≡ Risteys
FG R12 + FR

Documentation Changelog GitHub Contact & Feedback

Exophthalmic conditions

DOID EFO Endpoint Browser PheWeb

H7_EXOPTHALMUS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H05.2
  • Hospital discharge: ICD-9 — 376[2-3]
  • Cause of death: ICD-10 — H05.2
  • Cause of death: ICD-9 — 376[2-3]

2 out of 7 registries used, show all original rules.

387

4. Check minimum number of events

None

387

5. Include endpoints

None

387

6. Filter based on genotype QC (FinnGen only)

387

Control definitions (FinnGen only)

Control exclude
H7_LIDLACRIMALORBIT

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H05
Name in latin
Exophthalmus

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2738 1729 982
Only index persons 2452 1594 858
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.03
Only index persons 0.05 0.06 0.03
Median age at first event (years)
Whole population 55.09 55.33 54.47
Only index persons 54.37 54.68 53.79

-FinnGen-

Key figures

All Female Male
Number of individuals 387 253 134
Unadjusted period prevalence (%) 0.08 0.09 0.06
Median age at first event (years) 52.25 52.15 52.44

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
343
Matched controls
3428
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H05.2
ICD-10 Finland
Exophthalmic conditions
+∞
323.0
317
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
87.3
80
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
34.3
75.4
99
40
H03BB01
ATC
carbimazole; oral
16.0
44.7
75
59
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
4.9
42.4
221
918
H03AA01
ATC
levothyroxine sodium; systemic
4.7
36.0
160
536
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
18.3
35.8
56
36
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
133.5
34.4
36
*
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
+∞
31.8
30
*
H062, E050
ICD-10 Finland
NA
+∞
30.7
29
*
104
Kela drug reimbursment
Thyroid insufficiency
7.3
29.1
75
127
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.9
28.8
110
302
H04.10
ICD-10 Finland
Dry eye syndrome
10.0
28.5
59
70
H53.2
ICD-10 Finland
Diplopia
13.8
27.5
48
40
CAC30
NOMESCO Finland
Decompression of orbit to sinuses
+∞
26.4
25
*
XCK00
NOMESCO Finland
Perimetry
8.2
26.2
61
88
BAA60
NOMESCO Finland
Total thyroidectomy
16.1
24.1
39
27
H02.3
ICD-10 Finland
Blepharochalasis
85.8
22.0
24
*
H50.2
ICD-10 Finland
Vertical strabismus
44.8
20.7
25
6
CAA30
NOMESCO Finland
Biopsy of orbit
+∞
20.0
19
*
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
+∞
20.0
19
*
H02.4
ICD-10 Finland
Ptosis of eyelid
111.5
19.8
21
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
11.6
17.9
33
31
D31.6
ICD-10 Finland
Benign neoplasm: Orbit, unspecified
+∞
17.9
17
*
3763A
ICD-9 Finland
Disorders of the orbit, Other exophthalmic conditions
+∞
16.8
16
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
14.4
16.8
28
21
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.2
16.7
68
190
H02AB06
ATC
prednisolone; systemic
2.6
16.0
192
1129
XCD10
NOMESCO Finland
Electrophysiological examination of eye
13.8
16.0
27
21
XCK10
NOMESCO Finland
Photography of fundus of eye
4.2
15.0
61
169
H05.1
ICD-10 Finland
Chronic inflammatory disorders of orbit
+∞
14.7
14
*
3762A
ICD-9 Finland
Disorders of the orbit, Endocrine exophthalmos
+∞
13.6
13
*
A02BC02
ATC
pantoprazole; systemic
2.5
13.2
246
1738
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
23.6
13.0
18
8
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
12.9
144
782
CA1DG
NOMESCO Finland
Eye and orbita very extensive MRI examination with high intensity magnet
+∞
12.6
12
*
H05.0
ICD-10 Finland
Acute inflammation of orbit
+∞
12.6
12
*
H02AB07
ATC
prednisone; oral
3.1
12.0
72
272
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.2
11.7
46
123
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
67.3
11.7
13
*
CAC44
NOMESCO Finland
Combined decompression of orbit
+∞
10.5
10
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
10.4
83
371
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
6.0
10.4
28
50
ZXA10
NOMESCO Finland
Bilateral
2.7
10.1
77
335
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.2
10.1
126
707
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
17.3
10.0
15
9
CAB00
NOMESCO Finland
Anterior orbitotomy with excision of lesion
+∞
9.4
9
*
CA1BD
NOMESCO Finland
Extensive orbita CT
+∞
9.4
9
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
9.1
108
585
H57.1
ICD-10 Finland
Ocular pain
6.6
8.9
22
35
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
51.3
8.7
10
*
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
12.0
8.6
15
13
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.8
8.6
59
238
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.4
8.4
40
127
CBK00
NOMESCO Finland
Myotomy or resection of tarsal muscle or levator muscle of eyelid for correction of retraction
+∞
8.4
8
*
ZXA05
NOMESCO Finland
Left side
2.2
8.2
97
521
AA1AD
NOMESCO Finland
CT of head and brain
2.3
8.1
89
461
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
34.2
8.1
10
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.0
7.9
31
84
2420A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic diffuse goitre
46.0
7.7
9
*
UDM02
NOMESCO Finland
Sinoscopy
6.4
7.7
19
31
C07AA05
ATC
propranolol; systemic
2.3
7.5
76
380
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
81.7
7.4
8
*
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
81.7
7.4
8
*
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
8.7
7.4
15
18
E03.89
ICD-10 Finland
Other specified hypothyroidism
4.9
7.3
23
50
H02.5
ICD-10 Finland
Other disorders affecting eyelid function
+∞
7.3
7
*
H02.1
ICD-10 Finland
Ectropion of eyelid
+∞
7.3
7
*
CAC20
NOMESCO Finland
Lateral decompression of orbit
+∞
7.3
7
*
H50.1
ICD-10 Finland
Divergent concomitant strabismus
14.1
6.9
11
8
S01GX01
ATC
cromoglicic acid; ophthalmic
2.2
6.9
73
370
CEC00
NOMESCO Finland
Recession of extraocular muscle
17.1
6.8
10
6
WX002
NOMESCO Finland
Sedation and analgesia
2.2
6.7
75
391
CD2S4
NOMESCO Finland
Photography of eye
23.0
6.7
9
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
6.7
148
1003
R51.80
ICD-10 Finland
Headache
2.5
6.5
53
234
CS494
NOMESCO Finland
Other visual field testing
7.6
6.5
14
19
CA1AD
NOMESCO Finland
Orbita CT
71.1
6.4
7
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.7
6.3
20
45
CBH30
NOMESCO Finland
Tarsorraphy
+∞
6.3
6
*
CBJ40
NOMESCO Finland
Resection of levator muscle of eyelid
+∞
6.3
6
*
CBB10
NOMESCO Finland
Excision of redundant skin of eyelid
+∞
6.3
6
*
H50.6
ICD-10 Finland
Mechanical strabismus
+∞
6.3
6
*
CAB10
NOMESCO Finland
Lateral orbitotomy with excision of lesion
+∞
6.3
6
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
6.2
59
287
J45.9
ICD-10 Finland
Asthma, unspecified
2.2
6.2
63
316
H02AB04
ATC
methylprednisolone; systemic
2.2
6.1
62
310

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
83
76
13.63
80.86
2.8
1.6
3.0
5.3
iu/l
0.79
37
24
35
47
8.09
25.02
2.2
1.9
1.0
0.9
g/l
0.19
27
41
327
2465
3.11
15.46
7.2
3.9
15.3
14.8
pmol/l
2.85
307
2236
18
28
6.69
11.19
1.6
1.3
—
—
—
0
0
249
1792
2.09
10.74
11.5
8.9
4.3
4.1
e9/l
1.03
221
1570
157
962
2.06
10.49
8.0
5.2
—
—
—
0
0
17
28
6.30
10.01
1.6
1.3
3.0
2.8
g/l
0.19
11
22
17
28
6.30
10.01
1.6
1.3
6.1
6.0
g/l
0.05
11
22
17
28
6.30
10.01
1.6
1.3
0.3
0.3
g/l
0.40
11
22
63
271
2.58
9.73
3.0
1.9
305.4
387.4
nmol/l
2.91
57
251
211
1464
1.97
9.68
7.7
5.6
26.9
28.0
%
0.70
197
1362
216
1518
1.96
9.47
8.1
6.7
1.2
1.2
mmol/l
0.09
184
1284
207
1444
1.93
9.17
7.5
5.4
58.2
57.4
%
0.45
195
1350
219
1568
1.91
8.85
7.2
5.4
1.9
1.9
e9/l
0.03
200
1385
213
1519
1.89
8.64
7.1
5.4
0.6
0.6
e9/l
2.20
187
1316
197
1374
1.88
8.52
7.9
5.5
0.7
0.7
%
0.07
185
1271
213
1529
1.87
8.36
7.3
5.5
0.0
0.0
e9/l
1.42
188
1324
201
1421
1.86
8.24
7.9
5.5
2.9
2.8
%
0.06
186
1323
197
1386
1.86
8.18
7.5
5.7
1.2
1.2
mmol/l
0.22
182
1258
13
20
6.69
8.11
1.2
1.1
—
—
—
0
0
218
1588
1.85
8.05
7.6
5.7
0.2
0.2
e9/l
0.62
197
1404
124
759
1.93
7.88
7.9
6.4
—
—
—
0
0
200
1429
1.83
7.77
8.3
5.8
8.9
8.5
%
1.02
189
1339
342
2932
2.43
7.54
8.4
4.6
1.8
2.3
mu/l
0.58
322
2676
11
16
7.05
7.18
1.5
3.2
4117.5
795.1
u/ml
0.42
11
16
50
228
2.37
6.77
7.9
8.3
—
—
—
0
0
14
29
4.97
6.50
2.1
1.4
—
—
—
0
0
232
1818
1.69
5.83
5.6
4.4
6.7
6.6
mmol/l
0.07
220
1688
179
1317
1.67
5.68
5.2
4.3
34.9
35.7
g/l
1.13
168
1227
141
975
1.70
5.66
2.5
2.2
—
—
—
0
0
18
53
3.51
5.37
1.2
1.3
—
—
—
0
0
24
85
2.94
5.35
4.0
1.9
37.5
38.1
g/l
0.32
24
74
118
790
1.71
5.27
3.4
2.9
—
—
—
0
0
74
432
1.88
5.23
1.9
1.9
29.0
29.6
s
0.45
67
420
41
193
2.26
5.16
3.3
2.5
—
—
—
0
0
89
555
1.78
5.08
4.5
3.7
652.0
225.1
ng/l
0.52
74
420
170
1262
1.62
5.04
2.1
2.0
—
—
—
0
0
51
265
2.06
5.02
1.5
1.4
—
—
—
0
0
94
603
1.74
4.85
2.4
2.5
4.4
5.4
e6/l
0.37
81
542
144
1041
1.61
4.68
4.7
3.6
91.7
107.1
e6/l
0.14
103
737
119
821
1.65
4.66
3.4
3.0
0.3
0.4
e6/l
0.62
92
611
70
416
1.83
4.66
1.5
1.3
437.3
510.5
titre
0.24
15
93
76
464
1.79
4.63
3.9
3.4
0.8
0.8
mmol/l
0.09
71
432
162
1211
1.58
4.54
2.1
2.0
96.9
96.8
pmol/l
0.01
87
613
131
932
1.61
4.52
2.6
2.0
187.9
184.7
u/l
0.03
124
876
57
322
1.90
4.43
8.2
9.2
2.0
1.3
mmol/l
0.78
45
260
114
787
1.64
4.43
5.6
4.0
—
—
—
0
0
279
2373
1.63
4.41
5.4
3.9
14.3
11.8
mm/h
1.86
264
2184
70
424
1.79
4.37
2.1
1.9
—
—
—
0
0
29
129
2.35
4.17
3.9
2.7
25.7
24.3
mmol/l
1.48
29
115
125
894
1.59
4.16
3.6
3.1
42.4
67.2
e6/l
0.48
95
682
58
340
1.83
4.02
1.9
1.6
—
—
—
0
0
184
1446
1.52
3.97
4.2
4.0
—
—
—
0
0
42
223
1.99
3.91
1.8
2.9
205.4
178.0
ng/l
0.16
35
204
253
2136
1.53
3.83
5.7
4.0
—
—
—
0
0
127
929
1.55
3.78
5.3
3.8
7.4
7.4
ph
0.49
22
179
14
45
3.19
3.68
1.4
1.5
63.0
56.7
%
0.47
14
45
11
30
3.74
3.66
1.1
1.0
—
—
—
0
0
160
1239
1.50
3.61
12.1
7.7
1.2
1.2
inr
0.30
48
377
194
1562
1.49
3.61
5.3
4.8
0.0
0.0
estimate
0.50
44
295
86
580
1.62
3.60
2.7
2.6
538.4
552.1
mosm/kgh2o
0.25
72
506
9
17
5.39
3.53
1.2
1.2
—
—
—
0
0
141
1068
1.50
3.53
4.3
3.4
2.4
2.4
mmol/l
0.78
123
924
11
31
3.62
3.50
1.0
1.3
—
—
nmol/l
—
0
0
348
3200
1.87
3.45
20.9
12.9
24.3
22.9
mg/l
0.30
291
2498
51
304
1.78
3.36
1.5
1.5
—
—
—
0
0
90
625
1.57
3.32
1.4
1.5
2.4
2.5
g/l
0.05
51
388
65
417
1.67
3.30
1.2
1.2
—
—
—
0
0
193
1578
1.44
3.18
3.8
3.6
0.1
0.0
estimate
0.40
39
287
280
2460
1.50
3.15
10.1
6.9
79.6
78.5
u/l
0.18
265
2288
190
1553
1.44
3.12
3.8
3.5
0.0
0.0
estimate
0.00
41
299
28
140
2.08
3.09
11.5
14.0
—
—
—
0
0
10
29
3.51
3.06
1.4
1.4
—
—
—
0
0
129
984
1.47
3.04
2.7
2.4
57.7
56.4
u/l
0.15
124
910
40
229
1.83
3.01
1.5
1.2
159.3
137.1
iu/ml
0.15
13
100
122
923
1.47
2.99
3.6
3.0
7.1
7.5
mmol/l
0.36
101
776
20
88
2.34
2.99
1.7
1.5
304.2
276.1
mu/l
0.29
20
82
10
30
3.40
2.92
1.0
1.0
1.1
9.3
u/ml
—
5
7
45
270
1.75
2.91
3.5
3.0
3.3
2.2
mmol/l
0.95
36
213
15
58
2.65
2.91
2.3
2.5
—
—
—
0
0
24
116
2.14
2.89
1.9
2.3
1.6
1.4
g/l
0.31
19
104
97
706
1.50
2.87
4.0
3.5
—
—
—
0
0
201
1677
1.41
2.86
7.1
5.8
10.7
10.8
umol/l
0.02
194
1593
81
570
1.53
2.80
3.5
2.9
2.5
2.4
mmol/l
2.76
66
503
7
15
4.73
2.61
1.0
3.7
61.6
113.2
nmol/l
—
7
15
45
280
1.69
2.57
3.6
3.0
—
—
—
0
0
10
33
3.08
2.54
1.0
1.3
—
—
—
0
0
121
939
1.42
2.53
3.5
3.0
—
—
—
0
0
58
387
1.59
2.53
1.6
1.6
—
—
—
0
0
34
196
1.81
2.53
1.3
1.4
—
—
—
0
0
52
338
1.62
2.52
1.8
1.6
—
—
—
0
0
9
26
3.52
2.49
3.0
4.6
—
—
—
0
0
40
245
1.71
2.43
2.5
2.9
67.6
71.1
e9/l
0.34
28
191
169
1399
1.37
2.38
11.7
8.9
0.0
0.0
e9/l
0.36
139
1143
105
804
1.42
2.35
2.7
2.5
342.9
8630.9
umol/l
4.12
94
697
146
1184
1.37
2.33
3.5
3.4
49.2
43.7
ng/l
0.14
94
816
96
730
1.42
2.23
2.2
2.1
3.0
3.1
mg/l
0.17
87
622
30
175
1.77
2.17
1.6
1.8
—
—
—
0
0
334
3116
1.52
2.16
5.1
4.4
6.1
5.9
mmol/l
0.71
307
2851
22
116
1.95
2.15
1.1
1.1
—
—
—
0
0
66
470
1.49
2.15
1.7
1.7
—
—
—
0
0
27
153
1.82
2.14
2.4
2.5
—
—
—
0
0
17
82
2.12
2.10
2.1
3.0
—
—
—
0
0
19
96
2.03
2.09
2.3
3.3
0.5
0.2
g/l
0.65
12
36
90
684
1.41
2.09
1.8
1.7
1.6
1.2
mg/l
0.41
69
533
110
868
1.37
2.04
3.9
3.1
561.5
205.5
mg/l
0.33
75
551
12
50
2.44
2.04
1.5
1.2
—
—
—
0
0
116
924
1.36
2.03
4.5
3.9
12.9
8.1
mg/mmol
0.61
76
581
77
572
1.43
2.02
1.4
1.3
14.3
37.1
iu/ml
3.16
20
186
77
572
1.43
2.02
2.1
1.7
1054.8
1245.1
nmol/l
1.03
56
429
93
722
1.38
1.90
4.5
4.8
—
—
—
0
0
19
100
1.95
1.89
1.6
1.6
—
—
—
0
0
39
255
1.59
1.88
3.5
4.8
1.1
1.0
%
0.16
14
76
37
240
1.60
1.84
3.5
4.9
0.0
0.1
%
2.24
12
67
34
216
1.63
1.84
1.4
1.3
—
—
—
0
0
43
291
1.54
1.79
1.6
1.5
—
—
—
0
0
73
551
1.40
1.76
1.4
1.3
28.3
13.2
u/ml
0.49
25
224
8
31
2.61
1.66
1.0
1.2
—
—
—
0
0
158
1348
1.29
1.66
3.1
2.7
151.2
121.1
ug/l
0.58
149
1241
91
720
1.35
1.64
1.5
1.5
19.2
21.1
nmol/l
0.70
74
597
5
14
3.60
1.62
1.2
2.0
—
—
—
0
0
52
375
1.45
1.61
18.2
22.0
1.5
1.3
inr
—
5
57
35
232
1.56
1.61
3.5
4.9
0.0
1.7
%
0.60
11
58
53
384
1.44
1.60
1.2
1.2
—
—
—
0
0
6
20
3.03
1.58
1.8
1.3
13.3
10.6
%
—
6
20
34
225
1.56
1.58
3.4
4.8
0.7
0.6
%
0.17
11
52
37
250
1.53
1.57
1.3
1.2
—
—
—
0
0
5
15
3.36
1.53
2.2
1.5
—
—
—
0
0
10
45
2.25
1.47
2.1
1.7
—
—
—
0
0
7
28
2.53
1.46
1.4
2.0
—
—
—
0
0
7
28
2.53
1.46
1.0
1.0
—
—
—
0
0
11
52
2.15
1.45
2.0
2.6
—
—
—
0
0
317
2987
1.34
1.41
6.8
5.5
40.8
39.6
mmol/mol
1.38
293
2787
11
53
2.11
1.40
2.0
2.5
—
—
—
0
0
17
97
1.79
1.37
1.2
1.3
281.9
314.6
ug/g
—
9
53
14
75
1.90
1.36
1.3
1.3
9.0
8.7
u/l
—
8
60
347
3321
1.43
1.36
18.6
12.2
—
—
—
0
0
32
217
1.52
1.36
3.6
3.0
4.7
4.0
e9/l
0.57
24
172
20
121
1.69
1.33
1.8
1.8
0.3
1.5
ug/l
1.82
15
109
27
178
1.56
1.30
3.3
3.0
7.4
7.4
ph
—
8
24
8
35
2.31
1.27
1.1
1.1
—
—
—
0
0
8
36
2.25
1.25
2.0
2.9
—
—
—
0
0
8
36
2.25
1.25
2.1
3.3
—
—
—
0
0
6
25
2.42
1.25
1.0
1.2
—
—
—
0
0
12
63
1.93
1.24
1.2
1.7
—
—
—
0
0
12
64
1.90
1.19
1.4
2.0
—
—
—
0
0
6
26
2.33
1.19
1.2
1.3
—
—
—
0
0
8
38
2.13
1.19
1.0
1.1
—
—
—
0
0
33
233
1.46
1.17
1.5
1.4
—
—
—
0
0
343
3294
1.36
1.14
23.7
15.0
4.0
4.0
mmol/l
0.32
338
3197
338
3239
1.34
1.14
5.3
4.8
2.8
2.8
mmol/l
0.06
314
2992
20
127
1.61
1.14
1.1
1.0
—
—
—
0
0
11
58
1.92
1.13
3.8
3.6
52.3
60.9
%
1.57
11
58
306
2899
1.27
1.09
22.9
13.9
39.6
40.1
%
0.57
232
2098
5
21
2.40
1.09
1.4
1.1
—
—
—
0
0
10
52
1.95
1.07
1.3
1.2
—
—
—
0
0
320
3053
1.28
1.04
4.3
3.9
1.5
1.3
mmol/l
3.73
290
2813
45
344
1.35
1.04
1.9
2.3
6.0
7.7
umol/l
0.58
39
296
5
22
2.29
1.03
1.6
2.0
—
—
—
0
0
14
83
1.71
1.03
1.1
1.3
138.4
243.5
miu/ml
—
8
41
7
35
2.02
1.00
1.0
1.1
—
—
—
0
0
331
3176
1.29
0.99
4.7
4.4
4.8
4.7
mmol/l
0.03
312
2954
15
92
1.66
0.98
1.3
1.2
—
—
—
0
0
35
260
1.38
0.97
1.3
1.4
—
—
—
0
0
9
50
1.82
0.97
1.6
1.8
—
—
—
0
0
10
55
1.84
0.93
2.7
3.4
3.3
5.0
e9/l
—
10
55
6
29
2.09
0.89
1.0
1.4
233.2
373.2
pmol/l
—
6
23
6
29
2.09
0.89
1.8
1.9
—
—
—
0
0
78
657
1.23
0.88
1.9
1.7
427.3
13345961.8
pmol/l
0.50
66
547
6
30
2.02
0.87
1.5
1.2
—
—
—
0
0
98
847
1.21
0.86
4.4
3.8
0.0
0.0
estimate
0.50
44
295
6
32
1.89
0.82
1.3
3.0
2.5
3.7
nmol/l
—
6
32
363
3544
1.39
0.81
30.4
19.3
256.5
252.2
e9/l
0.52
354
3457
328
3162
1.24
0.81
4.7
4.4
1.4
1.5
mmol/l
1.55
300
2928
25
182
1.40
0.80
1.2
1.2
—
—
—
0
0
11
66
1.69
0.79
4.8
4.5
—
—
—
0
0
6
33
1.83
0.79
1.2
1.5
33.2
31.9
pg
—
6
33
363
3547
1.38
0.77
30.3
19.3
4.4
4.5
e12/l
1.20
353
3454
18
124
1.47
0.76
1.6
1.3
32.7
25.8
iu/l
0.33
13
104
363
3548
1.37
0.76
30.3
19.3
7.1
6.6
e9/l
2.78
353
3458
11
67
1.66
0.76
2.0
2.3
8.3
7.9
kpa
0.48
11
61
239
2247
1.17
0.75
4.2
3.7
—
—
—
0
0
5
24
2.10
0.75
1.2
1.2
—
—
—
0
0
42
336
1.28
0.74
5.0
3.8
282.4
39.1
ug/l
0.42
33
283
7
39
1.81
0.73
1.4
1.9
—
—
—
0
0
351
3418
1.29
0.73
14.0
9.7
26.1
26.4
u/l
0.11
342
3290
10
60
1.68
0.72
4.4
2.8
—
—
—
0
0
34
266
1.30
0.71
5.9
3.5
—
—
—
0
0
14
204
0.67
0.70
1.9
1.4
—
—
—
0
0
13
85
1.55
0.70
1.2
1.3
—
—
—
0
0
13
85
1.55
0.70
1.3
1.1
—
—
—
0
0
36
285
1.29
0.69
6.2
3.8
—
—
—
0
0
5
27
1.86
0.68
2.2
2.9
—
—
—
0
0
98
866
1.18
0.68
3.4
3.3
—
—
—
0
0
46
377
1.25
0.68
1.5
1.4
—
—
—
0
0
78
678
1.19
0.66
4.0
3.8
1.0
1.0
kg/l
—
7
88
25
190
1.34
0.64
7.5
6.7
—
—
—
0
0
13
87
1.51
0.64
1.0
1.0
—
—
—
0
0
5
29
1.73
0.64
2.0
2.7
—
—
—
0
0
16
113
1.43
0.62
2.2
2.8
13.6
1509.7
u/ml
0.64
11
95
28
221
1.29
0.57
1.5
1.7
—
—
—
0
0
32
258
1.26
0.56
2.8
3.7
1.2
1.2
mmol/l
0.32
26
225
14
99
1.43
0.55
1.4
1.2
—
—
—
0
0
14
99
1.43
0.55
1.3
1.2
—
—
—
0
0
14
99
1.43
0.55
1.3
1.2
—
—
—
0
0
14
100
1.42
0.52
1.4
1.2
—
—
—
0
0
17
126
1.37
0.52
3.6
3.0
—
—
—
0
0
26
208
1.27
0.49
3.5
2.6
78.8
71.0
u/ml
0.06
26
202
95
861
1.14
0.48
1.6
1.6
1.4
1.4
mmol/l
0.18
80
727
10
68
1.48
0.47
2.2
1.2
—
—
—
0
0
7
48
1.47
0.47
1.0
1.3
—
—
—
0
0
16
120
1.35
0.47
8.6
4.4
—
—
—
0
0
11
77
1.44
0.46
1.7
2.1
837.2
49.1
ug/min
—
5
44
12
162
0.73
0.43
2.4
3.4
—
—
—
0
0
5
31
1.62
0.43
1.0
1.9
—
—
—
0
0
5
31
1.62
0.43
1.0
1.9
—
—
—
0
0
5
31
1.62
0.43
1.0
1.9
—
—
—
0
0
5
31
1.62
0.43
1.0
1.9
—
—
—
0
0
85
771
1.13
0.43
4.6
4.3
2.5
2.4
ug/l
0.04
80
685
8
58
1.39
0.41
2.3
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
4.3
—
—
—
0
0
11
79
1.40
0.41
1.4
1.2
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
8
60
1.34
0.40
1.1
1.5
—
—
—
0
0
28
334
0.83
0.40
1.1
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
2.8
—
36.6
—
0
12
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
40
345
1.18
0.39
1.2
1.3
—
—
—
0
0
78
708
1.13
0.39
1.4
1.3
1.5
2.0
u/ml
0.26
22
205
43
374
1.17
0.39
1.8
2.2
89.1
135.6
ug/g
1.35
35
297
12
90
1.34
0.36
1.2
1.2
—
—
—
0
0
6
41
1.47
0.36
1.5
1.2
—
—
—
0
0
6
46
1.31
0.33
1.2
1.2
—
—
—
0
0
99
922
1.10
0.32
4.2
3.6
—
—
—
0
0
7
100
0.69
0.31
8.0
8.7
—
—
—
0
0
17
139
1.23
0.29
1.1
1.1
—
—
—
0
0
29
254
1.15
0.26
3.2
3.3
—
—
—
0
0
88
828
1.08
0.23
1.5
1.4
—
—
—
0
0
7
92
0.76
0.22
2.9
4.2
—
—
—
0
0
10
79
1.27
0.22
3.2
2.4
1.6
1.5
mg/l
—
10
73
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
8
105
0.76
0.21
1.5
2.5
—
—
—
0
0
0
13
0.00
0.21
0.0
4.8
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
0.7
—
0
9
6
51
1.18
0.19
1.7
1.1
—
—
—
0
0
9
80
1.13
0.15
1.0
1.2
—
55.0
—
0
8
9
80
1.13
0.15
5.7
3.5
65.1
28.5
u/ml
—
9
80
28
261
1.08
0.10
2.0
2.3
6.7
6.3
ug/l
0.08
22
238
19
206
0.92
0.09
2.3
2.8
—
—
—
0
0
117
1195
0.97
0.08
3.0
2.8
—
—
—
0
0
6
70
0.85
0.07
1.5
2.0
—
—
—
0
0
14
129
1.09
0.05
1.2
1.8
—
—
—
0
0
12
128
0.94
0.02
1.2
1.2
—
—
—
0
0
45
449
1.00
0.00
3.2
2.6
0.6
0.8
ug/l
1.57
27
274
16
164
0.97
0.00
2.9
2.5
1.3
0.2
e6/l
0.50
16
155
0
5
0.00
0.00
0.0
1.0
—
20.0
—
0
5
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
1.2
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
9
98
0.92
0.00
1.3
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
2.9
—
0
8
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
20.9
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
6
59
1.02
0.00
9.0
2.8
3.1
3.2
mmol/l
—
6
37
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_EXOPTHALMUS and mortality.

Females

Parameter HR [95% CI] p-value
H7_EXOPTHALMUS 1.549 [1.32, 1.81] < 0.001
Birth year 0.995 [0.99, 1.0] 0.273

During the follow-up period (1.1.1998 — 31.12.2019), 278 out of 1435 females with H7_EXOPTHALMUS died.

Males

Parameter HR [95% CI] p-value
H7_EXOPTHALMUS 1.813 [1.45, 2.26] < 0.001
Birth year 0.984 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 235 out of 830 males with H7_EXOPTHALMUS died.

Mortality risk

Mortality risk for people of age

years, who have H7_EXOPTHALMUS.

N-year risk Females Males
1 0.196% 0.362%
5 1.061% 2.038%
10 2.346% 4.945%
15 4.535% 8.688%
20 7.683% 14.48%

Relationships between endpoints

↥

Index endpoint: H7_EXOPTHALMUS – Exophthalmic conditions

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data