No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
172 |
4. Check minimum number of eventsNone |
172 |
5. Include endpointsNone |
172 |
6. Filter based on genotype QC (FinnGen only) |
172 |
Control definitions (FinnGen only)
- Control exclude
- H7_LIDLACRIMALORBIT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified disorders of orbit
based on the number of shared cases.
Similar with more cases:
- Disorders of orbit
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1041 | 548 | 489 |
| Only index persons | 942 | 504 | 438 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 56.46 | 57.28 | 55.63 |
| Only index persons | 55.79 | 56.02 | 55.53 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 172 | 99 | 73 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 61.82 | 60.45 | 63.66 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 144
- Matched controls
- 1440
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H05.9
ICD-10 Finland
Disorder of orbit, unspecified
+∞
87.7
75
*
H05.8
ICD-10 Finland
Other disorders of orbit
+∞
78.5
68
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
+∞
20.3
19
*
CAA30
NOMESCO Finland
Biopsy of orbit
+∞
19.2
18
*
H02.4
ICD-10 Finland
Ptosis of eyelid
+∞
12.7
12
*
H05.0
ICD-10 Finland
Acute inflammation of orbit
+∞
11.6
11
*
H05.2
ICD-10 Finland
Exophthalmic conditions
+∞
11.6
11
*
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
129.9
11.6
12
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.8
11.2
41
111
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
64.9
10.8
12
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.2
9.8
75
366
CAB00
NOMESCO Finland
Anterior orbitotomy with excision of lesion
+∞
9.5
9
*
CA1DG
NOMESCO Finland
Eye and orbita very extensive MRI examination with high intensity magnet
95.3
8.5
9
*
H02.3
ICD-10 Finland
Blepharochalasis
95.3
8.5
9
*
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
+∞
8.4
8
*
H57.1
ICD-10 Finland
Ocular pain
14.1
8.0
13
10
F29
ICPC
Eye symptom/complaint other
5.1
7.9
25
57
D31.6
ICD-10 Finland
Benign neoplasm: Orbit, unspecified
84.2
7.5
8
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.6
6.8
65
345
WX140
NOMESCO Finland
Parabulbar anesthesy
7.5
6.7
15
22
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
5.4
6.6
19
39
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
72.9
6.5
7
*
CBA10
NOMESCO Finland
Biopsy of eyelid
72.9
6.5
7
*
CAW99
NOMESCO Finland
Other operation on orbit
72.9
6.5
7
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
6.3
6
*
H05.1
ICD-10 Finland
Chronic inflammatory disorders of orbit
+∞
6.3
6
*
C85.1
ICD-10 Finland
B-cell lymphoma, unspecified
+∞
6.3
6
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.6
6.2
58
300
Z3226
NOMESCO Finland
Physiotherapist
3.1
6.2
37
146
ZXA00
NOMESCO Finland
Right side
2.7
6.1
48
226
WX002
NOMESCO Finland
Sedation and analgesia
3.0
6.1
37
148
Mortality – FinRegistry
↥Association
Association between endpoint H7_ORBITNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ORBITNAS | 1.807 [1.27, 2.57] | 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.157 |
During the follow-up period (1.1.1998 — 31.12.2019), 62 out of 411 females with H7_ORBITNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ORBITNAS | 1.939 [1.29, 2.91] | 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.021 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 371 males with H7_ORBITNAS died.
Mortality risk
Mortality risk for people of age
years, who have H7_ORBITNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.144% | 0.383% |
| 5 | 0.889% | 2.239% |
| 10 | 2.464% | 5.928% |
| 15 | 4.762% | 11.4% |
| 20 | 8.392% | 19.205% |
Relationships between endpoints
↥Index endpoint: H7_ORBITNAS – Other and unspecified disorders of orbit
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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