Scleritis and episcleritis in diseases classified elsewhere

H7_SCLERITISINOTH

eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H19.0, H19.0A18.5, H19.0A52.79, H19.0A69.2, H19.0B02.3 Cause of death:* ICD-10 — H19.0, H19.0A18.5, H19.0A52.79, H19.0A69.2, H19.0*B02.3 2 out of 7 registries used, show all original rules.	40
4. Check minimum number of events None	40
5. Include endpoints None	40
6. Filter based on genotype QC (FinnGen only)	40

Control definitions (FinnGen only)

Control exclude: H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	H7_SCLERITISINOTH
CONTROL_EXCLUDE	H7_SCLERACORNEA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H190
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H190
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Scleritis and episcleritis in diseases classified elsewhere based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	307	186	120
Only index persons	289	176	113
Unadjusted period prevalence (%)
Whole population	0.00	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	57.81	59.47	55.41
Only index persons	55.85	56.90	54.22

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	40	25	15
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	62.22	56.50	71.77

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

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(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3042936) Bacteria identified in Isolate by Culture

3.56

2.95

1.9

2.0

—

(3023368) Bacteria identified in Blood by Culture

2.82

2.51

4.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

3.70

2.41

1.4

1.6

—

(3007853) Bacteria identified in Skin by Aerobe culture

3.44

2.24

2.2

1.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

3.73

2.24

1.0

1.6

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

149

2.53

2.08

2.3

2.0

105.1

96.8

pmol/l

0.27

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

5.02

2.00

1.6

5.0

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

3.63

1.98

1.0

1.8

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.31

1.82

1.6

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

187

2.37

1.71

9.0

7.0

1.2

mmol/l

1.16

154

(3022145) Colonoscopy Study observation

2.92

1.60

1.1

1.3

—

(3037467) Urinalysis macro (dipstick) panel - Urine

225

2.33

1.47

8.4

4.7

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.85

1.25

2.0

4.5

—

(3044640) Blood type and Crossmatch panel - Blood

110

1.95

1.16

2.4

2.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.00

1.13

2.3

2.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

121

1.89

1.08

7.3

3.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

158

1.87

1.08

3.9

4.0

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

105

1.87

1.02

2.6

2.1

57.7

53.8

u/l

0.22

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

2.43

0.98

1.8

2.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.13

0.96

1.3

1.2

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

125

1.80

0.95

1.9

3.4

2.3

2.4

mmol/l

0.97

102

(40760892) CBC W Ordered Manual Differential panel - Blood

1.95

0.94

10.0

6.1

—

(40768804) Tissue Pathology biopsy report

145

1.76

0.91

1.9

2.0

—

(40761535) Cells panel - Urine sediment

2.10

0.88

7.7

3.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

169

1.67

0.78

2.8

2.7

—

(1761868) Lipid panel - Serum or Plasma

103

0.51

0.75

6.3

3.3

—

(3030467) Casts [#/volume] in Urine by Automated count

1.71

0.74

3.5

3.0

0.6

0.3

e6/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.82

0.73

2.0

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.71

0.66

5.3

6.7

106.1

102.9

mmol/l

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

185

1.57

0.63

7.2

6.6

10.3

12.4

umol/l

0.67

171

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.62

0.0

1.8

—

(3019150) Specific gravity of Urine by Refractometry

1.69

0.59

14.9

4.7

—

1.0

—

(3012544) pH of Venous blood

1.68

0.57

4.7

2.9

—

(36304419) Bacteria [Presence] in Urine

1.57

0.55

3.3

3.0

—

(40768797) Stomach Pathology biopsy report

1.59

0.54

1.2

1.3

—

(3012516) Albumin [Mass/volume] in Urine

1.55

0.52

6.9

3.1

207.8

82.5

mg/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

116

1.47

0.46

16.7

4.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.64

0.44

1.2

1.7

—

(3015736) pH of Urine

118

1.43

0.42

12.5

3.8

—

(3013512) EKG study

118

1.43

0.42

2.9

4.2

—

(3044889) 12 lead EKG panel

237

1.43

0.40

3.8

4.2

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.44

0.39

2.4

3.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.47

0.39

14.5

4.1

—

(3019225) pH of Specimen

1.50

0.38

12.0

4.7

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

111

1.40

0.36

2.1

2.2

160.3

269.7

u/l

0.30

105

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.32

0.28

12.0

3.6

—

(3009542) Hematocrit [Volume Fraction] of Blood

298

1.37

0.25

18.3

16.0

36.3

38.5

0.35

189

(4035726)

1.32

0.24

1.2

1.4

—

(3026008) Bacteria identified in Urine by Culture

118

1.29

0.23

6.3

3.2

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.21

0.0

2.3

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.21

0.0

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.21

0.0

1.1

—

(1002224) Polysomnography panel

0.00

0.21

0.0

1.1

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.21

0.0

1.1

—

(3024928) Oxygen saturation in Venous blood

0.00

0.21

0.0

2.3

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.21

0.0

1.2

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

3.5

—

18.2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.21

0.20

10.0

8.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.13

0.10

2.2

1.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.10

0.10

2.2

1.6

—

(40761511) CBC panel - Blood by Automated count

353

0.93

0.10

22.7

14.1

—

(40758558) Short blood count panel - Blood

1.18

0.09

7.8

8.9

—

(42870588) Differential panel, method unspecified - Blood

113

1.09

0.02

9.8

5.2

—

(3032080) INR in Blood by Coagulation assay

147

0.93

0.02

6.0

10.9

1.1

1.3

inr

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.0

3.0

—

45.8

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

1.6

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.6

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

2.9

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.0

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.0

2.4

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.2

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

36.9

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3003694) ABO and Rh group [Type] in Blood

0.90

0.00

1.1

1.4

—

(4094501)

0.00

0.0

1.5

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

1.7

—

55.3

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

1.4

—

4.8

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.96

0.00

1.2

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

4.4

—

222.7

—

(4027681)

0.00

0.0

1.2

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.0

1.3

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

1.1

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

1.04

0.00

2.3

3.1

1.0

0.7

ug/l

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

5.0

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

0.00

0.0

1.5

—

36.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_SCLERITISINOTH and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_SCLERITISINOTH.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H7_SCLERITISINOTH – Scleritis and episcleritis in diseases classified elsewhere

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Scleritis and episcleritis in diseases classified elsewhere

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints