No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
180 |
4. Check minimum number of eventsNone |
180 |
5. Include endpointsNone |
180 |
6. Filter based on genotype QC (FinnGen only) |
175 |
Control definitions (FinnGen only)
- Control exclude
- H7_LIDLACRIMALORBIT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified disorders of orbit
based on the number of shared cases.
Similar with more cases:
- Disorders of orbit
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1041 | 548 | 489 |
| Only index persons | 942 | 504 | 438 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 56.46 | 57.28 | 55.63 |
| Only index persons | 55.79 | 56.02 | 55.53 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 175 | 98 | 77 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | 61.74 | 60.22 | 63.66 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 180
- Matched controls
- 1800
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H05.9
ICD-10 Finland
Disorder of orbit, unspecified
+∞
107.3
92
*
H05.8
ICD-10 Finland
Other disorders of orbit
+∞
103.4
89
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
301.9
26.4
26
*
CAA30
NOMESCO Finland
Biopsy of orbit
+∞
24.5
23
*
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
93.4
15.9
17
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.1
15.6
55
175
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.5
15.6
105
511
H05.2
ICD-10 Finland
Exophthalmic conditions
+∞
14.8
14
*
H05.0
ICD-10 Finland
Acute inflammation of orbit
+∞
14.8
14
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.8
13.0
33
81
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
5.9
12.9
25
48
CA1DG
NOMESCO Finland
Eye and orbita very extensive MRI examination with high intensity magnet
139.3
12.6
13
*
H02.4
ICD-10 Finland
Ptosis of eyelid
40.6
12.4
15
*
CAB00
NOMESCO Finland
Anterior orbitotomy with excision of lesion
+∞
11.6
11
*
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
127.8
11.6
12
*
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
+∞
10.5
10
*
H02.3
ICD-10 Finland
Blepharochalasis
27.8
10.0
13
5
H04.10
ICD-10 Finland
Dry eye syndrome
4.9
9.9
23
52
F29
ICPC
Eye symptom/complaint other
3.9
9.4
31
92
XCK10
NOMESCO Finland
Photography of fundus of eye
3.8
9.1
30
89
WX140
NOMESCO Finland
Parabulbar anesthesy
5.1
9.1
20
43
ZXD10
NOMESCO Finland
Scheduled procedure
2.6
9.0
85
461
D31.6
ICD-10 Finland
Benign neoplasm: Orbit, unspecified
94.3
8.5
9
*
WX002
NOMESCO Finland
Sedation and analgesia
2.9
8.5
47
193
CAW99
NOMESCO Finland
Other operation on orbit
+∞
8.4
8
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
9.1
8.0
16
19
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.4
7.6
75
407
F01
ICPC
Eye pain
9.0
7.5
15
18
ZXA00
NOMESCO Finland
Right side
2.5
7.5
63
318
S01ED51
ATC
timolol, combinations; ophthalmic
3.9
7.4
23
65
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
7.3
7
*
CAE10
NOMESCO Finland
Revision and secondary implant in orbit
+∞
7.3
7
*
H05.1
ICD-10 Finland
Chronic inflammatory disorders of orbit
+∞
7.3
7
*
Z3229
NOMESCO Finland
Other healthcare associate professional
3.7
7.3
25
76
H53.2
ICD-10 Finland
Diplopia
6.8
7.1
17
27
H02AB06
ATC
prednisolone; systemic
2.3
7.0
98
614
H01.0
ICD-10 Finland
Blepharitis
6.6
7.0
17
28
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
4.6
6.9
17
40
J01FF01
ATC
clindamycin; systemic
2.4
6.9
62
321
H57.1
ICD-10 Finland
Ocular pain
6.1
6.6
17
30
XCK00
NOMESCO Finland
Perimetry
4.2
6.6
18
46
ZXE10
NOMESCO Finland
More than one and less than three hours
2.3
6.5
78
456
CBA10
NOMESCO Finland
Biopsy of eyelid
18.8
6.3
9
5
CCA10
NOMESCO Finland
Biopsy of lacrimal gland
+∞
6.3
6
*
CA1AD
NOMESCO Finland
Orbita CT
+∞
6.3
6
*
CAE00
NOMESCO Finland
Removal of implant from orbit
+∞
6.3
6
*
C85.1
ICD-10 Finland
B-cell lymphoma, unspecified
+∞
6.3
6
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
27.7
6.3
8
*
ZXE00
NOMESCO Finland
One hour or less
2.2
6.2
82
497
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.2
6.1
26
91
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
26
33
9.04
19.68
1.7
1.7
2.08
2.89
iu/l
—
10
11
127
846
2.70
8.57
12.9
9.3
4.57
4.09
e9/l
0.98
112
746
111
702
2.52
8.22
6.1
6.5
1.22
1.22
mmol/l
0.17
95
587
23
69
3.68
6.82
3.6
3.6
4.32
4.49
pmol/l
0.50
23
63
30
113
2.99
6.20
2.6
2.9
68.51
67.02
g/l
0.52
30
101
143
1113
2.39
5.37
6.0
3.9
11.59
11.88
mm/h
0.10
138
1018
35
158
2.51
5.10
5.3
3.9
214.26
249.54
u/l
1.94
35
146
50
265
2.23
5.08
3.8
2.6
2.45
2.45
mmol/l
0.05
45
231
111
799
2.02
4.88
7.3
5.7
10.05
11.07
umol/l
1.01
106
760
77
488
2.01
4.87
3.9
3.1
2.36
2.35
mmol/l
0.10
70
430
72
447
2.02
4.81
3.6
2.7
0.38
0.55
e6/l
0.35
54
328
14
31
4.81
4.67
1.3
1.3
—
38.58
—
0
6
74
470
1.98
4.59
2.8
2.3
54.21
57.29
u/l
0.30
67
432
15
46
3.47
4.29
2.3
1.4
—
—
—
0
0
14
41
3.62
4.28
1.7
1.5
—
—
—
0
0
32
153
2.33
4.10
1.8
1.7
—
—
—
0
0
32
156
2.28
3.91
1.8
1.8
—
—
—
0
0
13
33
4.16
3.88
1.2
1.1
—
—
—
0
0
81
560
1.81
3.69
4.0
2.9
—
—
—
0
0
31
155
2.21
3.57
4.1
3.3
—
—
—
0
0
137
1124
1.92
3.42
5.1
3.7
14.54
14.78
pmol/l
0.54
127
1011
140
1158
1.94
3.39
10.3
7.1
77.03
78.66
u/l
0.17
135
1083
9
19
4.93
3.28
1.1
1.1
—
—
—
0
0
55
350
1.82
3.21
2.2
2.1
3.09
3.11
mg/l
0.02
48
300
12
35
3.60
3.17
1.2
1.2
—
1.60
—
0
7
12
35
3.60
3.17
1.4
1.1
—
—
—
0
0
11
30
3.84
3.14
1.6
1.2
—
—
—
0
0
44
265
1.87
3.04
2.8
2.5
1.81
1.02
e6/l
0.38
25
144
169
1519
2.84
3.04
21.9
13.0
21.45
23.01
mg/l
0.31
149
1181
12
37
3.40
3.00
2.3
2.1
—
—
—
0
0
43
262
1.84
2.86
1.8
1.7
1131.73
1216.45
nmol/l
0.26
35
192
12
40
3.14
2.75
1.3
1.3
—
—
—
0
0
75
546
1.64
2.63
2.2
1.9
88.42
96.44
pmol/l
0.56
32
266
41
254
1.80
2.57
1.3
1.6
—
—
—
0
0
38
230
1.83
2.57
1.8
1.9
—
—
—
0
0
16
69
2.45
2.57
1.8
1.9
—
—
—
0
0
5
7
7.30
2.56
1.2
1.1
12.60
17.43
u/l
—
5
7
6
12
5.13
2.42
1.3
1.2
—
—
—
0
0
5
8
6.39
2.38
1.4
4.3
57.80
87.50
nmol/l
—
5
8
19
92
2.19
2.37
1.5
1.4
—
—
—
0
0
97
767
1.57
2.33
4.9
3.6
0.00
0.02
estimate
0.50
22
142
96
759
1.57
2.30
6.2
4.9
0.00
0.00
estimate
-0.00
23
147
6
13
4.73
2.29
1.3
1.1
—
—
—
0
0
156
1392
1.91
2.29
6.1
4.4
2.04
1.94
mu/l
0.43
144
1258
89
694
1.56
2.25
18.6
13.1
1.32
1.24
inr
0.35
28
203
41
264
1.72
2.25
1.3
1.3
31.09
44.04
iu/ml
0.34
11
79
5
9
5.68
2.23
1.0
1.3
—
—
—
0
0
6
14
4.39
2.17
1.2
1.5
—
—
—
0
0
9
31
3.00
2.10
1.3
1.2
—
—
—
0
0
33
204
1.76
2.08
2.7
2.3
21.84
22.11
%
0.03
28
173
78
600
1.53
2.05
2.7
2.4
75.91
77.05
nmol/l
0.14
71
527
38
246
1.69
2.04
3.0
2.7
1.44
1.92
e6/l
0.26
19
125
17
84
2.13
2.03
1.9
2.0
—
—
—
0
0
24
136
1.88
1.99
3.9
3.7
2.87
2.31
mmol/l
0.38
18
111
93
748
1.50
1.95
5.0
3.6
0.00
0.01
estimate
0.50
24
163
5
11
4.64
1.95
1.2
1.2
—
—
—
0
0
6
16
3.84
1.95
1.0
1.5
—
—
—
0
0
57
421
1.52
1.77
5.3
3.8
0.00
0.00
estimate
-0.00
23
146
20
112
1.88
1.73
5.3
6.6
9.17
9.90
mmol/l
0.20
20
105
109
920
1.47
1.71
2.6
3.0
—
—
—
0
0
10
40
2.59
1.69
1.7
1.2
—
—
—
0
0
8
32
2.57
1.61
1.8
1.3
—
—
—
0
0
8
32
2.57
1.61
1.8
1.3
—
—
—
0
0
11
50
2.28
1.60
1.3
2.8
3.21
2.89
g/l
0.44
11
45
7
26
2.76
1.59
1.1
1.2
—
—
—
0
0
6
20
3.07
1.59
1.0
1.1
—
—
—
0
0
154
1408
1.65
1.56
6.7
5.7
40.22
39.92
mmol/mol
0.16
148
1306
56
422
1.47
1.56
3.0
3.3
1565.63
1255.70
ng/l
0.18
46
359
6
21
2.92
1.52
1.0
1.2
—
—
—
0
0
61
471
1.45
1.49
3.1
3.7
2.21
6.74
mg/mmol
2.52
39
295
27
174
1.65
1.48
3.7
5.7
101.96
103.73
mmol/l
1.27
27
174
7
28
2.56
1.46
3.3
3.3
56.14
57.11
%
—
7
28
9
40
2.31
1.42
5.1
1.9
—
—
—
0
0
7
29
2.47
1.40
1.0
1.6
—
—
—
0
0
9
43
2.15
1.32
1.3
2.9
38.79
38.06
g/l
—
9
38
11
55
2.07
1.30
1.3
2.7
7.82
7.28
g/l
0.56
11
50
11
55
2.07
1.30
1.3
2.7
—
—
—
0
0
11
55
2.07
1.30
1.3
2.7
4.17
3.55
g/l
1.15
11
50
58
454
1.41
1.30
2.0
2.0
135.30
214.09
u/l
0.86
53
424
146
1339
1.48
1.24
28.9
15.8
14.52
14.83
%
0.34
146
1319
158
1473
1.59
1.23
5.5
4.6
5.80
5.96
mmol/l
1.34
146
1338
5
19
2.68
1.22
3.2
1.5
18.40
18.35
ug/l
—
5
19
71
581
1.37
1.21
5.5
3.7
—
—
—
0
0
14
81
1.79
1.12
1.8
1.8
—
—
—
0
0
7
31
2.31
1.11
1.7
1.0
125.00
3.50
e6/l
—
7
26
7
31
2.31
1.11
1.7
1.1
792.57
284.85
e6/l
—
7
26
10
52
1.98
1.08
1.3
2.7
10.35
9.60
g/l
—
10
46
15
91
1.71
1.04
4.3
7.8
93.21
94.47
%
0.54
15
91
5
22
2.31
1.04
1.2
4.9
—
5075.00
—
0
5
5
22
2.31
1.04
1.0
1.6
—
—
—
0
0
154
1444
1.46
0.99
20.9
12.8
80.57
82.25
ml/min/173m2
0.43
131
1182
22
153
1.50
0.91
2.0
2.0
—
—
—
0
0
15
95
1.63
0.90
1.6
1.6
—
—
—
0
0
12
72
1.71
0.87
3.3
4.1
27.51
24.87
mmol/l
1.63
12
72
12
72
1.71
0.87
1.1
1.0
—
—
—
0
0
20
138
1.51
0.86
3.7
2.1
36.86
28.41
u/l
0.56
14
109
8
47
1.73
0.82
1.4
3.1
0.83
0.70
g/l
—
8
42
68
585
1.26
0.75
4.2
3.7
45.36
38.63
ng/l
0.11
46
416
174
1693
1.83
0.75
32.5
19.6
40.17
40.21
%
0.03
168
1587
5
25
2.03
0.73
1.0
1.6
—
—
—
0
0
47
388
1.29
0.72
2.6
2.6
341.72
8339.66
umol/l
1.97
40
332
5
26
1.95
0.71
2.2
1.5
—
—
—
0
0
7
41
1.74
0.71
1.1
1.2
—
—
—
0
0
110
1005
1.24
0.70
3.6
2.9
50.41
49.21
u/l
0.06
104
938
5
27
1.88
0.69
1.0
1.6
—
—
—
0
0
5
27
1.88
0.69
1.0
1.6
—
—
—
0
0
80
710
1.23
0.66
2.9
2.4
—
—
—
0
0
22
165
1.38
0.64
2.2
2.2
—
—
—
0
0
174
1695
1.80
0.64
33.0
19.7
134.79
135.35
g/l
0.20
174
1666
5
30
1.69
0.62
1.8
1.3
—
—
—
0
0
5
30
1.69
0.62
2.0
1.6
—
—
—
0
0
41
340
1.27
0.61
1.7
1.5
23.49
21.17
nmol/l
0.40
36
282
6
35
1.74
0.58
1.2
1.4
—
—
—
0
0
11
75
1.50
0.52
3.3
2.3
0.73
0.71
%
0.08
11
75
11
78
1.44
0.44
3.4
2.5
1.32
1.24
%
0.10
11
78
5
31
1.63
0.43
1.2
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.7
—
—
—
0
0
5
34
1.48
0.40
1.2
1.7
129.40
194.65
%
—
5
34
36
310
1.20
0.39
1.9
1.8
448.07
414.50
pmol/l
0.44
28
258
30
254
1.22
0.39
1.2
1.3
1.26
13.89
u/ml
—
10
108
6
45
1.34
0.34
1.2
1.1
—
—
—
0
0
6
46
1.31
0.33
1.2
1.1
—
—
—
0
0
7
53
1.33
0.31
1.4
1.4
—
—
—
0
0
39
351
1.14
0.26
2.7
2.1
—
—
—
0
0
5
37
1.36
0.23
1.0
1.6
—
—
—
0
0
35
387
0.88
0.23
3.8
4.3
19.21
21.67
%
0.39
18
183
5
38
1.32
0.23
1.0
1.6
—
—
—
0
0
5
40
1.26
0.22
1.6
1.6
—
—
—
0
0
5
42
1.20
0.21
1.6
1.8
—
—
—
0
0
25
221
1.15
0.21
1.4
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.1
—
—
—
0
0
0
13
0.00
0.21
0.0
2.0
—
—
—
0
0
0
13
0.00
0.21
0.0
2.0
—
—
—
0
0
46
426
1.11
0.20
1.5
1.6
1.31
1.38
mmol/l
0.21
36
357
20
175
1.16
0.19
10.3
7.9
—
—
—
0
0
15
128
1.19
0.19
1.7
1.8
—
—
—
0
0
25
275
0.89
0.16
2.6
2.6
0.49
0.74
ug/l
2.00
19
170
149
1515
0.90
0.15
5.0
4.5
4.53
4.63
mmol/l
0.52
139
1411
156
1541
1.09
0.11
5.6
5.0
2.60
2.72
mmol/l
1.04
146
1420
34
327
1.05
0.05
1.9
1.6
2.32
1.18
mg/l
0.31
24
258
35
338
1.04
0.04
1.3
1.2
0.82
1.42
u/ml
—
9
91
150
1506
0.98
0.00
4.8
4.5
1.40
1.48
mmol/l
1.34
139
1392
146
1461
1.00
0.00
4.4
4.0
1.39
1.28
mmol/l
0.99
136
1345
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
9.78
—
0
8
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
8
83
0.96
-0.00
1.3
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.5
—
16.46
—
0
8
0
7
0.00
-0.00
0.0
3.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
5
50
1.00
-0.00
3.4
2.8
15.40
328.70
u/ml
—
5
40
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
69
0.87
-0.00
2.2
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_ORBITNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ORBITNAS | 1.807 [1.27, 2.57] | 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.157 |
During the follow-up period (1.1.1998 — 31.12.2019), 62 out of 411 females with H7_ORBITNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ORBITNAS | 1.939 [1.29, 2.91] | 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.021 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 371 males with H7_ORBITNAS died.
Mortality risk
Mortality risk for people of age
years, who have H7_ORBITNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.144% | 0.383% |
| 5 | 0.889% | 2.239% |
| 10 | 2.464% | 5.928% |
| 15 | 4.762% | 11.4% |
| 20 | 8.392% | 19.205% |
Relationships between endpoints
↥Index endpoint: H7_ORBITNAS – Other and unspecified disorders of orbit
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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