No definition available.
Keratitis and keratoconjunctivitis in other diseases classified elsewhere
DOID EFO Endpoint Browser PheWeb
H7_KERATITISINOTH
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1346 |
4. Check minimum number of eventsNone |
1346 |
5. Include endpointsNone |
1346 |
6. Filter based on genotype QC (FinnGen only) |
1346 |
Control definitions (FinnGen only)
- Control exclude
- H7_SCLERACORNEA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Keratitis and keratoconjunctivitis in other diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Keratitis
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9965 | 6270 | 3655 |
| Only index persons | 9295 | 5917 | 3378 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.18 | 0.10 |
| Only index persons | 0.19 | 0.22 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 57.25 | 57.87 | 56.25 |
| Only index persons | 56.48 | 57.07 | 55.45 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1346 | 894 | 452 |
| Unadjusted period prevalence (%) | 0.27 | 0.30 | 0.20 |
| Median age at first event (years) | 57.26 | 54.83 | 62.07 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1215
- Matched controls
- 12150
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H19.3*M35.0
ICD-10 Finland
Keratoconjunctivitis sicca
560.0
323.0
331
8
H19.2*B02.3
ICD-10 Finland
Keratitis and keratoconjunctivitis (interstitial) in zoster
+∞
323.0
417
*
S01AD03
ATC
aciclovir; ophthalmic
39.3
296.7
380
139
H19.2*B30.0
ICD-10 Finland
Epidemic keratoconjunctivitis
+∞
200.7
187
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
6.4
190.8
879
3531
H19.3
ICD-10 Finland
Keratitis and keratoconjunctivitis in other diseases classified elsewhere
+∞
178.6
167
*
H19.2
ICD-10 Finland
Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere
+∞
160.0
150
*
H04.10
ICD-10 Finland
Dry eye syndrome
7.8
130.2
336
569
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
21.6
121.2
182
98
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
146.4
101.9
107
8
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
1027.9
98.5
95
*
J05AB01
ATC
aciclovir; systemic
4.2
97.4
466
1555
H16.0
ICD-10 Finland
Corneal ulcer
28.1
95.0
131
52
B02.3
ICD-10 Finland
Zoster ocular disease
175.4
93.6
97
6
J05AB11
ATC
valaciclovir; oral
4.9
91.3
351
933
H16.9
ICD-10 Finland
Keratitis, unspecified
325.9
90.1
90
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
3.1
73.5
597
2872
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
4.1
59.2
259
745
H22.0*B02.3
ICD-10 Finland
Zoster iridocyclitis
+∞
58.8
56
*
P01BA02
ATC
hydroxychloroquine; oral
4.6
56.2
214
536
H16.2
ICD-10 Finland
Keratoconjunctivitis
149.3
54.3
57
*
B02.9
ICD-10 Finland
Zoster without complication
5.4
52.7
171
359
S01XA18
ATC
ciclosporin; ophthalmic
31.4
43.0
57
19
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.0
40.8
281
1119
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
5.0
38.9
132
288
S01GX01
ATC
cromoglicic acid; ophthalmic
2.6
36.8
328
1514
H02AB06
ATC
prednisolone; systemic
2.1
35.0
640
4161
H19.1
ICD-10 Finland
Herpesviral keratitis and keratoconjunctivitis
+∞
34.5
33
*
TCC40
NOMESCO Finland
Closure of lacrimal canaliculus with plug
35.0
34.2
44
13
CG2S4
NOMESCO Finland
Photography of cornea
78.5
34.0
38
5
H03.1*B02.3
ICD-10 Finland
Zoster blepharitis
28.2
30.3
41
15
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.0
30.1
195
730
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
3.3
30.0
165
551
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.1
29.1
477
2888
N03AX16
ATC
pregabalin; oral
2.2
28.3
343
1816
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
27.2
26
*
G53.0*B02.20
ICD-10 Finland
Trigeminal neuralgia after shingles
99.0
26.8
29
*
L04AX01
ATC
azathioprine; systemic
4.7
25.9
92
210
H01.0
ICD-10 Finland
Blepharitis
4.0
25.7
108
290
H57.1
ICD-10 Finland
Ocular pain
6.2
25.4
70
119
J01DB01
ATC
cefalexin; oral
2.1
24.0
991
8241
B00.5
ICD-10 Finland
Herpesviral ocular disease
85.1
22.7
25
*
H15.1
ICD-10 Finland
Episcleritis
23.4
22.7
32
14
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.4
22.6
115
362
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
20.9
527
3610
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
3.4
20.8
104
323
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
4.2
20.4
79
197
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
4.8
20.1
68
148
B02.8
ICD-10 Finland
Zoster with other complications
15.6
19.8
32
21
R06.0
ICD-10 Finland
Dyspnoea
2.0
19.7
323
1896
G53.0
ICD-10 Finland
Postzoster neuralgia
15.9
19.3
31
20
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
19.2
458
3057
CG2T4
NOMESCO Finland
Topography assessment of cornea
23.0
19.1
27
12
S01BC03
ATC
diclofenac; ophthalmic
5.8
18.9
54
97
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
7.8
18.7
43
57
B02
ICD-10 Finland
Zoster [herpes zoster]
4.1
18.4
72
182
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
44.7
18.3
22
5
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
3.5
18.1
86
257
S01AA01
ATC
chloramphenicol; ophthalmic (antibiotics)
3.3
17.9
94
303
H17.1
ICD-10 Finland
Other central corneal opacity
+∞
17.7
17
*
H10.4
ICD-10 Finland
Chronic conjunctivitis
10.6
17.7
34
33
N03AX12
ATC
gabapentin; oral
2.1
17.2
215
1126
N02AX02
ATC
tramadol; systemic, rectal
1.7
16.7
512
3645
ZXA05
NOMESCO Finland
Left side
1.8
16.6
321
1976
ZXE00
NOMESCO Finland
One hour or less
1.7
16.5
476
3325
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
6.0
16.4
45
77
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
16.3
176
862
A02BC02
ATC
pantoprazole; systemic
1.7
16.3
776
6236
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.8
16.2
110
419
H10.1
ICD-10 Finland
Acute atopic conjunctivitis
5.3
16.2
49
95
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
15.9
356
2300
S01AX11
ATC
[U] ofloxacin; ophthalmic
3.7
15.9
69
192
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.8
15.8
104
389
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
60.8
15.8
18
*
ZXA00
NOMESCO Finland
Right side
1.8
15.5
340
2173
H02AB04
ATC
methylprednisolone; systemic
2.1
15.5
201
1062
N02BE01
ATC
paracetamol; systemic, rectal
1.9
15.2
1026
9035
S01ED51
ATC
timolol, combinations; ophthalmic
2.7
15.2
109
432
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.0
15.1
226
1263
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
6.2
15.1
40
66
A02BC01
ATC
omeprazole; systemic
1.8
15.0
347
2252
H10.5
ICD-10 Finland
Blepharoconjunctivitis
5.6
14.9
43
79
J01MA02
ATC
ciprofloxacin; systemic
1.7
14.8
462
3271
ZXD10
NOMESCO Finland
Scheduled procedure
1.7
14.8
470
3350
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.6
14.7
68
199
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.5
14.7
119
504
H22.0*B00.5
ICD-10 Finland
Herpesviral iridocyclitis
+∞
14.6
14
*
CCC00
NOMESCO Finland
Occlusion of lacrimal punctum or canaliculus
+∞
14.6
14
*
H16.8
ICD-10 Finland
Other keratitis
+∞
14.6
14
*
286
Kela drug reimbursment
Ciclosporin eye drop
81.1
14.6
16
*
R51.80
ICD-10 Finland
Headache
2.1
14.4
187
987
S01GX05
ATC
lodoxamide; ophthalmic
5.6
14.3
41
75
E0000UV
ATC
NA
1.6
14.3
469
3360
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.8
14.2
264
1596
J01AA02
ATC
doxycycline; systemic
1.7
14.1
922
7899
A07EC01
ATC
sulfasalazine; oral, rectal
2.5
14.1
117
502
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
14.1
286
1776
A02BC03
ATC
lansoprazole; oral
1.7
13.8
362
2431
H03.1
ICD-10 Finland
Involvement of eyelid in other infectious diseases classified elsewhere
54.0
13.8
16
*
A07AA02
ATC
nystatin; oral
2.7
13.8
97
380
H16.1
ICD-10 Finland
Other superficial keratitis without conjunctivitis
+∞
13.6
13
*
L04AA01
ATC
[U] ciclosporin; systemic
5.7
13.5
38
68
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.2
13.5
72
236
F29
ICPC
Eye symptom/complaint other
2.5
13.4
108
457
H02AB07
ATC
prednisone; oral
2.0
13.4
184
996
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
13.3
451
3246
R03AC02
ATC
salbutamol; inhalant
1.6
13.1
612
4763
S01GX08
ATC
ketotifen; ophthalmic
3.5
13.0
60
176
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
12.9
407
2864
L04AA13
ATC
leflunomide; oral
4.3
12.9
47
112
S01ED01
ATC
timolol; ophthalmic
3.5
12.9
61
183
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
4.7
12.9
43
94
M79.6
ICD-10 Finland
Pain in limb
1.6
12.7
417
2965
H18.8
ICD-10 Finland
Other specified disorders of cornea
70.6
12.6
14
*
Z3231
NOMESCO Finland
Registered nurse
1.7
12.5
322
2142
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
2.8
12.5
82
309
B30.0
ICD-10 Finland
Keratoconjunctivitis due to adenovirus
131.3
12.5
13
*
H17.8
ICD-10 Finland
Other corneal scars and opacities
131.3
12.5
13
*
H13.1*B02.3
ICD-10 Finland
Zoster conjunctivitis
131.3
12.5
13
*
S01KA02
ATC
hypromellose; ophthalmic
4.4
12.5
44
102
L88
ICPC
Rheumatoid/seropositive arthritis
3.2
12.3
63
201
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
4.0
12.2
48
123
TDM10
NOMESCO Finland
Puncture of maxillary antrum
3.2
12.1
63
203
H01.80
ICD-10 Finland
Prolonged inflammation in the edge of the eyelid
12.5
12.1
21
17
J01MA12
ATC
levofloxacin; systemic
1.8
12.1
219
1303
L04AA11
ATC
[U] etanercept; parenteral
21.5
12.0
17
8
S01FA04
ATC
cyclopentolate; ophthalmic
9.7
11.8
23
24
J01FA10
ATC
azithromycin; systemic
1.5
11.8
650
5213
Z2221
NOMESCO Finland
Medical doctor
1.7
11.7
323
2184
M25.5
ICD-10 Finland
Pain in joint
1.7
11.7
323
2184
A02BC05
ATC
esomeprazole; systemic
1.6
11.7
476
3552
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
11.6
562
4366
SBA10
NOMESCO Finland
Measurement of excretion of saliva
7.6
11.5
26
35
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
121.1
11.4
12
*
R06AE07
ATC
cetirizine; oral
1.5
11.4
507
3857
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.1
11.3
126
624
H11.1
ICD-10 Finland
Conjunctival degenerations and deposits
9.7
11.3
22
23
R50.9
ICD-10 Finland
Fever, unspecified
2.0
11.3
158
856
TEA00
NOMESCO Finland
Biopsy of lip
7.7
11.2
25
33
N06AX21
ATC
duloxetine; oral
2.1
11.1
138
714
N06AX11
ATC
mirtazapine; oral
1.6
11.1
370
2620
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.0
11.1
157
856
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.3
11.0
106
491
L04AA06
ATC
mycophenolic acid; systemic
5.4
10.9
32
61
XCH00
NOMESCO Finland
Eye pressure measurement
3.0
10.9
63
219
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
10.9
317
2167
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
3.9
10.8
44
117
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
10.8
216
1324
J01FF01
ATC
clindamycin; systemic
1.6
10.8
308
2097
ELA30
NOMESCO Finland
Biopsy of salivary gland
28.3
10.7
14
5
F01
ICPC
Eye pain
4.3
10.7
39
94
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.8
10.6
68
253
H18.4
ICD-10 Finland
Corneal degeneration
60.5
10.6
12
*
H13.1
ICD-10 Finland
Conjunctivitis in infectious and parasitic diseases classified elsewhere
60.5
10.6
12
*
ZXA10
NOMESCO Finland
Bilateral
1.7
10.6
224
1398
J01FA06
ATC
roxithromycin; oral
1.5
10.6
465
3507
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
3.2
10.6
54
173
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.1
10.5
127
649
A01AB09
ATC
miconazole; local oral
2.1
10.4
124
629
R05
ICD-10 Finland
Cough
1.7
10.4
228
1439
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.2
10.3
106
507
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
4.6
10.2
34
75
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
10.2
154
858
S01GX09
ATC
olopatadine; ophthalmic
3.5
10.2
46
134
J01DA01
ATC
[U] cefalexin; systemic
1.5
10.1
725
6058
H10
ICD-10 Finland
Conjunctivitis
2.5
10.0
75
306
H03.1*B00.5
ICD-10 Finland
Herpesviral dermatitis of eyelid
14.7
10.0
16
11
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
3.6
10.0
44
126
H13.1*B30.1
ICD-10 Finland
Conjunctivitis due to adenovirus
40.4
10.0
12
*
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.6
9.8
304
2101
H03AA01
ATC
levothyroxine sodium; systemic
1.6
9.8
289
1971
L04AB01
ATC
etanercept; parenteral
5.2
9.7
29
57
Z3229
NOMESCO Finland
Other healthcare associate professional
2.1
9.7
108
532
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
5.4
9.7
28
53
R03AC03
ATC
terbutaline; inhalant
1.8
9.7
172
1013
WX110
NOMESCO Finland
Local anesthesy
1.5
9.7
753
6375
CBG00
NOMESCO Finland
Epilation of cilia by electrolysis
55.4
9.7
11
*
M05BA04
ATC
alendronic acid; oral
2.0
9.6
123
646
TCC10
NOMESCO Finland
Probing of lacrimal canaliculus/duct
9.2
9.5
19
21
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.2
9.5
95
446
WX002
NOMESCO Finland
Sedation and analgesia
1.7
9.5
223
1434
7102B
ICD-9 Finland
Diffuse diseases of connective tissue, Sicca syndrome[SYNDROMA SICCUM SECUNDARIUM]
100.8
9.4
10
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.7
9.4
199
1239
H20.8
ICD-10 Finland
Other iridocyclitis
+∞
9.4
9
*
H16.4
ICD-10 Finland
Corneal neovascularization
+∞
9.4
9
*
H15.0
ICD-10 Finland
Scleritis
+∞
9.4
9
*
N06AB04
ATC
citalopram; systemic
1.6
9.4
251
1671
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
8.1
9.4
20
25
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
9.4
307
2150
G44.2
ICD-10 Finland
Tension-type headache
1.8
9.2
155
898
R53
ICD-10 Finland
Malaise and fatigue
1.6
9.2
242
1601
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.5
9.2
362
2649
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.1
9.1
109
557
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
3.1
9.1
49
164
XCK10
NOMESCO Finland
Photography of fundus of eye
1.9
9.1
125
675
ZX120
NOMESCO Finland
Intravenous
2.0
9.0
108
553
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.9
8.9
135
754
M79.7
ICD-10 Finland
Fibromyalgia
3.0
8.9
51
176
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.0
8.9
109
560
G73.7*M35.0
ICD-10 Finland
Myopathy in sicca syndrome [Sjögren]
24.2
8.9
12
5
G53.0*B02.21
ICD-10 Finland
Postherpetic geniculate ganglionitis
24.2
8.9
12
5
Z2446
NOMESCO Finland
Social worker
2.3
8.8
78
347
A06AC01
ATC
ispaghula (psylla seeds); oral
1.6
8.8
289
2021
P01AB01
ATC
metronidazole; oral, rectal
1.5
8.8
437
3357
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.5
8.7
340
2474
E000001
ATC
NA
1.6
8.7
237
1581
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
8.7
508
4028
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
8.7
180
1115
M01CB01
ATC
sodium aurothiomalate; parenteral
4.4
8.6
30
70
J01FA09
ATC
clarithromycin; systemic
1.5
8.6
347
2540
J01MA14
ATC
moxifloxacin; systemic
2.0
8.6
107
554
J01AA07
ATC
tetracycline; systemic
1.7
8.6
173
1060
XCK00
NOMESCO Finland
Perimetry
2.2
8.6
89
425
ZXE20
NOMESCO Finland
More than three and less than five hours
1.8
8.5
156
930
M01CB03
ATC
auranofin; oral
6.5
8.5
21
33
S01GX04
ATC
nedocromil; ophthalmic
3.8
8.5
34
91
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.9
8.5
127
706
Z94.7
ICD-10 Finland
Corneal transplant status
90.6
8.4
9
*
H192, B005
ICD-10 Finland
NA
+∞
8.3
8
*
S18
ICPC
Laceration/cut
1.5
8.3
454
3540
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.6
8.3
60
239
N06AA09
ATC
amitriptyline; systemic
1.9
8.3
128
719
M54.4
ICD-10 Finland
Lumbago with sciatica
1.7
8.3
181
1136
XX9XE
NOMESCO Finland
Other ultrasound examination
7.1
8.3
19
27
H02AB09
ATC
hydrocortisone; systemic
3.6
8.2
35
99
S01EC04
ATC
brinzolamide; ophthalmic
2.8
8.2
50
183
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
4.2
8.1
29
70
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
33.6
8.1
10
*
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
3.8
8.1
32
85
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.0
8.0
96
488
N06AX16
ATC
venlafaxine; oral
1.8
8.0
153
922
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.1
8.0
90
449
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.8
8.0
127
722
M01AH01
ATC
celecoxib; oral (coxibs)
1.6
8.0
211
1396
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.0
8.0
102
535
R52.9
ICD-10 Finland
Pain, unspecified
2.0
8.0
100
521
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.2
7.9
82
392
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
7.9
444
3472
N03AX09
ATC
lamotrigine; oral
2.8
7.9
50
185
S70
ICPC
Herpes zoster
3.2
7.9
39
124
R4110
NOMESCO Finland
Physiotherapy
1.5
7.9
296
2131
R03BA02
ATC
budesonide; inhalant
1.6
7.8
195
1266
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
4.2
7.8
28
68
M45
ICD-10 Finland
Ankylosing spondylitis
4.0
7.8
29
73
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.9
7.7
116
647
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
7.7
231
1576
H25.1
ICD-10 Finland
Senile nuclear cataract
1.5
7.7
281
2007
R20.2
ICD-10 Finland
Paraesthesia of skin
2.2
7.7
78
371
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
2.4
7.6
65
285
J02AC01
ATC
fluconazole; systemic
1.4
7.6
456
3604
N03AF01
ATC
carbamazepine; oral, rectal
2.3
7.6
68
307
7102A
ICD-9 Finland
Diffuse diseases of connective tissue, Sicca syndrome[SYNDROMA SICCUM PRIMARIUM]
25.2
7.6
10
*
UJF32
NOMESCO Finland
Coloscopy
1.5
7.6
282
2022
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.2
7.5
77
368
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
7.2
7.5
17
24
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.7
7.5
150
919
TCF00
NOMESCO Finland
Subconjunctival therapeutic injection
80.6
7.4
8
*
L04AA17
ATC
[U] adalimumab; parenteral
13.4
7.4
12
9
L04AD01
ATC
ciclosporin; systemic
4.0
7.4
28
72
Z3226
NOMESCO Finland
Physiotherapist
1.6
7.4
208
1399
S76
ICPC
Skin infection other
2.4
7.3
61
266
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
3.6
7.3
31
88
S01EC01
ATC
acetazolamide; systemic
3.6
7.3
31
88
H18.2
ICD-10 Finland
Other corneal oedema
+∞
7.3
7
*
H22.0
ICD-10 Finland
Iridocyclitis in infectious and parasitic diseases classified elsewhere
+∞
7.3
7
*
SPAT1301
SPAT
No procedures
1.5
7.3
347
2617
127
Kela drug reimbursment
Transplant complication
4.5
7.3
24
54
N05CF01
ATC
zopiclone; oral
1.4
7.3
364
2774
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
3.2
7.2
35
110
R01AD09
ATC
mometasone; nasal
1.4
7.2
488
3936
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.0
7.2
86
440
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
7.2
214
1456
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.6
7.2
224
1544
NDG77
NOMESCO Finland
Other excision, reconstruction or fusion of joint of first finger
30.2
7.2
9
*
R06AX27
ATC
desloratadine; oral
1.5
7.1
285
2071
CD2S4
NOMESCO Finland
Photography of eye
20.1
7.1
10
5
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.4
7.1
558
4611
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.7
7.1
145
893
M54.5
ICD-10 Finland
Low back pain
1.4
7.1
358
2733
K11.70
ICD-10 Finland
Hypoptyalism
6.1
7.1
18
30
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.8
7.1
45
167
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.8
7.0
124
727
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
1.9
7.0
95
511
A01AB04
ATC
amphotericin B; local oral
2.2
7.0
66
303
H00.1
ICD-10 Finland
Chalazion
2.7
7.0
46
177
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.7
7.0
144
889
B07.9
ICD-10 Finland
Verruca simplex
2.7
7.0
45
170
F45.8
ICD-10 Finland
Other somatoform disorders
2.2
7.0
71
339
B00.10
ICD-10 Finland
Herpes simplex facialis
6.4
6.9
17
27
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.6
6.9
213
1458
H26.2
ICD-10 Finland
Complicated cataract
5.5
6.9
19
35
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.9
6.9
96
523
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.8
6.8
121
713
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
6.8
576
4810
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
6.7
6.8
16
24
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
6.8
340
2586
H00.03
ICD-10 Finland
Preseptal cellulite in the eyelid
11.0
6.8
12
11
S01EE01
ATC
latanoprost; ophthalmic
2.1
6.8
77
387
CJB10
NOMESCO Finland
Laser discission of secondary cataract
1.9
6.8
93
501
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
3.4
6.8
31
94
S01GX02
ATC
levocabastine; ophthalmic
2.1
6.8
72
352
XKD00
NOMESCO Finland
Uroflowmetry
1.7
6.8
145
906
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
22.6
6.7
9
*
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
22.6
6.7
9
*
K11.2
ICD-10 Finland
Sialoadenitis
2.8
6.7
40
146
M04AA01
ATC
allopurinol; systemic
1.7
6.6
129
781
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
4.2
6.6
23
55
Z01.2
ICD-10 Finland
Dental examination
1.4
6.6
420
3331
F02
ICPC
Red eye
2.5
6.6
47
189
ACC51
NOMESCO Finland
Release of median nerve
2.0
6.6
80
413
SBB10
NOMESCO Finland
Teeth copy
2.2
6.6
66
313
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.6
6.6
46
182
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.1
6.6
68
328
SAA04
NOMESCO Finland
Special inverstigation of mouth
2.2
6.6
63
293
D06BX01
ATC
metronidazole; topical
1.7
6.5
122
732
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.0
6.5
85
448
M03BX02
ATC
tizanidine; oral
1.4
6.5
669
5747
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.9
6.5
87
466
N80.0
ICD-10 Finland
Endometriosis of uterus
3.2
6.5
32
103
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
6.2
6.5
16
26
SXA10
NOMESCO Finland
Epithel biopsy of mouth
5.4
6.5
18
34
D07AB02
ATC
hydrocortisone butyrate; topical
1.4
6.5
297
2218
D06BB03
ATC
aciclovir; topical
2.2
6.4
60
277
SPAT1263
SPAT
Sampling
1.4
6.4
458
3706
R60.0
ICD-10 Finland
Localized oedema
1.7
6.4
119
713
M01AH02
ATC
rofecoxib; oral
1.6
6.4
154
993
6BA02
NOMESCO Finland
NA
14.4
6.4
10
7
H53.1
ICD-10 Finland
Subjective visual disturbances
2.1
6.4
72
362
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.8
6.4
113
665
F03
ICPC
Eye discharge
2.1
6.4
65
314
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.4
6.3
49
207
R06AX13
ATC
loratadine; oral
1.6
6.3
165
1083
N02AA05
ATC
oxycodone; systemic
1.6
6.3
162
1058
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.6
6.3
147
938
M05BA01
ATC
etidronic acid; systemic
6.0
6.3
16
27
E000002
ATC
NA
1.7
6.3
121
729
TCG10
NOMESCO Finland
Removal of sutures from cornea
9.3
6.3
12
13
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
3.1
6.3
32
106
WZA90
NOMESCO Finland
Other doctors statement
1.5
6.3
230
1638
H191, B023
ICD-10 Finland
NA
+∞
6.3
6
*
TCG30
NOMESCO Finland
Imaging of anterior and posterior part of cornea
+∞
6.3
6
*
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
6.3
6
*
H18.9
ICD-10 Finland
Disorder of cornea, unspecified
+∞
6.3
6
*
H16.3
ICD-10 Finland
Interstitial and deep keratitis
+∞
6.3
6
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
6.2
222
1572
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.8
6.2
107
625
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.9
6.2
83
445
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
6.2
741
6501
SCA01
NOMESCO Finland
Simple analysis and advice of nutrition with regard to dentistry
1.5
6.2
276
2047
SAA03
NOMESCO Finland
Extended examination of mouth
1.4
6.2
386
3051
C08CA05
ATC
nifedipine; systemic
2.0
6.2
74
380
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
6.1
421
3378
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
3.6
6.1
25
70
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.4
6.1
311
2366
R03AK07
ATC
formoterol and budesonide; inhalant
1.5
6.1
194
1338
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.4
6.1
323
2475
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.7
6.1
127
786
Z71.8
ICD-10 Finland
Other specified counselling
1.5
6.1
245
1782
R03DC03
ATC
montelukast; oral
1.6
6.1
174
1172
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
8.6
6.1
12
14
N06AB10
ATC
escitalopram; oral
1.5
6.0
206
1442
Mortality – FinRegistry
↥Association
Association between endpoint H7_KERATITISINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_KERATITISINOTH | 1.172 [1.06, 1.3] | 0.003 |
| Birth year | 0.997 [0.99, 1.01] | 0.498 |
During the follow-up period (1.1.1998 — 31.12.2019), 1256 out of 5773 females with H7_KERATITISINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_KERATITISINOTH | 1.287 [1.12, 1.47] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 808 out of 3332 males with H7_KERATITISINOTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_KERATITISINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.122% | 0.217% |
| 5 | 0.79% | 1.381% |
| 10 | 1.877% | 3.322% |
| 15 | 3.525% | 6.138% |
| 20 | 6.137% | 10.284% |
Relationships between endpoints
↥Index endpoint: H7_KERATITISINOTH – Keratitis and keratoconjunctivitis in other diseases classified elsewhere
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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