Acute inflammation of orbit

H7_ORBITINFLAMACU

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H05.0
  • Hospital discharge: ICD-9 3760
  • Hospital discharge: ICD-8 3690[0-2]
  • Cause of death: ICD-10 H05.0
  • Cause of death: ICD-9 3760
  • Cause of death: ICD-8 3690[0-2]

2 out of 7 registries used, show all original rules.

241

4. Check minimum number of events

None

241

5. Include endpoints

None

241

6. Filter based on genotype QC (FinnGen only)

241

Control definitions (FinnGen only)

Control exclude
H7_LIDLACRIMALORBIT

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H05
Name in latin
Inflammatio orbitae acuta

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2945 1284 1650
Only index persons 2527 1123 1404
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.05
Only index persons 0.05 0.04 0.05
Median age at first event (years)
Whole population 24.56 30.24 19.99
Only index persons 23.68 29.27 19.21

-FinnGen-

Key figures

All Female Male
Number of individuals 241 132 109
Unadjusted period prevalence (%) 0.05 0.04 0.05
Median age at first event (years) 43.10 40.65 46.08

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
216
Matched controls
2160
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H05.0
ICD-10 Finland
Acute inflammation of orbit
+∞
210.3
166
*
H00.03
ICD-10 Finland
Preseptal cellulite in the eyelid
+∞
42.1
39
*
3760A
ICD-9 Finland
Disorders of the orbit, Acute inflammation of orbit
+∞
32.1
30
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
73.0
18.0
20
*
CAA00
NOMESCO Finland
Puncture of orbital abscess
+∞
14.7
14
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
11.7
14.2
26
25
H01.0
ICD-10 Finland
Blepharitis
9.4
12.7
26
31
H05.2
ICD-10 Finland
Exophthalmic conditions
+∞
12.6
12
*
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
13.5
12.4
21
17
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
+∞
11.6
11
*
36900
ICD-8 Finland
Other inflammatory diseases of eye, Abscessus orbitae
+∞
11.6
11
*
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
+∞
11.6
11
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.6
11.4
56
189
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.9
11.4
87
404
J01.0
ICD-10 Finland
Acute maxillary sinusitis
3.2
11.2
68
269
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
6.3
11.2
30
54
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
11.5
11.0
20
19
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
+∞
9.4
9
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.7
8.8
75
360
H57.1
ICD-10 Finland
Ocular pain
8.8
8.8
18
22
UDH02
NOMESCO Finland
Rhinopharyngoscopy
4.9
8.8
28
63
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
8.7
96
530
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
5.6
8.5
24
47
DM1BD
NOMESCO Finland
Extensive CT of paranasal sinuses and face area
+∞
8.4
8
*
H02.4
ICD-10 Finland
Ptosis of eyelid
+∞
8.4
8
*
CA1BD
NOMESCO Finland
Extensive orbita CT
+∞
8.4
8
*
H05.9
ICD-10 Finland
Disorder of orbit, unspecified
+∞
8.4
8
*
36902
ICD-8 Finland
Other inflammatory diseases of eye, Tenonitis
+∞
8.4
8
*
J31.0
ICD-10 Finland
Chronic rhinitis
4.4
8.2
29
73
H04.3
ICD-10 Finland
Acute and unspecified inflammation of lacrimal passages
34.8
8.1
10
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.6
8.0
71
347
TDM10
NOMESCO Finland
Puncture of maxillary antrum
6.6
7.7
19
31
CA1AD
NOMESCO Finland
Orbita CT
82.8
7.5
8
*
J01FF01
ATC
clindamycin; systemic
2.5
7.3
65
314
CCD60
NOMESCO Finland
Transnasal dacryocystorhinostomy
+∞
7.3
7
*
CA1DG
NOMESCO Finland
Eye and orbita very extensive MRI examination with high intensity magnet
+∞
7.3
7
*
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
+∞
7.3
7
*
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
+∞
7.3
7
*
J05AB11
ATC
valaciclovir; oral
3.6
7.3
33
104
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
4.8
7.2
23
52
R01AD09
ATC
mometasone; nasal
2.2
7.2
102
619
H02AB06
ATC
prednisolone; systemic
2.2
7.2
102
622
H04.10
ICD-10 Finland
Dry eye syndrome
5.8
7.1
19
35
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.2
6.8
37
132
XCK10
NOMESCO Finland
Photography of fundus of eye
3.6
6.6
29
89
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
4.7
6.6
21
48
J01DB01
ATC
cefalexin; oral
2.4
6.3
180
1453
WX002
NOMESCO Finland
Sedation and analgesia
2.8
6.3
42
170
H02.3
ICD-10 Finland
Blepharochalasis
+∞
6.3
6
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
6.3
6
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
8.1
6.2
13
17
UDM02
NOMESCO Finland
Sinoscopy
7.0
6.1
14
21
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.1
6.1
99
627

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
72
192
4.92
26.07
2.3
1.6
—
—
—
0
0
62
227
3.33
13.65
2.1
1.8
—
—
—
0
0
88
421
2.72
11.81
4.4
4.0
—
—
—
0
0
103
606
2.22
8.20
9.4
6.0
—
—
—
0
0
139
959
2.06
6.95
9.6
5.9
1.9
2.1
e9/l
0.25
129
856
134
922
2.02
6.64
9.8
5.9
0.6
0.6
e9/l
1.06
124
800
134
925
2.01
6.55
9.8
5.9
0.0
0.0
e9/l
0.51
124
804
44
199
2.48
6.27
2.0
1.3
—
—
—
0
0
18
48
3.97
6.21
1.6
1.3
—
—
—
0
0
21
63
3.56
6.16
2.3
2.3
—
—
—
0
0
135
953
1.95
5.99
10.0
6.3
0.2
0.2
e9/l
0.75
124
850
34
141
2.64
5.77
5.1
5.3
—
—
—
0
0
78
466
2.00
5.57
3.3
2.2
122.0
204.0
u/l
2.17
71
440
145
1065
1.91
5.54
14.0
9.4
4.3
4.0
e9/l
0.78
136
933
128
906
1.88
5.46
10.3
5.9
28.1
28.8
%
0.29
121
853
105
700
1.89
5.38
6.3
4.7
35.8
36.4
g/l
0.54
99
665
33
140
2.57
5.35
5.2
5.3
1.2
2.0
mmol/l
0.74
25
106
58
326
2.03
4.84
3.3
2.6
544.8
578.6
mosm/kgh2o
0.50
51
277
60
350
1.95
4.48
3.6
2.4
7.9
5.4
e6/l
0.43
52
310
27
114
2.54
4.42
1.9
1.2
277.2
248.5
u/ml
0.10
27
104
102
710
1.76
4.30
11.1
5.5
1.2
1.2
mmol/l
0.44
95
652
108
770
1.73
4.15
13.4
6.5
1.2
1.2
mmol/l
1.55
98
663
119
873
1.72
4.11
10.9
5.8
3.4
2.7
%
1.29
113
813
135
1028
1.71
4.05
6.9
3.9
6.5
6.5
mmol/l
0.05
121
933
115
846
1.69
3.86
10.5
5.9
0.6
0.7
%
0.55
110
789
71
474
1.71
3.34
10.5
7.2
—
—
—
0
0
70
466
1.71
3.32
6.9
3.5
7.4
7.4
ph
0.33
12
86
44
255
1.89
3.31
3.9
2.3
13.4
13.5
umol/l
0.01
39
233
21
92
2.41
3.20
1.5
1.6
—
—
—
0
0
41
235
1.90
3.19
1.5
1.4
373.3
495.0
titre
0.31
12
48
111
842
1.59
3.11
3.6
2.6
168.2
111.7
ug/l
0.77
105
779
47
285
1.81
3.06
4.5
3.3
218.9
169.5
ng/l
0.14
30
199
71
486
1.65
3.01
2.1
2.0
—
—
—
0
0
34
187
1.95
2.98
3.5
2.8
1.6
1.7
%
0.46
34
171
11
35
3.25
2.97
2.7
1.7
0.8
0.8
g/l
0.01
11
30
70
479
1.65
2.96
3.7
2.9
0.2
0.2
e6/l
0.00
53
359
65
438
1.66
2.91
5.9
3.7
92.3
93.7
%
0.16
65
431
76
534
1.62
2.89
3.9
2.9
20.4
58.9
e6/l
1.48
59
408
14
53
2.74
2.85
1.4
1.8
214.6
150.5
u/ml
—
8
32
37
213
1.87
2.84
4.3
2.4
20.0
22.5
%
0.56
31
189
9
23
4.02
2.80
5.7
2.4
—
—
—
0
0
84
610
1.58
2.77
9.8
6.5
1.1
1.2
inr
0.79
21
182
76
539
1.60
2.77
2.6
2.2
74.3
54.8
u/l
0.43
70
500
163
1374
1.58
2.74
11.1
7.0
82.2
78.1
u/l
0.49
155
1284
26
135
2.04
2.67
7.5
7.9
—
—
—
0
0
212
1918
1.88
2.62
21.7
11.6
21.1
22.7
mg/l
0.29
183
1456
14
56
2.59
2.58
1.7
1.5
—
—
—
0
0
13
50
2.69
2.57
2.1
1.5
1.3
5.8
iu/l
—
7
16
67
469
1.59
2.55
3.7
2.8
—
—
—
0
0
30
168
1.90
2.51
1.9
1.9
345.0
371.6
nmol/l
0.31
25
154
159
1347
1.53
2.49
6.4
3.7
14.2
10.3
mm/h
2.17
145
1255
42
262
1.73
2.48
1.9
1.6
—
—
—
0
0
94
715
1.52
2.47
2.1
1.9
—
—
—
0
0
5
8
6.35
2.38
1.4
1.3
—
—
—
0
0
84
631
1.51
2.31
4.7
3.4
41.5
105.3
e6/l
0.74
59
439
7
18
3.97
2.27
1.4
1.3
—
—
—
0
0
27
152
1.87
2.23
2.7
2.4
0.2
0.2
g/l
0.45
27
143
8
24
3.41
2.20
3.3
3.0
—
—
—
0
0
21
109
2.02
2.18
1.3
1.2
—
—
—
0
0
9
30
3.08
2.17
4.1
3.1
—
—
—
0
0
7
19
3.76
2.16
1.4
1.1
—
—
—
0
0
7
19
3.76
2.16
1.4
1.2
—
—
—
0
0
74
548
1.51
2.16
3.5
3.2
2.3
2.4
mmol/l
0.63
65
492
15
68
2.29
2.16
1.5
1.5
11.5
7.4
u/l
—
8
59
25
139
1.89
2.15
1.1
1.2
28.2
150.9
iu/ml
—
7
55
114
921
1.45
2.14
8.1
6.1
10.3
11.5
umol/l
0.89
108
872
74
549
1.50
2.14
3.3
2.3
—
—
—
0
0
21
110
2.00
2.13
1.6
3.4
4.6
4.8
pmol/l
0.55
21
97
18
89
2.11
2.12
3.9
2.4
2015.2
4959.2
u/l
—
9
34
8
25
3.27
2.11
1.6
1.2
—
—
—
0
0
55
384
1.56
2.10
2.0
1.7
—
—
—
0
0
107
857
1.45
2.09
12.2
8.5
0.0
0.0
e9/l
0.50
96
683
5
10
5.08
2.08
1.0
1.5
—
—
—
0
0
6
15
4.07
2.05
2.7
3.3
4676.8
893.5
u/ml
—
6
15
6
15
4.07
2.05
1.2
1.1
—
—
—
0
0
10
38
2.70
2.03
1.4
1.3
60.5
63.2
pmol/l
—
10
38
15
70
2.22
2.03
1.2
1.2
—
—
—
0
0
9
32
2.88
2.02
1.1
1.1
—
—
—
0
0
146
1246
1.44
1.99
6.2
3.7
—
—
—
0
0
163
1420
1.46
1.98
4.7
3.5
14.6
14.7
pmol/l
0.11
155
1292
83
640
1.45
1.96
2.2
1.7
89.2
97.6
pmol/l
1.02
47
332
9
33
2.79
1.95
4.0
2.9
9.1
8.8
kpa
—
9
33
9
33
2.79
1.95
4.0
2.9
5.4
5.0
kpa
—
9
33
44
298
1.58
1.91
1.4
1.3
45.4
30.5
iu/ml
0.40
13
93
8
28
2.92
1.88
1.4
1.4
—
—
—
0
0
52
369
1.52
1.84
1.6
1.4
18.3
20.7
nmol/l
0.79
44
317
5
12
4.23
1.83
1.0
1.1
—
—
—
0
0
10
41
2.50
1.78
1.4
1.2
—
—
—
0
0
8
30
2.72
1.74
2.8
2.9
—
—
—
0
0
207
1911
1.59
1.73
22.7
12.7
4.0
4.0
mmol/l
0.05
202
1851
5
13
3.90
1.72
1.0
1.2
—
—
—
0
0
26
159
1.71
1.67
1.5
1.6
—
—
—
0
0
22
128
1.79
1.67
1.9
2.3
—
17.9
—
0
7
16
84
1.97
1.64
8.1
4.0
—
—
—
0
0
16
84
1.97
1.64
5.4
1.7
—
—
—
0
0
70
539
1.42
1.63
5.7
3.2
8.2
8.1
mmol/l
0.06
59
473
54
713
0.69
1.63
2.4
2.5
—
—
—
0
0
62
467
1.44
1.63
3.6
2.7
—
—
—
0
0
22
129
1.78
1.63
13.9
7.8
9.8
7.9
mmol/l
0.69
22
122
60
450
1.44
1.61
5.9
3.2
82.4
76.4
mg/l
0.05
45
301
6
20
3.05
1.59
1.2
1.8
—
—
—
0
0
6
20
3.05
1.59
1.2
1.8
—
—
—
0
0
6
20
3.05
1.59
1.2
1.8
—
—
—
0
0
6
20
3.05
1.59
1.2
1.8
—
—
—
0
0
39
269
1.54
1.57
2.0
1.6
1146.9
1161.6
nmol/l
0.04
34
210
20
116
1.79
1.54
1.1
1.2
—
32.0
—
0
5
5
15
3.38
1.53
1.2
1.1
—
—
—
0
0
5
15
3.38
1.53
1.0
1.1
—
—
—
0
0
53
393
1.45
1.51
3.7
3.1
—
—
—
0
0
56
420
1.43
1.50
3.9
2.6
325.2
8374.8
umol/l
2.02
48
367
56
422
1.43
1.46
5.1
4.3
—
—
—
0
0
140
1223
1.35
1.45
4.1
3.3
—
—
—
0
0
76
605
1.37
1.45
3.9
3.4
28.9
38.4
ng/l
0.45
52
385
9
39
2.36
1.44
4.0
2.8
7.4
7.4
ph
—
9
33
5
16
3.17
1.44
2.2
2.9
—
—
—
0
0
7
29
2.45
1.40
1.3
1.2
—
—
—
0
0
83
674
1.35
1.39
3.7
2.9
—
—
—
0
0
27
176
1.60
1.39
1.3
1.1
—
—
—
0
0
13
68
1.96
1.36
11.5
7.7
—
—
—
0
0
61
475
1.38
1.32
6.8
3.9
18.0
10.9
mg/mmol
0.28
43
305
24
154
1.62
1.32
1.6
1.4
—
—
—
0
0
6
24
2.54
1.31
1.3
1.2
—
—
—
0
0
8
35
2.33
1.28
1.3
1.1
—
—
—
0
0
12
63
1.95
1.25
1.2
1.1
—
—
—
0
0
102
867
1.31
1.22
5.5
4.3
0.0
0.0
estimate
0.00
20
180
5
19
2.66
1.22
2.0
1.5
—
—
—
0
0
24
161
1.54
1.12
8.7
6.1
-0.1
1.0
mmol/l
0.39
18
123
7
32
2.22
1.09
3.7
3.0
3.9
3.9
e9/l
—
7
32
7
33
2.15
1.06
4.4
2.9
56.4
56.1
%
—
7
33
212
2012
1.45
1.06
22.3
13.2
77.8
75.1
umol/l
0.34
212
2012
102
881
1.27
1.05
4.0
3.2
0.0
0.0
estimate
0.00
20
172
13
77
1.73
0.97
1.5
1.4
15.8
23.2
iu/l
—
8
68
19
126
1.55
0.94
1.5
1.4
—
—
—
0
0
37
283
1.36
0.91
1.8
1.8
—
—
—
0
0
6
29
2.10
0.90
1.5
1.1
—
—
—
0
0
26
187
1.44
0.90
6.3
6.0
104.6
104.2
mmol/l
0.16
26
180
8
42
1.94
0.89
4.3
3.2
—
—
—
0
0
38
294
1.35
0.87
1.3
1.3
7.4
12.9
u/ml
0.43
12
121
68
571
1.27
0.86
1.7
1.6
—
—
—
0
0
184
1726
1.28
0.86
5.6
4.2
1.8
1.8
mu/l
0.55
178
1590
99
869
1.24
0.85
4.1
3.1
0.0
0.0
estimate
0.00
19
182
18
256
0.68
0.81
1.3
1.4
—
—
—
0
0
10
58
1.76
0.81
1.7
1.3
—
—
—
0
0
15
98
1.57
0.80
18.5
7.8
25.9
24.8
mmol/l
0.55
15
98
25
185
1.39
0.75
1.2
1.4
—
—
—
0
0
5
24
2.11
0.75
1.0
1.2
—
—
—
0
0
5
24
2.11
0.75
4.0
2.5
—
—
—
0
0
34
269
1.31
0.69
2.8
2.4
236.3
87.7
ug/g
0.68
29
214
5
27
1.87
0.69
1.2
1.2
—
—
—
0
0
18
128
1.44
0.68
2.2
1.7
—
—
—
0
0
18
129
1.43
0.65
2.2
1.7
—
—
—
0
0
17
121
1.44
0.64
2.2
1.7
—
—
—
0
0
18
130
1.42
0.63
2.2
1.7
—
—
—
0
0
18
130
1.42
0.63
2.2
1.7
—
—
—
0
0
53
449
1.23
0.63
1.6
1.7
1.3
1.4
mmol/l
0.29
47
388
209
2016
1.28
0.60
18.6
10.7
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
4.0
—
3.2
—
0
22
10
64
1.59
0.59
1.1
1.1
—
—
—
0
0
18
132
1.39
0.59
4.4
3.0
—
—
—
0
0
20
151
1.35
0.56
6.3
3.2
—
—
—
0
0
27
214
1.29
0.55
1.1
1.2
—
—
—
0
0
9
60
1.52
0.55
1.8
2.1
—
—
—
0
0
15
108
1.41
0.54
6.4
2.2
68.2
67.2
g/l
0.15
15
103
9
61
1.49
0.54
6.1
4.2
—
—
—
0
0
9
63
1.44
0.53
1.9
1.7
—
—
—
0
0
15
109
1.40
0.52
1.0
1.3
—
—
—
0
0
20
153
1.33
0.52
11.8
4.2
—
—
—
0
0
6
40
1.51
0.52
11.0
1.1
38.0
38.5
g/l
—
6
35
54
469
1.20
0.51
3.6
3.5
—
—
—
0
0
7
45
1.57
0.49
6.3
3.3
3.8
3.8
mmol/l
—
7
39
12
86
1.42
0.45
1.1
1.1
—
—
—
0
0
7
51
1.38
0.44
1.3
1.2
—
—
—
0
0
53
467
1.17
0.43
4.7
3.4
0.0
0.0
estimate
0.00
20
173
222
2172
1.28
0.42
31.0
17.1
250.4
252.2
e9/l
0.15
217
2124
18
141
1.30
0.41
5.7
3.7
0.5
0.4
%
—
6
33
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
19
151
1.28
0.40
2.0
4.8
2.6
37.9
ug/l
0.68
13
125
54
480
1.16
0.39
1.5
1.3
0.9
1.1
u/ml
0.33
14
121
58
519
1.15
0.39
3.5
4.3
7.0
1.9
ug/l
0.44
44
471
222
2175
1.26
0.39
30.9
17.1
4.4
4.6
e12/l
2.36
216
2120
26
216
1.23
0.39
1.9
1.8
—
—
—
0
0
222
2177
1.25
0.36
31.0
17.1
6.9
6.7
e9/l
0.60
216
2120
6
41
1.47
0.36
3.7
2.8
22.1
24.0
mmol/l
—
6
36
45
399
1.16
0.34
3.6
3.1
1.0
1.0
kg/l
—
8
49
7
97
0.71
0.31
1.0
1.1
—
—
—
0
0
17
138
1.25
0.31
5.5
4.0
0.0
0.0
%
—
6
39
7
53
1.33
0.31
2.9
2.9
—
—
—
0
0
13
102
1.29
0.30
2.5
1.8
—
—
—
0
0
15
122
1.24
0.27
14.5
4.1
4.9
5.1
kpa
0.24
15
115
26
225
1.17
0.27
1.2
1.2
—
—
—
0
0
48
437
1.12
0.26
2.1
1.4
2.5
2.2
g/l
0.58
31
260
5
40
1.26
0.22
1.0
1.1
—
—
—
0
0
5
40
1.26
0.22
1.0
1.1
—
—
—
0
0
33
297
1.13
0.22
2.8
2.6
0.5
0.8
ug/l
3.03
22
187
0
11
0.00
0.21
0.0
1.4
—
108040.0
—
0
5
0
11
0.00
0.21
0.0
6.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
921.2
—
0
6
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
5
43
1.17
0.21
1.8
2.1
—
—
—
0
0
42
385
1.11
0.21
2.1
1.8
2.3
1.1
mg/l
0.47
31
290
0
13
0.00
0.21
0.0
1.0
—
236.4
—
0
5
6
48
1.26
0.20
1.5
1.5
—
66.0
—
0
5
18
156
1.17
0.19
5.7
3.8
0.7
0.8
%
—
7
49
6
52
1.16
0.19
1.5
1.5
—
—
—
0
0
23
204
1.14
0.19
1.5
1.4
—
—
—
0
0
17
147
1.17
0.18
6.0
3.9
0.0
0.2
%
—
7
45
5
68
0.73
0.17
1.6
1.6
—
—
—
0
0
53
498
1.08
0.16
3.8
2.8
—
—
—
0
0
180
1830
0.94
0.14
4.5
4.0
1.4
1.5
mmol/l
0.85
167
1706
179
1762
1.06
0.12
4.9
4.0
5.9
5.8
mmol/l
0.25
164
1628
170
1672
1.06
0.12
6.2
4.9
39.5
39.0
mmol/mol
0.22
162
1568
5
45
1.11
0.10
1.8
2.0
38.2
8.9
e6/l
—
5
37
5
45
1.11
0.10
1.8
2.0
48.2
205.4
e6/l
—
5
38
24
258
0.92
0.10
1.5
1.5
—
—
—
0
0
13
116
1.13
0.09
3.7
2.1
—
—
—
0
0
13
144
0.90
0.08
1.2
1.3
—
—
—
0
0
11
98
1.13
0.08
17.0
4.1
—
—
—
0
0
6
70
0.85
0.07
1.3
1.5
—
—
—
0
0
6
70
0.85
0.07
1.3
1.5
—
—
—
0
0
182
1838
0.96
0.07
4.5
4.0
4.6
4.7
mmol/l
0.50
171
1722
10
90
1.12
0.05
2.9
2.3
—
—
—
0
0
168
1665
1.03
0.05
25.4
14.0
13.8
13.5
%
0.57
162
1635
185
1862
0.97
0.03
5.2
4.4
2.8
2.8
mmol/l
0.26
171
1736
178
1773
1.02
0.01
4.1
3.6
1.3
1.3
mmol/l
0.25
166
1646
10
99
1.01
0.00
1.4
1.7
—
—
—
0
0
181
1812
1.00
0.00
22.7
12.2
40.0
40.6
%
0.57
139
1432
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
4.0
—
—
—
0
0
0
6
0.00
0.00
0.0
5.8
—
12.1
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
7
72
0.97
0.00
1.4
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
2.3
—
55.7
—
0
7
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
3.6
—
0
6

Mortality – FinRegistry

Association

Association between endpoint H7_ORBITINFLAMACU and mortality.

Females

Parameter HR [95% CI] p-value
H7_ORBITINFLAMACU 1.673 [1.29, 2.17] < 0.001
Birth year 0.995 [0.99, 1.0] 0.21

During the follow-up period (1.1.1998 — 31.12.2019), 110 out of 905 females with H7_ORBITINFLAMACU died.

Males

Parameter HR [95% CI] p-value
H7_ORBITINFLAMACU 1.943 [1.47, 2.57] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 135 out of 1125 males with H7_ORBITINFLAMACU died.

Mortality risk

Mortality risk for people of age

years, who have H7_ORBITINFLAMACU.

N-year risk Females Males
1 0.162% 0.408%
5 0.981% 2.215%
10 2.452% 5.405%
15 4.582% 9.94%
20 7.866% 16.688%

Relationships between endpoints

Index endpoint: H7_ORBITINFLAMACU – Acute inflammation of orbit

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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