No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
241 |
4. Check minimum number of eventsNone |
241 |
5. Include endpointsNone |
241 |
6. Filter based on genotype QC (FinnGen only) |
241 |
Control definitions (FinnGen only)
- Control exclude
- H7_LIDLACRIMALORBIT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H05
- Name in latin
- Inflammatio orbitae acuta
Similar endpoints
↥List of similar endpoints to
Acute inflammation of orbit
based on the number of shared cases.
Similar with more cases:
- Disorders of orbit
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2945 | 1284 | 1650 |
| Only index persons | 2527 | 1123 | 1404 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.05 |
| Only index persons | 0.05 | 0.04 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 24.56 | 30.24 | 19.99 |
| Only index persons | 23.68 | 29.27 | 19.21 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 241 | 132 | 109 |
| Unadjusted period prevalence (%) | 0.05 | 0.04 | 0.05 |
| Median age at first event (years) | 43.10 | 40.65 | 46.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 216
- Matched controls
- 2160
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H05.0
ICD-10 Finland
Acute inflammation of orbit
+∞
210.3
166
*
H00.03
ICD-10 Finland
Preseptal cellulite in the eyelid
+∞
42.1
39
*
3760A
ICD-9 Finland
Disorders of the orbit, Acute inflammation of orbit
+∞
32.1
30
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
73.0
18.0
20
*
CAA00
NOMESCO Finland
Puncture of orbital abscess
+∞
14.7
14
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
11.7
14.2
26
25
H01.0
ICD-10 Finland
Blepharitis
9.4
12.7
26
31
H05.2
ICD-10 Finland
Exophthalmic conditions
+∞
12.6
12
*
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
13.5
12.4
21
17
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
+∞
11.6
11
*
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
+∞
11.6
11
*
36900
ICD-8 Finland
Other inflammatory diseases of eye, Abscessus orbitae
+∞
11.6
11
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.6
11.4
56
189
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.9
11.4
87
404
J01.0
ICD-10 Finland
Acute maxillary sinusitis
3.2
11.2
68
269
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
6.3
11.2
30
54
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
11.5
11.0
20
19
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
+∞
9.4
9
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.7
8.8
75
360
H57.1
ICD-10 Finland
Ocular pain
8.8
8.8
18
22
UDH02
NOMESCO Finland
Rhinopharyngoscopy
4.9
8.8
28
63
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
8.7
96
530
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
5.6
8.5
24
47
H02.4
ICD-10 Finland
Ptosis of eyelid
+∞
8.4
8
*
CA1BD
NOMESCO Finland
Extensive orbita CT
+∞
8.4
8
*
36902
ICD-8 Finland
Other inflammatory diseases of eye, Tenonitis
+∞
8.4
8
*
H05.9
ICD-10 Finland
Disorder of orbit, unspecified
+∞
8.4
8
*
DM1BD
NOMESCO Finland
Extensive CT of paranasal sinuses and face area
+∞
8.4
8
*
J31.0
ICD-10 Finland
Chronic rhinitis
4.4
8.2
29
73
H04.3
ICD-10 Finland
Acute and unspecified inflammation of lacrimal passages
34.8
8.1
10
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.6
8.0
71
347
TDM10
NOMESCO Finland
Puncture of maxillary antrum
6.6
7.7
19
31
CA1AD
NOMESCO Finland
Orbita CT
82.8
7.5
8
*
J01FF01
ATC
clindamycin; systemic
2.5
7.3
65
314
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
+∞
7.3
7
*
CCD60
NOMESCO Finland
Transnasal dacryocystorhinostomy
+∞
7.3
7
*
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
+∞
7.3
7
*
CA1DG
NOMESCO Finland
Eye and orbita very extensive MRI examination with high intensity magnet
+∞
7.3
7
*
J05AB11
ATC
valaciclovir; oral
3.6
7.3
33
104
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
4.8
7.2
23
52
R01AD09
ATC
mometasone; nasal
2.2
7.2
102
619
H02AB06
ATC
prednisolone; systemic
2.2
7.2
102
622
H04.10
ICD-10 Finland
Dry eye syndrome
5.8
7.1
19
35
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.2
6.8
37
132
XCK10
NOMESCO Finland
Photography of fundus of eye
3.6
6.6
29
89
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
4.7
6.6
21
48
J01DB01
ATC
cefalexin; oral
2.4
6.3
180
1453
WX002
NOMESCO Finland
Sedation and analgesia
2.8
6.3
42
170
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
6.3
6
*
H02.3
ICD-10 Finland
Blepharochalasis
+∞
6.3
6
*
ZXD05
NOMESCO Finland
Urgent procedure
2.2
6.3
74
411
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
8.1
6.2
13
17
UDM02
NOMESCO Finland
Sinoscopy
7.0
6.1
14
21
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.1
6.1
99
627
Mortality – FinRegistry
↥Association
Association between endpoint H7_ORBITINFLAMACU and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ORBITINFLAMACU | 1.673 [1.29, 2.17] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.21 |
During the follow-up period (1.1.1998 — 31.12.2019), 110 out of 905 females with H7_ORBITINFLAMACU died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ORBITINFLAMACU | 1.943 [1.47, 2.57] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 135 out of 1125 males with H7_ORBITINFLAMACU died.
Mortality risk
Mortality risk for people of age
years, who have H7_ORBITINFLAMACU.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.162% | 0.408% |
| 5 | 0.981% | 2.215% |
| 10 | 2.452% | 5.405% |
| 15 | 4.582% | 9.94% |
| 20 | 7.866% | 16.688% |
Relationships between endpoints
↥Index endpoint: H7_ORBITINFLAMACU – Acute inflammation of orbit
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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