Chronic inflammatory disorders of orbit

H7_ORBITINFLAMCHRON

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H05.1 Hospital discharge: ICD-9 — 3761 Cause of death: ICD-10 — H05.1 Cause of death: ICD-9 — 3761 2 out of 7 registries used, show all original rules.	101
4. Check minimum number of events None	101
5. Include endpoints None	101
6. Filter based on genotype QC (FinnGen only)	97

Control definitions (FinnGen only)

Control exclude: H7_LIDLACRIMALORBIT

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H05
Name in latin: Inflammatio orbitae chronica

NAME	H7_ORBITINFLAMCHRON
CONTROL_EXCLUDE	H7_LIDLACRIMALORBIT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H051
HD_ICD_9	3761
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H051
COD_ICD_9	3761
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Chronic inflammatory disorders of orbit based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	733	362	363
Only index persons	668	330	338
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	50.37	54.07	46.47
Only index persons	49.07	52.64	45.59

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	97	51	46
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	53.27	50.66	56.17

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
101: Matched controls
1010

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H05.1

ICD-10 Finland

Chronic inflammatory disorders of orbit

+∞

130.4

H05.2

ICD-10 Finland

Exophthalmic conditions

+∞

17.2

Z01.0

ICD-10 Finland

Examination of eyes and vision

6.0

16.6

CA1CG

NOMESCO Finland

Eye and orbita extensive MRI examination with high intensity magnet

+∞

16.1

H02AB06

ATC

prednisolone; systemic

6.2

15.7

344

CAA30

NOMESCO Finland

Biopsy of orbit

+∞

13.9

H04.10

ICD-10 Finland

Dry eye syndrome

11.6

12.3

H57.1

ICD-10 Finland

Ocular pain

15.4

10.6

XCK00

NOMESCO Finland

Perimetry

10.5

10.4

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

3.7

9.5

279

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic

3.5

8.6

216

D31.6

ICD-10 Finland

Benign neoplasm: Orbit, unspecified

+∞

8.4

3761A

ICD-9 Finland

Disorders of the orbit, Chronic inflammatory disorders of orbit

+∞

8.4

H02.4

ICD-10 Finland

Ptosis of eyelid

+∞

8.4

H01.0

ICD-10 Finland

Blepharitis

9.3

8.0

XCW99

NOMESCO Finland

Other investigative procedure of eye

5.1

7.8

H02AB07

ATC

prednisone; oral

4.2

7.4

H53.2

ICD-10 Finland

Diplopia

12.2

7.0

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

3.0

6.8

211

M60.9

ICD-10 Finland

Myositis, unspecified

74.3

6.5

S05.1

ICD-10 Finland

Contusion of eyeball and orbital tissues

28.7

6.3

H05.0

ICD-10 Finland

Acute inflammation of orbit

+∞

6.3

CA1DG

NOMESCO Finland

Eye and orbita very extensive MRI examination with high intensity magnet

+∞

6.3

CA1CM

NOMESCO Finland

Eye and orbita extensive MRI examination with 3 Tesla magnet

+∞

6.3

H06.2*E05.9

ICD-10 Finland

Dysthyroid exophthalmos

+∞

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

10.14

11.96

2.5

1.7

1.41

7.08

iu/l

—

(4062490) Immunoglobulin typing, IgG

24.80

11.06

1.6

1.3

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

22.40

8.70

1.4

1.8

3781.00

941.83

u/ml

—

(3005719) IgG [Mass/volume] in Serum or Plasma

4.59

8.35

2.1

2.0

10.81

9.89

g/l

0.33

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

7.34

7.32

1.8

1.3

—

(3037522) Nuclear Ab [Titer] in Serum

102

3.59

7.10

1.9

1.4

413.33

715.29

titre

—

(40760892) CBC W Ordered Manual Differential panel - Blood

376

2.68

5.44

12.3

6.1

—

(4035726) Immunohistochemistry procedure

3.47

5.37

1.5

1.4

—

(3018418) pH of Serum or Plasma

228

2.54

4.85

3.6

4.0

7.39

7.41

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

364

2.49

4.78

6.8

1.21

1.22

mmol/l

0.15

307

(3019832) Treponema pallidum Ab [Presence] in Serum

3.07

4.60

1.5

1.6

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

463

2.55

4.59

17.7

9.9

5.25

4.05

e9/l

3.03

401

(3001604) Monocytes [#/volume] in Blood

407

2.36

4.17

11.1

5.6

0.65

0.57

e9/l

1.41

350

(3006315) Basophils [#/volume] in Blood

408

2.35

4.14

11.1

5.6

0.04

e9/l

0.28

352

(3013115) Eosinophils [#/volume] in Blood

422

2.31

3.97

11.7

5.7

0.19

e9/l

0.01

376

(3019198) Lymphocytes [#/volume] in Blood

418

2.25

3.78

11.2

5.6

1.83

2.18

e9/l

0.62

374

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

4.61

3.63

2.4

2.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.72

3.61

2.0

1.5

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

4.44

3.52

1.7

1.5

0.30

0.25

g/l

0.59

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

6.10

3.41

1.8

3.0

—

(3044290) Cell count panel - Cerebral spinal fluid

6.10

3.41

1.7

1.1

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

4.28

3.41

1.6

1.5

1.42

1.17

g/l

1.38

(3013826) Glucose [Moles/volume] in Serum or Plasma

472

2.15

3.27

3.2

4.0

7.01

6.66

mmol/l

0.45

431

(3021601) Nitrite [Presence] in Urine by Test strip

388

2.08

3.20

5.0

4.9

0.00

estimate

-0.00

(3035350) Ketones [Presence] in Urine by Test strip

390

2.06

3.13

3.8

3.5

0.00

estimate

-0.00

(3037467) Urinalysis macro (dipstick) panel - Urine

550

2.18

3.07

5.5

4.1

—

(3009261) Glucose [Presence] in Urine by Test strip

393

2.03

3.04

3.8

3.6

0.00

estimate

-0.00

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

126

2.31

2.98

2.6

1.9

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

7.00

2.91

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

7.00

2.91

1.0

—

(4200892) Spirometry reversibility

2.96

2.84

1.5

1.2

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

8.68

2.78

1.2

1.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

6.30

2.74

1.0

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

619

2.14

2.64

5.4

3.8

14.65

14.66

pmol/l

0.02

563

(3029937) Albumin [Presence] in Urine by Test strip

203

2.02

2.63

4.2

3.7

0.00

estimate

-0.00

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.45

2.54

2.6

7.4

104.88

103.78

mmol/l

0.49

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.31

2.46

6.9

5.5

0.96

0.99

mmol/l

0.36

(3011397) Hemoglobin [Presence] in Urine by Test strip

175

2.02

2.46

3.9

3.1

—

(3026389) Candida sp identified in Specimen by Organism specific culture

6.50

2.40

1.0

1.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.30

2.34

1.6

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.30

2.34

1.6

1.7

—

(40768795) Lymph node Pathology biopsy report

5.77

2.24

1.0

1.1

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.81

2.22

2.0

1.6

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

3.88

2.19

1.4

1.3

407.43

393.79

mg/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

284

1.82

2.18

4.6

2.8

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.74

2.16

2.3

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

217

1.85

2.11

2.2

1.9

130.00

250.65

u/l

0.75

209

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.99

2.06

1.6

2.9

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

307

1.77

2.03

3.9

3.5

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

752

2.13

1.88

6.1

4.4

1.80

1.91

mu/l

0.36

682

(3021589) Normoblasts [#/volume] in Blood

378

1.71

1.86

13.6

9.7

0.00

0.01

e9/l

0.27

301

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

142

1.91

1.86

1.5

1.3

10.00

40.77

iu/ml

—

(3042631) Mycobacterium sp identified in Specimen

4.32

1.84

2.2

4.8

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

3.19

1.83

2.0

1.4

—

(3021440) Promyelocytes/100 leukocytes in Blood

2.30

1.80

4.7

4.6

0.14

0.35

—

(3017181) Myelocytes/100 leukocytes in Blood

2.23

1.80

4.6

4.4

1.13

1.14

—

(3044640) Blood type and Crossmatch panel - Blood

253

1.73

1.80

4.2

2.1

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

3.99

1.73

1.2

1.1

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

229

1.73

1.4

1.7

1.53

1.38

mmol/l

0.47

186

(3018095) Leukocytes [#/volume] in Urine

282

1.69

1.73

4.4

3.5

18.26

173.21

e6/l

0.89

190

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.40

1.70

2.5

1.7

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.93

1.68

1.1

1.2

—

(40761535) Cells panel - Urine sediment

2.35

1.63

6.8

3.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

3.70

1.63

1.0

1.1

—

(3003740) Influenza virus B Ag [Presence] in Specimen

3.70

1.63

1.0

1.1

—

(3023183) Ammonium ion [Moles/volume] in Plasma

3.70

1.63

1.2

4.9

28.60

32.14

umol/l

—

(3037756) Immunofixation for Serum or Plasma

3.70

1.63

1.2

1.1

—

(3002179) Metamyelocytes/100 leukocytes in Blood

2.25

1.62

4.8

4.5

2.43

0.47

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

2.02

1.61

1.9

1.6

1.20

1.33

0.43

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.81

1.61

2.0

1.2

—

(3022217) INR in Platelet poor plasma by Coagulation assay

352

1.63

1.58

15.0

13.2

1.36

1.27

inr

0.22

110

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.54

1.57

3.3

6.5

26.84

24.62

mmol/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

185

1.71

1.51

4.7

2.1

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

211

1.68

1.50

2.4

2.9

2105.19

1044.07

ng/l

0.47

177

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

424

1.59

1.47

9.0

6.4

9.55

10.69

umol/l

0.80

411

(3030467) Casts [#/volume] in Urine by Automated count

221

1.66

1.46

3.5

2.6

0.31

0.34

e6/l

0.07

155

(3025159) Blasts/100 leukocytes in Blood

2.13

1.45

3.6

4.5

0.00

0.40

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

129

1.79

1.44

3.0

2.5

0.28

1.24

e6/l

2.42

(3008898) HLA-B27 [Presence]

2.52

1.42

1.1

—

(36304419) Bacteria [Presence] in Urine

215

1.64

1.39

3.6

2.6

—

(3012544) pH of Venous blood

2.16

1.38

2.3

3.5

—

(3042936) Bacteria identified in Isolate by Culture

107

1.83

1.37

2.5

1.8

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

298

1.57

1.33

3.0

18.44

51.23

ng/l

1.42

189

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

2.20

1.32

7.4

3.2

1.44

1.88

mmol/l

—

(3022313) Gas panel - Capillary blood

2.39

1.30

10.9

2.9

—

(3011288) Drugs identified in Urine by Screen method

2.87

1.30

1.2

2.0

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

2.87

1.30

5.0

1.5

—

(3027315) Oxygen [Partial pressure] in Blood

2.87

1.30

4.0

3.1

9.08

8.59

kpa

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

2.87

1.30

5.0

1.5

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

2.87

1.30

2.0

1.2

—

(3013290) Carbon dioxide [Partial pressure] in Blood

2.87

1.30

4.0

3.1

5.30

4.99

kpa

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

102

1.80

1.26

1.4

1.7

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

285

1.53

1.21

1.6

1.8

106.06

101.61

pmol/l

0.21

153

(3023368) Bacteria identified in Blood by Culture

206

1.57

1.17

5.3

4.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

131

1.66

1.10

1.4

1.7

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.87

1.06

1.2

1.8

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.82

1.05

2.6

2.0

—

(3020891) Body temperature

2.34

1.04

4.4

4.3

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

126

1.63

1.00

3.5

2.7

1.47

3.48

e6/l

0.73

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

0.00

0.98

0.0

4.2

—

331.88

—

(40761536) Microorganisms panel - Urine sediment

1.78

0.93

4.7

3.8

—

(3002582) Erythrocytes [#/volume] in Urine

244

1.46

0.91

3.8

2.8

10.76

48.90

e6/l

1.49

178

(3020682) Albumin/Creatinine [Ratio] in Urine

235

1.46

0.91

3.7

3.8

5.55

9.02

mg/mmol

0.43

145

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.13

0.91

2.5

2.1

—

(3012516) Albumin [Mass/volume] in Urine

219

1.45

0.87

3.1

3.2

47.28

58.07

mg/l

0.11

134

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

848

1.74

0.86

22.3

12.5

23.63

21.55

mg/l

0.20

657

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

769

1.55

0.85

6.1

5.2

41.08

39.52

mmol/mol

0.74

721

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.93

0.83

5.7

2.4

—

(3002385) Erythrocyte distribution width [Ratio]

739

1.49

0.80

23.7

15.4

13.87

14.94

2.57

727

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.80

0.0

1.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

169

1.47

0.79

1.6

1.4

3.19

2.51

g/l

0.59

110

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.23

0.77

1.2

1.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.63

0.76

2.9

2.2

—

(3044889) 12 lead EKG panel

584

1.38

0.76

4.0

3.5

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.67

0.75

2.7

1.7

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.97

0.71

5.0

1.7

—

(3026782) Osmolality of Urine

155

1.45

0.70

3.1

2.8

568.52

569.07

mosm/kgh2o

0.00

134

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

138

1.46

0.69

1.6

—

(3041096) Erythrocytes [Presence] in Urine by Automated

230

1.37

0.65

3.3

—

(3000991) Gas panel - Venous blood

1.65

0.63

2.4

6.2

—

(40758558) Short blood count panel - Blood

205

1.36

0.61

14.7

6.8

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

888

1.60

0.59

24.1

14.8

79.04

76.01

umol/l

0.30

888

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

380

1.28

0.54

4.2

2.5

—

(3000494) Fungus identified in Specimen by Culture

1.47

0.53

3.5

1.3

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

800

1.39

0.53

17.9

12.2

83.67

82.95

ml/min/173m2

0.11

653

(3000492) Spirometry study

1.52

0.53

2.0

1.4

—

(3026493) Urate [Moles/volume] in Serum or Plasma

210

1.32

0.52

3.2

2.5

327.92

4260.71

umol/l

0.80

187

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.55

0.52

2.1

2.4

0.21

0.22

g/l

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.53

0.49

1.4

1.8

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.41

0.0

1.1

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.41

0.0

1.1

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.49

0.41

1.4

2.7

1.18

1.38

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.49

0.41

4.2

9.1

93.90

94.56

—

(40768443) Skin Pathology biopsy report

1.45

0.40

1.2

—

(40768797) Stomach Pathology biopsy report

116

1.34

0.40

1.1

1.2

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.39

0.0

1.7

—

(40768804) Tissue Pathology biopsy report

324

1.22

0.39

2.6

1.9

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.41

0.39

1.6

4.2

144.20

128.03

g/l

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.37

0.33

13.2

7.1

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

830

1.24

0.27

4.3

4.65

4.71

mmol/l

0.21

775

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.26

0.26

2.2

3.9

—

(3022145) Colonoscopy Study observation

1.30

0.25

1.3

1.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.30

0.25

1.5

1.7

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

162

1.21

0.25

2.4

1.9

—

(3002256) Pathology report gross observation

1.27

0.24

1.2

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

843

1.23

0.24

4.7

2.77

2.81

mmol/l

0.15

785

(1761868) Lipid panel - Serum or Plasma

308

1.16

0.23

2.5

2.7

—

(3019060) Gas panel - Arterial blood

1.26

0.23

3.6

5.0

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.21

0.0

1.4

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.3

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.21

0.0

1.1

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

541

0.88

0.20

2.9

3.2

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

804

1.18

0.20

4.9

4.3

6.58

5.90

mmol/l

1.01

747

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.24

0.20

1.7

1.6

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.20

0.0

1.4

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.19

0.20

1.0

1.6

—

(3025941) Bacteria identified in Stool by Culture

1.20

0.18

1.3

1.2

—

(3019225) pH of Specimen

1.21

0.17

11.4

4.0

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

159

1.16

0.16

1.9

2.8

0.66

0.69

ug/l

0.07

104

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.11

0.15

1.3

1.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

113

1.17

0.14

1.4

1.3

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

176

0.89

0.10

1.3

1.02

0.88

u/ml

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

826

1.10

0.08

4.3

4.2

1.37

1.47

mmol/l

1.28

765

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.04

0.07

1.4

1.8

—

(3026008) Bacteria identified in Urine by Culture

208

1.07

0.06

5.0

3.4

—

(40761511) CBC panel - Blood by Automated count

890

1.10

0.05

21.4

11.6

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

800

0.94

0.04

4.2

3.8

1.61

1.26

mmol/l

2.60

738

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

212

0.99

0.00

3.5

4.0

24.72

21.01

—

(3013512) EKG study

228

1.01

0.00

3.0

3.8

—

(3003694) ABO and Rh group [Type] in Blood

242

0.99

0.00

1.5

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

2.6

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

2.8

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.0

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

141.77

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.0

1.1

—

6.44

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.1

—

(3024731) MCV [Entitic volume]

937

1.05

-0.00

34.7

18.6

91.62

91.13

0.46

924

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

3.0

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.92

-0.00

1.2

1.4

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

4.0

—

60.60

—

(3035880) pH of Pleural fluid

0.00

-0.00

0.0

1.2

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

0.88

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

1.56

—

(3015183) Erythrocyte sedimentation rate

0.00

-0.00

0.0

1.0

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.2

—

(3020485) Acetaminophen [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

89.80

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3035941) MCH [Entitic mass]

936

1.06

-0.00

34.6

18.5

30.44

30.33

0.22

923

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3045788) Cell count panel - Pleural fluid

0.00

-0.00

0.0

1.5

—

(36660697) Celiac disease serology panel - Serum

0.95

-0.00

1.0

1.2

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

-0.00

0.0

1.0

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

18.59

—

(3000963) Hemoglobin [Mass/volume] in Blood

937

1.05

-0.00

35.0

18.7

135.09

136.61

g/l

0.42

922

(21494755) Public health laboratory ask at order entry panel

0.92

-0.00

1.3

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

2.2

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

-0.00

0.0

1.8

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_ORBITINFLAMCHRON and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_ORBITINFLAMCHRON	1.538 [1.15, 2.05]	0.004
Birth year	0.999 [0.99, 1.01]	0.863

During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 272 females with H7_ORBITINFLAMCHRON died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_ORBITINFLAMCHRON.

N-year risk	Females	Males
1	0.183%	No data
5	1.03%	No data
10	2.504%	No data
15	4.872%	No data
20	8.812%	No data

Relationships between endpoints

↥

Index endpoint: H7_ORBITINFLAMCHRON – Chronic inflammatory disorders of orbit

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Chronic inflammatory disorders of orbit

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints