No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
836 |
4. Check minimum number of eventsNone |
836 |
5. Include endpointsNone |
836 |
6. Filter based on genotype QC (FinnGen only) |
802 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Graves ophthalmopathy, strict
based on the number of shared cases.
Similar with more cases:
- Graves ophthalmopathy
- Disorders of lacrimal system and orbit in diseases classified elsewhere
- Disorders of orbit
- Thyrotoxicosis, other and/or unspecified
- Thyrotoxicosis
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3679 | 2975 | 690 |
| Only index persons | 3569 | 2906 | 663 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.09 | 0.02 |
| Only index persons | 0.09 | 0.11 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 51.38 | 51.28 | 51.88 |
| Only index persons | 51.22 | 51.20 | 51.31 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 802 | 659 | 143 |
| Unadjusted period prevalence (%) | 0.20 | 0.23 | 0.07 |
| Median age at first event (years) | 53.03 | 52.75 | 54.33 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 836
- Matched controls
- 8360
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
83.0
307.7
441
111
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
46.0
307.7
229
68
H03BB01
ATC
carbimazole; oral
179.2
307.7
663
175
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
307.7
828
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
471.2
307.7
723
112
H03AA01
ATC
levothyroxine sodium; systemic
19.3
307.7
683
1570
BAA60
NOMESCO Finland
Total thyroidectomy
46.5
307.7
301
100
104
Kela drug reimbursment
Thyroid insufficiency
14.6
294.6
327
352
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
48.6
228.1
135
33
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
41.8
208.4
128
36
H062, E050,
ICD-10 Finland
727.0
183.1
174
*
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
+∞
173.1
160
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
65.5
159.0
88
15
H50.2
ICD-10 Finland
Vertical strabismus
48.4
148.0
87
20
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
7.6
145.8
668
2871
H53.2
ICD-10 Finland
Diplopia
13.3
139.3
142
127
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
223.5
130.8
132
7
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.2
119.2
537
2152
XCK00
NOMESCO Finland
Perimetry
7.5
94.5
151
239
C07AA05
ATC
propranolol; systemic
4.3
91.2
364
1275
H05.2
ICD-10 Finland
Exophthalmic conditions
198.9
87.1
89
5
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.3
82.4
200
471
T85
ICPC
Hyperthyroidism/thyrotoxicosis
27.0
66.4
46
18
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.5
58.1
124
257
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
11.3
52.9
57
54
H02AB06
ATC
prednisolone; systemic
3.0
52.4
529
3020
ZX120
NOMESCO Finland
Intravenous
4.3
52.1
157
430
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
13.2
51.6
50
40
CAC30
NOMESCO Finland
Decompression of orbit to sinuses
+∞
51.6
49
*
H50.0
ICD-10 Finland
Convergent concomitant strabismus
18.2
49.2
40
23
CA1AD
NOMESCO Finland
Orbita CT
254.3
47.5
48
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
6.0
46.1
87
160
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.1
45.0
241
956
XCD10
NOMESCO Finland
Electrophysiological examination of eye
8.4
43.9
59
75
T86
ICPC
Hypothyroidism/myxoedema
5.4
43.2
91
185
H50.6
ICD-10 Finland
Mechanical strabismus
+∞
42.0
40
*
CEC00
NOMESCO Finland
Recession of extraocular muscle
62.1
40.7
47
8
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.1
39.1
204
791
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
12.9
37.7
37
30
TPH04
NOMESCO Finland
Cathetrisation of vein
2.8
37.4
250
1107
ZXA10
NOMESCO Finland
Bilateral
2.9
37.3
230
975
CAC44
NOMESCO Finland
Combined decompression of orbit
361.7
35.2
35
*
H04.10
ICD-10 Finland
Dry eye syndrome
3.1
34.1
171
644
H50.8
ICD-10 Finland
Other specified strabismus
125.2
33.9
36
*
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
121.6
32.9
35
*
A02BC02
ATC
pantoprazole; systemic
2.7
32.1
651
4721
E03
ICD-10 Finland
Other hypothyroidism
3.7
30.9
107
319
CAC20
NOMESCO Finland
Lateral decompression of orbit
+∞
30.4
29
*
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
5.0
29.7
67
144
L04AX03
ATC
methotrexate; systemic
3.1
29.3
139
504
C07AB07
ATC
bisoprolol; oral
2.3
29.2
440
2755
WF099
NOMESCO Finland
Other radiotherapy
27.2
28.6
39
15
H02AB07
ATC
prednisone; oral
2.7
27.6
174
735
CBK00
NOMESCO Finland
Myotomy or resection of tarsal muscle or levator muscle of eyelid for correction of retraction
+∞
26.2
25
*
CS494
NOMESCO Finland
Other visual field testing
5.9
26.0
48
86
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.6
23.7
58
133
H02.5
ICD-10 Finland
Other disorders affecting eyelid function
37.5
23.1
29
8
A11CC03
ATC
alfacalcidol; systemic
6.5
22.9
38
61
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
6.8
22.7
36
55
2AB04, ,
NOMESCO Finland
46.4
22.5
27
6
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
22.4
259
1423
XCK10
NOMESCO Finland
Photography of fundus of eye
3.0
22.0
108
397
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
39.8
21.8
27
7
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
118.1
21.7
23
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
21.1
368
2347
CEW99
NOMESCO Finland
Other operation on extraocular muscle
59.0
20.0
23
*
CA1BM
NOMESCO Finland
Eye and orbita MRI examination with 3 Tesla magnet
+∞
19.9
19
*
CEC90
NOMESCO Finland
Total transposition of extraocular muscle or muscles
+∞
19.9
19
*
L04AA06
ATC
mycophenolic acid; systemic
6.6
19.8
32
50
Z3231
NOMESCO Finland
Registered nurse
2.1
19.7
263
1514
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
29.8
19.7
26
9
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
19.6
345
2192
WX402
NOMESCO Finland
General anaesthesia
2.2
19.5
213
1135
WF002
NOMESCO Finland
Radical radiotherapy
4.0
19.2
56
147
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
16.3
18.9
30
19
N05CF01
ATC
zopiclone; oral
2.0
18.9
310
1918
E05.5
ICD-10 Finland
Thyroid crisis or storm
71.6
18.8
21
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
3.2
18.4
79
268
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.7
18.3
106
425
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
27.4
17.9
24
9
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
4.0
17.8
52
137
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
4.9
17.4
39
83
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
17.4
388
2637
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
14.3
17.4
29
21
E05.89
ICD-10 Finland
Other thyrotoxicosis
41.0
16.4
20
5
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
14.9
15.9
26
18
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.9
15.1
72
259
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
5.1
13.9
29
58
Z3229
NOMESCO Finland
Other healthcare associate professional
2.7
13.8
80
320
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.1
13.7
149
784
H57.1
ICD-10 Finland
Ocular pain
3.1
12.9
54
180
CE2W4
NOMESCO Finland
Eye movement mapping
50.8
12.9
15
*
H02AB09
ATC
hydrocortisone; systemic
4.3
12.8
33
79
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
1.8
12.7
290
1940
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
8.9
12.1
25
29
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
14.9
11.8
19
13
1XC02, ,
NOMESCO Finland
10.7
11.8
22
21
Z2221
NOMESCO Finland
Medical doctor
1.7
11.4
251
1652
106
Kela drug reimbursment
Hypoparathyroidism
15.7
10.9
17
11
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
18.1
10.8
16
9
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
60.8
10.6
12
*
CBK99
NOMESCO Finland
Other operation for retraction of eyelid
111.4
10.4
11
*
S01KA02
ATC
hypromellose; ophthalmic
4.4
10.4
26
61
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
4.0
10.2
29
75
WX002
NOMESCO Finland
Sedation and analgesia
1.8
9.9
168
1021
H03BA02
ATC
propylthiouracil; oral
26.4
9.8
13
5
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
9.7
9.8
19
20
S01GX01
ATC
cromoglicic acid; ophthalmic
1.7
9.7
202
1300
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
13.6
9.7
16
12
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
11.5
9.6
17
15
H02.4
ICD-10 Finland
Ptosis of eyelid
3.3
9.4
36
114
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
9.0
191
1235
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
4.6
8.9
21
47
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
8.6
124
713
H50.52
ICD-10 Finland
Exophoria
4.6
8.6
20
44
CBB21
NOMESCO Finland
Correction of lax skin and resection of herniated fat in upper eyelid
8.3
8.6
18
22
ZXE00
NOMESCO Finland
One hour or less
1.6
8.4
329
2465
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
7.2
8.3
19
27
A11CC02
ATC
dihydrotachysterol; oral
14.6
8.2
13
9
ZX090
NOMESCO Finland
Other technic of radiotherapy
3.1
8.2
33
108
H02.3
ICD-10 Finland
Blepharochalasis
2.2
8.2
66
307
BBA70
NOMESCO Finland
Implantation or transplantation of parathyroid gland
33.7
8.1
10
*
CD2S4
NOMESCO Finland
Photography of eye
10.2
8.0
15
15
CA1BD
NOMESCO Finland
Extensive orbita CT
22.3
8.0
11
5
H40.0
ICD-10 Finland
Glaucoma suspect
2.1
7.9
71
346
F29
ICPC
Eye symptom/complaint other
2.0
7.9
92
494
H50.1
ICD-10 Finland
Divergent concomitant strabismus
10.9
7.8
14
13
H01.0
ICD-10 Finland
Blepharitis
2.2
7.8
67
321
N07BA03
ATC
varenicline; oral
2.5
7.7
49
206
WX892
NOMESCO Finland
Monitored bed care
2.3
7.6
59
271
ZX050
NOMESCO Finland
Stereotactic radiotherapy
9.0
7.6
15
17
ZXA00
NOMESCO Finland
Right side
1.6
7.5
212
1467
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
7.5
114
668
H02.8
ICD-10 Finland
Other specified disorders of eyelid
11.0
7.3
13
12
CAB00
NOMESCO Finland
Anterior orbitotomy with excision of lesion
+∞
7.3
7
*
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
7.4
7.2
16
22
R4110
NOMESCO Finland
Physiotherapy
1.6
7.2
223
1574
ZXE40
NOMESCO Finland
More than seven and less than nine hours
3.6
7.2
23
65
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
3.4
7.2
25
75
ZXC95
NOMESCO Finland
Use of surgical navigator
4.1
7.1
19
47
107
Kela drug reimbursment
Pernicious anaemia
4.1
7.1
19
47
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.2
6.9
60
289
WX110
NOMESCO Finland
Infiltration anesthesia
1.5
6.9
584
5057
TCC40
NOMESCO Finland
Closure of lacrimal canaliculus with plug
12.4
6.6
11
9
ZXE20
NOMESCO Finland
More than three and less than five hours
1.8
6.5
105
625
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.5
6.5
41
172
H05.0
ICD-10 Finland
Acute inflammation of orbit
26.9
6.2
8
*
E05.4
ICD-10 Finland
Thyrotoxicosis factitia
26.9
6.2
8
*
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
26.9
6.2
8
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
1.8
6.1
88
506
CB9S4
NOMESCO Finland
Photography of eyelids and eyebrows
12.6
6.1
10
8
E83.51
ICD-10 Finland
Hypocalcemia
6.8
6.1
14
21
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
461
216
46.35
307.65
5.2
1.7
6.23
4.99
iu/l
0.69
327
72
449
500
18.24
307.65
8.0
3.2
4.60
4.54
pmol/l
0.36
426
433
815
5859
16.57
63.30
15.1
4.3
15.85
14.62
pmol/l
34.33
789
5370
202
612
4.03
58.88
1.4
1.2
210.13
147.87
iu/ml
1.26
94
252
540
3382
2.69
40.33
7.3
6.0
1.21
1.22
mmol/l
1.70
461
2858
498
3066
2.54
37.45
6.2
5.2
1.21
1.22
mmol/l
1.31
471
2783
819
6800
11.05
33.04
16.6
5.0
1.64
2.06
mu/l
1.58
793
6266
149
527
3.22
32.97
2.8
3.5
51.51
81.20
ng/l
9.64
134
466
590
4128
2.46
30.66
9.3
8.8
3.84
3.96
e9/l
0.81
515
3631
385
2391
2.13
24.79
3.4
3.3
2.33
2.36
mmol/l
4.44
346
2117
458
3123
2.03
22.02
2.8
2.3
76.12
78.03
nmol/l
0.80
419
2812
480
3405
1.96
19.76
5.7
5.7
28.50
28.77
%
0.23
457
3193
681
5485
2.30
19.68
8.8
7.0
76.21
76.98
u/l
0.16
662
5149
471
3372
1.91
18.29
5.7
5.5
56.02
56.67
%
0.62
449
3154
143
681
2.33
17.04
2.4
2.1
360.19
374.28
nmol/l
0.43
131
628
649
5350
1.95
14.40
4.7
4.1
11.57
11.63
mm/h
0.03
613
4942
513
3938
1.78
14.31
4.4
4.1
6.40
6.59
mmol/l
1.43
481
3673
34
77
4.56
14.13
3.8
4.8
49.93
55.08
u/ml
—
9
25
799
7310
3.10
11.25
16.7
13.7
139.87
139.71
mmol/l
1.12
786
7114
800
7331
3.12
11.09
16.9
13.8
3.91
3.94
mmol/l
2.20
786
7122
382
2879
1.60
9.95
4.0
4.2
35.96
35.97
g/l
0.01
357
2692
366
2743
1.59
9.68
2.1
1.9
99.69
97.59
pmol/l
0.35
183
1354
736
6581
1.99
9.60
6.0
5.3
38.77
39.25
mmol/mol
0.85
698
6125
779
7118
2.38
9.56
14.0
12.5
21.28
20.85
mg/l
0.13
616
5553
220
1487
1.65
8.71
1.5
1.5
2.19
2.32
g/l
0.48
114
910
249
1738
1.62
8.65
1.4
1.3
1.42
1.42
u/ml
0.00
58
467
762
6957
2.08
8.45
5.0
4.4
5.82
5.85
mmol/l
0.25
725
6391
46
184
2.59
7.95
1.2
1.2
55.52
42.36
u/ml
—
5
19
251
1788
1.58
7.89
3.0
2.8
0.24
0.43
e6/l
1.54
177
1347
22
59
3.80
7.39
1.1
1.1
1.13
1.16
nmol/l
—
7
6
809
7635
2.85
7.20
14.2
9.9
24.05
24.89
u/l
1.03
796
7382
747
6842
1.86
7.19
14.0
11.3
84.16
83.13
ml/min/173m2
0.75
648
5595
563
4829
1.51
7.00
3.4
2.9
35.87
44.35
u/l
3.04
540
4525
177
1191
1.62
6.97
4.2
3.4
232.25
293.93
ng/l
0.13
142
845
150
973
1.66
6.82
2.9
2.7
4.58
3.28
e6/l
0.44
74
495
185
1268
1.59
6.73
3.0
2.7
2.43
2.45
mmol/l
1.58
157
1120
236
1720
1.52
6.50
4.3
3.3
92.33
95.99
%
1.40
231
1669
157
1045
1.62
6.43
3.4
2.9
0.82
0.81
mmol/l
0.11
143
982
225
1632
1.52
6.31
2.1
2.0
—
—
—
0
0
105
636
1.74
6.13
2.2
2.2
28.69
39.49
u/l
2.00
91
536
154
1056
1.56
5.52
2.7
2.5
1.96
1.23
e6/l
0.52
78
576
119
771
1.63
5.40
2.1
2.4
6.29
6.78
umol/l
0.21
97
664
253
1947
1.43
5.09
3.2
3.0
38.09
54.75
e6/l
0.37
180
1490
35
158
2.27
4.75
2.3
2.0
4.88
5.15
mmol/24h
0.25
29
139
119
796
1.58
4.73
4.9
4.8
1.04
1.03
mmol/l
0.15
104
729
73
435
1.74
4.53
2.7
2.8
157.30
165.39
ng/l
0.08
64
402
291
2353
1.36
4.23
3.3
2.9
27.03
29.16
u/l
1.36
272
2245
48
258
1.91
4.16
1.6
2.1
—
—
—
0
0
10
17
5.94
4.14
1.6
1.2
0.51
0.41
ug/l
—
5
11
821
7963
2.73
3.93
26.2
18.6
40.32
39.96
%
1.08
786
7509
15
49
3.10
3.82
1.6
1.7
—
—
—
0
0
821
7969
2.69
3.81
26.2
18.7
261.54
258.24
e9/l
0.84
805
7786
821
7974
2.65
3.70
26.1
18.6
4.51
4.46
e12/l
2.50
804
7769
211
1652
1.37
3.69
2.6
2.1
2.61
3.03
mg/l
2.34
187
1395
54
315
1.76
3.65
2.1
2.2
42.79
40.04
u/l
0.42
48
280
38
198
1.96
3.63
1.2
1.8
38.38
38.80
g/l
0.19
32
180
8
13
6.20
3.50
1.0
1.1
—
—
—
0
0
377
3242
1.30
3.38
3.6
2.7
90.58
101.11
ug/l
0.67
349
3016
40
218
1.88
3.37
1.5
1.6
0.31
0.09
iu/ml
—
6
37
39
211
1.89
3.36
1.2
2.0
0.88
0.59
g/l
0.13
33
192
417
3638
1.29
3.33
5.7
5.7
11.28
10.47
umol/l
0.65
397
3447
173
1345
1.36
3.13
1.3
1.3
8.15
10.85
u/ml
0.21
51
530
40
226
1.81
3.04
1.2
1.8
9.81
10.36
g/l
0.52
34
207
152
1167
1.37
2.97
1.6
1.7
1051.42
1206.30
nmol/l
1.46
112
862
40
228
1.79
2.96
1.2
1.8
3.04
2.95
g/l
0.22
34
210
175
1377
1.34
2.92
2.4
2.5
7.08
7.28
e6/l
0.05
147
1236
245
2031
1.29
2.80
2.2
2.1
161.55
192.28
u/l
0.27
223
1912
236
1952
1.29
2.74
1.7
1.7
1.33
1.35
mmol/l
0.19
204
1648
17
72
2.39
2.74
1.2
1.2
—
—
—
0
0
192
1552
1.31
2.64
1.4
1.5
19.95
21.59
nmol/l
1.01
168
1320
397
3508
1.25
2.63
5.0
4.8
0.00
0.00
estimate
0.50
75
658
24
121
2.01
2.57
1.7
1.6
—
—
—
0
0
6
11
5.49
2.54
4.2
1.5
260.67
109.09
u/l
—
6
11
336
2924
1.25
2.52
11.7
11.8
1.23
1.19
inr
0.25
86
879
399
3543
1.24
2.49
3.5
3.6
0.00
0.01
estimate
0.80
73
635
64
433
1.52
2.48
1.3
1.3
27.64
30.35
iu/l
0.28
50
373
22
109
2.05
2.48
1.2
1.1
3.00
1.50
u/ml
0.50
11
30
40
242
1.69
2.45
1.2
1.8
4.25
3.66
g/l
0.41
34
224
40
242
1.69
2.45
1.2
1.8
7.73
7.53
g/l
0.32
34
224
40
242
1.69
2.45
1.2
1.8
—
—
—
0
0
393
3490
1.24
2.43
3.5
3.6
0.00
0.00
estimate
0.74
77
694
375
3327
1.23
2.30
2.5
2.4
—
—
—
0
0
66
458
1.48
2.29
1.4
1.8
—
—
—
0
0
72
509
1.45
2.27
1.4
2.8
65.96
67.44
g/l
0.89
62
469
23
121
1.93
2.22
1.2
1.4
—
—
—
0
0
23
121
1.93
2.22
1.2
1.4
—
—
—
0
0
172
1403
1.28
2.19
1.3
1.3
22.98
31.98
iu/ml
0.66
47
475
89
660
1.39
2.17
7.5
7.2
1.18
1.44
mmol/l
0.32
69
538
89
661
1.39
2.15
2.9
4.0
232.64
248.87
u/l
0.39
83
628
22
116
1.92
2.12
1.0
1.0
2.17
2.01
u/ml
—
6
50
51
341
1.53
2.12
1.5
1.7
—
—
—
0
0
116
903
1.33
2.08
2.6
2.2
2.43
2.40
g/l
0.21
107
833
30
176
1.73
2.08
1.5
3.6
36.10
40.85
mg/l
0.27
21
140
117
913
1.33
2.07
1.9
2.1
118.85
112.58
ug/g
0.05
93
722
518
4784
1.22
2.04
3.1
3.2
—
—
—
0
0
196
1642
1.25
2.00
2.0
1.7
0.92
0.99
mg/l
0.16
143
1261
14
64
2.21
1.95
1.1
1.1
—
—
—
0
0
14
64
2.21
1.95
1.1
1.1
—
—
—
0
0
25
143
1.77
1.91
2.6
3.4
59.84
57.75
%
0.29
25
143
14
65
2.17
1.89
1.1
1.1
—
—
—
0
0
14
65
2.17
1.89
1.1
1.1
—
—
—
0
0
14
65
2.17
1.89
1.1
1.1
—
—
—
0
0
76
565
1.38
1.85
3.4
3.5
1.22
1.23
mmol/l
1.42
71
481
24
137
1.77
1.85
2.5
3.1
4.66
4.24
e9/l
0.28
24
137
236
2036
1.22
1.83
2.8
3.0
7.12
7.14
mmol/l
0.02
200
1723
29
176
1.67
1.81
1.5
3.6
29.89
26.72
mg/l
0.33
20
138
15
73
2.07
1.81
1.5
1.2
0.61
1.14
u/ml
—
8
33
34
216
1.60
1.79
1.2
1.3
—
—
—
0
0
28
170
1.67
1.75
1.5
3.6
—
1.98
—
0
19
9
36
2.52
1.74
1.0
1.0
—
—
—
0
0
55
394
1.42
1.67
1.0
1.0
—
—
—
0
0
740
7153
1.30
1.65
4.2
4.3
4.80
4.83
mmol/l
0.27
693
6664
7
25
2.81
1.65
1.3
2.0
39.43
54.34
ug/l
—
7
25
89
694
1.32
1.61
1.8
1.7
—
—
—
0
0
39
266
1.49
1.54
1.5
1.8
—
—
—
0
0
20
115
1.76
1.53
1.3
1.1
2.73
5.50
u/ml
0.54
15
40
17
93
1.85
1.52
2.1
2.6
—
897.12
—
0
8
89
703
1.30
1.48
1.9
1.8
—
—
—
0
0
750
7280
1.29
1.47
4.9
4.8
2.89
2.86
mmol/l
0.35
698
6751
123
1013
1.25
1.47
1.9
1.8
—
—
—
0
0
9
38
2.38
1.46
1.0
1.1
—
—
—
0
0
122
1008
1.25
1.42
2.7
2.2
13.94
13.35
umol/l
0.41
115
931
38
264
1.46
1.39
2.6
2.9
24.92
24.26
mmol/l
0.83
38
258
30
199
1.53
1.36
2.2
1.6
—
—
—
0
0
10
47
2.14
1.34
1.1
1.1
—
—
—
0
0
67
517
1.32
1.34
2.6
2.9
0.70
0.75
ug/l
0.23
41
322
36
250
1.46
1.33
1.6
1.8
1.40
1.53
g/l
0.51
27
215
103
842
1.25
1.32
2.9
2.3
22.92
22.72
%
0.05
83
715
18
107
1.70
1.26
1.2
1.4
378.00
112.20
u/ml
—
5
28
16
92
1.75
1.25
1.1
1.3
—
—
—
0
0
19
115
1.67
1.25
1.6
1.5
—
—
—
0
0
17
277
0.61
1.24
1.3
1.8
—
—
—
0
0
8
36
2.23
1.24
1.0
1.1
—
—
—
0
0
30
204
1.49
1.24
1.3
1.4
244.24
305.16
ug/g
0.95
17
120
13
72
1.82
1.15
2.4
2.1
—
—
—
0
0
5
20
2.51
1.15
1.0
1.2
—
—
—
0
0
18
111
1.64
1.12
1.0
1.0
0.92
1.65
u/ml
—
9
48
160
1393
1.18
1.12
1.5
1.5
—
—
—
0
0
24
160
1.51
1.10
1.3
1.2
17.54
13.02
u/l
0.54
19
128
731
7119
1.21
1.08
4.2
4.3
1.51
1.54
mmol/l
1.16
680
6602
5
22
2.28
1.03
1.2
1.0
47.24
27.19
u/ml
—
5
22
18
114
1.59
1.03
1.1
1.1
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
22
148
1.50
0.98
5.0
2.5
0.36
0.36
u/ml
—
7
80
5
23
2.18
0.98
1.0
1.2
—
—
—
0
0
26
182
1.44
0.97
6.0
2.1
183.50
175.37
%
0.19
26
174
46
356
1.31
0.95
1.3
1.7
—
—
—
0
0
8
144
0.55
0.94
1.3
1.7
—
—
—
0
0
31
226
1.39
0.93
1.1
1.2
—
—
—
0
0
24
167
1.45
0.93
2.5
2.6
—
—
—
0
0
31
227
1.38
0.91
1.1
1.1
—
—
—
0
0
34
253
1.36
0.91
1.1
1.3
208.06
245.17
miu/ml
0.24
18
124
27
193
1.41
0.91
1.1
1.2
—
—
—
0
0
240
2191
1.13
0.89
2.7
2.3
54.28
58.67
u/l
0.74
225
2030
12
71
1.70
0.89
1.8
1.6
—
—
—
0
0
8
42
1.91
0.88
1.1
1.0
—
—
—
0
0
208
1884
1.14
0.87
3.0
3.1
365.34
267.11
mg/l
0.11
121
1143
13
80
1.63
0.85
1.7
1.5
—
—
—
0
0
8
45
1.79
0.84
1.1
1.3
—
21.25
—
0
8
64
527
1.23
0.83
2.7
3.1
2.37
2.19
mmol/l
0.19
45
437
8
46
1.75
0.82
1.6
1.4
—
—
—
0
0
15
225
0.66
0.82
2.2
4.6
1.21
1.22
mmol/l
0.02
15
220
0
28
0.00
0.76
0.0
1.1
—
112.43
—
0
21
0
28
0.00
0.76
0.0
1.1
—
0.28
—
0
23
54
444
1.23
0.73
1.6
1.6
—
—
—
0
0
11
170
0.64
0.71
1.4
1.5
—
—
—
0
0
57
682
0.82
0.71
1.7
1.7
—
—
—
0
0
180
1640
1.12
0.70
1.3
1.4
—
—
—
0
0
21
152
1.39
0.69
1.9
1.6
1504.56
12556.69
e6/l
1.93
16
111
63
531
1.20
0.68
2.6
3.1
5.73
5.85
kpa
0.50
56
520
7
44
1.60
0.65
1.7
1.5
1.73
5.93
u/l
—
7
36
19
137
1.40
0.65
1.0
1.1
0.36
3.00
u/ml
—
9
67
107
948
1.15
0.64
3.3
1.8
30.59
29.34
s
0.61
101
915
215
1993
1.11
0.62
3.6
3.7
6.67
6.49
mg/mmol
0.03
115
1189
47
562
0.83
0.60
2.4
2.4
65.76
68.96
ml/min/173m2
0.25
21
221
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
26
201
1.30
0.59
4.2
1.8
94.31
94.44
%
0.01
26
192
189
1747
1.11
0.58
2.4
2.8
1050.10
877.39
ng/l
0.26
157
1451
6
35
1.72
0.57
1.5
2.3
—
—
—
0
0
75
856
0.86
0.57
7.2
6.5
—
—
—
0
0
8
55
1.46
0.56
1.1
1.2
—
—
—
0
0
8
55
1.46
0.56
1.1
1.2
—
—
—
0
0
6
37
1.63
0.55
1.7
1.6
—
—
—
0
0
49
414
1.20
0.54
1.2
1.4
—
—
—
0
0
27
215
1.26
0.51
1.4
1.5
—
—
—
0
0
92
822
1.13
0.51
1.4
1.7
1.39
1.39
%
0.01
80
726
700
6877
1.11
0.51
3.8
3.8
1.23
1.26
mmol/l
0.61
642
6337
99
890
1.13
0.50
4.5
4.6
2.75
2.31
ug/l
0.30
88
787
185
1726
1.09
0.47
2.3
2.4
7114.95
5343.20
umol/l
0.18
166
1505
10
68
1.48
0.47
2.1
3.5
—
—
—
0
0
79
706
1.13
0.45
3.5
4.1
20.88
21.57
%
0.17
30
323
8
56
1.43
0.42
1.1
1.1
—
—
—
0
0
5
32
1.57
0.42
3.2
2.8
67180.00
34064.00
ug/l
—
5
32
5
34
1.47
0.40
1.2
1.6
—
—
—
0
0
0
18
0.00
0.40
0.0
3.2
—
—
—
0
0
0
18
0.00
0.40
0.0
3.2
—
—
—
0
0
5
35
1.43
0.39
1.0
1.1
—
—
—
0
0
262
2502
1.07
0.38
2.8
3.3
23.88
45.85
ng/l
0.73
141
1593
69
620
1.12
0.38
2.4
2.1
0.22
0.22
g/l
0.01
61
583
13
98
1.33
0.37
2.2
1.7
—
—
—
0
0
8
112
0.71
0.37
1.6
1.5
—
—
—
0
0
5
37
1.35
0.37
1.0
1.4
—
—
—
0
0
24
199
1.21
0.35
1.1
1.1
—
—
—
0
0
6
43
1.40
0.35
1.0
1.2
—
—
—
0
0
54
481
1.13
0.35
8.0
6.7
8.40
8.67
mmol/l
0.12
47
460
11
82
1.35
0.34
2.5
1.5
—
—
—
0
0
11
82
1.35
0.34
2.5
1.5
—
—
—
0
0
17
136
1.26
0.33
2.2
2.1
130.67
130.17
g/l
0.03
12
100
15
118
1.28
0.33
1.2
1.2
—
—
—
0
0
28
239
1.18
0.31
1.4
1.5
—
—
—
0
0
7
98
0.71
0.31
1.6
1.5
—
—
—
0
0
7
56
1.25
0.29
2.9
1.5
—
—
—
0
0
8
107
0.75
0.29
2.8
1.6
53.50
43.51
nmol/l
—
8
102
24
204
1.18
0.29
1.3
1.4
—
—
—
0
0
24
204
1.18
0.29
1.3
1.4
—
—
—
0
0
79
730
1.09
0.28
7.5
6.2
104.63
104.18
mmol/l
0.40
79
730
24
205
1.18
0.27
1.4
1.4
—
—
—
0
0
24
205
1.18
0.27
1.4
1.4
—
—
—
0
0
11
138
0.79
0.25
4.5
3.7
37.60
23.15
mg/l
—
5
82
10
126
0.79
0.24
2.2
1.6
—
—
—
0
0
180
1875
0.95
0.23
3.9
4.0
0.00
0.00
estimate
1.08
76
654
5
39
1.28
0.23
2.2
2.1
—
—
—
0
0
23
200
1.15
0.22
1.4
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.4
—
0.49
—
0
7
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
62
665
0.93
0.20
3.0
4.1
11.37
15.32
ug/l
0.20
48
534
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
11
90
1.23
0.19
1.0
1.1
—
—
—
0
0
20
228
0.87
0.19
1.2
1.4
78.40
233.86
pmol/l
1.34
20
223
46
497
0.92
0.18
2.2
2.4
7.09
5.68
ug/l
0.28
37
441
7
58
1.21
0.18
3.1
2.0
—
—
—
0
0
10
121
0.82
0.18
1.0
1.5
—
—
—
0
0
42
387
1.09
0.18
1.4
1.5
—
—
—
0
0
13
110
1.18
0.17
1.2
1.2
320.00
261.22
u/ml
—
7
66
5
68
0.73
0.17
1.8
1.5
—
—
—
0
0
5
68
0.73
0.17
1.8
1.5
—
—
—
0
0
5
68
0.73
0.17
1.8
1.5
—
—
—
0
0
13
111
1.17
0.16
1.1
1.1
—
—
—
0
0
38
351
1.09
0.15
1.3
1.5
—
—
—
0
0
6
77
0.78
0.15
2.7
1.7
—
—
—
0
0
39
361
1.08
0.15
1.2
1.4
—
—
—
0
0
20
178
1.13
0.15
2.2
3.8
16.45
33.62
u/ml
1.57
20
172
41
381
1.08
0.15
3.1
3.3
5.44
5.15
kpa
0.79
41
368
11
93
1.19
0.14
1.2
1.3
—
—
—
0
0
147
1517
0.96
0.14
3.5
3.9
1.02
1.02
kg/l
0.39
21
196
28
256
1.10
0.14
1.6
1.9
—
—
—
0
0
26
237
1.10
0.14
1.4
1.7
—
—
—
0
0
29
315
0.92
0.13
1.7
1.8
2.90
4.99
mg/l
0.53
20
225
11
126
0.87
0.11
2.3
1.7
—
—
—
0
0
5
44
1.14
0.10
1.2
1.2
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
44
1.14
0.10
1.0
1.2
—
—
—
0
0
5
45
1.11
0.10
1.2
1.0
—
—
—
0
0
10
87
1.15
0.09
1.2
1.1
—
—
—
0
0
5
47
1.06
0.09
1.6
1.3
—
—
—
0
0
76
735
1.04
0.09
1.8
1.8
—
—
—
0
0
14
154
0.91
0.08
1.1
1.4
—
—
—
0
0
13
143
0.91
0.07
1.1
1.7
—
—
—
0
0
8
76
1.05
0.07
1.4
1.1
—
—
—
0
0
8
91
0.88
0.06
1.0
1.4
—
—
—
0
0
8
91
0.88
0.06
1.0
1.4
—
—
—
0
0
8
90
0.89
0.06
1.0
1.4
—
—
—
0
0
8
90
0.89
0.06
1.0
1.4
—
—
—
0
0
8
95
0.84
0.06
2.5
1.6
—
—
—
0
0
34
356
0.95
0.06
1.7
1.5
—
—
—
0
0
11
99
1.11
0.06
1.4
1.2
14.78
21.69
u/l
0.55
11
85
9
100
0.90
0.06
1.0
1.2
—
—
—
0
0
18
168
1.07
0.06
1.4
1.5
624.50
167.38
e6/l
0.34
12
136
18
168
1.07
0.06
1.4
1.4
10.27
11.52
e6/l
0.04
11
132
13
121
1.08
0.03
1.2
1.2
—
—
—
0
0
13
121
1.08
0.03
2.3
1.5
—
—
—
0
0
13
121
1.08
0.03
2.3
1.5
—
—
—
0
0
37
360
1.03
0.03
2.9
3.2
1.65
1.91
mmol/l
0.15
30
270
83
820
1.01
0.02
2.0
1.9
—
—
—
0
0
271
2722
0.99
0.02
3.7
3.7
—
—
—
0
0
147
1460
1.01
0.01
1.6
1.7
96825821.92
21053070.12
pmol/l
0.56
126
1216
14
147
0.95
0.01
1.9
2.3
5.27
87.28
ug/min
—
9
85
17
166
1.02
0.00
2.0
1.7
—
—
—
0
0
17
174
0.98
0.00
1.3
1.3
—
—
—
0
0
28
285
0.98
0.00
1.5
2.1
217.56
4018.95
u/l
—
9
116
17
173
0.98
0.00
2.0
1.6
—
—
—
0
0
12
122
0.98
0.00
2.2
1.7
—
—
—
0
0
13
132
0.98
0.00
4.0
3.7
185.41
2205.90
u/ml
0.56
13
124
87
873
1.00
0.00
4.6
4.4
32.73
33.00
%
0.08
60
585
18
181
0.99
0.00
1.8
1.6
—
—
—
0
0
16
161
0.99
0.00
1.1
1.2
—
—
—
0
0
12
125
0.96
0.00
2.2
1.3
—
—
—
0
0
5
56
0.89
0.00
1.6
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
6.51
—
0
8
8
89
0.90
-0.00
1.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
70
700
1.00
-0.00
3.1
3.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
8.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
88
0.91
-0.00
1.0
1.1
—
—
—
0
0
8
89
0.90
-0.00
1.0
1.4
—
—
—
0
0
6
61
0.98
-0.00
1.7
2.5
60.67
51.81
%
—
6
54
6
62
0.97
-0.00
1.3
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
7
71
0.99
-0.00
1.9
1.8
137.57
214.48
pmol/l
—
7
66
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_GRAVES_OPHT_STRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GRAVES_OPHT_STRICT | 1.019 [0.88, 1.18] | 0.809 |
| Birth year | 0.997 [0.99, 1.01] | 0.467 |
During the follow-up period (1.1.1998 — 31.12.2019), 232 out of 2730 females with E4_GRAVES_OPHT_STRICT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GRAVES_OPHT_STRICT | 0.955 [0.75, 1.22] | 0.706 |
| Birth year | 0.988 [0.98, 1.0] | 0.021 |
During the follow-up period (1.1.1998 — 31.12.2019), 86 out of 636 males with E4_GRAVES_OPHT_STRICT died.
Mortality risk
Mortality risk for people of age
years, who have E4_GRAVES_OPHT_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.132% | 0.18% |
| 5 | 0.714% | 1.192% |
| 10 | 1.575% | 3.121% |
| 15 | 2.786% | 5.749% |
| 20 | 5.019% | 9.82% |
Relationships between endpoints
↥Index endpoint: E4_GRAVES_OPHT_STRICT – Graves ophthalmopathy, strict
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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