Chronic inflammatory disorders of orbit

H7_ORBITINFLAMCHRON

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H05.1 Hospital discharge: ICD-9 — 3761 Cause of death: ICD-10 — H05.1 Cause of death: ICD-9 — 3761 2 out of 7 registries used, show all original rules.	95
4. Check minimum number of events None	95
5. Include endpoints None	95
6. Filter based on genotype QC (FinnGen only)	95

Control definitions (FinnGen only)

Control exclude: H7_LIDLACRIMALORBIT

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H05
Name in latin: Inflammatio orbitae chronica

NAME	H7_ORBITINFLAMCHRON
CONTROL_EXCLUDE	H7_LIDLACRIMALORBIT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H051
HD_ICD_9	3761
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H051
COD_ICD_9	3761
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Chronic inflammatory disorders of orbit based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	733	362	363
Only index persons	668	330	338
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	50.37	54.07	46.47
Only index persons	49.07	52.64	45.59

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	95	52	43
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	49.88	47.05	53.29

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
85: Matched controls
849

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H05.1

ICD-10 Finland

Chronic inflammatory disorders of orbit

+∞

107.6

H05.2

ICD-10 Finland

Exophthalmic conditions

+∞

15.0

H02AB06

ATC

prednisolone; systemic

6.1

12.9

295

Z01.0

ICD-10 Finland

Examination of eyes and vision

7.4

12.8

CA1CG

NOMESCO Finland

Eye and orbita extensive MRI examination with high intensity magnet

75.7

12.0

CAA30

NOMESCO Finland

Biopsy of orbit

+∞

11.7

H57.1

ICD-10 Finland

Ocular pain

22.4

10.7

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

4.4

9.6

215

XCK00

NOMESCO Finland

Perimetry

9.5

9.3

3761A

ICD-9 Finland

Disorders of the orbit, Chronic inflammatory disorders of orbit

+∞

8.5

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

4.1

8.4

163

H04.10

ICD-10 Finland

Dry eye syndrome

9.1

7.8

H01.0

ICD-10 Finland

Blepharitis

12.5

7.6

M60.9

ICD-10 Finland

Myositis, unspecified

+∞

7.4

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

6.4

6.6

XCW99

NOMESCO Finland

Other investigative procedure of eye

6.2

6.4

H02.4

ICD-10 Finland

Ptosis of eyelid

+∞

6.3

A02BC02

ATC

pantoprazole; systemic

3.4

6.2

400

H53.2

ICD-10 Finland

Diplopia

9.1

6.1

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

8.88

13.66

2.8

1.6

1.4

7.2

iu/l

—

(3005719) IgG [Mass/volume] in Serum or Plasma

4.90

8.63

2.2

2.1

11.0

10.0

g/l

0.31

(4062490)

19.35

8.32

1.8

1.3

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

6.39

7.28

2.0

1.3

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

16.36

6.03

1.4

1.8

4906.7

941.8

u/ml

—

(4035726)

3.89

5.98

1.5

1.4

—

(3037522) Nuclear Ab [Titer] in Serum

3.21

5.35

1.9

1.4

413.3

776.0

titre

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

5.28

5.15

2.4

—

(3019832) Treponema pallidum Ab [Presence] in Serum

3.00

4.24

1.5

1.6

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

432

2.48

4.14

18.1

10.0

5.2

4.1

e9/l

2.73

374

(3007853) Bacteria identified in Skin by Aerobe culture

2.93

4.05

2.0

1.5

—

(3035350) Ketones [Presence] in Urine by Test strip

361

2.34

3.95

3.8

3.6

0.0

estimate

0.00

(3021601) Nitrite [Presence] in Urine by Test strip

361

2.34

3.95

5.1

5.0

0.0

estimate

0.00

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

343

2.33

3.94

7.3

7.0

1.2

mmol/l

0.13

286

(3013826) Glucose [Moles/volume] in Serum or Plasma

442

2.37

3.78

3.2

4.0

6.9

6.7

mmol/l

0.32

402

(3009261) Glucose [Presence] in Urine by Test strip

366

2.29

3.77

3.8

3.7

0.0

estimate

0.00

(3018418) pH of Serum or Plasma

213

2.31

3.66

3.8

4.1

7.4

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

4.18

3.62

1.8

1.5

0.3

0.2

g/l

—

(3044290) Cell count panel - Cerebral spinal fluid

6.60

3.58

1.8

1.2

—

(42870588) Differential panel, method unspecified - Blood

256

2.24

3.58

10.7

5.0

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

6.13

3.42

1.8

3.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

516

2.36

3.36

5.5

4.1

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

9.04

3.31

1.0

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

3.87

3.29

1.7

1.5

1.2

g/l

—

(3029937) Albumin [Presence] in Urine by Test strip

191

2.21

3.20

4.2

3.9

0.0

estimate

0.00

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

7.91

3.10

1.0

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

7.91

3.10

1.0

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

10.45

3.01

1.2

1.0

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

157

2.22

2.95

4.0

3.3

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.51

2.87

6.9

5.7

1.0

mmol/l

0.38

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

288

1.98

2.68

3.9

3.6

—

(3026389) Candida sp identified in Specimen by Organism specific culture

7.46

2.58

1.0

1.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

166

2.08

2.53

9.3

5.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

121

2.19

2.48

2.8

1.9

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.98

2.47

2.3

2.4

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.98

2.47

2.0

1.5

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

3.57

2.46

1.6

3.2

—

(40768795) Lymph node Pathology biopsy report

6.52

2.40

1.0

1.1

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

203

1.96

2.35

2.1

1.8

131.6

256.5

u/l

0.72

195

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

4.11

2.30

1.4

1.2

407.4

402.2

mg/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

266

1.87

2.24

4.4

2.9

—

(3044640) Blood type and Crossmatch panel - Blood

233

1.88

2.18

4.3

2.2

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

582

1.98

2.13

5.5

3.7

14.6

14.7

pmol/l

0.04

531

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

3.69

2.10

2.0

1.5

—

(3032080) INR in Blood by Coagulation assay

272

1.81

2.05

8.8

8.4

1.4

1.3

inr

0.31

(3021440) Promyelocytes/100 leukocytes in Blood

2.44

2.01

4.7

4.6

0.1

0.4

—

(3017181) Myelocytes/100 leukocytes in Blood

2.35

1.99

4.6

4.4

1.0

1.3

—

(3042631) Mycobacterium sp identified in Specimen

4.73

1.96

2.2

5.3

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

132

1.98

1.96

1.5

1.3

10.0

43.4

iu/ml

—

(40761535) Cells panel - Urine sediment

2.57

1.93

6.8

3.4

—

(3018095) Leukocytes [#/volume] in Urine

260

1.77

1.88

4.2

3.6

18.8

188.4

e6/l

0.89

174

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.52

1.85

2.5

1.6

—

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.20

1.84

2.0

1.2

7.1

7.5

g/l

—

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.20

1.84

2.0

1.2

3.8

4.0

g/l

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.20

1.84

2.0

1.2

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

201

1.80

1.83

2.4

2.9

2105.2

971.1

ng/l

0.51

169

(3002179) Metamyelocytes/100 leukocytes in Blood

2.40

1.82

4.8

4.6

0.6

0.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.14

1.82

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

169

1.83

1.78

4.8

2.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.12

1.77

1.7

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

2.09

1.72

1.9

1.5

1.2

1.3

0.34

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

396

1.69

1.72

9.3

6.5

9.7

10.6

umol/l

0.58

385

(3021589) Normoblasts [#/volume] in Blood

351

1.67

1.65

13.5

9.8

0.0

e9/l

0.28

278

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

704

2.02

1.64

6.2

4.4

1.8

1.9

mu/l

0.15

639

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.63

1.64

3.3

6.7

26.8

24.6

mmol/l

—

(3037756) Immunofixation for Serum or Plasma

3.71

1.63

1.2

1.1

—

(3025159) Blasts/100 leukocytes in Blood

2.27

1.63

3.6

4.6

0.0

0.5

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

279

1.67

1.60

3.1

18.9

53.5

ng/l

1.38

175

(3012544) pH of Venous blood

2.31

1.57

2.3

3.6

—

(3030467) Casts [#/volume] in Urine by Automated count

205

1.68

1.44

3.2

2.7

0.3

e6/l

0.01

143

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.89

1.42

1.4

1.7

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

269

1.61

1.40

1.6

1.9

106.1

100.9

pmol/l

0.25

147

(3027315) Oxygen [Partial pressure] in Blood

3.04

1.37

4.0

3.2

9.1

8.6

kpa

—

(3013290) Carbon dioxide [Partial pressure] in Blood

3.04

1.37

4.0

3.2

5.3

4.9

kpa

—

(3011288) Drugs identified in Urine by Screen method

3.04

1.37

1.2

2.0

—

(36304419) Bacteria [Presence] in Urine

201

1.64

1.31

3.3

2.7

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

126

1.74

1.27

1.4

1.8

—

(4010399)

2.16

1.27

1.7

1.2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

119

1.75

1.23

2.6

2.5

0.2

1.1

e6/l

1.92

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.72

1.23

1.2

1.0

—

(3020891) Body temperature

2.72

1.23

4.4

4.7

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.97

1.20

1.3

1.8

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.90

1.18

2.6

1.9

—

(40761536) Microorganisms panel - Urine sediment

1.88

1.06

4.7

3.9

—

(3020682) Albumin/Creatinine [Ratio] in Urine

220

1.53

1.06

4.0

4.2

5.7

8.4

mg/mmol

0.31

136

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

2.01

1.06

8.0

3.3

1.3

1.9

mmol/l

—

(3022313) Gas panel - Capillary blood

2.14

1.05

12.1

3.0

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.34

1.04

1.2

1.1

—

(3007164) IgA [Mass/volume] in Serum or Plasma

159

1.59

1.04

1.6

1.4

3.2

2.5

g/l

0.64

102

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

212

1.53

1.04

1.4

1.7

1.6

1.4

mmol/l

0.51

172

(3023368) Bacteria identified in Blood by Culture

195

1.54

1.02

5.6

4.2

—

(3042936) Bacteria identified in Isolate by Culture

101

1.70

1.01

2.7

1.8

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

0.00

0.99

0.0

4.3

—

373.9

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.84

0.98

2.7

1.7

—

(3012516) Albumin [Mass/volume] in Urine

207

1.50

0.94

3.2

3.3

49.3

55.2

mg/l

0.06

124

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.22

0.93

2.5

2.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

217

1.48

0.92

3.3

3.4

—

(3008898) HLA-B27 [Presence]

2.14

0.91

1.2

1.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

349

1.42

0.90

5.7

4.0

—

(3002582) Erythrocytes [#/volume] in Urine

228

1.46

0.88

3.5

2.8

11.5

44.6

e6/l

1.15

164

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.70

0.86

2.9

2.1

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.00

0.86

5.7

2.4

—

(3002385) Erythrocyte distribution width [Ratio]

668

1.49

0.82

24.0

15.8

13.6

13.7

0.22

656

(3044889) 12 lead EKG panel

543

1.41

0.81

4.2

3.5

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.80

0.0

1.3

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.05

0.74

5.0

1.7

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

795

1.66

0.73

23.2

12.5

23.4

21.6

mg/l

0.16

614

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

119

1.52

0.73

3.0

2.7

1.7

3.3

e6/l

0.47

(3026782) Osmolality of Urine

146

1.47

0.71

3.1

2.7

577.5

573.9

mosm/kgh2o

0.03

125

(40758558) Short blood count panel - Blood

191

1.42

0.71

13.5

7.0

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

719

1.47

0.69

6.3

5.4

41.0

39.5

mmol/mol

0.63

675

(3001019) Free T4 and TSH panel - Serum or Plasma

1.68

0.68

1.4

1.8

—

(3000991) Gas panel - Venous blood

1.69

0.64

2.4

6.3

—

(3026493) Urate [Moles/volume] in Serum or Plasma

195

1.38

0.63

3.2

2.6

329.7

4600.5

umol/l

0.80

172

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.61

0.0

1.6

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.50

0.55

2.2

2.5

0.2

g/l

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

137

1.39

0.52

1.6

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.51

0.50

13.2

7.5

—

(40768797) Stomach Pathology biopsy report

111

1.42

0.50

1.1

1.2

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

830

1.57

0.49

25.0

14.7

79.8

76.2

umol/l

0.34

830

(1761868) Lipid panel - Serum or Plasma

290

1.27

0.46

2.5

2.7

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.65

0.44

1.4

2.9

1.2

1.4

—

(3000492) Spirometry study

1.48

0.43

1.9

1.4

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.59

0.43

4.2

9.5

93.9

94.4

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.54

0.42

1.6

4.5

144.2

127.8

g/l

—

(40768443) Skin Pathology biopsy report

1.54

0.42

1.2

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.41

0.0

1.1

—

(3022145) Colonoscopy Study observation

1.42

0.40

1.3

1.4

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.40

0.0

1.7

—

(3000494) Fungus identified in Specimen by Culture

1.40

0.40

3.7

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.40

0.40

2.2

3.9

—

(3019060) Gas panel - Arterial blood

1.41

0.39

3.6

4.7

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

751

1.31

0.38

18.6

12.1

83.4

83.1

ml/min/173m2

0.05

613

(46235355) HIV 1 and 2 tests - Meaningful Use set

156

1.27

0.34

2.4

1.9

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.37

0.34

1.5

1.8

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.35

0.31

1.6

2.8

7.5

8.4

umol/l

0.09

(3025941) Bacteria identified in Stool by Culture

1.32

0.31

1.3

1.2

—

(3019225) pH of Specimen

1.25

0.28

11.4

4.1

—

(40768804) Tissue Pathology biopsy report

309

1.16

0.23

2.6

1.9

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

145

1.21

0.22

1.9

2.8

0.6

0.7

ug/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

512

0.87

0.22

2.9

3.3

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.3

—

(3026008) Bacteria identified in Urine by Culture

194

1.17

0.21

5.0

3.5

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.29

0.21

1.7

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.21

0.0

1.1

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.21

0.0

1.4

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.27

0.20

1.0

1.6

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.20

0.0

1.4

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.20

0.0

1.1

—

(3002256) Pathology report gross observation

1.24

0.18

1.2

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

779

1.17

0.16

4.5

4.2

4.6

4.7

mmol/l

0.12

728

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

792

1.15

0.13

4.8

4.7

2.8

mmol/l

0.05

738

(3003694) ABO and Rh group [Type] in Blood

222

1.11

0.11

1.5

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

754

1.11

0.10

5.0

4.3

6.6

5.9

mmol/l

0.99

699

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.07

0.07

1.4

1.8

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

109

1.12

0.06

1.3

—

(3013512) EKG study

209

1.07

0.05

3.0

3.8

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

749

0.95

0.03

4.3

3.8

1.6

1.3

mmol/l

3.11

693

(40761511) CBC panel - Blood by Automated count

834

1.06

0.01

22.4

11.5

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

166

0.96

0.00

1.3

1.2

1.0

0.9

u/ml

—

(3009542) Hematocrit [Volume Fraction] of Blood

726

0.97

0.00

22.5

13.4

40.2

0.01

567

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

775

1.04

0.00

4.4

4.2

1.4

1.5

mmol/l

1.27

720

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

196

1.03

0.00

3.6

4.0

25.6

20.9

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.2

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

2.6

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.8

—

(3020876) Protein [Mass/time] in 24 hour Urine

0.00

0.0

1.6

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.4

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

0.9

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

0.0

1.2

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.0

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(3035880) pH of Pleural fluid

0.00

0.0

1.2

—

(21494755) Public health laboratory ask at order entry panel

0.92

0.00

1.3

—

(3000963) Hemoglobin [Mass/volume] in Blood

878

1.03

0.00

35.9

18.7

134.7

136.3

g/l

0.43

863

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.1

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

2.2

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

2.8

—

(36660697) Celiac disease serology panel - Serum

1.02

0.00

1.0

1.1

—

(3024731) MCV [Entitic volume]

878

1.03

0.00

35.6

18.6

91.6

91.1

0.40

865

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.0

1.1

—

6.4

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.00

0.00

1.4

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(4211845)

0.00

0.0

1.3

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(3035941) MCH [Entitic mass]

877

1.05

0.00

35.5

18.5

30.4

30.3

0.16

864

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.5

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

13.9

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.8

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_ORBITINFLAMCHRON and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_ORBITINFLAMCHRON	1.538 [1.15, 2.05]	0.004
Birth year	0.999 [0.99, 1.01]	0.863

During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 272 females with H7_ORBITINFLAMCHRON died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_ORBITINFLAMCHRON.

N-year risk	Females	Males
1	0.183%	No data
5	1.03%	No data
10	2.504%	No data
15	4.872%	No data
20	8.812%	No data

Relationships between endpoints

↥

Index endpoint: H7_ORBITINFLAMCHRON – Chronic inflammatory disorders of orbit

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Chronic inflammatory disorders of orbit

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints