No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
95 |
4. Check minimum number of eventsNone |
95 |
5. Include endpointsNone |
95 |
6. Filter based on genotype QC (FinnGen only) |
95 |
Control definitions (FinnGen only)
- Control exclude
- H7_LIDLACRIMALORBIT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H05
- Name in latin
- Inflammatio orbitae chronica
Similar endpoints
↥List of similar endpoints to
Chronic inflammatory disorders of orbit
based on the number of shared cases.
Similar with more cases:
- Disorders of orbit
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 733 | 362 | 363 |
| Only index persons | 668 | 330 | 338 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 50.37 | 54.07 | 46.47 |
| Only index persons | 49.07 | 52.64 | 45.59 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 95 | 52 | 43 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 49.88 | 47.05 | 53.29 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 85
- Matched controls
- 849
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H05.1
ICD-10 Finland
Chronic inflammatory disorders of orbit
+∞
107.6
79
*
H05.2
ICD-10 Finland
Exophthalmic conditions
+∞
15.0
14
*
H02AB06
ATC
prednisolone; systemic
6.1
12.9
65
295
Z01.0
ICD-10 Finland
Examination of eyes and vision
7.4
12.8
34
70
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
75.7
12.0
13
*
CAA30
NOMESCO Finland
Biopsy of orbit
+∞
11.7
11
*
H57.1
ICD-10 Finland
Ocular pain
22.4
10.7
15
8
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
4.4
9.6
51
215
XCK00
NOMESCO Finland
Perimetry
9.5
9.3
19
25
3761A
ICD-9 Finland
Disorders of the orbit, Chronic inflammatory disorders of orbit
+∞
8.5
8
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
4.1
8.4
42
163
H04.10
ICD-10 Finland
Dry eye syndrome
9.1
7.8
16
21
H01.0
ICD-10 Finland
Blepharitis
12.5
7.6
13
12
M60.9
ICD-10 Finland
Myositis, unspecified
+∞
7.4
7
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
6.4
6.6
17
32
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.2
6.4
17
33
H02.4
ICD-10 Finland
Ptosis of eyelid
+∞
6.3
6
*
A02BC02
ATC
pantoprazole; systemic
3.4
6.2
64
400
H53.2
ICD-10 Finland
Diplopia
9.1
6.1
12
15
Mortality – FinRegistry
↥Association
Association between endpoint H7_ORBITINFLAMCHRON and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ORBITINFLAMCHRON | 1.538 [1.15, 2.05] | 0.004 |
| Birth year | 0.999 [0.99, 1.01] | 0.863 |
During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 272 females with H7_ORBITINFLAMCHRON died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have H7_ORBITINFLAMCHRON.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.183% | No data |
| 5 | 1.03% | No data |
| 10 | 2.504% | No data |
| 15 | 4.872% | No data |
| 20 | 8.812% | No data |
Relationships between endpoints
↥Index endpoint: H7_ORBITINFLAMCHRON – Chronic inflammatory disorders of orbit
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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