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Other and unspecified disorders of orbit

DOID Endpoint Browser PheWeb

H7_ORBITNAS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H05.8, H05.9
  • Hospital discharge: ICD-9 — 376[8-9]
  • Cause of death: ICD-10 — H05.8, H05.9
  • Cause of death: ICD-9 — 376[8-9]

2 out of 7 registries used, show all original rules.

172

4. Check minimum number of events

None

172

5. Include endpoints

None

172

6. Filter based on genotype QC (FinnGen only)

172

Control definitions (FinnGen only)

Control exclude
H7_LIDLACRIMALORBIT

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1041 548 489
Only index persons 942 504 438
Unadjusted period prevalence (%)
Whole population 0.01 0.02 0.01
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 56.46 57.28 55.63
Only index persons 55.79 56.02 55.53

-FinnGen-

Key figures

All Female Male
Number of individuals 172 99 73
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 61.82 60.45 63.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
144
Matched controls
1440
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H05.9
ICD-10 Finland
Disorder of orbit, unspecified
+∞
87.7
75
*
H05.8
ICD-10 Finland
Other disorders of orbit
+∞
78.5
68
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
+∞
20.3
19
*
CAA30
NOMESCO Finland
Biopsy of orbit
+∞
19.2
18
*
H02.4
ICD-10 Finland
Ptosis of eyelid
+∞
12.7
12
*
H05.0
ICD-10 Finland
Acute inflammation of orbit
+∞
11.6
11
*
H05.2
ICD-10 Finland
Exophthalmic conditions
+∞
11.6
11
*
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
129.9
11.6
12
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.8
11.2
41
111
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
64.9
10.8
12
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.2
9.8
75
366
CAB00
NOMESCO Finland
Anterior orbitotomy with excision of lesion
+∞
9.5
9
*
H02.3
ICD-10 Finland
Blepharochalasis
95.3
8.5
9
*
CA1DG
NOMESCO Finland
Eye and orbita very extensive MRI examination with high intensity magnet
95.3
8.5
9
*
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
+∞
8.4
8
*
H57.1
ICD-10 Finland
Ocular pain
14.1
8.0
13
10
F29
ICPC
Eye symptom/complaint other
5.1
7.9
25
57
D31.6
ICD-10 Finland
Benign neoplasm: Orbit, unspecified
84.2
7.5
8
*
WX140
NOMESCO Finland
Parabulbar anesthesy
7.5
6.7
15
22
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
5.4
6.6
19
39
CAW99
NOMESCO Finland
Other operation on orbit
72.9
6.5
7
*
CBA10
NOMESCO Finland
Biopsy of eyelid
72.9
6.5
7
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
72.9
6.5
7
*
C85.1
ICD-10 Finland
B-cell lymphoma, unspecified
+∞
6.3
6
*
H05.1
ICD-10 Finland
Chronic inflammatory disorders of orbit
+∞
6.3
6
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
6.3
6
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.6
6.2
58
300
ZXA00
NOMESCO Finland
Right side
2.7
6.1
48
226
WX002
NOMESCO Finland
Sedation and analgesia
3.0
6.1
37
148

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
25
32
8.97
18.80
1.8
1.7
2.1
2.9
iu/l
—
10
11
13
13
10.74
11.48
2.2
1.3
—
—
—
0
0
108
630
2.92
10.46
7.4
5.6
3.0
2.9
%
0.08
103
594
113
679
2.94
10.28
7.8
5.5
0.6
0.6
e9/l
1.46
96
594
113
681
2.92
10.19
7.9
5.5
0.0
0.0
e9/l
0.43
96
596
80
411
2.77
9.70
5.3
3.8
7.4
7.4
ph
0.69
15
87
109
656
2.81
9.66
7.4
5.8
27.2
27.1
%
0.03
103
615
19
37
5.65
9.60
1.3
1.1
—
—
—
0
0
113
699
2.80
9.39
7.9
5.5
2.0
1.8
e9/l
0.55
99
629
107
647
2.73
9.25
7.3
5.6
57.9
58.0
%
0.01
102
613
113
704
2.76
9.17
8.3
5.6
0.2
0.2
e9/l
0.11
99
631
46
188
2.98
8.40
1.9
1.9
—
—
—
0
0
121
807
2.68
8.13
13.0
9.1
4.6
4.1
e9/l
1.10
107
712
44
181
2.92
7.90
1.5
1.3
333.3
444.7
titre
0.27
12
34
79
445
2.43
7.46
7.1
4.9
—
—
—
0
0
30
102
3.35
7.40
2.6
2.2
68.5
66.9
g/l
0.56
30
90
37
146
2.95
7.11
1.8
1.5
—
—
—
0
0
26
84
3.47
6.93
2.2
2.0
—
—
—
0
0
50
245
2.47
6.24
1.7
1.9
—
—
—
0
0
11
19
6.12
6.19
1.3
1.2
—
—
—
0
0
49
254
2.30
5.31
3.8
2.6
2.5
2.4
mmol/l
0.05
44
221
137
1064
2.41
5.24
6.1
3.9
11.7
11.7
mm/h
0.01
132
972
63
364
2.15
5.23
9.3
6.5
—
—
—
0
0
31
131
2.67
5.18
1.6
1.4
—
—
—
0
0
24
89
2.97
5.09
1.4
1.6
—
—
—
0
0
20
68
3.20
4.90
4.0
3.6
4.3
4.5
pmol/l
0.60
20
61
74
464
2.04
4.88
4.0
3.1
2.4
2.4
mmol/l
0.04
67
405
42
214
2.27
4.69
1.6
1.6
—
—
—
0
0
69
427
2.03
4.68
3.7
2.7
0.4
0.6
e6/l
0.42
50
312
71
447
2.00
4.57
2.8
2.3
54.6
57.8
u/l
0.30
64
412
105
760
1.98
4.48
7.5
5.7
9.9
11.0
umol/l
1.00
100
723
30
136
2.46
4.33
1.6
1.7
—
—
—
0
0
32
150
2.39
4.30
1.4
1.6
—
—
—
0
0
93
654
1.92
4.24
13.1
8.9
0.0
0.0
e9/l
0.48
74
528
11
27
4.28
4.23
1.1
1.3
—
—
—
0
0
65
409
1.95
4.11
3.6
2.6
—
—
—
0
0
54
332
1.91
3.59
2.2
2.1
3.1
3.1
mg/l
0.01
47
285
8
13
6.39
3.54
1.1
1.2
—
—
—
0
0
25
115
2.37
3.49
3.9
2.8
68.1
75.7
e9/l
0.52
19
86
57
362
1.86
3.41
5.6
4.0
—
—
—
0
0
69
465
1.81
3.41
3.8
2.9
20.8
37.7
e6/l
0.63
51
348
8
16
5.19
3.09
2.4
2.9
—
—
—
0
0
133
1108
1.88
3.04
10.6
7.0
77.5
78.8
u/l
0.12
128
1033
41
244
1.89
2.96
1.9
1.7
1144.1
1227.7
nmol/l
0.24
33
178
130
1079
1.84
2.96
5.2
3.7
14.6
14.7
pmol/l
0.33
120
971
123
1007
1.78
2.90
3.8
3.8
—
—
—
0
0
48
303
1.81
2.87
3.3
2.4
6.6
5.0
e6/l
0.30
39
276
161
1448
2.75
2.85
22.1
12.8
21.8
22.9
mg/l
0.20
141
1128
74
533
1.68
2.77
4.4
3.5
166.2
71.8
e6/l
0.66
52
376
33
188
1.93
2.70
2.7
2.3
21.8
22.5
%
0.09
28
158
76
555
1.66
2.68
12.0
7.6
1.3
1.2
inr
0.47
24
165
72
520
1.66
2.64
2.2
1.9
87.8
97.3
pmol/l
0.68
31
249
30
168
1.95
2.57
1.3
1.2
—
—
—
0
0
63
444
1.66
2.52
2.7
3.0
8.3
7.8
mmol/l
0.29
51
373
77
574
1.62
2.45
2.4
2.0
—
—
—
0
0
49
325
1.71
2.44
3.7
3.6
—
—
—
0
0
5
8
6.39
2.38
1.4
4.3
57.8
87.5
nmol/l
—
5
8
93
730
1.60
2.36
4.9
3.6
0.0
0.0
estimate
0.50
20
134
92
722
1.59
2.33
6.2
4.9
0.0
0.0
estimate
0.00
21
139
28
159
1.91
2.31
1.4
1.3
—
—
—
0
0
9
29
3.22
2.26
1.1
1.1
—
—
—
0
0
5
9
5.68
2.23
1.0
1.3
—
—
—
0
0
104
848
1.57
2.17
4.7
4.1
6.6
6.6
mmol/l
0.07
99
770
20
104
2.04
2.11
5.3
6.4
9.2
9.5
mmol/l
0.08
20
97
39
253
1.70
2.09
1.3
1.3
31.1
45.0
iu/ml
0.37
11
76
8
26
3.18
2.04
1.4
1.9
—
—
—
0
0
8
26
3.18
2.04
1.6
1.3
—
—
—
0
0
89
710
1.53
1.99
4.9
3.6
0.0
0.0
estimate
0.00
20
146
148
1331
1.80
1.94
6.2
4.4
2.0
1.9
mu/l
0.22
136
1202
42
284
1.63
1.92
4.7
2.5
575.7
559.0
mosm/kgh2o
0.18
35
245
116
985
1.55
1.90
5.1
4.1
—
—
—
0
0
22
125
1.87
1.82
4.1
3.7
2.6
2.2
mmol/l
0.24
15
98
11
47
2.43
1.82
1.9
2.8
—
—
—
0
0
56
414
1.52
1.74
2.8
3.2
27.2
361.1
mg/l
0.87
34
264
43
302
1.57
1.68
1.7
1.3
2.9
2.6
g/l
0.31
32
178
6
19
3.23
1.67
2.3
1.3
30.5
33.1
pg
—
6
19
53
393
1.50
1.61
5.3
3.8
0.0
0.0
estimate
0.00
21
137
58
441
1.48
1.56
3.2
3.9
2.2
7.0
mg/mmol
2.47
37
274
19
109
1.84
1.54
4.1
5.6
0.1
0.2
%
—
8
32
7
27
2.66
1.53
1.7
2.7
—
—
—
0
0
7
27
2.66
1.53
3.0
2.7
3.7
4.8
e9/l
—
7
27
20
117
1.80
1.53
1.6
1.5
—
—
—
0
0
20
117
1.80
1.53
3.9
5.4
0.7
0.9
%
—
9
37
19
110
1.82
1.50
4.3
2.2
—
—
—
0
0
15
80
1.96
1.50
1.6
3.9
—
—
—
0
0
7
28
2.56
1.47
3.3
3.3
56.1
57.1
%
—
7
28
7
28
2.56
1.47
4.3
2.9
3.8
1.8
mmol/l
—
7
16
21
127
1.74
1.45
4.2
3.7
—
—
—
0
0
7
29
2.47
1.41
4.0
4.7
—
—
—
0
0
18
105
1.80
1.39
4.2
5.7
0.0
0.0
%
—
7
29
5
17
3.00
1.37
1.2
1.1
—
—
—
0
0
146
1341
1.59
1.35
6.7
5.8
40.1
39.8
mmol/mol
0.16
140
1243
24
154
1.65
1.35
2.0
1.3
—
—
—
0
0
55
426
1.43
1.32
1.9
1.9
108.4
211.2
u/l
1.47
50
399
6
24
2.55
1.31
1.8
1.1
—
—
—
0
0
20
123
1.71
1.31
6.2
3.2
—
—
—
0
0
9
44
2.10
1.29
14.7
11.1
—
—
—
0
0
136
1237
1.48
1.26
28.3
17.0
331.4
332.2
g/l
0.43
136
1231
6
25
2.45
1.25
1.5
1.5
—
—
—
0
0
136
1239
1.47
1.23
29.9
15.9
13.9
13.7
%
0.93
136
1218
25
167
1.58
1.21
3.6
5.6
101.8
103.6
mmol/l
1.12
25
161
8
38
2.16
1.20
1.5
1.2
—
—
—
0
0
17
104
1.70
1.14
4.4
5.3
0.2
0.4
%
—
6
25
7
30
2.39
1.13
1.7
1.1
792.6
296.6
e6/l
—
7
25
7
30
2.39
1.13
1.7
1.0
125.0
3.4
e6/l
—
7
25
7
32
2.24
1.09
1.4
1.2
559.9
431.1
mg/l
—
7
32
7
32
2.24
1.09
4.3
3.1
7.4
7.4
ph
—
7
27
43
331
1.40
1.06
7.6
5.3
—
—
—
0
0
54
432
1.36
1.06
4.6
2.7
—
—
—
0
0
150
1407
1.52
1.02
5.5
4.5
5.8
5.9
mmol/l
1.32
138
1275
41
316
1.39
1.00
5.2
3.7
1.0
1.0
kg/l
—
7
34
26
184
1.49
0.99
1.2
1.3
—
—
—
0
0
17
109
1.62
0.98
4.8
3.4
—
—
—
0
0
46
365
1.36
0.94
2.6
2.6
340.6
7782.0
umol/l
1.73
40
311
49
395
1.34
0.90
1.5
1.5
—
—
—
0
0
6
29
2.11
0.90
2.7
2.1
—
—
—
0
0
10
56
1.83
0.90
1.6
1.9
—
—
—
0
0
14
88
1.64
0.87
4.1
7.8
93.0
94.6
%
0.67
14
88
8
44
1.86
0.87
1.5
1.4
—
—
—
0
0
8
44
1.86
0.87
1.5
1.4
—
—
—
0
0
8
44
1.86
0.87
1.5
1.4
—
—
—
0
0
8
44
1.86
0.87
1.6
1.4
—
—
—
0
0
8
44
1.86
0.87
1.5
1.4
—
—
—
0
0
6
33
1.85
0.80
1.2
1.2
—
—
—
0
0
0
24
0.00
0.80
0.0
2.3
—
4.9
—
0
18
18
124
1.50
0.79
5.2
7.1
—
—
—
0
0
40
320
1.33
0.78
1.7
1.6
24.0
21.2
nmol/l
0.49
35
266
9
53
1.74
0.77
4.7
3.8
—
—
—
0
0
5
24
2.11
0.75
1.2
1.1
—
—
—
0
0
9
55
1.67
0.75
1.1
1.1
—
—
—
0
0
7
38
1.88
0.74
1.3
1.1
—
—
—
0
0
9
56
1.64
0.73
1.6
1.2
—
—
—
0
0
7
39
1.83
0.73
1.6
1.8
—
—
—
0
0
5
27
1.88
0.69
2.2
1.6
70.6
59.5
%
—
5
27
7
43
1.65
0.67
1.6
1.4
—
—
—
0
0
7
44
1.62
0.66
1.3
3.3
3.8
3.9
mmol/l
—
7
38
166
1617
1.76
0.64
32.6
19.4
90.8
91.0
fl
0.18
166
1590
166
1617
1.76
0.64
32.6
19.3
30.2
30.3
pg
0.28
166
1590
9
140
0.62
0.63
1.7
1.4
—
—
—
0
0
63
553
1.22
0.57
4.2
3.6
47.4
38.9
ng/l
0.13
43
384
10
65
1.57
0.57
1.7
1.7
—
—
—
0
0
10
65
1.57
0.57
3.6
4.2
26.9
24.6
mmol/l
—
10
65
6
38
1.60
0.55
1.5
1.6
53.3
39.5
nmol/l
—
6
38
13
91
1.46
0.54
1.1
1.2
—
—
—
0
0
6
39
1.56
0.53
1.7
1.4
—
—
—
0
0
166
1620
1.71
0.53
33.0
19.5
134.5
135.3
g/l
0.32
166
1592
15
109
1.41
0.53
2.0
1.4
—
—
—
0
0
48
547
0.83
0.47
3.2
3.0
—
—
—
0
0
7
48
1.48
0.47
4.7
2.7
—
—
—
0
0
21
167
1.29
0.44
2.7
2.0
305.7
109.2
ug/g
0.36
15
134
29
241
1.24
0.44
1.2
1.3
1.2
14.6
u/ml
—
9
101
5
31
1.63
0.43
4.0
3.3
10.9
7.9
mmol/l
—
5
31
5
32
1.58
0.42
4.0
3.2
2.1
1.5
mmol/l
—
5
32
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
46
406
1.18
0.39
5.3
3.3
—
—
—
0
0
137
1318
1.19
0.37
24.6
13.4
39.6
39.9
%
0.17
103
959
10
73
1.39
0.35
3.4
2.4
1.2
1.2
%
—
10
73
6
44
1.38
0.35
1.2
1.1
—
—
—
0
0
7
53
1.33
0.31
1.9
1.6
—
—
—
0
0
156
1528
1.23
0.27
18.6
12.1
—
—
—
0
0
11
86
1.30
0.27
6.5
3.5
—
—
—
0
0
44
402
1.13
0.24
1.5
1.6
1.3
1.4
mmol/l
0.17
35
337
5
37
1.36
0.23
1.0
1.3
—
—
—
0
0
141
1443
0.87
0.23
5.0
4.5
4.5
4.6
mmol/l
0.73
131
1341
10
79
1.28
0.23
1.2
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
32
291
1.12
0.19
1.9
1.9
442.7
417.6
pmol/l
0.28
24
240
7
88
0.79
0.15
2.3
3.4
—
7.4
—
0
11
7
90
0.77
0.15
2.3
3.3
5.0
5.1
kpa
—
7
83
48
455
1.08
0.13
2.7
2.2
—
—
—
0
0
14
124
1.14
0.11
1.4
1.5
—
—
—
0
0
24
259
0.91
0.11
2.5
2.6
0.5
0.8
ug/l
1.86
18
158
40
417
0.95
0.07
4.8
3.8
—
—
—
0
0
142
1435
0.94
0.07
4.8
4.5
1.4
1.5
mmol/l
0.93
131
1322
138
1393
0.95
0.05
4.4
4.0
1.3
1.3
mmol/l
0.42
128
1282
148
1468
1.06
0.05
5.6
5.0
2.6
2.7
mmol/l
1.18
138
1349
12
110
1.10
0.05
2.8
4.6
—
—
—
0
0
30
312
0.95
0.04
2.0
1.6
2.7
1.1
mg/l
0.38
20
249
34
331
1.03
0.02
1.3
1.2
0.8
1.4
u/ml
—
8
91
15
149
1.01
0.00
1.3
1.7
—
—
—
0
0
11
112
0.98
0.00
1.3
1.1
—
—
—
0
0
5
49
1.02
0.00
3.4
2.8
15.4
328.7
u/ml
—
5
40
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
6
66
0.91
0.00
2.0
3.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
101.6
—
0
9
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
21.7
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_ORBITNAS and mortality.

Females

Parameter HR [95% CI] p-value
H7_ORBITNAS 1.807 [1.27, 2.57] 0.001
Birth year 0.993 [0.98, 1.0] 0.157

During the follow-up period (1.1.1998 — 31.12.2019), 62 out of 411 females with H7_ORBITNAS died.

Males

Parameter HR [95% CI] p-value
H7_ORBITNAS 1.939 [1.29, 2.91] 0.001
Birth year 0.989 [0.98, 1.0] 0.021

During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 371 males with H7_ORBITNAS died.

Mortality risk

Mortality risk for people of age

years, who have H7_ORBITNAS.

N-year risk Females Males
1 0.144% 0.383%
5 0.889% 2.239%
10 2.464% 5.928%
15 4.762% 11.4%
20 8.392% 19.205%

Relationships between endpoints

↥

Index endpoint: H7_ORBITNAS – Other and unspecified disorders of orbit

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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