No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
387 |
4. Check minimum number of eventsNone |
387 |
5. Include endpointsNone |
387 |
6. Filter based on genotype QC (FinnGen only) |
387 |
Control definitions (FinnGen only)
- Control exclude
- H7_LIDLACRIMALORBIT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H05
- Name in latin
- Exophthalmus
Similar endpoints
↥List of similar endpoints to
Exophthalmic conditions
based on the number of shared cases.
Similar with more cases:
- Disorders of orbit
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2738 | 1729 | 982 |
| Only index persons | 2452 | 1594 | 858 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.03 |
| Only index persons | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 55.09 | 55.33 | 54.47 |
| Only index persons | 54.37 | 54.68 | 53.79 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 387 | 253 | 134 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.06 |
| Median age at first event (years) | 52.25 | 52.15 | 52.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 343
- Matched controls
- 3428
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H05.2
ICD-10 Finland
Exophthalmic conditions
+∞
323.0
317
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
87.3
80
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
34.3
75.4
99
40
H03BB01
ATC
carbimazole; oral
16.0
44.7
75
59
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
4.9
42.4
221
918
H03AA01
ATC
levothyroxine sodium; systemic
4.7
36.0
160
536
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
18.3
35.8
56
36
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
133.5
34.4
36
*
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
+∞
31.8
30
*
H062, E050
ICD-10 Finland
NA
+∞
30.7
29
*
104
Kela drug reimbursment
Thyroid insufficiency
7.3
29.1
75
127
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.9
28.8
110
302
H04.10
ICD-10 Finland
Dry eye syndrome
10.0
28.5
59
70
H53.2
ICD-10 Finland
Diplopia
13.8
27.5
48
40
CAC30
NOMESCO Finland
Decompression of orbit to sinuses
+∞
26.4
25
*
XCK00
NOMESCO Finland
Perimetry
8.2
26.2
61
88
BAA60
NOMESCO Finland
Total thyroidectomy
16.1
24.1
39
27
H02.3
ICD-10 Finland
Blepharochalasis
85.8
22.0
24
*
H50.2
ICD-10 Finland
Vertical strabismus
44.8
20.7
25
6
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
+∞
20.0
19
*
CAA30
NOMESCO Finland
Biopsy of orbit
+∞
20.0
19
*
H02.4
ICD-10 Finland
Ptosis of eyelid
111.5
19.8
21
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
11.6
17.9
33
31
D31.6
ICD-10 Finland
Benign neoplasm: Orbit, unspecified
+∞
17.9
17
*
3763A
ICD-9 Finland
Disorders of the orbit, Other exophthalmic conditions
+∞
16.8
16
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
14.4
16.8
28
21
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.2
16.7
68
190
H02AB06
ATC
prednisolone; systemic
2.6
16.0
192
1129
XCD10
NOMESCO Finland
Electrophysiological examination of eye
13.8
16.0
27
21
XCK10
NOMESCO Finland
Photography of fundus of eye
4.2
15.0
61
169
H05.1
ICD-10 Finland
Chronic inflammatory disorders of orbit
+∞
14.7
14
*
3762A
ICD-9 Finland
Disorders of the orbit, Endocrine exophthalmos
+∞
13.6
13
*
A02BC02
ATC
pantoprazole; systemic
2.5
13.2
246
1738
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
23.6
13.0
18
8
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
12.9
144
782
H05.0
ICD-10 Finland
Acute inflammation of orbit
+∞
12.6
12
*
CA1DG
NOMESCO Finland
Eye and orbita very extensive MRI examination with high intensity magnet
+∞
12.6
12
*
H02AB07
ATC
prednisone; oral
3.1
12.0
72
272
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.2
11.7
46
123
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
67.3
11.7
13
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.3
11.2
151
885
ZXE10
NOMESCO Finland
More than one and less than three hours
2.3
11.2
145
835
CAC44
NOMESCO Finland
Combined decompression of orbit
+∞
10.5
10
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
10.4
83
371
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
6.0
10.4
28
50
ZXA10
NOMESCO Finland
Bilateral
2.7
10.1
77
335
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.2
10.1
126
707
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
17.3
10.0
15
9
CAB00
NOMESCO Finland
Anterior orbitotomy with excision of lesion
+∞
9.4
9
*
CA1BD
NOMESCO Finland
Extensive orbita CT
+∞
9.4
9
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
9.1
108
585
H57.1
ICD-10 Finland
Ocular pain
6.6
8.9
22
35
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
51.3
8.7
10
*
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
12.0
8.6
15
13
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.8
8.6
59
238
Z3231
NOMESCO Finland
Registered nurse
2.2
8.4
104
572
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.4
8.4
40
127
CBK00
NOMESCO Finland
Myotomy or resection of tarsal muscle or levator muscle of eyelid for correction of retraction
+∞
8.4
8
*
ZXA05
NOMESCO Finland
Left side
2.2
8.2
97
521
AA1AD
NOMESCO Finland
CT of head and brain
2.3
8.1
89
461
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
34.2
8.1
10
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.0
7.9
31
84
ZXE20
NOMESCO Finland
More than three and less than five hours
2.6
7.8
59
255
2420A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic diffuse goitre
46.0
7.7
9
*
UDM02
NOMESCO Finland
Sinoscopy
6.4
7.7
19
31
ZXE00
NOMESCO Finland
One hour or less
1.9
7.6
139
890
C07AA05
ATC
propranolol; systemic
2.3
7.5
76
380
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
81.7
7.4
8
*
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
81.7
7.4
8
*
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
8.7
7.4
15
18
E03.89
ICD-10 Finland
Other specified hypothyroidism
4.9
7.3
23
50
H02.1
ICD-10 Finland
Ectropion of eyelid
+∞
7.3
7
*
CAC20
NOMESCO Finland
Lateral decompression of orbit
+∞
7.3
7
*
H02.5
ICD-10 Finland
Other disorders affecting eyelid function
+∞
7.3
7
*
H50.1
ICD-10 Finland
Divergent concomitant strabismus
14.1
6.9
11
8
S01GX01
ATC
cromoglicic acid; ophthalmic
2.2
6.9
73
370
CEC00
NOMESCO Finland
Recession of extraocular muscle
17.1
6.8
10
6
WX002
NOMESCO Finland
Sedation and analgesia
2.2
6.7
75
391
CD2S4
NOMESCO Finland
Photography of eye
23.0
6.7
9
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
6.7
148
1003
R51.80
ICD-10 Finland
Headache
2.5
6.5
53
234
CS494
NOMESCO Finland
Other visual field testing
7.6
6.5
14
19
CA1AD
NOMESCO Finland
Orbita CT
71.1
6.4
7
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.7
6.3
20
45
CBH30
NOMESCO Finland
Tarsorraphy
+∞
6.3
6
*
CBB10
NOMESCO Finland
Excision of redundant skin of eyelid
+∞
6.3
6
*
CAB10
NOMESCO Finland
Lateral orbitotomy with excision of lesion
+∞
6.3
6
*
CBJ40
NOMESCO Finland
Resection of levator muscle of eyelid
+∞
6.3
6
*
H50.6
ICD-10 Finland
Mechanical strabismus
+∞
6.3
6
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
6.2
59
287
J45.9
ICD-10 Finland
Asthma, unspecified
2.2
6.2
63
316
Z3229
NOMESCO Finland
Other healthcare associate professional
3.0
6.1
35
127
H02AB04
ATC
methylprednisolone; systemic
2.2
6.1
62
310
Mortality – FinRegistry
↥Association
Association between endpoint H7_EXOPTHALMUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_EXOPTHALMUS | 1.549 [1.32, 1.81] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.273 |
During the follow-up period (1.1.1998 — 31.12.2019), 278 out of 1435 females with H7_EXOPTHALMUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_EXOPTHALMUS | 1.813 [1.45, 2.26] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 235 out of 830 males with H7_EXOPTHALMUS died.
Mortality risk
Mortality risk for people of age
years, who have H7_EXOPTHALMUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.196% | 0.362% |
| 5 | 1.061% | 2.038% |
| 10 | 2.346% | 4.945% |
| 15 | 4.535% | 8.688% |
| 20 | 7.683% | 14.48% |
Relationships between endpoints
↥Index endpoint: H7_EXOPTHALMUS – Exophthalmic conditions
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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