No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
403 |
4. Check minimum number of eventsNone |
403 |
5. Include endpointsNone |
403 |
6. Filter based on genotype QC (FinnGen only) |
388 |
Control definitions (FinnGen only)
- Control exclude
- H7_LIDLACRIMALORBIT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H05
- Name in latin
- Exophthalmus
Similar endpoints
↥List of similar endpoints to
Exophthalmic conditions
based on the number of shared cases.
Similar with more cases:
- Disorders of orbit
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2738 | 1729 | 982 |
| Only index persons | 2452 | 1594 | 858 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.03 |
| Only index persons | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 55.09 | 55.33 | 54.47 |
| Only index persons | 54.37 | 54.68 | 53.79 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 388 | 251 | 137 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.06 |
| Median age at first event (years) | 53.42 | 52.59 | 54.92 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 403
- Matched controls
- 4030
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H05.2
ICD-10 Finland
Exophthalmic conditions
+∞
307.7
376
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
33.3
164.2
112
46
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
99.1
91
*
H03BB01
ATC
carbimazole; oral
16.8
96.9
88
66
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
17.2
72.3
63
43
H03AA01
ATC
levothyroxine sodium; systemic
4.8
52.3
189
631
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
4.8
50.7
269
1191
H53.2
ICD-10 Finland
Diplopia
10.7
49.2
57
61
XCK00
NOMESCO Finland
Perimetry
7.9
46.6
70
104
104
Kela drug reimbursment
Thyroid insufficiency
6.8
45.9
81
143
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
164.1
42.7
44
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.5
41.5
134
401
H04.10
ICD-10 Finland
Dry eye syndrome
6.3
39.0
73
136
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
11.0
35.9
40
40
H062, E050,
ICD-10 Finland
+∞
32.8
31
*
BAA60
NOMESCO Finland
Total thyroidectomy
9.7
32.1
39
44
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
+∞
31.7
30
*
CAC30
NOMESCO Finland
Decompression of orbit to sinuses
+∞
27.4
26
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.4
26.6
76
202
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.6
24.0
63
156
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
57.7
23.4
27
5
XCK10
NOMESCO Finland
Photography of fundus of eye
4.2
22.9
68
185
H02.3
ICD-10 Finland
Blepharochalasis
29.3
22.6
30
11
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
6.6
22.0
37
61
CAA30
NOMESCO Finland
Biopsy of orbit
220.9
20.8
21
*
H02.4
ICD-10 Finland
Ptosis of eyelid
30.7
19.9
26
9
D31.6
ICD-10 Finland
Benign neoplasm: Orbit, unspecified
209.9
19.7
20
*
H50.2
ICD-10 Finland
Vertical strabismus
29.5
19.0
25
9
XCD10
NOMESCO Finland
Electrophysiological examination of eye
7.3
18.5
28
41
H02AB06
ATC
prednisolone; systemic
2.5
18.3
233
1417
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
13.4
17.4
30
24
E03.89
ICD-10 Finland
Other specified hypothyroidism
5.7
17.1
33
62
H05.1
ICD-10 Finland
Chronic inflammatory disorders of orbit
+∞
16.8
16
*
3763A
ICD-9 Finland
Disorders of the orbit, Other exophthalmic conditions
+∞
16.8
16
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.1
16.7
82
308
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
16.5
176
975
H02AB07
ATC
prednisone; oral
3.0
16.3
84
324
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
22.1
14.8
21
10
3762A
ICD-9 Finland
Disorders of the orbit, Endocrine exophthalmos
+∞
14.7
14
*
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
55.4
13.9
16
*
A02BC02
ATC
pantoprazole; systemic
2.4
13.7
301
2205
ZXD10
NOMESCO Finland
Scheduled procedure
2.2
13.7
178
1053
H05.0
ICD-10 Finland
Acute inflammation of orbit
+∞
13.6
13
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.2
13.3
162
932
CA1DG
NOMESCO Finland
Eye and orbita very extensive MRI examination with high intensity magnet
41.6
13.2
16
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.4
13.2
125
646
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
12.7
172
1028
UDM02
NOMESCO Finland
Sinoscopy
6.5
12.6
21
34
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
13.8
12.6
21
16
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
11.1
104
530
Z3231
NOMESCO Finland
Registered nurse
2.1
10.6
126
706
H02AB04
ATC
methylprednisolone; systemic
2.5
10.5
74
332
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
+∞
10.5
10
*
CAB00
NOMESCO Finland
Anterior orbitotomy with excision of lesion
+∞
10.5
10
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.6
10.4
36
108
AA1AD
NOMESCO Finland
CT of head and brain
2.1
10.3
120
667
ZXA10
NOMESCO Finland
Bilateral
2.3
10.2
88
431
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
17.2
9.9
15
9
WX002
NOMESCO Finland
Sedation and analgesia
2.3
9.8
89
446
CEC00
NOMESCO Finland
Recession of extraocular muscle
56.4
9.7
11
*
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
11.8
9.6
17
15
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
9.5
75
353
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.8
9.5
49
187
2420A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic diffuse goitre
102.3
9.5
10
*
CAC44
NOMESCO Finland
Combined decompression of orbit
102.3
9.5
10
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
9.4
195
1319
H57.1
ICD-10 Finland
Ocular pain
4.5
9.2
23
54
ZXE20
NOMESCO Finland
More than three and less than five hours
2.5
9.2
66
297
H02AB09
ATC
hydrocortisone; systemic
7.3
9.1
21
30
CA1BD
NOMESCO Finland
Extensive orbita CT
51.1
8.7
10
*
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
11.9
8.6
15
13
R03BB04
ATC
tiotropium bromide; inhalant
2.6
8.4
50
206
CBK00
NOMESCO Finland
Myotomy or resection of tarsal muscle or levator muscle of eyelid for correction of retraction
+∞
8.4
8
*
H02.2
ICD-10 Finland
Lagophthalmos
+∞
8.4
8
*
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
+∞
8.4
8
*
CAC20
NOMESCO Finland
Lateral decompression of orbit
+∞
8.4
8
*
H02.1
ICD-10 Finland
Ectropion of eyelid
+∞
8.4
8
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
8.3
107
612
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.5
8.1
56
247
CD2S4
NOMESCO Finland
Photography of eye
22.6
8.1
11
5
WX892
NOMESCO Finland
Monitored bed care
3.0
8.0
37
133
ZXE00
NOMESCO Finland
One hour or less
1.8
8.0
164
1092
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
3.4
8.0
29
90
XF400
NOMESCO Finland
ECG with 12 standard connections
2.2
7.8
69
340
CA1AD
NOMESCO Finland
Orbita CT
45.9
7.7
9
*
A04
ICPC
Weakness/tiredness general
2.3
7.7
63
301
H01.0
ICD-10 Finland
Blepharitis
3.5
7.7
26
77
Z3229
NOMESCO Finland
Other healthcare associate professional
2.7
7.4
40
156
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.2
7.4
20
50
CBB20
NOMESCO Finland
Correction of lax skin of eyelid and resection of herniated fat
+∞
7.3
7
*
CBB10
NOMESCO Finland
Excision of redundant skin of eyelid
+∞
7.3
7
*
H02.5
ICD-10 Finland
Other disorders affecting eyelid function
+∞
7.3
7
*
CBJ40
NOMESCO Finland
Resection of levator muscle of eyelid
+∞
7.3
7
*
H50.1
ICD-10 Finland
Divergent concomitant strabismus
16.1
7.3
11
7
ZXA05
NOMESCO Finland
Left side
1.9
7.1
106
633
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
4.5
7.0
17
39
S01KA02
ATC
hypromellose; ophthalmic
6.5
7.0
17
27
S01GX01
ATC
cromoglicic acid; ophthalmic
2.0
7.0
86
480
R4110
NOMESCO Finland
Physiotherapy
1.9
7.0
119
741
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
4.1
7.0
19
48
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.6
6.9
41
169
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
40.8
6.8
8
*
L04AX03
ATC
methotrexate; systemic
2.4
6.8
47
208
H10.4
ICD-10 Finland
Chronic conjunctivitis
12.5
6.6
11
9
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
10.3
6.6
12
12
WX110
NOMESCO Finland
Infiltration anesthesia
1.8
6.5
281
2271
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
2.8
6.5
32
119
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.2
6.5
26
86
CB9S4
NOMESCO Finland
Photography of eyelids and eyebrows
70.9
6.4
7
*
T86
ICPC
Hypothyroidism/myxoedema
3.2
6.4
25
81
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
14.6
6.4
10
7
C07AA05
ATC
propranolol; systemic
1.9
6.4
91
533
Z3226
NOMESCO Finland
Physiotherapist
2.0
6.4
81
456
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
11.3
6.3
11
10
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.1
6.3
62
318
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
3.0
6.3
27
93
CBB21
NOMESCO Finland
Correction of lax skin and resection of herniated fat in upper eyelid
+∞
6.3
6
*
CAB10
NOMESCO Finland
Lateral orbitotomy with excision of lesion
+∞
6.3
6
*
H50.6
ICD-10 Finland
Mechanical strabismus
+∞
6.3
6
*
H05.8
ICD-10 Finland
Other disorders of orbit
+∞
6.3
6
*
CA1BM
NOMESCO Finland
Eye and orbita MRI examination with 3 Tesla magnet
+∞
6.3
6
*
CBH30
NOMESCO Finland
Tarsorraphy
+∞
6.3
6
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
6.2
118
756
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
3.9
6.2
18
48
E03
ICD-10 Finland
Other hypothyroidism
2.7
6.0
33
130
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
6.0
146
1003
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
88
80
13.79
86.20
2.7
1.6
3.02
5.10
iu/l
0.73
37
25
342
2562
3.21
16.79
7.1
3.8
15.32
14.81
pmol/l
3.04
319
2323
45
130
3.77
13.77
1.8
2.4
41.02
39.29
u/l
0.18
40
119
263
1868
2.17
12.19
12.0
8.9
4.29
4.07
e9/l
0.80
234
1639
229
1578
2.05
11.07
8.4
6.7
1.22
1.22
mmol/l
0.17
195
1343
223
1543
2.00
10.42
7.8
5.6
27.06
27.99
%
0.59
211
1452
219
1519
1.97
10.02
7.5
5.4
57.58
57.33
%
0.11
208
1428
209
1436
1.95
9.74
7.9
5.7
1.22
1.22
mmol/l
0.15
195
1311
65
284
2.54
9.69
3.0
1.9
310.49
387.57
nmol/l
2.66
59
264
33
107
3.27
8.46
5.4
1.8
3.04
2.85
g/l
0.40
33
98
358
3058
2.53
8.27
8.3
4.6
1.84
2.29
mu/l
0.58
336
2791
34
116
3.11
8.02
5.3
1.8
4.11
3.63
g/l
0.62
34
107
34
116
3.11
8.02
5.3
1.8
7.73
7.46
g/l
0.27
34
107
34
116
3.11
8.02
5.2
1.8
—
—
—
0
0
86
480
2.01
7.01
2.2
1.9
—
—
—
0
0
30
105
3.01
6.79
5.8
1.8
10.05
10.05
g/l
0.00
30
95
27
90
3.14
6.63
6.3
1.9
37.27
38.56
g/l
0.79
27
81
244
1894
1.73
6.56
5.9
4.5
6.67
6.66
mmol/l
0.04
232
1765
188
1373
1.69
6.21
5.2
4.5
34.82
35.70
g/l
1.27
177
1283
80
454
1.95
6.17
2.0
2.0
29.11
29.56
s
0.35
73
441
173
1256
1.66
5.72
2.1
2.0
95.26
96.32
pmol/l
0.09
93
632
94
576
1.82
5.70
4.4
3.8
618.86
245.58
ng/l
0.47
78
437
295
2460
1.74
5.68
5.3
3.9
15.68
11.96
mm/h
2.70
279
2271
115
752
1.74
5.58
2.5
2.2
—
—
—
0
0
128
865
1.70
5.51
3.3
3.0
0.65
0.42
e6/l
0.24
98
650
24
84
2.97
5.45
2.3
2.5
—
—
—
0
0
81
490
1.82
5.08
3.8
3.4
0.81
0.81
mmol/l
0.01
76
457
156
1136
1.61
4.91
3.3
3.0
—
—
—
0
0
11
17
6.62
4.80
1.5
3.6
4117.45
778.24
u/ml
0.42
11
17
59
331
1.92
4.67
2.2
1.8
—
—
—
0
0
59
335
1.89
4.51
2.3
1.9
—
—
—
0
0
19
65
3.02
4.50
1.2
1.2
20.29
7.04
e6/l
0.32
14
52
19
65
3.02
4.50
1.3
1.3
19.86
159.19
e6/l
0.85
14
53
135
970
1.59
4.41
2.5
2.0
190.81
187.51
u/l
0.03
128
913
191
1488
1.54
4.34
17.0
12.6
1.29
1.21
inr
0.48
56
458
10
16
6.38
4.32
1.0
1.0
—
—
—
0
0
7
6
11.84
4.29
1.6
1.2
6.19
7.73
umol/l
—
7
6
192
1511
1.52
4.09
2.8
2.5
—
—
—
0
0
149
1114
1.54
4.01
4.2
3.5
2.38
2.36
mmol/l
1.11
133
975
58
340
1.82
4.01
8.3
9.0
1.84
1.22
mmol/l
0.75
46
278
203
1623
1.51
3.97
5.3
4.8
0.00
0.00
estimate
0.50
47
308
364
3334
1.95
3.91
21.1
13.0
23.93
23.20
mg/l
0.15
305
2606
295
2558
1.57
3.90
10.3
7.0
79.44
78.61
u/l
0.13
280
2386
43
232
1.96
3.82
1.8
2.9
206.53
175.04
ng/l
0.19
36
213
17
63
2.77
3.53
1.9
1.2
—
—
—
0
0
17
63
2.77
3.53
1.9
1.2
—
—
—
0
0
213
1747
1.47
3.51
7.2
5.9
10.76
10.77
umol/l
0.00
206
1661
202
1644
1.46
3.45
3.8
3.6
0.07
0.01
estimate
0.40
41
302
48
280
1.81
3.38
3.5
3.0
3.02
2.11
mmol/l
0.86
40
229
136
1029
1.49
3.35
2.7
2.4
58.31
56.23
u/l
0.29
131
952
199
1621
1.45
3.35
3.9
3.5
0.00
0.00
estimate
0.50
49
332
6
7
8.68
3.27
1.5
1.1
—
—
—
0
0
6
7
8.68
3.27
1.0
1.0
—
—
—
0
0
21
91
2.38
3.23
6.5
3.8
—
3.15
—
0
8
21
91
2.38
3.23
1.7
1.5
312.10
273.16
mu/l
0.45
21
85
130
984
1.47
3.17
3.6
3.0
7.18
7.46
mmol/l
0.28
108
834
114
842
1.49
3.14
2.6
2.4
342.74
9048.87
umol/l
4.58
101
742
86
599
1.55
3.10
3.4
3.0
2.51
2.45
mmol/l
2.84
71
527
21
93
2.33
3.09
6.5
3.9
37.45
27.79
mg/l
0.37
16
74
21
93
2.33
3.09
6.5
3.9
35.48
58.84
mg/l
0.81
16
73
139
1073
1.45
3.04
2.9
3.0
31.08
31.21
u/l
0.01
128
1027
37
208
1.86
2.94
1.9
1.6
—
—
—
0
0
77
532
1.55
2.87
1.3
1.4
—
—
—
0
0
103
758
1.48
2.86
2.2
2.1
2.98
3.08
mg/l
0.18
94
650
5
6
8.42
2.75
1.6
1.7
—
—
—
0
0
19
85
2.30
2.75
1.2
1.2
—
—
—
0
0
40
236
1.77
2.74
1.5
1.2
159.31
143.02
iu/ml
0.11
13
102
25
126
2.05
2.72
1.9
2.2
1.59
1.43
g/l
0.23
20
113
6
10
6.07
2.70
1.5
1.3
—
—
—
0
0
154
1235
1.40
2.66
3.6
3.4
50.08
43.28
ng/l
0.19
102
859
71
490
1.54
2.66
3.5
2.8
3.80
2.67
e6/l
0.27
38
260
8
20
4.06
2.58
1.0
1.5
—
53.33
—
0
6
74
521
1.51
2.53
3.2
2.7
1.09
1.12
e6/l
0.02
41
289
95
705
1.45
2.51
1.8
1.7
1.50
1.17
mg/l
0.37
74
549
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
19
89
2.19
2.49
2.4
2.2
0.35
0.37
u/ml
0.10
11
51
8
21
3.86
2.47
1.1
1.6
—
—
—
0
0
13
51
2.60
2.47
1.5
3.1
—
1179.17
—
0
6
47
300
1.64
2.44
2.4
2.4
30.19
34.35
u/l
0.44
42
251
81
586
1.48
2.43
1.4
1.3
14.30
36.40
iu/ml
3.09
20
198
165
1356
1.37
2.41
2.4
2.3
76.22
77.07
nmol/l
0.16
149
1209
7
17
4.17
2.37
1.0
3.6
61.57
107.24
nmol/l
—
7
17
235
2052
1.35
2.26
3.0
3.0
—
—
—
0
0
18
86
2.14
2.26
2.0
1.5
—
—
—
0
0
99
755
1.41
2.24
1.6
1.5
19.01
20.99
nmol/l
0.80
82
627
349
3258
1.53
2.24
5.1
4.4
6.09
5.94
mmol/l
0.73
322
2980
80
589
1.45
2.19
2.0
1.7
1038.94
1239.30
nmol/l
1.15
58
443
9
30
3.04
2.16
4.1
4.9
—
—
—
0
0
124
989
1.37
2.14
4.3
3.7
19.54
7.94
mg/mmol
0.82
79
622
77
566
1.45
2.13
1.3
1.3
26.32
14.75
u/ml
0.38
27
231
8
25
3.24
2.10
1.0
1.1
—
—
—
0
0
5
10
5.05
2.07
3.2
3.1
68760.00
33670.50
ug/l
—
5
10
13
56
2.37
2.07
1.8
1.6
—
—
—
0
0
30
178
1.74
2.05
3.3
3.5
1.45
1.82
mmol/l
0.22
22
136
7
21
3.37
1.97
1.6
3.2
—
—
—
0
0
8
27
3.00
1.94
1.3
1.2
—
—
—
0
0
8
27
3.00
1.94
1.0
1.1
—
—
—
0
0
9
33
2.77
1.94
1.1
1.2
—
—
—
0
0
16
78
2.09
1.93
1.1
1.6
—
—
—
0
0
166
1403
1.31
1.90
3.0
2.7
151.45
120.18
ug/l
0.64
157
1295
28
168
1.72
1.86
2.0
1.8
—
—
—
0
0
5
12
4.20
1.83
1.0
1.4
237.40
71.83
nmol/24h
—
5
12
7
23
3.08
1.80
1.1
1.0
—
—
—
0
0
15
74
2.07
1.77
1.2
1.2
—
31.06
—
0
7
54
385
1.46
1.76
8.9
6.7
103.57
104.23
mmol/l
0.42
54
385
6
18
3.37
1.75
1.2
1.1
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
13
3.88
1.72
1.0
1.2
—
—
—
0
0
48
336
1.49
1.71
3.1
3.3
—
—
—
0
0
333
3121
1.39
1.70
6.9
5.5
40.76
39.67
mmol/mol
1.33
309
2909
8
31
2.61
1.66
1.0
1.2
—
—
—
0
0
5
14
3.60
1.62
1.8
5.8
—
—
—
0
0
110
896
1.31
1.61
2.8
3.1
1094.04
1270.70
ng/l
0.26
92
758
246
2223
1.27
1.57
3.5
2.9
46.01
47.56
u/l
0.16
229
2084
14
71
2.01
1.55
1.4
1.3
—
—
—
0
0
15
81
1.88
1.42
1.4
1.2
—
—
—
0
0
354
3382
1.38
1.33
5.3
4.8
2.80
2.81
mmol/l
0.15
330
3131
21
129
1.66
1.32
1.7
1.8
0.44
1.41
ug/l
1.48
16
117
359
3440
1.40
1.30
23.9
15.2
3.95
3.96
mmol/l
0.54
354
3339
5
18
2.80
1.29
1.0
1.7
—
—
—
0
0
5
18
2.80
1.29
1.0
1.7
—
—
—
0
0
333
3160
1.31
1.25
19.8
12.2
81.58
81.04
ml/min/173m2
0.17
293
2597
17
101
1.71
1.21
1.2
1.3
281.89
316.88
ug/g
—
9
54
16
94
1.73
1.19
1.1
1.2
—
—
—
0
0
23
150
1.57
1.17
1.1
1.0
—
—
—
0
0
13
73
1.81
1.12
1.1
1.7
—
—
—
0
0
13
73
1.81
1.12
1.7
1.2
—
—
—
0
0
13
73
1.81
1.12
2.4
2.3
8.42
7.88
kpa
0.82
13
73
13
73
1.81
1.12
1.1
1.7
—
—
—
0
0
346
3314
1.31
1.10
4.7
4.4
4.73
4.75
mmol/l
0.09
326
3090
7
32
2.21
1.08
1.0
1.9
—
—
—
0
0
7
32
2.21
1.08
1.0
1.9
—
—
—
0
0
7
33
2.14
1.06
3.0
2.4
—
—
—
0
0
19
122
1.58
1.04
2.3
1.9
—
—
—
0
0
11
60
1.86
1.03
3.8
3.7
52.27
60.58
%
1.49
11
60
47
363
1.33
1.02
1.9
2.3
6.19
7.91
umol/l
0.60
41
312
5
109
0.45
1.02
2.2
1.5
—
—
—
0
0
333
3183
1.27
1.01
4.3
3.9
1.50
1.31
mmol/l
3.63
301
2933
13
76
1.73
1.00
1.0
1.1
—
—
—
0
0
9
49
1.86
0.99
1.1
1.6
—
—
—
0
0
5
23
2.19
0.98
1.2
1.2
—
—
—
0
0
5
23
2.19
0.98
1.2
1.2
—
—
—
0
0
7
36
1.96
0.97
1.6
2.9
2.34
3.85
nmol/l
—
7
36
14
85
1.67
0.95
1.1
1.3
138.38
235.94
miu/ml
—
8
40
379
3694
1.44
0.94
30.5
19.4
256.03
252.25
e9/l
0.45
370
3600
103
887
1.22
0.93
4.4
3.8
0.00
0.00
estimate
0.50
45
310
10
55
1.84
0.93
1.1
1.6
—
—
—
0
0
379
3697
1.42
0.90
30.5
19.4
4.43
4.49
e12/l
1.40
369
3596
6
29
2.08
0.89
1.8
1.9
—
—
—
0
0
17
111
1.55
0.89
2.4
1.8
—
—
—
0
0
10
56
1.81
0.88
1.2
1.2
—
—
—
0
0
367
3564
1.33
0.88
14.2
9.8
26.16
26.28
u/l
0.05
358
3430
8
44
1.83
0.86
1.0
1.7
—
—
—
0
0
16
104
1.56
0.86
1.8
2.0
—
—
—
0
0
8
45
1.79
0.84
1.0
1.8
—
—
—
0
0
8
45
1.79
0.84
1.0
1.8
—
—
—
0
0
10
57
1.77
0.84
2.7
3.4
3.35
4.88
e9/l
—
10
57
19
130
1.48
0.82
1.5
1.3
32.67
26.96
iu/l
0.26
13
110
342
3301
1.24
0.80
4.7
4.4
1.44
1.50
mmol/l
1.77
313
3061
6
33
1.83
0.79
1.0
1.6
—
—
—
0
0
6
33
1.83
0.79
1.0
1.1
—
—
—
0
0
35
270
1.32
0.79
3.7
3.7
1.23
1.23
mmol/l
0.22
29
233
44
353
1.28
0.76
4.9
4.1
266.65
37.75
ug/l
0.42
35
298
5
24
2.10
0.74
1.2
1.2
—
—
—
0
0
5
24
2.10
0.74
1.2
1.2
—
—
—
0
0
5
24
2.10
0.74
1.2
1.2
—
—
—
0
0
7
38
1.86
0.74
1.1
1.6
—
—
—
0
0
142
1284
1.16
0.73
4.0
3.6
—
—
—
0
0
9
56
1.62
0.73
1.1
1.7
—
—
—
0
0
7
40
1.76
0.71
1.6
1.2
—
—
—
0
0
80
693
1.19
0.69
1.8
1.7
424.93
12652087.43
pmol/l
0.50
68
577
377
3692
1.33
0.68
31.1
19.4
39.81
40.19
%
0.60
360
3460
13
86
1.53
0.67
2.4
2.5
25.06
25.31
mmol/l
0.06
13
86
5
28
1.80
0.66
1.0
1.7
—
—
—
0
0
25
189
1.34
0.66
1.4
1.4
—
—
—
0
0
5
29
1.73
0.64
1.2
1.5
—
—
—
0
0
5
29
1.73
0.64
1.6
1.5
—
—
—
0
0
84
738
1.17
0.62
1.4
1.3
1.43
2.21
u/ml
0.45
24
213
8
50
1.61
0.61
1.0
1.6
—
—
—
0
0
12
80
1.52
0.60
1.2
1.1
—
—
—
0
0
6
40
1.51
0.52
1.0
1.1
—
—
—
0
0
92
828
1.14
0.51
4.6
4.3
2.40
2.38
ug/l
0.01
86
739
32
262
1.24
0.50
2.6
2.6
59.60
66.23
ml/min/173m2
0.48
15
99
7
47
1.50
0.48
1.1
1.6
—
—
—
0
0
7
47
1.50
0.48
1.4
1.3
6.71
7.34
mmol/l
—
7
38
12
85
1.42
0.47
1.9
2.1
698.00
49.71
ug/min
—
6
49
17
129
1.33
0.46
1.8
1.8
—
—
—
0
0
11
77
1.44
0.46
1.5
1.4
—
—
—
0
0
5
31
1.62
0.43
1.0
1.1
—
—
—
0
0
16
122
1.32
0.43
2.2
3.3
13.64
1422.87
u/ml
0.65
11
102
10
70
1.44
0.42
1.0
1.1
—
16.24
—
0
5
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
5
35
1.43
0.39
1.6
1.3
—
—
—
0
0
26
215
1.22
0.39
3.5
2.6
78.82
69.21
u/ml
0.08
26
209
60
536
1.14
0.38
1.3
1.5
—
—
—
0
0
5
36
1.39
0.38
1.2
1.4
—
—
—
0
0
5
36
1.39
0.38
1.2
1.4
—
—
—
0
0
20
161
1.25
0.38
1.6
1.4
—
—
—
0
0
5
37
1.36
0.37
1.2
1.4
—
—
—
0
0
5
37
1.36
0.37
1.2
1.4
—
—
—
0
0
5
37
1.36
0.37
1.2
1.4
—
—
—
0
0
5
37
1.36
0.37
1.2
1.4
—
—
—
0
0
98
906
1.11
0.36
1.6
1.6
1.45
1.40
mmol/l
0.31
82
760
12
91
1.33
0.34
1.2
1.2
—
—
—
0
0
12
92
1.31
0.32
1.2
1.2
—
—
—
0
0
7
53
1.33
0.31
1.0
1.3
—
—
—
0
0
11
84
1.32
0.30
3.2
2.4
1.76
1.53
mg/l
0.35
11
76
13
102
1.28
0.30
1.5
1.7
—
—
—
0
0
8
106
0.75
0.29
2.0
1.6
—
—
—
0
0
8
67
1.20
0.26
1.8
1.3
—
—
—
0
0
27
308
0.87
0.25
2.0
1.7
—
—
—
0
0
31
274
1.14
0.25
1.9
2.3
6.30
6.32
ug/l
0.01
24
251
13
106
1.23
0.23
1.4
1.4
—
—
—
0
0
71
664
1.08
0.22
4.3
3.8
21.58
21.89
%
0.05
31
303
5
41
1.22
0.22
1.6
2.1
—
—
—
0
0
13
107
1.22
0.22
1.7
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
11
0.00
0.21
0.0
3.2
—
117.09
—
0
11
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
6
48
1.25
0.20
1.2
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
6
49
1.23
0.20
1.3
1.0
—
—
—
0
0
6
52
1.16
0.19
2.7
2.0
—
—
—
0
0
37
402
0.91
0.17
4.8
4.5
33.52
32.57
%
0.23
31
266
9
82
1.10
0.15
5.7
3.8
55.89
28.24
u/ml
—
9
82
5
44
1.14
0.10
1.0
1.0
—
—
—
0
0
16
176
0.91
0.09
2.9
2.6
1.25
0.15
e6/l
0.50
16
167
5
62
0.80
0.08
2.0
1.6
—
—
—
0
0
41
401
1.02
0.02
8.5
7.4
—
—
—
0
0
29
284
1.02
0.00
2.0
1.8
—
—
—
0
0
48
482
1.00
0.00
3.3
2.6
0.55
0.76
ug/l
2.09
30
301
25
251
1.00
0.00
1.8
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
106.83
—
0
6
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
8
0.00
-0.00
0.0
1.0
—
138.88
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
1.27
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
27.74
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
42.63
—
0
8
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_EXOPTHALMUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_EXOPTHALMUS | 1.549 [1.32, 1.81] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.273 |
During the follow-up period (1.1.1998 — 31.12.2019), 278 out of 1435 females with H7_EXOPTHALMUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_EXOPTHALMUS | 1.813 [1.45, 2.26] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 235 out of 830 males with H7_EXOPTHALMUS died.
Mortality risk
Mortality risk for people of age
years, who have H7_EXOPTHALMUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.196% | 0.362% |
| 5 | 1.061% | 2.038% |
| 10 | 2.346% | 4.945% |
| 15 | 4.535% | 8.688% |
| 20 | 7.683% | 14.48% |
Relationships between endpoints
↥Index endpoint: H7_EXOPTHALMUS – Exophthalmic conditions
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data