
323
2188
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
17.0
13.0
20
12
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
14.6
12.3
20
14
S01KA02
ATC
hypromellose; ophthalmic
4.5
12.2
30
69
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
47.3
11.9
14
*
H03BA02
ATC
propylthiouracil; oral
30.4
11.7
15
5
CE2W4
NOMESCO Finland
Eye movement mapping
30.4
11.7
15
5
Z3229
NOMESCO Finland
Other healthcare associate professional
2.4
11.5
82
361
H02.4
ICD-10 Finland
Ptosis of eyelid
3.4
11.3
41
125
1XC02, ,
NOMESCO Finland
9.8
11.3
22
23
106
Kela drug reimbursment
Hypoparathyroidism
14.1
11.0
18
13
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
11.4
10.6
19
17
CBK99
NOMESCO Finland
Other operation for retraction of eyelid
111.2
10.4
11
*
WX002
NOMESCO Finland
Sedation and analgesia
1.8
10.2
186
1149
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
3.7
10.2
32
89
H40.0
ICD-10 Finland
Glaucoma suspect
2.2
10.1
83
389
S01GX01
ATC
cromoglicic acid; ophthalmic
1.7
10.0
224
1465
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
7.7
9.9
22
29
CA1BD
NOMESCO Finland
Extensive orbita CT
26.3
9.8
13
5
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
8.9
9.8
20
23
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
13.5
9.7
16
12
N07BA03
ATC
varenicline; oral
2.5
9.3
57
234
Z2221
NOMESCO Finland
Medical doctor
1.6
9.2
267
1861
BBA70
NOMESCO Finland
Implantation or transplantation of parathyroid gland
37.1
9.0
11
*
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.3
8.9
71
328
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
8.8
210
1393
H50.52
ICD-10 Finland
Exophoria
4.5
8.6
21
48
H01.0
ICD-10 Finland
Blepharitis
2.2
8.6
76
366
CBB21
NOMESCO Finland
Correction of lax skin and resection of herniated fat in upper eyelid
8.3
8.6
18
22
XCH00
NOMESCO Finland
Eye pressure measurement
2.6
8.4
47
185
ZX090
NOMESCO Finland
Other technic of radiotherapy
3.0
8.2
35
119
ZXE00
NOMESCO Finland
One hour or less
1.5
8.1
361
2756
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
7.8
7.9
17
22
A11CC02
ATC
dihydrotachysterol; oral
13.2
7.9
13
10
CD2S4
NOMESCO Finland
Photography of eye
8.5
7.8
16
19
H02.8
ICD-10 Finland
Other specified disorders of eyelid
10.9
7.8
14
13
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
25.2
7.6
10
*
H02.3
ICD-10 Finland
Blepharochalasis
2.1
7.5
70
345
WX100
NOMESCO Finland
Conjunctival surface anesthesia
1.9
7.5
104
590
WX892
NOMESCO Finland
Monitored bed care
2.2
7.5
64
305
F29
ICPC
Eye symptom/complaint other
1.9
7.4
98
547
TCC40
NOMESCO Finland
Closure of lacrimal canaliculus with plug
13.5
7.4
12
9
CAB00
NOMESCO Finland
Anterior orbitotomy with excision of lesion
+∞
7.3
7
*
H50.1
ICD-10 Finland
Divergent concomitant strabismus
9.5
7.3
14
15
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.0
7.2
73
371
ZXC95
NOMESCO Finland
Use of surgical navigator
4.0
7.2
20
51
E05.4
ICD-10 Finland
Thyrotoxicosis factitia
30.3
7.2
9
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
7.1
130
799
2420A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic diffuse goitre
20.2
7.1
10
5
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
3.1
7.1
28
91
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
3.7
7.1
22
61
ZX050
NOMESCO Finland
Stereotactic radiotherapy
7.6
6.9
15
20
107
Kela drug reimbursment
Pernicious anaemia
3.8
6.8
20
53
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.5
6.7
217
1538
H11.1
ICD-10 Finland
Conjunctival degenerations and deposits
10.1
6.5
12
12
WX110
NOMESCO Finland
Infiltration anesthesia
1.5
6.5
650
5692
E06.3
ICD-10 Finland
Autoimmune thyroiditis
6.2
6.5
16
26
E50.0
ICD-10 Finland
Vitamin A deficiency with conjunctival xerosis
70.3
6.4
7
*
H01CB02
ATC
octreotide; parenteral
14.4
6.4
10
7
24200
ICD-8 Finland
Thyrotoxicosis with or without goitre, Cum struma diffusa et exophthalmo. Morbus Basedowi
+∞
6.3
6
*
H05.9
ICD-10 Finland
Disorder of orbit, unspecified
+∞
6.3
6
*
H060, E050,
ICD-10 Finland
+∞
6.3
6
*
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.3
6.2
44
194
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
6.2
376
3004
TLW10
NOMESCO Finland
Transfer of fresh embryo
4.0
6.2
17
43
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
478
570
16.03
307.65
7.9
3.3
4.63
4.53
pmol/l
0.67
453
498
489
237
41.92
307.65
5.1
1.7
6.27
4.78
iu/l
1.03
345
81
916
6592
16.26
70.69
14.9
4.3
15.81
14.63
pmol/l
36.19
885
6052
215
679
3.81
58.41
1.4
1.2
221.11
149.95
iu/ml
1.60
100
280
600
3806
2.59
42.37
7.1
6.1
1.21
1.22
mmol/l
2.17
515
3223
547
3450
2.40
37.15
6.0
5.2
1.21
1.22
mmol/l
1.57
519
3134
919
7646
10.04
36.16
16.4
5.1
1.63
2.03
mu/l
1.81
889
7054
656
4648
2.36
31.73
9.1
8.9
3.83
3.97
e9/l
1.07
572
4086
160
617
2.92
30.04
2.8
3.5
51.42
80.27
ng/l
10.66
143
548
427
2697
2.07
25.60
3.2
3.3
2.33
2.36
mmol/l
4.37
383
2387
516
3527
2.03
24.48
2.7
2.3
77.05
78.01
nmol/l
0.33
474
3179
765
6175
2.28
21.64
8.5
7.1
76.60
76.80
u/l
0.04
742
5799
538
3836
1.94
21.45
5.7
5.9
28.57
28.71
%
0.12
509
3589
529
3802
1.90
20.04
5.7
5.6
56.17
56.72
%
0.52
500
3551
156
758
2.27
17.58
2.3
2.1
366.79
373.58
nmol/l
0.17
144
693
724
5989
1.91
15.32
4.7
4.1
11.63
11.74
mm/h
0.08
685
5536
564
4425
1.69
13.29
4.3
4.2
6.39
6.58
mmol/l
1.46
530
4125
900
8223
3.22
13.01
16.4
13.9
3.91
3.94
mmol/l
2.51
883
7986
36
91
4.07
13.00
3.6
5.1
49.93
56.64
u/ml
—
9
28
898
8198
3.13
12.94
16.2
13.8
139.83
139.71
mmol/l
0.77
883
7977
415
3094
1.61
11.28
2.1
1.9
99.39
97.02
pmol/l
0.44
207
1520
876
7996
2.40
10.86
13.7
12.6
21.22
21.02
mg/l
0.06
695
6225
824
7391
1.93
10.07
5.9
5.3
38.87
39.19
mmol/mol
0.54
778
6874
858
7821
2.11
9.76
5.0
4.4
5.83
5.84
mmol/l
0.10
814
7179
248
1676
1.65
9.75
1.5
1.5
2.17
2.32
g/l
0.75
133
1011
280
1954
1.62
9.67
1.4
1.3
1.29
1.75
u/ml
0.39
70
516
911
8572
3.03
8.72
13.8
10.0
24.03
25.13
u/l
1.53
896
8291
419
3267
1.51
8.59
4.0
4.2
35.95
35.98
g/l
0.05
390
3063
49
201
2.52
8.02
1.2
1.2
60.77
40.80
u/ml
—
6
21
784
7054
1.67
7.84
20.7
15.0
14.69
14.82
%
0.27
778
6932
836
7671
1.81
7.58
13.6
11.4
84.17
83.01
ml/min/173m2
0.93
719
6265
23
65
3.60
7.18
1.1
1.1
1.13
0.89
nmol/l
—
7
8
629
5437
1.47
7.06
3.4
2.9
36.36
44.06
u/l
2.82
603
5090
272
2014
1.49
6.82
2.9
2.9
0.26
0.41
e6/l
1.22
193
1505
195
1363
1.54
6.37
4.1
3.4
221.98
289.95
ng/l
0.16
149
969
202
1423
1.53
6.36
2.9
2.7
2.43
2.45
mmol/l
1.56
172
1250
172
1192
1.54
5.80
3.2
2.9
0.82
0.82
mmol/l
0.05
157
1119
162
1116
1.55
5.61
2.8
2.7
4.38
3.48
e6/l
0.31
81
570
244
1851
1.43
5.20
2.2
2.1
—
—
—
0
0
244
1865
1.42
4.96
2.5
2.1
2.54
3.00
mg/l
3.23
218
1580
252
1939
1.41
4.92
4.2
3.3
92.88
95.86
%
1.09
247
1881
923
8941
2.79
4.59
25.5
18.8
262.09
258.42
e9/l
1.06
902
8733
126
860
1.54
4.53
2.0
2.4
6.18
7.04
umol/l
0.45
104
742
133
921
1.52
4.47
4.6
4.7
1.06
1.03
mmol/l
0.47
117
847
923
8947
2.75
4.46
25.4
18.8
4.51
4.46
e12/l
2.83
901
8714
922
8935
2.67
4.42
25.5
18.8
40.41
39.92
%
2.00
880
8421
52
281
1.90
4.41
1.6
2.1
—
—
—
0
0
166
1206
1.46
4.41
2.7
2.6
1.84
1.21
e6/l
0.47
85
658
923
8950
2.73
4.40
25.5
18.9
135.26
134.01
g/l
2.48
917
8830
276
2195
1.36
4.35
3.1
3.0
35.65
84.35
e6/l
0.78
197
1667
81
505
1.66
4.25
2.7
2.8
148.67
159.45
ng/l
0.12
72
466
108
725
1.55
4.19
2.2
2.2
28.57
38.43
u/l
2.08
92
607
10
17
5.93
4.13
1.6
1.2
0.51
0.41
ug/l
—
5
11
427
3643
1.32
4.12
3.5
2.7
90.56
101.42
ug/l
0.80
396
3390
472
4090
1.31
4.04
5.5
5.7
11.05
10.48
umol/l
0.48
450
3879
36
179
2.05
3.88
2.3
2.1
4.80
5.16
mmol/24h
0.37
30
155
194
1483
1.39
3.86
1.3
1.3
7.29
11.96
u/ml
0.48
58
587
46
253
1.86
3.73
1.5
1.6
0.23
0.08
iu/ml
—
8
40
319
2661
1.30
3.49
3.3
2.9
27.12
29.30
u/l
1.50
300
2540
74
479
1.59
3.38
1.3
1.3
26.71
30.42
iu/l
0.46
60
414
9
18
5.04
3.37
1.0
1.1
—
—
—
0
0
40
220
1.85
3.28
1.2
1.8
38.39
38.86
g/l
0.23
34
201
217
1734
1.33
3.21
1.4
1.5
20.43
21.73
nmol/l
0.73
189
1471
588
5343
1.27
3.08
3.1
3.2
—
—
—
0
0
15
56
2.71
3.07
1.6
1.7
—
—
—
0
0
196
1555
1.33
3.03
1.3
1.3
22.28
31.02
iu/ml
0.75
55
523
263
2175
1.29
3.00
1.7
1.7
1.32
1.35
mmol/l
0.24
226
1835
169
1314
1.35
2.99
1.6
1.7
1073.09
1191.91
nmol/l
1.09
124
968
56
350
1.64
2.98
2.1
2.2
42.72
39.91
u/l
0.46
50
314
41
235
1.78
2.97
1.1
1.9
0.83
0.74
g/l
0.04
35
215
374
3260
1.24
2.70
11.4
11.8
1.22
1.19
inr
0.19
99
969
270
2269
1.27
2.68
2.2
2.1
158.70
187.88
u/l
0.29
246
2139
421
3731
1.23
2.57
2.5
2.4
—
—
—
0
0
42
255
1.68
2.53
1.2
1.9
9.74
10.45
g/l
0.74
36
235
190
1539
1.29
2.52
2.4
2.5
7.21
7.33
e6/l
0.03
161
1378
42
256
1.67
2.49
1.2
1.9
3.02
2.93
g/l
0.26
36
237
18
82
2.22
2.48
1.2
1.2
—
—
—
0
0
87
628
1.42
2.43
3.2
3.5
1.22
1.23
mmol/l
1.44
82
531
74
518
1.47
2.43
1.4
1.8
—
—
—
0
0
58
386
1.54
2.42
1.4
1.7
—
—
—
0
0
6
13
4.64
2.27
4.2
1.5
260.67
346.38
u/l
—
6
13
24
128
1.90
2.23
1.0
1.0
2.23
1.91
u/ml
—
7
54
131
1026
1.32
2.22
2.0
2.2
113.41
112.60
ug/g
0.01
105
805
267
2284
1.24
2.22
2.8
3.0
7.02
7.16
mmol/l
0.19
227
1942
25
138
1.83
2.11
1.7
1.6
—
—
—
0
0
35
214
1.66
2.09
2.6
2.1
173.27
240.96
ug/l
0.42
30
197
5
10
5.02
2.07
2.0
1.7
—
—
—
0
0
42
271
1.58
2.04
1.2
1.8
4.23
3.62
g/l
0.45
36
252
42
271
1.58
2.04
1.2
1.8
7.65
7.44
g/l
0.33
36
252
42
271
1.58
2.04
1.2
1.8
—
—
—
0
0
437
3951
1.20
2.03
4.9
4.8
0.00
0.00
estimate
0.50
85
732
17
83
2.07
2.02
1.5
1.2
0.54
1.00
u/ml
—
9
38
8
26
3.09
2.01
1.3
2.1
38.25
53.21
ug/l
—
8
26
45
296
1.55
2.01
1.5
1.8
—
—
—
0
0
20
105
1.92
1.96
1.2
1.3
—
—
—
0
0
97
742
1.34
1.95
3.1
4.1
230.46
248.62
u/l
0.51
91
708
434
3933
1.19
1.94
3.4
3.6
0.00
0.00
estimate
0.75
87
771
440
3993
1.19
1.93
3.4
3.6
0.00
0.01
estimate
0.80
82
708
78
579
1.38
1.90
1.4
2.7
66.19
67.45
g/l
0.79
68
533
140
1135
1.27
1.85
1.8
1.8
—
—
—
0
0
128
1026
1.29
1.85
2.5
2.2
2.42
2.39
g/l
0.24
118
949
97
749
1.33
1.84
7.3
6.9
1.19
1.33
mmol/l
0.17
75
610
39
259
1.53
1.71
1.3
1.7
0.23
0.23
g/l
0.21
34
247
22
126
1.76
1.69
1.0
1.0
0.75
1.43
u/ml
0.38
11
58
23
134
1.73
1.67
1.2
1.4
—
—
—
0
0
23
134
1.73
1.67
1.2
1.4
—
—
—
0
0
13
62
2.11
1.66
1.1
1.2
—
—
—
0
0
61
447
1.39
1.63
1.0
1.0
—
—
—
0
0
36
238
1.53
1.62
1.2
1.2
—
—
—
0
0
137
1138
1.24
1.49
2.6
2.3
13.83
13.33
umol/l
0.36
128
1053
31
203
1.55
1.47
1.5
3.5
36.65
39.89
mg/l
0.19
22
160
828
8038
1.25
1.45
4.3
4.3
4.80
4.82
mmol/l
0.19
774
7491
841
8179
1.27
1.45
4.9
4.8
2.88
2.86
mmol/l
0.31
781
7584
182
1566
1.20
1.41
1.5
1.5
—
—
—
0
0
9
40
2.26
1.40
1.0
1.0
—
—
—
0
0
22
134
1.66
1.40
1.2
1.2
3.00
3.56
u/ml
0.09
11
39
39
272
1.45
1.39
1.3
1.7
1.17
1.19
g/l
0.12
34
257
14
74
1.91
1.39
1.1
1.1
—
—
—
0
0
14
74
1.91
1.39
1.1
1.1
—
—
—
0
0
40
281
1.44
1.38
1.6
1.8
1.43
1.47
g/l
0.15
30
244
19
310
0.60
1.37
1.4
1.8
—
—
—
0
0
14
75
1.88
1.35
1.1
1.1
—
—
—
0
0
14
75
1.88
1.35
1.1
1.1
—
—
—
0
0
14
75
1.88
1.35
1.1
1.1
—
—
—
0
0
96
778
1.26
1.31
1.7
1.7
—
—
—
0
0
21
129
1.64
1.30
1.6
1.5
—
—
—
0
0
9
43
2.10
1.30
1.0
1.1
—
—
—
0
0
115
953
1.24
1.30
2.7
2.3
22.73
22.74
%
0.00
92
814
30
203
1.49
1.26
1.5
3.5
30.70
41.86
mg/l
0.32
21
159
208
1831
1.17
1.24
2.0
1.7
0.89
1.00
mg/l
0.33
153
1406
238
2118
1.17
1.24
2.9
3.2
323.66
271.96
mg/l
0.06
137
1287
96
785
1.25
1.23
1.9
1.8
—
—
—
0
0
29
197
1.49
1.20
1.5
3.5
—
1.93
—
0
20
25
165
1.53
1.18
2.6
3.7
59.84
57.96
%
0.26
25
165
14
79
1.78
1.17
1.6
1.6
—
—
—
0
0
26
174
1.51
1.16
1.3
1.2
16.51
13.01
u/l
0.43
21
137
273
2467
1.15
1.16
2.7
2.3
54.35
58.50
u/l
0.79
257
2286
17
103
1.66
1.13
2.1
3.2
—
2842.70
—
0
10
24
159
1.52
1.13
2.5
3.4
4.66
4.24
e9/l
0.29
24
159
9
162
0.55
1.09
1.2
1.7
—
—
—
0
0
15
89
1.70
1.08
1.6
1.5
—
—
—
0
0
35
253
1.40
1.08
1.1
1.1
—
—
—
0
0
52
401
1.31
1.07
1.3
1.7
—
—
—
0
0
10
52
1.93
1.06
1.1
1.1
—
—
—
0
0
820
8000
1.20
1.06
4.3
4.3
1.52
1.54
mmol/l
0.66
761
7412
35
254
1.39
1.06
1.1
1.1
—
—
—
0
0
72
581
1.26
1.06
2.7
2.9
0.71
0.75
ug/l
0.22
45
358
23
154
1.51
1.04
1.0
1.1
0.67
2.86
u/ml
1.62
12
76
73
595
1.25
0.99
2.7
3.2
2.39
2.17
mmol/l
0.26
48
497
31
223
1.40
0.99
2.2
1.6
—
—
—
0
0
5
23
2.18
0.98
1.2
1.0
47.24
34.85
u/ml
—
5
23
246
2235
1.14
0.96
3.5
3.7
5.99
6.23
mg/mmol
0.05
132
1337
9
51
1.77
0.94
1.6
1.4
—
—
—
0
0
19
127
1.51
0.89
1.2
1.3
331.00
107.70
u/ml
—
6
31
8
43
1.87
0.87
1.0
1.0
—
—
—
0
0
20
136
1.48
0.87
1.3
1.2
2.73
5.10
u/ml
0.57
15
52
31
230
1.36
0.85
1.3
1.4
265.89
302.70
ug/g
0.42
18
132
19
129
1.48
0.84
1.1
1.1
—
—
—
0
0
24
171
1.41
0.83
2.0
1.6
2657.00
14701.09
e6/l
2.09
19
127
12
190
0.63
0.83
1.3
1.5
—
—
—
0
0
8
46
1.75
0.82
1.1
1.1
—
—
—
0
0
60
491
1.24
0.82
1.5
1.5
—
—
—
0
0
27
198
1.37
0.81
3.2
2.7
—
—
—
0
0
39
303
1.30
0.81
2.5
2.9
24.90
24.29
mmol/l
0.77
39
295
51
628
0.80
0.80
2.4
2.4
67.72
68.52
ml/min/173m2
0.06
25
248
17
247
0.68
0.80
2.1
4.4
1.29
1.26
mmol/l
0.04
17
242
5
24
2.09
0.74
1.0
1.1
—
—
—
0
0
213
1950
1.12
0.74
2.5
2.8
977.85
869.71
ng/l
0.17
179
1619
71
599
1.20
0.74
2.7
3.1
5.65
5.86
kpa
1.06
62
587
9
55
1.64
0.73
1.1
1.3
—
21.25
—
0
8
56
464
1.22
0.70
1.1
1.4
—
—
—
0
0
15
101
1.49
0.70
1.1
1.2
—
—
—
0
0
202
1851
1.12
0.69
1.3
1.4
—
—
—
0
0
37
293
1.27
0.69
1.7
1.9
—
—
—
0
0
5
27
1.86
0.68
1.0
1.1
—
—
—
0
0
31
241
1.30
0.66
1.4
1.5
—
—
—
0
0
5
28
1.79
0.66
3.2
4.9
—
—
—
0
0
36
286
1.27
0.66
1.1
1.3
198.32
244.62
miu/ml
0.33
19
139
66
771
0.85
0.64
1.7
1.7
—
—
—
0
0
28
216
1.31
0.64
1.1
1.2
—
—
—
0
0
34
270
1.27
0.63
1.6
1.8
—
—
—
0
0
8
49
1.64
0.62
1.6
1.5
1.64
6.45
u/l
—
8
41
15
105
1.44
0.60
1.2
2.2
3.36
5.48
umol/l
—
9
72
0
21
0.00
0.60
0.0
2.9
—
—
—
0
0
0
21
0.00
0.60
0.0
2.9
—
—
—
0
0
297
2798
1.09
0.59
2.8
3.3
23.13
43.45
ng/l
0.77
159
1787
85
964
0.87
0.58
6.8
6.5
—
—
—
0
0
13
89
1.47
0.58
2.4
2.3
—
—
—
0
0
6
35
1.72
0.57
1.2
1.1
1675.00
1727.37
miu/ml
—
6
35
6
39
1.54
0.53
1.7
1.6
—
—
—
0
0
208
1943
1.09
0.50
2.3
2.4
6319.53
4791.55
umol/l
0.17
188
1691
6
41
1.47
0.50
1.5
2.2
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
22
171
1.29
0.50
5.0
2.5
0.36
0.36
u/ml
—
7
93
174
1615
1.09
0.49
1.6
1.7
80263579.50
25280079.04
pmol/l
0.47
152
1341
11
76
1.45
0.48
2.1
3.7
—
—
—
0
0
28
228
1.24
0.45
1.3
1.4
—
—
—
0
0
28
228
1.24
0.45
1.3
1.4
—
—
—
0
0
33
274
1.21
0.45
1.3
1.5
—
—
—
0
0
28
229
1.23
0.44
1.3
1.4
—
—
—
0
0
28
229
1.23
0.44
1.3
1.4
—
—
—
0
0
17
130
1.31
0.44
1.2
1.2
—
—
—
0
0
5
31
1.62
0.43
2.6
1.4
—
—
—
0
0
10
139
0.72
0.42
1.0
1.5
—
—
—
0
0
784
7729
1.09
0.41
3.9
3.8
1.23
1.26
mmol/l
0.68
720
7113
26
213
1.23
0.41
6.0
2.1
183.50
173.15
%
0.26
26
204
0
17
0.00
0.40
0.0
1.0
—
—
—
0
0
0
17
0.00
0.40
0.0
1.2
—
—
—
0
0
198
2097
0.93
0.39
3.8
4.0
0.00
0.01
estimate
1.34
86
721
8
61
1.31
0.39
1.1
1.2
—
—
—
0
0
8
61
1.31
0.39
1.1
1.2
—
—
—
0
0
5
36
1.39
0.38
1.2
1.6
—
—
—
0
0
5
37
1.35
0.37
3.2
2.7
67180.00
35549.95
ug/l
—
5
37
108
997
1.09
0.36
4.5
4.6
2.66
2.28
ug/l
0.28
95
881
87
796
1.10
0.35
3.5
4.1
21.53
21.62
%
0.02
33
358
6
44
1.37
0.34
1.5
1.6
—
—
—
0
0
6
44
1.37
0.34
1.5
1.6
—
—
—
0
0
6
44
1.37
0.34
1.0
1.4
—
—
—
0
0
19
154
1.24
0.34
2.1
2.2
131.57
129.41
g/l
0.15
14
112
6
45
1.34
0.33
2.0
2.1
—
—
—
0
0
6
46
1.31
0.33
1.2
1.2
—
—
—
0
0
6
88
0.68
0.33
2.7
1.7
—
—
—
0
0
68
748
0.90
0.33
2.8
4.0
10.99
21.15
ug/l
0.54
53
598
17
137
1.25
0.32
2.1
1.5
—
—
—
0
0
17
137
1.25
0.32
2.1
1.5
—
—
—
0
0
23
193
1.20
0.31
2.2
3.7
15.70
34.25
u/ml
1.93
23
187
7
54
1.30
0.30
1.4
1.3
—
—
—
0
0
34
388
0.87
0.30
1.7
1.5
—
—
—
0
0
26
224
1.17
0.27
1.1
1.1
—
—
—
0
0
8
65
1.23
0.27
2.6
1.6
—
—
—
0
0
23
268
0.85
0.27
1.1
1.4
74.17
211.19
pmol/l
1.42
23
263
163
1709
0.94
0.26
3.4
4.0
1.02
1.02
kg/l
0.14
24
229
31
351
0.88
0.25
1.6
1.7
2.90
4.77
mg/l
0.53
22
251
26
226
1.15
0.25
1.4
1.3
—
—
—
0
0
9
75
1.20
0.25
1.7
1.5
—
—
—
0
0
9
75
1.20
0.25
1.7
1.5
—
—
—
0
0
9
75
1.20
0.25
1.7
1.5
—
—
—
0
0
98
920
1.07
0.24
1.4
1.7
1.36
1.40
%
0.15
85
812
10
126
0.79
0.24
1.5
1.5
—
—
—
0
0
5
40
1.25
0.22
1.0
1.1
—
—
—
0
0
114
1081
1.06
0.22
3.2
1.8
30.54
29.48
s
0.54
108
1045
44
401
1.10
0.22
1.3
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.4
—
0.49
—
0
7
13
155
0.84
0.20
4.0
3.9
34.67
23.50
mg/l
—
6
93
9
111
0.81
0.20
1.4
1.5
—
—
—
0
0
9
112
0.80
0.20
1.0
1.2
—
—
—
0
0
43
394
1.10
0.20
1.3
1.5
—
—
—
0
0
6
50
1.20
0.19
1.0
1.2
—
—
—
0
0
74
695
1.07
0.19
2.4
2.0
0.21
0.22
g/l
0.27
66
654
6
51
1.18
0.19
1.2
1.1
—
—
—
0
0
12
142
0.84
0.17
2.0
1.6
—
—
—
0
0
52
486
1.07
0.16
2.5
2.6
5.12
4.56
kpa
1.29
47
473
26
235
1.11
0.16
4.2
1.8
94.31
94.71
%
0.03
26
225
13
111
1.17
0.16
2.2
1.6
—
—
—
0
0
12
102
1.18
0.15
1.0
1.1
—
—
—
0
0
299
3051
0.97
0.15
3.7
3.7
—
—
—
0
0
11
93
1.18
0.14
2.5
1.5
—
—
—
0
0
11
93
1.18
0.14
2.5
1.5
—
—
—
0
0
10
118
0.85
0.14
2.7
1.6
53.60
43.96
nmol/l
—
10
113
100
972
1.03
0.09
4.7
4.4
33.72
32.94
%
0.28
71
654
75
775
0.96
0.08
3.0
3.0
—
—
—
0
0
5
61
0.82
0.08
1.2
1.5
0.85
1.01
g/l
—
5
61
5
62
0.81
0.08
1.6
1.1
—
—
—
0
0
94
915
1.03
0.08
2.1
1.9
—
—
—
0
0
7
68
1.03
0.08
1.3
1.0
—
—
—
0
0
7
68
1.03
0.08
3.1
2.1
—
—
—
0
0
85
828
1.03
0.07
7.2
6.2
104.54
104.16
mmol/l
0.33
85
828
13
142
0.91
0.06
2.1
1.7
—
—
—
0
0
21
197
1.07
0.06
1.9
1.6
—
—
—
0
0
84
820
1.03
0.06
1.9
1.8
—
—
—
0
0
15
162
0.92
0.06
1.9
2.3
9.14
81.61
ug/min
—
10
96
17
181
0.94
0.05
1.1
1.4
—
—
—
0
0
15
159
0.94
0.03
1.1
1.7
—
—
—
0
0
18
189
0.95
0.03
1.1
1.2
—
—
—
0
0
55
560
0.98
0.02
2.1
2.3
6.18
5.79
ug/l
0.08
45
496
42
411
1.02
0.02
3.0
3.2
1.84
1.85
mmol/l
0.00
32
308
10
107
0.93
0.02
2.2
1.6
—
—
—
0
0
12
113
1.06
0.02
1.3
1.2
14.35
20.32
u/l
0.53
12
96
15
143
1.05
0.01
3.6
3.7
161.16
2037.46
u/ml
0.57
15
135
32
313
1.02
0.01
1.5
2.1
213.50
3733.41
u/l
—
10
128
43
437
0.98
0.01
1.4
1.5
—
—
—
0
0
57
563
1.01
0.01
7.7
6.6
8.52
8.64
mmol/l
0.05
49
541
10
106
0.94
0.01
1.0
1.4
—
—
—
0
0
10
106
0.94
0.01
1.0
1.4
—
—
—
0
0
14
134
1.05
0.00
1.2
1.2
281.38
250.56
u/ml
—
8
79
14
146
0.96
0.00
2.1
1.4
—
—
—
0
0
20
194
1.03
0.00
1.4
1.3
—
—
—
0
0
10
104
0.96
0.00
1.0
1.4
—
—
—
0
0
10
104
0.96
0.00
1.0
1.4
—
—
—
0
0
13
134
0.97
0.00
2.2
1.7
—
—
—
0
0
18
184
0.98
0.00
1.4
1.4
10.27
14.41
e6/l
0.15
11
143
18
184
0.98
0.00
1.4
1.5
624.50
159.64
e6/l
0.34
12
147
10
98
1.02
0.00
1.0
1.1
—
—
—
0
0
10
97
1.03
0.00
1.2
1.1
—
—
—
0
0
13
133
0.98
0.00
1.1
1.1
—
—
—
0
0
19
189
1.01
0.00
1.9
1.6
—
—
—
0
0
10
105
0.95
0.00
1.0
1.4
—
—
—
0
0
10
105
0.95
0.00
1.0
1.4
—
—
—
0
0
14
145
0.96
0.00
1.1
1.2
—
—
—
0
0
19
195
0.97
0.00
1.7
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
6.51
—
0
8
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
7
70
1.00
-0.00
5.3
2.8
54.86
54.15
%
—
7
62
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
86
0.93
-0.00
1.4
1.1
—
—
—
0
0
5
50
1.00
-0.00
1.2
1.4
1.79
1.62
g/l
—
5
50
8
83
0.96
-0.00
1.9
1.8
154.25
212.38
pmol/l
—
8
77
0
8
0.00
-0.00
0.0
8.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.04
—
0
5
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
50
1.00
-0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint GRAVES_OPHT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GRAVES_OPHT | 0.959 [0.83, 1.1] | 0.558 |
| Birth year | 0.994 [0.99, 1.0] | 0.163 |
During the follow-up period (1.1.1998 — 31.12.2019), 269 out of 3299 females with GRAVES_OPHT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GRAVES_OPHT | 0.932 [0.75, 1.16] | 0.532 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 104 out of 762 males with GRAVES_OPHT died.
Mortality risk
Mortality risk for people of age
years, who have GRAVES_OPHT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.083% | 0.178% |
| 5 | 0.592% | 1.02% |
| 10 | 1.423% | 2.475% |
| 15 | 2.785% | 4.756% |
| 20 | 4.852% | 8.199% |
Relationships between endpoints
↥Index endpoint: GRAVES_OPHT – Graves ophthalmopathy
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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